Ischemic and hemorrhagic disturbances in cerebral circulation alter contractile responses of the rat middle cerebral artery.

abstract：:Two distinct serotonin receptors in mammalian brain are labeled respectively with [3H]serotonin (5-HT1) and [3H]spiperone (5-HT2). In general agonists display highest affinities for 5-HT1 while antagonists prefer 5-HT2 sites. To conduct regional studies of 5-HT receptors, we estimated 5-HT2 sites with [3H]spiperone, u...

journal_title：Brain research

authors： Peroutka SJ,Snyder SH

更新日期：1981-03-16 00:00:00

abstract：:Neuronal expression of brain-derived neurotrophic factor (BDNF) has been implicated in the mechanism of infarct tolerance (resistance to stroke) (H. Yanamoto et al., Infarct tolerance accompanied enhanced BDNF-like immunoreactivity in neuronal nuclei, submitted to Brain Res.), a process that takes more than 7 days fol...

journal_title：Brain research

authors： Yanamoto H,Nagata I,Sakata M,Zhang Z,Tohnai N,Sakai H,Kikuchi H

更新日期：2000-03-24 00:00:00

abstract：:Hippocampal CA1 pyramidal neurons undergo delayed neurodegeneration after transient forebrain ischemia, and the phenomenon is dependent upon hyperactivation of l-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subtype of glutamate receptors, resulting in aberrant intracellular calcium influx. The GluR2 sub...

journal_title：Brain research

authors： Kaur J,Zhao Z,Geransar RM,Papadakis M,Buchan AM

更新日期：2006-02-23 00:00:00

abstract：:Cholecystokinin octapeptide (CCK-8) is colocalized within a majority of dopamine (DA)-containing neurons of the rat midbrain. Exogenous CCK-8 can modulate the electrophysiological activity of DA neurons, at least in part, by direct actions on the somatodendritic region of these cells. If CCK-8 is somatodendritically r...

journal_title：Brain research

authors： Freeman AS,Chiodo LA,Lentz SI,Wade K,Bannon MJ

更新日期：1991-08-02 00:00:00

abstract：:This study used microdialysis to monitor extracellular levels of 5-HT and its metabolite, 5-hydroxyindole acetic acid (5-HIAA) in the lateral hypothalamus (LH) and hippocampus of freely moving rats that had developed a CTA to a 2.5 mM saccharin solution (CS) following its pairing with illness induced by lithium chlori...

journal_title：Brain research

authors： West HL,Mark GP,Hoebel BG

更新日期：1991-08-09 00:00:00

abstract：:To investigate the reversibility of neuronal functions during deep and mild hypothermia, we have examined changes in membrane properties of pyramidal neurons of the CA3 region of hippocampal slices during cooling and rewarming (8 approximately 37 degrees C) of the perfusion medium. Hypothermia reduced the excitatory p...

journal_title：Brain research

authors： Aihara H,Okada Y,Tamaki N

更新日期：2001-03-02 00:00:00

abstract：:We previously reported that angiotensin II type 2 (AT(2)) receptor signaling prevents neural damage and cognitive impairment after focal cerebral ischemia. We investigated the possible roles of the AT(2) receptor in the sex difference, focusing on cognitive function and ischemic brain damage using AT(2) receptor-defic...

journal_title：Brain research

authors： Sakata A,Mogi M,Iwanami J,Tsukuda K,Min LJ,Fujita T,Iwai M,Ito M,Horiuchi M

更新日期：2009-12-01 00:00:00

abstract：:Mouse VD-hemopressin(α) (VD-Hpα) is an undecapeptide that selectively activates CB1 cannabinoid receptor in in vitro functional tests, and exerts CB1-mediated central antinociception in the mouse tail-flick assay. The aim of the present study was to further investigate the analgesic properties of supraspinal mouse VD-...

journal_title：Brain research

authors： Zheng T,Zhang R,Zhang T,Zhang MN,Xu B,Song JJ,Li N,Tang HH,Wang P,Wang R,Fang Q

更新日期：2018-02-01 00:00:00

abstract：:Strychnine-sensitive, inhibitory glycine receptors have not until lately been considered to play a significant role in neurotransmission in mammalian forebrain regions. In order to investigate the role of glycine as a neurotransmitter in brain we have measured glycine induced chloride fluxes in different adult rat for...

journal_title：Brain research

authors： Engblom AC,Eriksson KS,Akerman KE

更新日期：1996-03-11 00:00:00

abstract：:This study was performed to understand the anatomical substrates of hypothalamic modulation of jaw movements. After cholera toxin B subunit (CTb) injection into the parvicellular reticular formation (RFp) of the rat medulla oblongata, where many trigeminal premotor neurons have been known to exist, numerous CTb-labele...

journal_title：Brain research

authors： Notsu K,Tsumori T,Yokota S,Sekine J,Yasui Y

更新日期：2008-12-09 00:00:00

abstract：:We examined the effect of prostaglandin (PG)E2 on the sleep-wake activity and on body temperature by microinjecting PGE2 into the preoptic area of rats that had been chronically implanted with guide cannulae and electrodes for the recordings of electroencephalogram and electromyogram. PGE2 at doses of 2.5 X 10(-13), 2...

journal_title：Brain research

authors： Matsumura H,Goh Y,Ueno R,Sakai T,Hayaishi O

更新日期：1988-03-22 00:00:00

abstract：:Non-specific convulsive behavior induced by intrathecal (IT) morphine microinjection appears to be tonically modulated by centrifugal pathways originating within the brain since the frequency of IT morphine-induced hindlimb seizures and myoclonic twitches are both increased following spinal transection. These effects ...

journal_title：Brain research

authors： Watkins LR,Frenk H,Miller J,Mayer DJ

更新日期：1984-09-24 00:00:00

abstract：:We have previously identified a cell senescence-related, detergent-insoluble cytoplasmic protein referred to as terminin, and have presented the development-dependent modification of terminin polypeptides in rat brain. In the present study, we characterize biochemically and immunocytochemically terminin expression in ...

journal_title：Brain research

authors： Yang G,Wang E

更新日期：1994-05-02 00:00:00

abstract：:The regional distribution of FLFQPQRFamide binding sites on fresh unfixed cryostate sections from post mortem specimens of human spinal cord and lower medulla oblongata was studied by quantitative autoradiographic methods using [125I]YLFQPQRFamide as ligand. Samples were taken from five cases who had died with no hist...

journal_title：Brain research

authors： Allard M,Jordan D,Zajac JM,Ries C,Martin D,Monkouanga D,Kopp N,Simonnet G

更新日期：1994-01-07 00:00:00

abstract：:Expression of the growth-associated protein GAP-43 is increased in the spinal cord of ALS patients and Wobbler (wr) mice, murine models of the disease. In this work we examined if expression of GAP-43 mRNA in control and wr mice was sensitive to steroid treatment. A group of control and wr mice received s.c. a 50 mg p...

journal_title：Brain research

authors： González Deniselle MC,Grillo CA,González S,Roig P,De Nicola AF

更新日期：1999-09-11 00:00:00

abstract：:High-affinity uptake of norepinephrine (NE) and dopamine (DA) were determined in synaptosomes of brain regions from four genetically related inbred rat strains, all derived from the Wistar-Kyoto rat: SHR, WKY, WKHA and WKHT strains. SHRs express hypertension and hyperactivity, WKHAs express hyperactivity alone, WKHTs ...

journal_title：Brain research

authors： Hendley ED,Fan XM

更新日期：1992-07-17 00:00:00

abstract：:The content of arginine vasopressin and oxytocin in various extrahypothalamic sites of the rat brain and spinal cord was determined by specific radioimmunoassays after lesions had been made in either the paraventricular (PVN), supraoptic (SON) or suprachiasmatic nuclei (SCN). In some animals all 3 nuclei were destroye...

journal_title：Brain research

authors： Hawthorn J,Ang VT,Jenkins JS

更新日期：1985-10-28 00:00:00

abstract：:Within 5 days after reduction of activity of the rat soleus muscle, there was remodelling of the neuromuscular junction. Post-synaptic clefts were shorter, wider, and flatter, whereas nerve terminals showed sprouting and longitudinal distortion. The results, which differ from those found after denervation or total dis...

journal_title：Brain research

authors： Fahim MA,Robbins N

更新日期：1986-09-24 00:00:00

abstract：:Symbolic visual cues indicating the location of an upcoming target are believed to invoke endogenous shifts of attention to cued locations. In the present study, we investigated how visual attention is shifted during such cuing paradigms by recording event-related potentials (ERPs). We focused on a component known to ...

journal_title：Brain research

authors： Woodman GF,Arita JT,Luck SJ

更新日期：2009-11-10 00:00:00

abstract：:The effects of infusing N-methyl-d-aspartate (NMDA) into the raphe nuclei on release of 5-HT in this brain region and also the frontal cortex of the same animal were studied using in vivo microdialysis in freely moving rats. Infusion of 25 microM NMDA into the raphe led to a substantial decrease in dialysate 5-HT in t...

journal_title：Brain research

authors： Pallotta M,Segieth J,Whitton PS

更新日期：1998-02-09 00:00:00

abstract：:The neural representation of facial expression within the human visual system is not well defined. Using an adaptation paradigm, we examined aftereffects on expression perception produced by various stimuli. Adapting to a face, which was used to create morphs between two expressions, substantially biased expression pe...

journal_title：Brain research

authors： Fox CJ,Barton JJ

更新日期：2007-01-05 00:00:00

abstract：:Multiple-unit activity (MUA) in the agranular medial prefrontal cortex (PFC) was recorded in conscious rabbits during a classical conditioning procedure involving repeated pairings of a 4-s tone conditioned stimulus (CS) with eye shock. Prior to behavioral training, significant tone-evoked increases in prefrontal MUA ...

journal_title：Brain research

authors： Gibbs CM,Powell DA

更新日期：1988-02-23 00:00:00

abstract：:To elucidate the intracellular mechanism of seizure discharge, phosphorylation of cellular protein during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. PTZ markedly enhanced the phosphorylation of proteins of 34,000 and 50,000 molecular weight. Similar effects were observed by a...

journal_title：Brain research

authors： Onozuka M,Imai S,Sugaya E

更新日期：1986-01-01 00:00:00

abstract：:A histo-enzymatic technique for visualizing and quantifying endogenous NAD(H) in brain tissue was developed, based on coupled enzymatic cycling reactions that reduce nitrotetrazolium blue chloride to produce formazan. Conditions were used where the endogenous level of nicotinamide adenine dinucleotides (NAD(H)) was th...

journal_title：Brain research

authors： Balan IS,Fiskum G,Kristian T

更新日期：2010-02-26 00:00:00

abstract：:Endothelins are potent vasoconstrictors and signaling molecules. Their effects are broad, impacting processes ranging from neurovascular and cardiovascular health to cell migration and survival. In stroke, traumatic brain injury or subarachnoid hemorrhage, endothelin-1 (ET-1) is induced resulting in cerebral vasospasm...

journal_title：Brain research

authors： Bickford JS,Ali NF,Nick JA,Al-Yahia M,Beachy DE,Doré S,Nick HS,Waters MF

更新日期：2014-11-07 00:00:00

abstract：:Several studies have demonstrated in the past that endogenous opioid peptides and opioid receptors may be involved as mediators of brain tissue growth and function in the neonate. Applying histological and autoradiographic methods, we have examined the effect of the mu-receptor-specific antagonist, naltrexone, on the ...

journal_title：Brain research

authors： Schmahl W,Funk R,Miaskowski U,Plendl J

更新日期：1989-05-08 00:00:00

abstract：:Pentobarbital-anesthetized rats received electrical hindpaw stimulation every 10 s to elicit a maximal hindlimb withdrawal reflex. The integrated EMG response in the ipsilateral tibialis anterior was sampled by a computer which also controlled the timing of electrical stimuli applied to the brain. A suppression of the...

journal_title：Brain research

authors： Duysens J,Dom R,Gybels J

更新日期：1989-10-09 00:00:00

abstract：:Unilateral injections of 1 microgram of kainic acid in the archistriatum of 5-day-old domestic chicks reduced fear, as expressed by distress calls (peeps), significantly more than did identical injections in the same structure on the left side. This result adds affective behavior to the growing list of functions that ...

journal_title：Brain research

authors： Phillips RE,Youngren OM

更新日期：1986-07-09 00:00:00

abstract：:Expertise offers a unique insight into how our brain functions. The purpose of this experiment was to determine if motor system activity and functional connectivity between the cognitive system and sensorimotor system is differentially modulated by an individual's level of expertise. This goal was achieved through the...

journal_title：Brain research

authors： Tomasino B,Maieron M,Guatto E,Fabbro F,Rumiati RI

更新日期：2013-12-02 00:00:00

abstract：:The purpose of this study was to compare the relative effects of mannitol and hypertonic saline (HTS) on calpain activity, apoptosis and neuroinflammatory response induced by experimental cortical contusion. Four groups of 5 Sprague-Dawley male rats were submitted to focal brain injury produced by exposing the parieta...

journal_title：Brain research

authors： Soustiel JF,Vlodavsky E,Zaaroor M

更新日期：2006-07-26 00:00:00