Abstract：
:Cholecystokinin octapeptide (CCK-8) is colocalized within a majority of dopamine (DA)-containing neurons of the rat midbrain. Exogenous CCK-8 can modulate the electrophysiological activity of DA neurons, at least in part, by direct actions on the somatodendritic region of these cells. If CCK-8 is somatodendritically released from DA neurons, it may influence DA cell function as has been shown for DA itself. In the present study, radioimmunoassay was used to determine if CCK-8 is released in vitro from slices of rat midbrain under basal and depolarizing (30 mM potassium) conditions. Low levels of CCK-8 were detected in the basal incubation medium. Thirty mM potassium caused about a 3-fold increase in the release of CCK-8. This stimulated release was abolished in calcium-free medium. The D2 receptor agonist quinpirole, but not the D1 agonist SKF 38393, attenuated the potassium-stimulated release of CCK-8 but did not affect basal release. These results show that CCK-8, like DA, can be released from midbrain slices, presumably from DA/CCK-8-containing neurons. This finding is in accordance with the possibility that CCK-8 plays a role in the regulation of DA neuronal function at the level of the cell body, where it might influence the excitability of the DA cell membrane.
journal_name
Brain Resjournal_title
Brain researchauthors
Freeman AS,Chiodo LA,Lentz SI,Wade K,Bannon MJdoi
10.1016/0006-8993(91)90353-wsubject
Has Abstractpub_date
1991-08-02 00:00:00pages
281-7issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90353-Wjournal_volume
555pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The misfolding and aggregation of the Aβ peptide - a fundamental event in the pathogenesis of Alzheimer׳s disease - can be instigated in the brains of experimental animals by the intracranial infusion of brain extracts that are rich in aggregated Aβ. Recent experiments have found that the peripheral (intraperitoneal) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.06.047
更新日期：2015-10-05 00:00:00
abstract：:We investigated the effect of repetitive transcranial magnetic stimulation (rTMS) on long-term potentiation (LTP) in the rat hippocampus. Rats were magnetically stimulated at a rate of 1000 pulses/day for 7 days by a round coil, in which the peak magnetic fields at the center of the coil were 0.75 and 1.00 T. LTP enha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.009
更新日期：2003-12-12 00:00:00
abstract：:Death receptors are associated with the homeostatic and pathologic induction of cell death. TR3 is a recently characterised member of the death receptor family that is expressed in the adult brain. In order to establish the role of TR3 in acute CNS disease and chronic neurodegeneration, we analysed brain regions from ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02417-8
更新日期：2000-02-28 00:00:00
abstract：:Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90665-6
更新日期：1984-01-16 00:00:00
abstract：:The suprachiasmatic nucleus (SCN) is involved in regulating many biological rhythms. Several lines of research implicate the SCN in affective behavior. The SCN is directly involved in regulating the daily rhythms of the hypothalamo-pituitary-adrenal (HPA) axis hormones involved in stress. Bilateral lesions of the SCN ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.063
更新日期：2004-03-19 00:00:00
abstract：:In the neonatal kitten, cuneate neurones activated by tactile stimulation of the forelimb foot pads are divisible into 3 functional classes each of which appears to receive its glabrous skin input selectively from a single class of tactile receptors. Their properties suggest that the functionally specific patterns of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90081-x
更新日期：1981-06-01 00:00:00
abstract：:Recently, this laboratory provided evidence that interleukin-1beta (IL-1beta), an immune and brain-derived cytokine, microinjected into the medial hypothalamus, potentiates defensive rage behavior in the cat elicited from the midbrain periaqueductal gray (PAG), and that such effects are blocked by a 5-HT2 receptor ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.086
更新日期：2005-06-28 00:00:00
abstract：:Levels of somatostatin-like immunoreactivity (SLI) were measured in the rat retina by radioimmunoassay during prenatal and postnatal development. SLI-containing cells were visualized by immunocytochemistry throughout this time period. SLI is present as early as embryonic day 15 (E15) and by E16 at concentrations 10-fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90209-4
更新日期：1987-08-01 00:00:00
abstract：:The projections of putative dopamine containing cells within the dorsal raphe nucleus (DR) were studied using a combination of tyrosine hydroxylase (TH) immunocytochemistry and fluorescent retrograde tracing. Substantial numbers of TH-immunoreactive cells in the DR were found to project to the nucleus accumbens. Progr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90239-8
更新日期：1990-03-12 00:00:00
abstract：:The conduction velocity and segmental distribution of afferent fibers in the rectal nerves of the female rat were determined. These afferent fibers had conduction velocities ranging from 0.5-23.5 m/s (Mode = 0.5 m/s; Median = 1 m/s). Sixty-six percent of the fibers had conduction velocities less than 2.5 m/s and were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91244-b
更新日期：1990-09-03 00:00:00
abstract：:The dmy rat is an autosomal recessive mutant that exhibits severe myelin destruction throughout the white matter of the central nervous system. Recently, a point mutation in intron 3 of the Mrs2 has been found in the dmy rat. Mrs2 encodes an essential component of the major electrophoretic Mg(2+) influx system in mito...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.009
更新日期：2011-05-10 00:00:00
abstract：:In an effort to further characterize the proteins of the auditory nerve, the effects of hair cell loss on rapidly transported proteins of the auditory nerve were studied. The effects were studied in the waltzing guinea pig, a genetically deaf animal which displays an age-dependent loss of sensory cells, and in normal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90693-x
更新日期：1982-12-16 00:00:00
abstract：:A water soluble benzodiazepine, clorazepate, has been used to establish the point of benzodiazepine proliferative arrest in the rat C6 glioma. Clorazepate inhibited C6 proliferation in a dose-dependent manner with an IC50 value of 280 microM, as judged by a nuclei counting procedure. Release of cells from a 48 h expos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91083-q
更新日期：1992-09-11 00:00:00
abstract：:The aim of the present study was to develop a model culture system for the study of factors controlling regeneration of axons from injured adult mammalian central nervous system. We show, for the first that retinal ganglion cells (RGC) dissociated from adult rat retina, regrow processes in vitro over long distances un...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90204-0
更新日期：1988-07-01 00:00:00
abstract：:Axonal loss and degeneration in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE) have been suggested by brain imaging, pathological and axonal transport studies. Further elucidation of the processes and mechanisms of axonal degeneration in demyelinating diseases is therefore of potential impor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01191-9
更新日期：1999-04-10 00:00:00
abstract：:Analysis of rat hypothalamic extracts by gel filtration and HPLC revealed the presence of a form of substance P-like immunoreactivity with a molecular weight of approximately 5,700 (6k-SP). 6k-SP is probably an N-terminally extended form of substance P; the peptide may be an intermediate in SP biosynthesis, or may fun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90310-x
更新日期：1984-12-10 00:00:00
abstract：:We investigated the effects of a novel Na(+)/H(+) exchanger-1 (NHE-1) inhibitor KR-33028 on glutamate excitotoxicity in cultured neuron cells in vitro and cerebral infarct in vivo by comparing its potency with that of zoniporide, a well-known, highly potent NHE-1 inhibitor. KR-33028 inhibited NHE-1 activation in a con...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.061
更新日期：2009-01-12 00:00:00
abstract：:After spinal cord injury (SCI), the rapidly upregulated chondroitin sulfate proteoglycans (CSPGs), the prominent chemical constituents and main repulsive factors of the glial scar, play an important role in the extremely limited ability to regenerate in adult mammals. Although many methods to overcome the inhibition h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.08.048
更新日期：2014-10-24 00:00:00
abstract：:Large bilateral aspiration lesions of the hippocampus had no significant effect on septal kindling, whereas large bilateral DC lesions of the pyriform lobe resulted in a small but significant increase in the number of septal stimulations required to complete kindling. Bilateral aspiration lesions of the dorsal hippoca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90826-8
更新日期：1988-06-28 00:00:00
abstract：:Brainstem noradrenergic neurons located in the A5, A6, and A7 catecholamine cell groups provide the entire noradrenergic innervation of the spinal cord. We have previously demonstrated that noradrenergic neurons in the A6 and A7 cell groups innervate the ventral and dorsal horns, respectively. Since the specific spina...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90210-e
更新日期：1993-07-09 00:00:00
abstract：:Altered expression of neurotrophins may contribute to the pathogenesis of schizophrenia. Several studies suggest sex steroid hormones may be involved in the regulation of brain-derived neurotrophic factor (BDNF) signaling, as well as the symptoms of schizophrenia. This study aimed to identify sex differences in BDNF-T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.060
更新日期：2011-04-12 00:00:00
abstract：:It has been reported that training affects motor responses evoked electrically from the dorsomedial frontal cortex (DMFC). Once a monkey had been trained to generate visually-guided saccadic eye movements of a particular size and direction, electrical stimulation of the DMFC elicited saccades of only that size and dir...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02663-9
更新日期：2000-09-15 00:00:00
abstract：:Immunocytochemical localization of specific neurotransmitters in the brain is becoming increasingly important in studies of maturation. We have used the trilaminar prepyriform cortex (PC) of rats to study the distribution, patterns and relative number of cells, fibers and terminals during postnatal development using a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90208-2
更新日期：1987-08-01 00:00:00
abstract：:The subpallial region of the avian telencephalon contains neural systems whose functions are critical to the survival of individual vertebrates and their species. The subpallial neural structures can be grouped into five major functional systems, namely the dorsal somatomotor basal ganglia; ventral viscerolimbic basal...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2011.09.037
更新日期：2011-11-18 00:00:00
abstract：:The ontogenic development of neurophysin has not been investigated so far. To study this problem, electron microscopic immunohistochemistry was performed on ultrathin sections of the posterior pituitary of foetal and newborn rats. A concomitant appearance of secretory granules and neurophysin was first noted in the po...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90007-5
更新日期：1977-07-01 00:00:00
abstract：:Angiotensin peptides are thought to act as neurotransmitters or neuromodulators in central osmoregulation. We tested the hypothesis that angiotensin peptides are released in the paraventricular nucleus (PVN) of the hypothalamus upon local osmotic stimulation. Brain microdialysis and radioimmunoassay (RIA) techniques w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91215-7
更新日期：1994-02-21 00:00:00
abstract：:Numerous studies of neonatal neuronal development in mammals have revealed that neuronal cell death following axotomy is apoptotic in nature. In adult animals, however, neuronal cell death following axonal injury may or may not exhibit features of apoptosis. Bcl-2 and Bax have been identified as inhibitor and promoter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01315-3
更新日期：1999-05-08 00:00:00
abstract：:Our recent study has shown that many afferent fibers in the ventral root are third branches of dorsal root ganglion cells in addition to their processes in the peripheral nerve and the dorsal root. From results of this study, we hypothesized that most of the afferent fibers in the normal ventral root are extra process...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91030-5
更新日期：1989-10-30 00:00:00
abstract：:Exposure of newborn rats to antiepileptics such as barbiturates has long-lasting detrimental effects on the hippocampus and hippocampus-dependent behavior. However, the long-term consequences of neonatal administration with barbiturates on the hippocampal synaptic plasticity remain unresolved. In this study, we invest...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.086
更新日期：2011-05-04 00:00:00
abstract：:A sample of 302 neurons in rat hindlimb granular cortex was studied between 2 and 3 weeks after transection and ligation of the sciatic nerve. These neurons were compared to a control sample obtained from normal rats under similar experimental conditions. After sciatic nerve transection the proportion of neurons drive...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91019-0
更新日期：1988-05-24 00:00:00
