Characterization and partial purification of a 5,700 dalton form of substance P-like immunoreactivity from the rat hypothalamus.

abstract：:In WAG/Rij rat genetic model of absence epilepsy, the first spike-wave discharges (EEG hallmark of absence epilepsy) are known to appear after puberty, and their incidence increases with age. WAG/Rij rats are known to have a genetic predisposition to absence epilepsy, and further development of epilepsy might be influ...

journal_title：Brain research

authors： Sitnikova E,Rutskova EM,Raevsky VV

更新日期：2015-01-12 00:00:00

abstract：:Climbing fiber responses (CFRs) evoked by white matter stimulation and parallel fiber responses (PFRs) elicited by the stimulation of the surface of the folium were compared using intracellular recording from the dendrites of Purkinje cells in the in vitro slice preparation of the guinea pig cerebellum. Intracellular ...

journal_title：Brain research

authors： Kimura H,Okamoto K,Sakai Y

更新日期：1985-12-02 00:00:00

abstract：:The short term effects of spinal cord hemisection on protein synthesis in the Cebus monkey were studied by measuring the uptake of [3H]lysine into the trichloroacetic acid (TCA) precipitable and non-precipitable fractions of spinal cord. Animals were sacrificed 3, 6, or 13 days after hemisection. Two normal animals an...

journal_title：Brain research

authors： Wells MR,Bernstein JJ

更新日期：1976-07-23 00:00:00

abstract：:The reversible blockade of geniculate PGO waves was carried out by localized cooling of the ponto-geniculate pathways during paradoxical sleep in chronic cats. In parallel, long-term recordings of unit activity were performed in non-specific visuooculomotor thalamic structures where no PGO waves occurred. Blockade of ...

journal_title：Brain research

authors： Laurent JP,Rondouin G,Benita M,Jouvet M

更新日期：1977-12-02 00:00:00

abstract：:In the cat, cells of the superior colliculus (SC) and the tectofugal pathways of the visual system are highly selective for the direction of a moving visual stimulus. Deep layer units of SC in addition respond to auditory and somatosensory stimuli, but the proportion of such non-visual cells is usually found to be muc...

journal_title：Brain research

authors： Rauschecker JP,Harris LR

更新日期：1989-06-19 00:00:00

abstract：:Normal adult albino and Sprague-Dawley rats, under intraperitoneal Nembutal anesthesia, were used to demonstrate enzymatic activity in the choroid plexus and ventricular ependyma. The brain tissues were perfused or immersed with cold 2% glutaraldehyde and 8% sucrose in 0.1 M cacodylate buffer (pH 7.2-7.4) for 30 min a...

journal_title：Brain research

authors： Masuzawa T,Saito T,Sato F

更新日期：1981-10-19 00:00:00

abstract：:Cytogenesis in the kitten retina has been investigated with [3H]thymidine autoradiography and a stain for mitotic figures. The nuclei of cells in S-phase are located adjacent to the inner margin of the cytoblast layer, near the inner plexiform layer. The nuclei then migrate toward the outer limiting membrane (OLM) to ...

journal_title：Brain research

authors： Robinson SR,Rapaport DH,Stone J

更新日期：1985-03-01 00:00:00

abstract：:Repeating a stimulus generally leads to a decreased response in neural activity compared to that for novel items. This neural attenuation provides a marker for stimulus-specific perceptual encoding and memory that can be detected using functional magnetic resonance imaging (fMRI). Although previously assumed to occur ...

journal_title：Brain research

authors： Yi DJ,Kelley TA,Marois R,Chun MM

更新日期：2006-03-29 00:00:00

abstract：:Leukocyte cell-derived chemotaxin 2 (LECT2) was first isolated as a chemotactic factor from phytohemagglutinin-activated human T-cell leukemia SKW-3 cells. LECT2 is expressed in various tissues, including in the brain, stomach and liver, but the functions of LECT2 in the brain remains unclear. To elucidate these funct...

journal_title：Brain research

authors： Koshimizu Y,Ohtomi M

更新日期：2010-01-22 00:00:00

abstract：:Single pulse stimuli were delivered to the Schaffer collaterals in the in vitro hippocampal slice preparation. Local application of bicuculline to the CA3 region resulted in a series of population cell bursts in CA3, resembling the neuronal patterns which occur in the normal, freely moving rat during hippocampal sharp...

journal_title：Brain research

authors： Buzsáki G,Haas HL,Anderson EG

更新日期：1987-12-01 00:00:00

abstract：:An acute pain animal model for fMRI study would provide useful spatial and temporal information for studying the supraspinal nociceptive neuronal responses. The aim of the present study was to investigate whether the nociceptive responses in different brain areas can be differentiated by using functional magnetic reso...

journal_title：Brain research

authors： Chang C,Shyu BC

更新日期：2001-04-06 00:00:00

abstract：:A brief noxious heat stimulus applied to half of the receptive field of each cutaneous nociceptor resulted in most cases in the enhanced responsiveness of that half to subsequent heat stimuli (sensitization). No change in responsiveness to heat was observed in the other half of the receptive field, indicating that the...

journal_title：Brain research

authors： Thalhammer JG,LaMotte RH

更新日期：1982-01-14 00:00:00

abstract：:Exposure of organotypic dorsal root ganglion-spinal cord cultures to taxol, a potent microtubule promoting and stabilizing agent, results in an unusual abundance of microtubules in neurons, and the presence of microtubule-endoplasmic reticulum arrays in their perikarya and processes. Ordered concentric arrays of micro...

journal_title：Brain research

authors： Masurovsky EB,Peterson ER,Crain SM,Horwitz SB

更新日期：1981-08-03 00:00:00

abstract：:Quantitative and qualitative data are reported for single cerebral hemispheric neurons in a 3-dimensional hydrated collagen lattice (HCL) culture system. Individual neurons not in contact with other cells or cell processes, including synapses, rapidly displayed two morphologically distinct classes of processes that co...

journal_title：Brain research

authors： Coates PW

更新日期：1986-02-01 00:00:00

abstract：:Swelling of glial and nerve cells is characteristic of brain damage in cerebral ischemia or trauma. The therapeutical efficiency of inhibition of Cl(-)-transport by a novel antagonist, the diuretic torasemide, on cytotoxic swelling of glial cells from lactacidosis, or glutamate was analyzed. Lactacidosis and the inter...

journal_title：Brain research

authors： Staub F,Peters J,Kempski O,Schneider GH,Schürer L,Baethmann A

更新日期：1993-04-30 00:00:00

abstract：:Hypothalamic nuclei close to the third ventricle (VIII) represent key structures in avian osmoregulation concerned with the control of salt gland activity and release of the antidiuretic hormone [Arg8]vasotocin (AVT). Nitric oxide (NO) acting as a paracrine transmitter in the hypothalamus has been shown to contribute ...

journal_title：Brain research

authors： Hübschle T,Küchenmeister I,Gerstberger R

更新日期：1999-04-17 00:00:00

abstract：:The ventral tegmental area has been suggested as a possible site of action for the rewarding effect of opiates on the basis of the fact that local morphine injections in this but not other regions are rewarding. That this is a necessary and not just a sufficient site of opiate rewarding action was suggested by the fac...

journal_title：Brain research

authors： Britt MD,Wise RA

更新日期：1983-01-03 00:00:00

abstract：:Endogenous gamma-aminobutyric acid (GABA) release from the rat medial preoptic area (MPOA) was measured in an in vitro slice technique with sensitive HPLC analysis. Oestrogen is demonstrated to increase GABA activity in the ovariectomised, oestrogen-primed (OVX-EB) rat prior to the luteinising hormone (LH) surge compa...

journal_title：Brain research

authors： Herbison AE,Heavens RP,Dyer RG

更新日期：1989-05-01 00:00:00

abstract：:Intracerebroventricular microinjection of thyrotropin-releasing hormone (TRH) potently blocked the development of, as well as promptly reversed, epinephrine-stimulated hyperglycemia in mice. The central antihyperglycemic effect was dose-related (0.1-10 micrograms), could be reproduced by an intravenous injection of a ...

journal_title：Brain research

authors： Amir S,Harel M,Rivkind AI

更新日期：1987-12-01 00:00:00

abstract：:Many of our daily movements use visual information to guide our arms toward objects of interest. Typically, these visually guided movements involve first focusing our gaze on the intended target and then reaching toward the direction of our gaze. The literature on eye-hand coordination provides a great deal of evidenc...

journal_title：Brain research

authors： Gorbet DJ,Sergio LE

更新日期：2009-08-11 00:00:00

abstract：:Lamprey retriculospinal neurons show phasic oscillations of their membrane potential during fictive locomotion. This modulation originates from the spinal cord locomotor networks. The aim of the present study was to elucidate the pattern of discharge of the spino-bulbar axons responsible for this modulation. Experimen...

journal_title：Brain research

authors： Vinay L,Grillner S

更新日期：1992-06-05 00:00:00

abstract：:The brain contains neurons which alter their firing rates when ambient glucose concentrations change. An ATP-sensitive K+ (Katp) channel on these neurons closes and increases cell firing when ATP is produced by intracellular glucose metabolism. Binding of the antidiabetic sulfonylurea drugs to a site linked to this ch...

journal_title：Brain research

authors： Levin BE,Brown KL,Dunn-Meynell AA

更新日期：1996-11-11 00:00:00

abstract：:The neurotoxicity of ionomycin, a Ca2+ ionophore, was investigated in cultured cortical neurons from embryonic rats. While about 90% of neurons survived 2 h after exposure to ionomycin, the surviving neurons had decreased by about 30 to 40% at 16 h. Both RNA and protein synthesis inhibitors blocked this neurotoxicity....

journal_title：Brain research

authors： Takei N,Endo Y

更新日期：1994-07-25 00:00:00

abstract：:Kappa opioid receptors (KORs) were immunocytochemically localized at four different levels of the spinal cord of normally-cycling female rats in estrus or diestrus. KOR labeling was primarily observed in fine processes and a few neuronal cell bodies in the superficial dorsal horn and the dorsolateral funiculus. Quanti...

journal_title：Brain research

authors： Harris JA,Drake CT

更新日期：2001-06-29 00:00:00

abstract：:Chemical (C) kindling by means of repeated spaced injections into the amygdala (AM) of a subconvulsive dose of L-glutamate and L-aspartate combined in a molar ratio of 1:3. (Glu/Asp) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled Stage 5 seizur...

journal_title：Brain research

authors： Mori N,Wada JA

更新日期：1987-11-03 00:00:00

abstract：:We have previously shown that prolonged preganglionic stimulation (e.g. 40 Hz 20 min) depletes the neurotensin (NT) store of preganglionic axon terminals in the stellate ganglion (SG) of the cat and that replenishment of the store requires several days. The present study investigates the mechanisms which control turno...

journal_title：Brain research

authors： Maher E,Bachoo B,Polosa C

更新日期：1994-03-21 00:00:00

abstract：:L-3, 4-Dihydroxyphenylalanine (L-dopa) has been widely used for the treatment of Parkinson's disease (PD), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. In this study, we examined the concentration of L-dopa in plasma and in the extracellular fluid (ECF) of the striatu...

journal_title：Brain research

authors： Zhang J,Qu FR,Nakatsuka A,Nomura T,Nagai M,Nomoto M

更新日期：2003-12-12 00:00:00

abstract：:Dissociated striatal neurons exhibited increased neurite outgrowth when co-cultured with myenteric plexus explants. Enriched enteric neurons or enriched enteric glia produced a less marked response; non-ganglionic cells had no effect. Increases in striatal neuron and glial cell numbers were seen in all co-cultures. Te...

journal_title：Brain research

authors： Höpker VH,Saffrey MJ,Burnstock G

更新日期：1994-06-20 00:00:00

abstract：:Microinjections of monosodium glutamate (MSG; 300 microgram/0.5 microliter) into the hippocampus of the adult rat result in only marginal damage to local neurons. Perforant path transections, removing glutamatergic afferents to hippocampal granule cells, make the latter markedly more vulnerable to a subsequent MSG inj...

journal_title：Brain research

authors： Köhler C,Schwarcz R

更新日期：1981-05-04 00:00:00

abstract：:The central myelin sheaths of the recessive autosomal mutant mouse, Shiverer, were investigated by electron microscopy with special reference to the pattern of myelin formation. The results obtained may be summarized as follows: (1) the major dense line of myelin lamellae generally failed to be formed, but the axons w...

journal_title：Brain research

authors： Inoue Y,Nakamura R,Mikoshiba K,Tsukada Y

更新日期：1981-08-24 00:00:00