Ventral tegmental site of opiate reward: antagonism by a hydrophilic opiate receptor blocker.

Abstract:

:The ventral tegmental area has been suggested as a possible site of action for the rewarding effect of opiates on the basis of the fact that local morphine injections in this but not other regions are rewarding. That this is a necessary and not just a sufficient site of opiate rewarding action was suggested by the fact that diallyl-normorphinium bromide, a hydrophilic opiate blocker, caused compensatory increases in intravenous heroin self-administration when injected into the ventral tegmental area but not other brain regions.

journal_name

Brain Res

journal_title

Brain research

authors

Britt MD,Wise RA

doi

10.1016/0006-8993(83)91232-5

subject

Has Abstract

pub_date

1983-01-03 00:00:00

pages

105-8

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(83)91232-5

journal_volume

258

pub_type

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