Abstract：
:125I-alpha-Scorpion toxin (alpha-ScTx) binds to a component of the voltage-sensitive Na+ channel. We have previously shown that receptor capacity on dissociated mouse brain cells increases between days 12 and 19 of fetal life as does the expression of neurotoxin-sensitive 22Na+ influx. In the present study we have investigated the distribution of Na+ channels at the cellular level. Quantitative analysis by light-microscopic autoradiography was carried out on dissociated brain cells labeled with 125I-alpha-ScTx at 13, 15 and 18 fetal days. We have shown that at day 13 a large population of cells (39% of total) is alpha-ScTx-labeled, providing direct confirmation for a wide-spread presence of Na+ channels at an early stage of mouse brain development. The subsequent increase in receptor number with age is due both to an increase in alpha-ScTx-labeled cells (to 53% and 97% at days 15 and 18, respectively) and to an increase in the receptor density on these cells (10.9, 12.7 and 34.5 silver grains/1000 microns2 of cell surface for the 3 stages studied).
journal_name
Brain Resjournal_title
Brain researchauthors
Martin-Moutot N,Cau P,Berwald-Netter Y,Couraud Fdoi
10.1016/0165-3806(87)90136-2subject
Has Abstractpub_date
1987-03-01 00:00:00pages
43-51issue
1eissn
0006-8993issn
1872-6240journal_volume
429pub_type
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