Abstract：
:The effects of chronic administration of naloxone, morphine and met-enkephalin on benzodiazepine (BDZ) receptor binding in rat brain were determined 2 and 50 days after treatments were accomplished. Two days after naloxone treatment (75 micrograms/h s.c. for 14 days), enhanced BDZ receptor binding was observed in cingulate, frontal, piriform, entorhinal and sensorimotor cortices; amygdala complex, hippocampus, substantia nigra and central gray. Two days after morphine treatment (20 mg/kg i.p. daily for 6 days), increased BDZ receptor binding was detected in cingulate, frontal, piriform, entorhinal and sensorimotor cortices; amygdala complex, hippocampus and substantia nigra. Two days after met-enkephalin treatment (10 micrograms/h i.c.v. for 6 days) enhanced BDZ receptor binding was shown only in sensorimotor cortex. No significant changes were observed 50 days after the treatments were completed. These data indicate an important interaction between GABAergic and opioid peptide systems.
journal_name
Brain Resjournal_title
Brain researchauthors
Rocha L,Tatsukawa K,Chugani HT,Engel J Jrdoi
10.1016/0006-8993(93)91668-isubject
Has Abstractpub_date
1993-05-28 00:00:00pages
247-52issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)91668-Ijournal_volume
612pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Based on the fact that several recent reports have indicated that non-immunosuppressive immunophilin ligands (IPLs) can activate neurite outgrowth or nerve regeneration, we investigated the neurotrophic factor-activating abilities of IPLs in vivo in order to clarify the molecular basis of neurotrophic-like activity. B...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02434-x
更新日期：2003-04-25 00:00:00
abstract：:Ischemic stroke brings a huge family and social burden. Although the reperfusion of ischemic cerebral tissue is the most important way to rescue ischemic stroke, ischemia-reperfusion (I/R) injury further results in brain damage and even lead to death. Recent studies demonstrated that Tongxinluo (TXL) helps to protect ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.01.036
更新日期：2018-04-15 00:00:00
abstract：:In vitro assays offer a means of screening potential therapeutics and accelerating the drug development process. Here, we utilized neuronal cultures on planar microelectrode arrays (MEA) as a functional assay to assess the neurotoxicity of amyloid-β 1-42 (Aβ42), a biomolecule implicated in the Alzheimer׳s disease (AD)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.09.036
更新日期：2015-12-10 00:00:00
abstract：:In seven female alpha-chloralose-anesthetized cats, 52 lateral thalamic neurons were tested with noxious distension of the urinary bladder, the distal colon and the lower esophagus. In addition, the neurons were characterized with innocuous and noxious mechanical stimulation of the skin and deep structures. Of the 52 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02180-0
更新日期：1999-12-18 00:00:00
abstract：:Close to 20% of the patients infected with the AIDS virus develops neurological deficit; eventhough HIV does not invade neurons. Consistently with the neurological deficit, HIV(+) subjects show abnormalities in brainstem auditory and visual evoked potentials (BSAEP and VEP) and in sleep patterns. The HIV-derived glyco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01572-3
更新日期：1999-07-31 00:00:00
abstract：:[125I]CGP 42112, first developed to identify angiotensin II receptor subtype 2 (AT2), was recently shown to bind to a novel non-angiotensin binding site in injured rat brain tissue. We addressed the question whether non-angiotensin [125I]CGP 42112 binding appears after kainic acid induced hippocampal neurodegeneration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01035-3
更新日期：1995-12-08 00:00:00
abstract：:Neurons located in the nucleus raphe magnus (NRM), a region important in the control of nociception, appear to be tonically inhibited by noradrenergic (NA) neurons. Anatomical studies have suggested that the A5 catecholamine nucleus may be the primary source of noradrenergic neurons whose terminals are located in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91108-x
更新日期：1986-04-02 00:00:00
abstract：:The effects of acute ethanol exposure of chick spinal cord neurons were studied in tissue culture, using whole-cell voltage-clamp techniques. Results indicate that ethanol produces a persistent increase in the sensitivity of spinal neurons to GABA and glycine, with no change in input resistance or resting membrane pot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90098-4
更新日期：1988-07-12 00:00:00
abstract：:Experimental traumatic brain injury (TBI) is known to produce an acute increase in cerebral glucose utilization, followed rapidly by a generalized cerebral metabolic depression. The current studies determined effects of single or multiple treatments with sodium pyruvate (SP; 1000mg/kg, i.p.) or ethyl pyruvate (EP; 40m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.04.005
更新日期：2016-07-01 00:00:00
abstract：:Ciliary ganglion neurons from chick embryo were grown in cell culture following enzymatic and mechanical dissociation. The culture conditions necessary for long-term (greater than 21 days) survival of the isolated neurons were investigated. Neurons could be cultured with and without non-neural cells by adjusting the c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90127-4
更新日期：1980-02-03 00:00:00
abstract：:The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91318-1
更新日期：1986-02-26 00:00:00
abstract：:In the laboratory rat, inhalation (30 s) of high (> 70%) CO2 concentrations resulted in short-term (1-3 min) anesthesia, followed by a prolonged (up to 60 min) mild antinociception. Exposure to 100% CO2 resulted in significant thermal (hot-plate, 52 degrees, and tail-flick) and mechanical (tail-pinch, 886 g force) ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91888-0
更新日期：1994-03-21 00:00:00
abstract：:In the present study, we used a repeated restraint stress animal model to observe the changes in the expression of brain-derived neurotrophic factor (BDNF) and B cell lymphoma protein-2 (Bcl-2) in hippocampal neurons of rats, monitored the time course of the expression over 3 weeks post-stress period, and examined the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.089
更新日期：2004-10-29 00:00:00
abstract：:Little is known about the association between brain white matter (WM) structure and motor function in humans. This study investigated complexity of brain WM interior shape as determined by magnetic resonance imaging (MRI) and its relationship with upper-extremity (UE) motor function in patients post stroke. We hypothe...
journal_title：Brain research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.brainres.2008.06.008
更新日期：2008-09-04 00:00:00
abstract：:The nigrostriatal projection was studied with a retrograde tracing method (Evans blue, EB) combined with a technique for dopamine histofluorescence. The study, realized in control rats and in animals with 6-hydroxydopamine-induced lesions of the dopaminergic pathway, yielded the following results. (1) In 3 control rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90235-3
更新日期：1981-06-01 00:00:00
abstract：:Peripheral input to lamina VIII interneurones was investigated by using extracellular and/or intracellular records from them. The interneurones were located in the L4-L5 spinal segments and projected to contralateral motor nuclei in the L7 segment. They constituted a non-homogeneous population but their input from mus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91618-q
更新日期：1990-12-10 00:00:00
abstract：:In the present study, we assessed the beneficial synergistic effects of concurrent treatment with low doses of cilostazol and probucol against focal cerebral ischemic infarct in rats. The ischemic infarct induced by 2-h occlusion of middle cerebral artery (MCA) and 22-h reperfusion was significantly reduced in rat bra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.051
更新日期：2007-07-09 00:00:00
abstract：:The technique of intracellular recording was used to assess the effect of SR 31742A, a selective sigma receptor ligand, on N-methyl-d-aspartate (NMDA) and (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated responses in pyramidal cells of the rat medial prefrontal cortex in vitro br...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00797-5
更新日期：1998-10-05 00:00:00
abstract：:Mouse neopallium was disaggregated at 3 developmental stages (E15, E18, PO) and grown in colony cultures for 7 days. On the seventh day of culturing the colonies of cells were transplanted into the cerebellums of neonatal mice. After 3 weeks the astrocytes within the transplants were identified with GFAP immunoperoxid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90096-2
更新日期：1983-01-01 00:00:00
abstract：:The expression of phosphorylated extracellular signal-regulated kinase 1/2 (pERK 1/2) was evaluated in the vestibular nuclei (VN) of rats following unilateral labyrinthectomy (UL). Immunohistochemistry revealed a significant asymmetrical increase in pERK 1/2 expression in the VN, 5 min after UL, after which pERK 1/2 i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.031
更新日期：2004-06-18 00:00:00
abstract：:Intracellular recordings were made from neurons in the isolated myenteric plexus of the guinea-pig ileum. Methionine- and leucine-enkephalin were applied to the neurons either by adding them to the perfusing solution in known concentrations or be ejecting them by microiontophoresis. When applied in the perfusion solut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90045-3
更新日期：1979-04-06 00:00:00
abstract：:The biosynthetic activity of extra-hypothalamic vasopressin (VP) neurons in the bed nucleus of the stria terminalis (BNST) is regulated by gonadal steroids. These neurons have also been implicated in a number of behaviors that are impaired in aging. We previously reported that VP mRNA labelling in the BNST is decrease...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(10)80030-7
更新日期：1992-06-26 00:00:00
abstract：:Previous studies resulted in conflicting conclusions that glutamate application either decreases or increases the activity of Ca2+ channels in hippocampal neurons. We studied whole-cell Ca2+ currents (ICa) in chick dorsal root ganglion neurons and rat hippocampal cells. For both cell types glutamate (1-30 microM) incr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90965-c
更新日期：1992-05-15 00:00:00
abstract：:The rate of 6-[14C]D-glucose oxidation in cerebral cells of SAMP8, a substrain of senescence accelerated mouse, was investigated in vitro. The production of 14CO2 in dissociated intact brain cells prepared from the cerebrum of 4-8-week-old SAMP8 was higher than that of age-matched SAMR2 as a control mouse, while no di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91226-2
更新日期：1994-02-21 00:00:00
abstract：:The study makes an attempt to find out the action of norepinephrine (NE) and phenoxybenzamine (PB), applied at medial preoptic area (mPOA), in altering the sleep-awake responses, in free moving rats, which has not yet been reported. Effects of application of NE during day and PB during night, at mPOA, on sleep-awake r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90125-2
更新日期：1984-11-26 00:00:00
abstract：:Our previous studies demonstrated that Austrolebias charrua annual fish is an excellent model to study adult brain cell proliferation and neurogenesis due to the presence of active and fast neurogenesis in several regions during its short lifespan. Our main goal was to identify and localize the cells that compose the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.08.003
更新日期：2017-10-15 00:00:00
abstract：:The ability of embryonic tissue to survive cross-transplantation between histologically incompatible rat strains was examined by transplanting septal neurons from Sprague Dawley fetuses to adult Wistar rats (Ag-B6 to Ag-B2 histocompatibility haplotype). Transplants were found to survive without rejection over a period...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91028-4
更新日期：1983-03-07 00:00:00
abstract：:This study aimed to identify sites and mechanisms of long-term plasticity following lower limb muscle training. Two groups performing either a postural stability maintenance training (SMT) or a ballistic ankle strength training (BST) were compared to a non-training group. The hypothesis was that practicing of a self-i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.08.048
更新日期：2007-11-07 00:00:00
abstract：:We used triple-labeling immunohistochemistry in rat midbrain sections to identify dopaminergic neurons that contain either one or both of the calcium-binding proteins, calretinin (CR) and calbindin-D28k (CB). Midbrain dopaminergic neurons were immunohistochemically labeled for tyrosine hydroxylase (TH), CR, and CB. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01950-2
更新日期：1999-10-30 00:00:00
abstract：:The substance P and Met-enkephalin content were measured in the rat lumbar spinal cord after monolateral section of the sciatic nerve. The proximal stump of the lesioned nerve was either ligated, limiting the formation of neuroma, or sutured intraperitoneally, allowing the formation of a very large neuroma. Both types...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91147-3
更新日期：1985-09-09 00:00:00
