Abstract:
:Intracellular recordings were made from neurons in the isolated myenteric plexus of the guinea-pig ileum. Methionine- and leucine-enkephalin were applied to the neurons either by adding them to the perfusing solution in known concentrations or be ejecting them by microiontophoresis. When applied in the perfusion solution, the enkephalin (1 nM-1micron) hyperpolarized the soma membrane of less than half the neurons. The hyperpolarization was of rapid onset and reversed fully when the enkephalin was washed out; in a proportion of cells the hyperpolarization was associated with a fall in neuronal input resistance. This hyperpolarization was reversed or prevented by naloxone. When applied by iontophoresis to the soma membrane, enkephalin never hyperpolarized the myenteric neurons. Hyperpolarization in response to iontophoretic application of enkephalin was observed only when the enkephalin was applied to the surface of the ganglion away from the soma membrane; such hyperpolarization was prevented by addition of naloxone to the perfusion solution. The results indicate that the site at which enkephalin causes the naloxone-reversible hyperpolarization is not the soma membrane. The possibility is discussed that enkephalin may cuase presynaptic inhibition in this preparation by hyperpolarizing or increasing the conductance sites on the cellular processes from which acetylcholine is released.
journal_name
Brain Resjournal_title
Brain researchauthors
North RA,Katayama Y,Williams JTdoi
10.1016/0006-8993(79)90045-3subject
Has Abstractpub_date
1979-04-06 00:00:00pages
67-77issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(79)90045-3journal_volume
165pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::In this report, using a push-pull perfusion technique, we examined in vivo the effects of exogenous dopamine (DA) on the output of neurochemical substances from the caudate nucleus (CN) of freely behaving rats. Exogenous DA, at concentrations of 10(-5) M, 5 x 10(-5) M and 10(-4) M, in modified Krebs-Ringer phosphate m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90803-2
更新日期:1989-03-06 00:00:00
abstract::Phosphocreatine-Mg-complex acetate (PCr-Mg-CPLX) is a creatine-derived compound that in previous in vitro research was able to increase neuronal creatine independently of the creatine transporter, thus providing hope to cure the hereditary syndrome of creatine transporter deficiency. In previous research we showed tha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.009
更新日期:2009-08-18 00:00:00
abstract::Most experimental spinal cord injury studies described to date have relied on a limited number of injury gradations, and have tacitly assumed that outcome (functional, histological, and/or neurophysiological) is a monotonically graded function of injury severity. In contrast, the present study provides evidence that f...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-08-05 00:00:00
abstract::The subfornical organ, along with other regions of the lamina terminalis, may contain osmoreceptors and is likely to be a site of action of blood-borne angiotensin II. The neural pathways by which these stimuli lead to vasopressin secretion, have been suggested to extend from the subfornical organ to hypothalamic site...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90708-4
更新日期:1991-08-30 00:00:00
abstract:STUDY OBJECTIVE:To examine the differential effects of acute and chronic sleep fragmentation (SF) on spatial learning and memory, and hippocampal long-term potentiation (LTP) in pubertal mice. METHODS:Two studies were performed during which adolescent C57/Bl6 mice were subjected to acute-SF 24h a day × 3 days or chron...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.04.037
更新日期:2015-07-30 00:00:00
abstract::The lateral geniculate nucleus (LGN) of a fetal rat was transplanted to the visual cortex (VC) of a neonatal rat. A current source-density analysis of field potentials and an intracellular study of neuronal responses were conducted in slice preparations by electrical stimulation of transplanted LGN and host VC. The re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90554-3
更新日期:1987-09-29 00:00:00
abstract::The effect of different steady-state cocaine concentration maintenance on the microdialysis extraction fraction of cocaine (in situ recovery; Ed) in the medial prefrontal cortex (mPFC) was examined. Male, adult Sprague-Dawley rats anesthetized with chloral hydrate were used. All rats were randomly divided into three g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00456-z
更新日期:1995-07-24 00:00:00
abstract::Serotonin 1A receptor (5-HT(1A)R) agonists have emerged as valuable supplements to l-DOPA therapy, demonstrating that they can decrease side effects and enhance motor function in animal models of Parkinson's disease (PD) and human PD patients. The precise mechanism by which these receptors act remains unknown and ther...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.05.005
更新日期:2007-07-16 00:00:00
abstract::Experiments were performed to test the hypothesis that subarachnoid hemorrhage (SAH) causes functionally relevant perturbations of cyclooxygenase activity in cerebral arteries. Four groups of rabbits were formed: (I) controls; (II) sham injected animals (2 ml physiological solution in the cisterna magna); (III) SAH gr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00053-5
更新日期:1998-04-20 00:00:00
abstract::The binding characteristics of [3H]cytisine, a putative CNS nicotinic receptor ligand, were examined in 4 regions of the human brain. [3H]Cytisine was found to bind non-cooperatively with high affinity to a single site in tissue homogenates and to exhibit low non-specific association. The binding characteristics of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90410-o
更新日期:1993-01-08 00:00:00
abstract::Single cell recordings were made from neurons in the lateral tegmental field of the medulla (LTFM) during electrical stimulation of the hypothalamic defense area (HDA) of the rabbit. Fifty-four cells were inhibited by HDA stimulation; 23 of these cells received barosensory input. Twenty-two LTFM cells showed an increa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90738-h
更新日期:1991-08-30 00:00:00
abstract::Abnormally hyperphosphorylated tau is the major protein component of neurofibrillary tangles, the characteristic lesion of Alzheimer's disease (AD). Protein phosphatases (PP) type 1 (PP-1), type 2A (PP-2A) and type 2B (PP-2B) appear to be involved in the regulation of tau phosphorylation. The incidence of neurofibrill...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00904-3
更新日期:1996-11-25 00:00:00
abstract::Time-course expression of Bax and Bcl-2 proteins, identified as apoptosis-regulating molecules, was assessed in gerbil hippocampus following transient forebrain ischemia. Brain sections from animals sacrificed at 48, 72, 96 h and 7 days following 5 min ischemia were immunohistochemically evaluated using polyclonal ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01436-5
更新日期:1996-03-04 00:00:00
abstract::Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived inna...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.07.033
更新日期:2009-10-06 00:00:00
abstract::The spinal cord projections of the 3 main forelimb nerves-median, radial and ulnar, were studied in the rat dorsal horn with transganglionic transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP), or using the disappearance of fluoride resistant acid phosphatase (FRAP) after nerve section. The projection ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91565-i
更新日期:1991-03-01 00:00:00
abstract::In the inferior colliculus of the mouse, 4 cell types project across the collicular commissure: small to medium sized spiny cells, small to medium sized spineless cells, medium sized sparsely spinous neurons and large cells. The axons of large cells give rise to a great number of ipsi- and contralateral collaterals te...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90571-8
更新日期:1986-03-19 00:00:00
abstract::Caspases, a family of cysteine proteases, are widely activated in neurons and glia in the injured brain, a response thought to induce apoptosis. However, caspase activation in astrocytes following injury is not strongly associated with apoptosis. The present study investigates the potential role of caspase activation ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.02.056
更新日期:2012-04-23 00:00:00
abstract::In scopolamine-treated (5.0 mg/kg, s.c.) rats hippocampal rhythmical slow activity (RSA) and neocortical low voltage fast activity (LVFA) occur only in close correlation with head movements, spontaneous changes in posture, or locomotion (Type I behavior). Previous work indicates that such scopolamine-resistant RSA and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91500-e
更新日期:1992-11-27 00:00:00
abstract::Endogenous long-duration burst-organizing potentials (driver potentials, DPs) generated by neurons in the lobster cardiac ganglion play a critical role in the ability of the system to generate rhythmic bursts of nerve impulses. The DPs are normally terminated by a voltage-dependent potassium current, but when this is ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90854-g
更新日期:1993-04-23 00:00:00
abstract::We have previously found that crocin (crocetin di-gentiobiose ester) antagonizes the inhibitory effect of ethanol on long-term potentiation in the rat hippocampus in vivo and in vitro. To explore mechanisms underlying the antagonism of crocin against ethanol, we investigated the effects of ethanol and crocin on synapt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01505-9
更新日期:1998-03-16 00:00:00
abstract::A procedure is described which allows for the selective and non-injectional staining of the three-dimensional microvasculatory bed (MVB) in thick sections (60-140 microm) of formalin-fixed brain tissue of white rats Rattus norvegicus. This histochemical method detects ATPase activity and takes place between pH 10.5 an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.11.059
更新日期:2006-01-27 00:00:00
abstract::Sleep spindles may be involved in synaptic plasticity. Learning-dependent increases in spindles have been observed in both humans and rats. In humans, the innate (i.e., baseline) number of spindles correlate with measures of academic potential such as Intelligence Quotient (IQ) tests. The present study investigated if...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.01.026
更新日期:2010-03-10 00:00:00
abstract::Nitric oxide synthase (NOS) activity was examined in forebrain, cerebellum and optic lobes of adult domestic fowl, having a hereditary primary generalized convulsive disorder. NOS was approximately 2-fold higher in only the forebrain of adult epileptic fowl compared to non-epileptic (carrier) hatchmates. A significant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00595-1
更新日期:1996-10-07 00:00:00
abstract::Intrathecally-administered clonidine inhibited the spontaneous firing of single neurons in the pontine nucleus locus coeruleus of rats. Such inhibition of neuron firing was not observed when the non-lipophilic alpha 2 adrenoceptor agonist (oxymetazoline) was administered intrathecally. It is concluded that lipophilic ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90752-7
更新日期:1983-10-16 00:00:00
abstract::Plectin is associated with intermediate filaments, such as glial fibrillary acidic protein (GFAP) and vimentin, which have an important role in the glial reactions after lesions. The present study investigates the plectin immunoreactivity following stab wounds in the cortex and the underlying white matter of adult rat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02399-9
更新日期:2000-02-28 00:00:00
abstract::The distribution of immunoreactive (IR) axons and neurons in the rat central nervous system (CNS) has been studied with an antiserum directed against the C-terminal sequence of rat a-calcitonin gene-related peptide (CGRP) and a durable peroxidase reaction product for detailed analysis in relation to normal cytoarchite...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90395-2
更新日期:1988-11-01 00:00:00
abstract::Voluntary saccades performed in total darkness provide the opportunity to investigate the brain system active during saccades without confounding effects caused by the saccade induced shifts of the retinal image. Using this approach saccade related activation has been demonstrated not only in parietal but also in stri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.07.108
更新日期:2008-10-03 00:00:00
abstract::Glutamate N-methyl-D-aspartate receptors (NMDARs) in the medial prefrontal cortex (mPFC) and hippocampus may play an integral role in complex cognitive and social deficits associated with a number of psychiatric illnesses including autism, mood disorders, and schizophrenia. We used localized infusions of adeno-associa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.10.037
更新日期:2015-03-10 00:00:00
abstract::The present studies examined the hypothesis that the N-methyl-D-aspartate (NMDA) receptor-nitric oxide (NO) pathway might be involved in the acute and chronic actions of delta 9-tetrahydrocannabinol (THC). The ability of dizocilpine (MK-801), a competitive NMDA receptor antagonist and NG-monomethyl-L-arginine (L-NMMA)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91715-9
更新日期:1994-12-19 00:00:00
abstract::IL-10 reduces pro-inflammatory responses after ischemic stroke primarily by acting on glia and endothelium, but relatively little is known about the direct effects of IL-10 on cortical neurons, which are often damaged in stroke. We found by PCR and immunohistochemistry that cortical neurons express IL-10 receptor. Tre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.11.096
更新日期:2011-02-10 00:00:00