Abstract：
:Experimental traumatic brain injury (TBI) is known to produce an acute increase in cerebral glucose utilization, followed rapidly by a generalized cerebral metabolic depression. The current studies determined effects of single or multiple treatments with sodium pyruvate (SP; 1000mg/kg, i.p.) or ethyl pyruvate (EP; 40mg/kg, i.p.) on cerebral glucose metabolism and neuronal injury in rats with unilateral controlled cortical impact (CCI) injury. In Experiment 1 a single treatment was given immediately after CCI. SP significantly improved glucose metabolism in 3 of 13 brain regions while EP improved metabolism in 7 regions compared to saline-treated controls at 24h post-injury. Both SP and EP produced equivalent and significant reductions in dead/dying neurons in cortex and hippocampus at 24h post-CCI. In Experiment 2 SP or EP were administered immediately (time 0) and at 1, 3 and 6h post-CCI. Multiple SP treatments also significantly attenuated TBI-induced reductions in cerebral glucose metabolism (in 4 brain regions) 24h post-CCI, as did multiple injections of EP (in 4 regions). The four pyruvate treatments produced significant neuroprotection in cortex and hippocampus 1day after CCI, similar to that found with a single SP or EP treatment. Thus, early administration of pyruvate compounds enhanced cerebral glucose metabolism and neuronal survival, with 40mg/kg of EP being as effective as 1000mg/kg of SP, and multiple treatments within 6h of injury did not improve upon outcomes seen following a single treatment.
journal_name
Brain Resjournal_title
Brain researchauthors
Moro N,Ghavim SS,Harris NG,Hovda DA,Sutton RLdoi
10.1016/j.brainres.2016.04.005subject
Has Abstractpub_date
2016-07-01 00:00:00pages
270-277eissn
0006-8993issn
1872-6240pii
S0006-8993(16)30198-6journal_volume
1642pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：BACKGROUND:Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder which is characterized by altered bowel habits. A growing number of studies investigate the association between IBS and cognitive impairments. Current studies report conflicting results regarding cognitive impairment in IBS patie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.05.036
更新日期：2019-09-15 00:00:00
abstract：:Dissociated striatal neurons exhibited increased neurite outgrowth when co-cultured with myenteric plexus explants. Enriched enteric neurons or enriched enteric glia produced a less marked response; non-ganglionic cells had no effect. Increases in striatal neuron and glial cell numbers were seen in all co-cultures. Te...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91137-1
更新日期：1994-06-20 00:00:00
abstract：:The axons in the nerve fiber layer (NFL) of the adult rat retina were examined by transmission electron microscopy. NFL axons range in size from 0.12 to about 2.0 microm, with a peak at 0.3-0.4 microm. In addition to conventional small mitochondria in the NFL axons contain some large ones, which are similar to astrocy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91222-2
更新日期：1983-01-03 00:00:00
abstract：:Two different ligands, tritiated oxytocin and a newly synthesized and monoiodinated oxytocin antagonist, were used to reveal sites which bind oxytocin in the brainstem and upper spinal cord of 12 human subjects. Tissue sections were incubated with either ligand at a concentration close to their respective dissociation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90317-x
更新日期：1989-10-23 00:00:00
abstract：:We have shown previously that progesterone linked with bovine serum albumin at position 3 of the progesterone molecule (P-3-BSA) was effective in modulating (both stimulating and inhibiting) amphetamine (AMPH)-evoked dopamine (DA) release in vitro from superfused corpus striatal (CS) tissue fragments of ovariectomized...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90395-c
更新日期：1991-01-04 00:00:00
abstract：:These experiments used in vivo microdialysis and high-performance liquid chromatography to examine, in rats, norepinephrine (NE) release in the amygdala induced by footshock and systemic administration of drugs affecting the opioid peptidergic system. A microdialysis probe was inserted into a previously implanted guid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00795-1
更新日期：1998-10-19 00:00:00
abstract：:We examined the expression of IL-6 in the substantia nigra pars reticulata (SNr) at various time points after transient (3 h) middle cerebral artery occlusion (MCAO) in rats. The animals were killed at 1, 3, 7 or 14 days following operation. Coronal brain sections were processed for immunohistochemistry with antibodie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03129-2
更新日期：2001-01-19 00:00:00
abstract：:Genetic abnormalities in amyloid precursor protein (APP) are associated with Down's syndrome and familial Alzheimer's disease where hallmark plaques contain A beta peptides derived from APP. Both APP and its derivatives are implicated in neurodegenerative processes and may play important physiological and pathophysiol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.09.024
更新日期：2008-12-03 00:00:00
abstract：:Neonatal (postnatal days 8-21) exposure of rats to the selective serotonin reuptake inhibitor (SSRI), citalopram, results in persistent changes in behavior including decreased sexual activity in adult animals. We hypothesized that this effect was a consequence of abnormal stimulation of 5-HT(1A) and/or 5-HT(1B) recept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.009
更新日期：2006-12-13 00:00:00
abstract：:Employing a paired-watering procedure to control for differential fluid intake confounds, adult male rats were exposed in the home cage to water containing 100 ppm cadmium chloride, or a control solution containing no added cadmium chloride. On Day 61 of exposure to their respective watering regimens, half the animals...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01060-2
更新日期：1995-12-08 00:00:00
abstract：:Embryonic cortex from 19-day fetuses was transplanted in a medial frontal cortex wound cavity of 105-day-old male rats. Nissl-stained tissue revealed little internal laminar organization. Graft sections impregnated by the Loyez method exhibited bands of myelinated fibers surrounding implants as well as long-interconne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91177-2
更新日期：1987-01-13 00:00:00
abstract：:We investigated the effects of collagen II-induced arthritis on two cerebrospinal fluid (CSF) enzymes converting dynorphin A and substance P (SP), namely dynorphin-converting enzyme (DCE) and substance P endopeptidase (SPE). The products generated by these enzymes are the bioactive fragments Leu-enkephalin-Arg6 and su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90718-o
更新日期：1992-05-29 00:00:00
abstract：:Activation of serotonin neurotransmission produces increase of plasma oxytocin, prolactin, vasopressin and ACTH levels. Using dual-immunocytochemistry, the number of oxytocinergic neurons in the hypothalamic magnocellular nuclei co-storing Fos after administration of D-fenfluramine was found to be 15-fold higher compa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01953-8
更新日期：1999-12-18 00:00:00
abstract：:Spontaneous and hypothalamically induced hippocampal rhythmical slow activity (RSA or theta) was studied acutely in rats anaesthetized with urethane or immobilized with D-tubocurarine. Systematic tracking of microelectrodes showed two foci of hippocampal RSA, one located in the basal part (stratum oriens) of CAl (mean...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90711-3
更新日期：1976-12-17 00:00:00
abstract：:We investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-d-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/macrophage activation. The excitotoxic lesion both damaged oligodendrocy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.007
更新日期：2010-05-06 00:00:00
abstract：:The retinohypothalamic tract, a monosynaptic retinal projection to the suprachiasmatic nucleus (SCN), is the path by which light entrains the circadian system to the external photoperiod. Serotonergic neurons in the mesencephalic median raphe nucleus (MnR) also give rise to a major SCN afferent projection. The present...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.083
更新日期：2005-05-17 00:00:00
abstract：:Surgical microscopy and electrophysiological techniques were used to standardize the nomenclature for the pudendal nerve and sacral plexus according to their somatic axonal composition in the male rat. We conclude that the pudendal nerve is the segment running from the L6-S1 trunk to the sacral plexus, carrying effere...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00408-3
更新日期：1997-07-25 00:00:00
abstract：:Structural equation modeling (SEM) and fMRI were used to test whether changes in the regional activity are accompanied by changes in the inter-regional connectivity as motor practice progresses. Ten healthy subjects were trained to perform finger movement task daily for 4 weeks. Three sessions of fMRI images were acqu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.073
更新日期：2010-03-08 00:00:00
abstract：:We have investigated the influence of central noradrenergic and dopaminergic systems on the susceptibility of rats to seizures in the kainic acid (KA)-model of epilepsy. In the dose range of 0.75 to 10 mg/kg s.c., KA dose-dependently induced characteristic behavioural changes. Partial depletion of noradrenaline (NA) a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90219-9
更新日期：1989-08-28 00:00:00
abstract：:We have previously described a rodent model of brief (30 min) middle cerebral artery occlusion followed by reperfusion, in which infarction develops gradually, reaching completion more than 3 days after ischemia, accompanied by morphological, biochemical, and pharmacological evidence of apoptosis. In the present study...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02822-0
更新日期：2001-11-02 00:00:00
abstract：:The median preoptic nucleus (MnPN) of the hypothalamus contains sleep-active neurons including sleep-active GABAergic neurons and is involved in the regulation of nonREM/REM sleep. The hypocretinergic (HCRT) neurons of the perifornical-lateral hypothalamic area (PF-LHA) and serotonergic (5-HT) neurons of the dorsal ra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.07.115
更新日期：2008-10-09 00:00:00
abstract：:The role of plantar pressure sensation in controlling compensatory stepping was explored via hypothermic anesthesia of the foot soles, in 10 healthy young adults. Stepping reactions were evoked by unpredictable platform translation in forward, backward and lateral directions. The findings suggest three specific direct...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02712-8
更新日期：2000-09-22 00:00:00
abstract：:Neuropeptide Y (NPY) blocks the effect of light on the mammalian circadian clock during the subjective night. The present study explores the role of the NPY Y1 receptor in this interaction. The effect of NPY when co-applied with NMDA, a glutamate agonist that can mimic the effect of light, was examined in NPY Y1-/- mi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.037
更新日期：2004-10-08 00:00:00
abstract：:Regeneration of severed hypothalamic peptidergic neurosecretory axons into the ventral pia-arachnoid was observed in rats at the light microscopic and fine-structural levels. A temporal increase occurred in the number of neurophysin-positive axons regenerating into the leptomeninges for distances up to 3.3 mm by 40 da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91557-0
更新日期：1988-05-31 00:00:00
abstract：:The main purpose of the present study was to determine whether specific lymphokines may be neurotrophic, by testing their effects on the survival of hippocampal neuronal cultures. Previous studies have shown that a variety of interleukins may be neurotrophic or neurotoxic, depending upon the culture conditions, as wel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90400-h
更新日期：1993-01-08 00:00:00
abstract：:Recent studies suggest that apolipoprotein E (apoE) might play a neurotrophic function in the central nervous system and that altered functioning of this molecule could result in neurodegeneration. The main objective of this study was to determine if neurodegenerative and cognitive alterations in apoE-deficient mice a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01420-5
更新日期：1997-03-21 00:00:00
abstract：:The expression of the immediate-early gene c-fos was used as a marker of neuronal activity to investigate the cervical spinal interneuron populations involved in the corticomotoneuronal pathway. Adult rats received unilateral kainate injections in the forelimb area of the primary motor cortex. After a survival period ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00365-4
更新日期：1996-06-24 00:00:00
abstract：:Prostaglandin E2 (PGE2) is a lipid mediator which plays a role in the generation of inflammatory and neuropathic pain. In the peripheral nervous system, PGE2 sensitizes nociceptive afferent neurons through E-prostanoid (EP) receptors. In the central nervous system, PGE2 modulates pain sensitivity and contributes to th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147153
更新日期：2021-01-01 00:00:00
abstract：:We determined that extracellular potassium ion concentration, [K+]o-induced depolarization, enhances 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) generation in the rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused through a micro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02238-6
更新日期：2000-01-10 00:00:00
abstract：:Intracisternal injections of hypocretin-1 (hcrt-1) have been shown to elicit sympathoexciatory responses. However, the location of central sites that may mediate these cardiovascular effects have not been clearly elucidated. This study was done in male Wistar rats to investigate the effects of microinjections of hcrt-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.008
更新日期：2003-11-21 00:00:00
