Abstract:
:We examined the expression of IL-6 in the substantia nigra pars reticulata (SNr) at various time points after transient (3 h) middle cerebral artery occlusion (MCAO) in rats. The animals were killed at 1, 3, 7 or 14 days following operation. Coronal brain sections were processed for immunohistochemistry with antibodies against GFAP, OX-42 and IL-6 and for Nissl staining. Microglial activation was detected 3 and 7 days after ischemia. Reactive astrocytes have been found 7 and 14 days after ischemia. IL-6 expression was detected 3 and 7 days after ischemia. IL-6-positive cells beared the typical morphology of neurons. Distribution of IL-6-positive cells within the SNr was not homogenous. The lateral area of the SNr bears the highest number of IL-6-positive neurons while the central core bears the lowest. Quantification of intact neurons in the SNr 14 days after reperfusion shows that the highest amount of cell loss was found in the central core of the SNr and less neuronal cell loss was observed in the lateral area of the SNr. Thus, the SNr area with the highest IL-6 expression 3 and 7 days after ischemia bears the highest number of intact neurons 14 days after ischemia. This finding could be a clue for the neuroprotective role of IL-6 in the remote region SNr after focal cerebral ischemia.
journal_name
Brain Resjournal_title
Brain researchauthors
Dihné M,Block Fdoi
10.1016/s0006-8993(00)03129-2subject
Has Abstractpub_date
2001-01-19 00:00:00pages
165-73issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)03129-2journal_volume
889pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Although chronic neuropathic pain disorders are more prevalent in the senescent population, little is known about how the aging process alters the thermal hyperalgesic sensitivity to peripheral nerve injury. In this study, neuropathic pain was induced in young, mature and aged FBNF1 hybrid rats via unilateral ligation...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01522-x
更新日期:1999-07-03 00:00:00
abstract::Intracellular recordings from CA3b/c neurons in rat hippocampal slices showed that reduction of the extracellular Cl- concentration from 136 to 53 mM produced a positive (+10 mV) shift in the reversal potential of GABAergic inhibitory postsynaptic potentials (IPSPs). This shift was not significantly different from the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91068-2
更新日期:1988-03-29 00:00:00
abstract::Mice lacking the GABA(A) receptor beta(3) subunit exhibit a profound disruption in thalamic circuitry. We have studied sleep in these mice under baseline conditions and following treatment with the benzodiazepine midazolam. Under baseline conditions, NREM sleep time did not differ between beta(3) subunit knockout mice...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03467-4
更新日期:2002-11-15 00:00:00
abstract::The purpose of this study was to identify the functional fields activated in relation to the NO-GO decision. Nine healthy subjects participated in the study which consisted of two test positron emission tomography (PET) scans (GO/NO-GO task and response selection task) and one control scan. In the response selection t...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1996-07-22 00:00:00
abstract:STUDY OBJECTIVE:To examine the differential effects of acute and chronic sleep fragmentation (SF) on spatial learning and memory, and hippocampal long-term potentiation (LTP) in pubertal mice. METHODS:Two studies were performed during which adolescent C57/Bl6 mice were subjected to acute-SF 24h a day × 3 days or chron...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.04.037
更新日期:2015-07-30 00:00:00
abstract::Temporo-nasal asymmetry in visual responses has been observed in many behavioural studies. These observations have typically been attributed to the anatomical asymmetry of fibres projecting to the Superior Colliculus (SC), even though this attribution is debated. The present study investigates temporo-nasal asymmetry ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.03.087
更新日期:2008-11-25 00:00:00
abstract::Serotonin (5-HT) nerve terminals in the locus coeruleus (LC) of adult rat were visualized by high-resolution radioautography, in order to examine their distribution, fine structural features and intimate relationships with norepinephrine neurons. In animals pretreated with a monoamine oxidase inhibitor, prolonged intr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90791-6
更新日期:1978-04-21 00:00:00
abstract::The cholinergic agonist pilocarpine injected intraperitoneally (ip) increases mean arterial pressure (MAP) and superior mesenteric (SM) vascular resistance and reduces submandibular/sublingual gland (SSG) vascular resistance. In the present study, we investigated the effects of electrolytic lesions of the anteroventra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.06.071
更新日期:2005-09-07 00:00:00
abstract::The effects of dopamine D1 and D2 selective drugs on the responses evoked in accumbens neurons by stimulation of cortical afferents were studied in an in vitro brain slice preparation. The D2-specific antagonist sulpiride (1-10 microM) increased, whereas the D2 agonist quinpirole (1-20 microM) occasionally attenuated ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90263-1
更新日期:1994-01-14 00:00:00
abstract::Milk ejection-related bursts of action potentials recurred at fairly regular intervals during suckling in oxytocin cells of anesthetized lactating rats. Additional milk ejection-related bursts were frequently induced in response to vaginal distension. The latency for the induced response was 2.9 +/- 0.2 s and the size...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91397-7
更新日期:1987-02-24 00:00:00
abstract::Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex molecular factors, alteration to protein homeostasis is emerging as a relevant pathological mec...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2016.04.053
更新日期:2016-10-01 00:00:00
abstract::In the search for cortical mechanisms subserving psychological phenomena, a better understanding of human cortical circuitry is crucial. In this report we describe aspects of intrinsic connectivity of supragranular layers in human visual cortex, revealed by extracellular injections of the anterograde tracer biocytin i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91148-8
更新日期:1992-10-30 00:00:00
abstract::Autism spectrum disorders (ASD) are associated with disturbances of neural connectivity. Functional connectivity between neural structures is typically examined within the context of a cognitive task, but also exists in the absence of a task (i.e., "rest"). Connectivity during rest is particularly active in a set of s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.11.057
更新日期:2010-02-08 00:00:00
abstract::The purpose of the present study was to examine the role of substrate availability in the regulation of the release and synthesis of serotonin by brain slices. Electrical field depolarization of the brain slices stimulated the synthesis and release of serotonin in the absence of changes in intracellular tryptophan con...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90580-8
更新日期:1979-08-31 00:00:00
abstract::Male Fischer-344 rats were injected i.p. with diethyldithiocarbamate or dithizone 15 min after kainic acid (KA), s.c. Diethyldithiocarbamate and dithizone reduced both the number of wet dog shakes and the latency to onset of seizures induced by KA. Moreover, they increased the severity of seizures. These compounds may...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91273-j
更新日期:1990-01-08 00:00:00
abstract::The effect of a single subcutaneous (s.c.) injection of the ultrapotent capsaicin analogue resiniferatoxin (RTX) on responses of adult rats to noxious thermal and mechanical stimulation was examined. The effects of RTX treatment on the nociceptive flexor reflex and activity-dependent increase in spinal excitability af...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01444-8
更新日期:1997-03-28 00:00:00
abstract::Fronto-limbic circuits in the primate brain are responsible for executive function, learning and memory, and emotions, including fear. Consequently, changes in gene expression in cortical and subcortical brain regions housing these circuits are associated with many important psychiatric and neurological disorders. Whi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.12.031
更新日期:2015-03-10 00:00:00
abstract::The properties of the beta amino acid transport system were examined in cultivated rat brain astrocytes, using the specific probe, beta-alanine. The uptake of beta-alanine is thought to be glial specific. Beta-alanine was not actively transported and the intracellular accumulation was not altered by coincubation with ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90856-3
更新日期:1982-05-06 00:00:00
abstract::The aim of the present study was to evaluate p38 MAPK activation following focal stroke and determine whether SB 239063, a novel second generation p38 inhibitor, would directly attenuate early neuronal injury. Following permanent middle cerebral artery occlusion (MCAO), brains were dissected into ischemic and non-isch...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03228-5
更新日期:2001-02-16 00:00:00
abstract::Treatment with the short-acting benzodiazepine, triazolam (Tz), 6 h before activity onset (CT 6) induces large phase advances in the circadian rhythm of locomotor activity in golden hamsters free-running in constant lighting conditions. These phase shifts are associated with acute increases in locomotor activity. The ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91208-i
更新日期:1991-09-27 00:00:00
abstract::Developmental delay, cognitive impairment, and refractory epilepsy are the most frequent consequences found in patients suffering from malformations of cortical development (MCD). However, therapeutic options for these psychiatric and neurological comorbidities are currently limited. The development of white matter un...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.07.012
更新日期:2015-10-05 00:00:00
abstract::Glioblastoma is the most aggressive form of gliomas and is associated with short survival. Recent advancements in molecular genetics resulted in the identification of glioma genomic, epigenomic and transcriptomic hallmarks, and multidimensional data allowed clustering of glioblastomas into molecular subtypes. Parallel...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.10.062
更新日期:2015-01-21 00:00:00
abstract:OBJECTIVE:The modern brain imaging studies in patients with eating disorders have shown that neurotransmitting regulation differs distinctly from control groups. These disturbances have involved serotonin and dopamine system can be inherited and conditioned by genes. The aim of this work has been the analysis of associ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.10.035
更新日期:2010-01-11 00:00:00
abstract::The morphology of so-called interplexiform (IP) cells immunoreactive to tyrosine hydroxylase (TH) or somatostatin (SOM) in the rat retina was described in comparison with those in the carp retina. In frozen cross-sections of the rat retina, many processes of TH-like immunoreactive cells were found to extend toward the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91103-5
更新日期:1985-10-28 00:00:00
abstract::The organization of the wing component of the dorsal column-medial lemniscal pathway, and somatosensory projections from the thalamus to the Wulst, are described for an oscine member of the major group of birds, the Passeriformes. Wing primary afferents terminate throughout the cervical spinal cord, but between the br...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00253-9
更新日期:1997-06-06 00:00:00
abstract::Despite insights into an increasingly significant role for delta opioid receptors in thermoregulation, it is unclear whether delta receptors located in the brain or periphery play the more critical role in body temperature regulation. Moreover, it is not entirely clear which delta receptor phenotype, delta1 or delta2,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.04.074
更新日期:2005-07-05 00:00:00
abstract::In order to study the effects of treatment with monosodium glutamate (MSG) during the neonatal period on the intrinsic circadian timekeeping system in rats, the locomotor activity of blinded MSG-treated and control (saline-treated) rats was analyzed with power spectral analysis and cross-correlation. In contrast to a ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90084-8
更新日期:1985-07-29 00:00:00
abstract::The present study examined the effects of excitotoxins which activate distinct excitatory amino acid (EAA) receptor subtypes on the levels of Methionine-enkephalin-like immunoreactivity (ME-i.r.) in the striatum and globus pallidus, with a view to developing a model of the striatopallidal enkephalin deficit that preva...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90029-b
更新日期:1990-12-17 00:00:00
abstract::This study examined the temporal appearance of c-fos expression in rat cerebella from birth to postnatal day 21 (P21) and following systemic kainic acid administration in adults. During development, Fos positive granule cells appeared first at P3 in caudal lobules and extended to all folia by P9. These reactive cells ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00263-7
更新日期:1998-06-08 00:00:00
abstract::In this study, we investigated the modulatory effect of 5alpha-pregnan-3alpha-ol-20-one, a neurosteroid, on the binding characteristics of [3H]flunitrazepam (2 nM), [3H]muscimol (5 nM), and 4 nM [35S]t-butylbicyclophosphorothionate (TBPS) in cerebral cortex, cerebellum, and hippocampus of control, ethanol-dependent, a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00649-0
更新日期:1998-09-14 00:00:00