Abstract：
:Glioblastoma is the most aggressive form of gliomas and is associated with short survival. Recent advancements in molecular genetics resulted in the identification of glioma genomic, epigenomic and transcriptomic hallmarks, and multidimensional data allowed clustering of glioblastomas into molecular subtypes. Parallel with these developments, much scientific attention has been attracted by the exploration of two functional processes linked to mitochondrial regulation. One of these processes involves genomic and mitochondrial gene mutations, mitochondrial protein expression modifications and altered metabolic regulation that define glioblastoma. The second mitochondrially-centered process involves complex molecular interactions and pathways that influence the extrinsic or the intrinsic mechanisms of apoptosis regulation and may underlie the uncontrolled spreading, recurrence and drug resistance of glioblastoma. While the available data are not yet comprehensive, these two complex processes represent important aspects of tumor cell biology, which may provide complementary opportunities for therapeutic manipulations of this highly resistant tumor type.
journal_name
Brain Resjournal_title
Brain researchauthors
Nagy A,Eder K,Selak MA,Kalman Bdoi
10.1016/j.brainres.2014.10.062subject
Has Abstractpub_date
2015-01-21 00:00:00pages
127-42eissn
0006-8993issn
1872-6240pii
S0006-8993(14)01484-Xjournal_volume
1595pub_type
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