Abstract:
:The effect of a single subcutaneous (s.c.) injection of the ultrapotent capsaicin analogue resiniferatoxin (RTX) on responses of adult rats to noxious thermal and mechanical stimulation was examined. The effects of RTX treatment on the nociceptive flexor reflex and activity-dependent increase in spinal excitability after conditioning C-fiber stimulation (CS) were also assessed. Finally, the expression of galanin message associated peptide (GMAP) mRNA in dorsal root ganglion (DRG) cells and the effects of the high affinity galanin receptor antagonist M35 on the flexor reflex in RTX-treated rats were evaluated. RTX, but not vehicle, produced marked thermal hypoalgesia on the hot plate test with partial recovery in about 50% of animals after about 2 weeks and no recovery in the remaining rats after 4 weeks. In all animals there was only a transient and moderate increase in paw withdrawal threshold to mechanical pressure. The flexor reflex in response to a C-fiber CS train was recorded 15-35 days after RTX or vehicle treatment. There was no difference between RTX and vehicle treated rats on baseline response, but RTX treatment lead to less wind-up during the CS and reduced hyperexcitability. This was particularly the case for rats which did not recover from RTX-induced hypoalgesia. The C-fiber mediated hyperexcitability was potentiated by the galanin receptor antagonist M35, more so in the non-recovered rats than in the partially recovered rats. The number of DRG cells expressing GMAP mRNA was significantly higher in non-recovered than in partially recovered rats. Thus, RTX produced marked and prolonged impairment of capsaicin-sensitive afferents and upregulation of the inhibitory neuropeptides GMAP and galanin in DRG neurons, which may underlie the prolonged effect of RTX.
journal_name
Brain Resjournal_title
Brain researchauthors
Xu XJ,Farkas-Szallasi T,Lundberg JM,Hökfelt T,Wiesenfeld-Hallin Z,Szallasi Adoi
10.1016/s0006-8993(96)01444-8subject
Has Abstractpub_date
1997-03-28 00:00:00pages
52-60issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(96)01444-8journal_volume
752pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The inhibitory effect of different concentrations of lithium (0.15-10 x 10(-3) M) on cAMP production induced by isoprenaline (1 x 10(-4) M) after the blockade of alpha(2)-adrenoceptors in the rat cerebral cortex was investigated. Low lithium concentrations (0.3-0.6 x 10(-3) M) exerted a significant inhibitory effect a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.019
更新日期:2003-12-19 00:00:00
abstract::Galectin-3 (Gal-3) is a member of a class of carbohydrate-binding proteins and plays a role in a number of cellular functions such as cell proliferation, angiogenesis and differentiation. We observed an up-regulated expression of Gal-3 in the ischemic brain following transient middle cerebral artery occlusion in rats....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.073
更新日期:2009-09-08 00:00:00
abstract::The subfornical organ (SFO), a neuroendocrine structure implicated in saltwater homeostasis, contains secretory structures histochemically similar to those in the neurohypophysis. Because of these morphological similarities, we compared levels of vasopressin (vp) in the SFO area and the adjacent hippocampal commissure...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90458-4
更新日期:1978-01-27 00:00:00
abstract::Current and voltage responses elicited by increasing or decreasing the concentration of L-glutamate or its analog kainate around isolated cone horizontal cells were measured with patch pipettes using the whole cell recording configuration. Application of these photoreceptor transmitter agonists induced inward currents...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90935-9
更新日期:1989-05-15 00:00:00
abstract::In order to establish the cellular and subcellular localization of the chemokine protein, vascular endothelial growth factor (VEGF) or vascular permeability factor, in adult human retina, we employed immunocytochemistry with double immunolabeling, using a primary antibody to amino acids 1-10 of VEGF, together with ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03766-6
更新日期:2003-04-18 00:00:00
abstract::Pentobarbital reversibly increased Na+-dependent GABA binding to bovine cerebral cortex membranes. This effect was chloride-dependent. Kinetic analysis of [3H]GABA binding revealed an increase of the apparent number of binding sites. Pretreatment of the membranes with Triton X-100 extremely diminished the effect of pe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90333-4
更新日期:1981-11-23 00:00:00
abstract::Multiple sclerosis patients typically experience increased pain that is relatively insensitive to opiate treatment. The mechanistic basis for this increased nociception is currently poorly understood. In the present study, we utilized the Theiler's murine encephalomyelitis virus (TMEV) model of MS to examine possible ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.11.034
更新日期:2008-01-29 00:00:00
abstract::Brain edema (BE) is an uncommon but life-threatening complication of severe diabetic ketoacidosis (DKA) and its treatment. Despite advances in treatment of DKA, the pathogenesis of both initiation and progression of the associated BE is unclear. In the present study we examined the blood brain barrier (BBB) integrity ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.11.100
更新日期:2009-02-13 00:00:00
abstract::Rhythmic caffeine hyperpolarizations generated in bullfrog sympathetic ganglion cells are assumed to be caused by periodic increase in gK due to rise in [Ca2+]i7--9,13. Caffeine-induced outward currents seem to be composed of two different components, which show different pharmacological natures and also different dep...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90263-3
更新日期:1982-07-15 00:00:00
abstract::The radioprotective thiophosphate S-2(3 amino-propyl-amino) phosphorothioic acid (WR 2721) induced an early reduction of striatal acetylcholinesterase activity followed by an increase, when intraperitoneally injected to rats, although it does not cross the blood-brain barrier. These results were obtained using an orig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90788-o
更新日期:1993-04-09 00:00:00
abstract::In the cat, cells of the superior colliculus (SC) and the tectofugal pathways of the visual system are highly selective for the direction of a moving visual stimulus. Deep layer units of SC in addition respond to auditory and somatosensory stimuli, but the proportion of such non-visual cells is usually found to be muc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90430-7
更新日期:1989-06-19 00:00:00
abstract::Ginseng is one of most extensively used traditional oriental medicines worldwide with beneficial efficacy on cognitive function disorders. Pharmacological researches on its active ingredient--ginsenoside Rg1 revealed that it can improve learning and memory potentially via modulating neurotransmission in the central ne...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.03.096
更新日期:2010-05-28 00:00:00
abstract::The distribution of carbonic anhydrase (CA) activity was determined histochemically using Hansson's cobalt phosphate method in cross-sections of peripheral nerves from rats. As the studied nerves contain either efferent, proprioceptive or exteroceptive myelinated fibres, our survey particularly focused on the question...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90895-0
更新日期:1989-07-17 00:00:00
abstract::Lesions of the anterior hypothalamus-medial preoptic area (AH-MPOA) impair courtship and copulatory behavior in male Cnemidophorus inornatus, a sexually reproducing species of whiptail lizard, and male-like pseudosexual behaviors in C. uniparens, an all-female species. These results suggest that, since C. inornatus is...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90046-9
更新日期:1994-04-18 00:00:00
abstract::The Leu-enkephalin dalargin does not normally penetrate the blood brain barrier when given intravenously. Drug targeting to the brain was investigated by using poly(butylcyanoacrylate) nanoparticles which were coated with polysorbate 80. When injected intravenously in mice, dalargin-loaded nanoparticles coated with th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01375-x
更新日期:1996-02-26 00:00:00
abstract::The window method of radiolabeled protein analysis was used to study the transport kinetics of axonally transported cytomatrix proteins as they move through segments of mouse optic axons. Three slow component b (SCb) proteins--actin, a 30 kDa protein, and clathrin--were radiolabeled in the eye and were followed for up...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91019-d
更新日期:1990-05-28 00:00:00
abstract::Normal adult albino and Sprague-Dawley rats, under intraperitoneal Nembutal anesthesia, were used to demonstrate enzymatic activity in the choroid plexus and ventricular ependyma. The brain tissues were perfused or immersed with cold 2% glutaraldehyde and 8% sucrose in 0.1 M cacodylate buffer (pH 7.2-7.4) for 30 min a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91035-0
更新日期:1981-10-19 00:00:00
abstract::Cerebellum is involved in the motion coordination and working memory, to which spike programming at Purkinje neurons are essential. The development of Purkinje neurons in the embryonic stage has been well studied. However, it is not clear about the maturation of their intrinsic property related to spike programming du...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.092
更新日期:2006-06-30 00:00:00
abstract::The ontogeny of muscarinic cholinergic receptors was studied in primary cultures of dissociated rat hippocampal cells. The specific [3H]quinuclidinyl benzilate [( 3H]QNB) to intact cells was detected after two days in culture. Scatchard analysis revealed only a unique binding site at all of the days tested, with a ver...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90019-8
更新日期:1987-09-01 00:00:00
abstract::The neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor are members of the endogenous opioid peptide family. In mammals N/OFQ modulates a variety of biological functions such as nociception, food intake, endocrine, control of neurotransmitter release, among others. In the molluscs Cepea nemoralis and Helix as...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.02.007
更新日期:2013-04-10 00:00:00
abstract::It was previously reported that brain areas containing serotonin (5-hydroxytryptamine, 5-HT) receptors mediate memory consolidation as well as short (STM)- and long-term memory (LTM). Here the effects of systemic and intrahippocampal administration of 5-HT agonists and antagonists on an autoshaping learning task were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.02.007
更新日期:2007-05-25 00:00:00
abstract::Patterns of proliferation and changes in non-neuronal cell number in the visual system of the goldfish have been quantitatively examined during optic axon regeneration after an optic nerve crush (ONC). In addition, in order to examine the effect of the regenerating axons on cellular responses in the visual pathways, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02339-2
更新日期:2000-01-31 00:00:00
abstract::The cytokine interleukin-12 (IL-12) is mainly produced in response to bacterial or parasitic infections. We examined the capacity of mouse brain microglia to release IL-12 forms upon challenge with bacterial lipopolysaccharide (LPS) and studied its modulation by sympathomimetics. LPS evoked the release of IL-12p40 whe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02174-6
更新日期:2001-04-27 00:00:00
abstract::Glia represents the most numerous group of nervous system cells and CNS development and function depend on glial cells. We developed a purified Muller glia culture to investigate the expression of several neurotransmitter markers on these cells, such as dopaminergic, cholinergic, GABAergic and peptidergic receptors or...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.01.031
更新日期:2005-03-21 00:00:00
abstract::Seven days after adrenalectomy (ADX) the number of vasoactive intestinal peptide (VIP)- and corticotropin-releasing factor (CRF)-immunoreactive cells in the parvocellular part of the rat paraventricular nucleus (PVN) increased markedly. Dexamethasone in the drinking water (started immediately after ADX) or its local i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91272-i
更新日期:1990-01-08 00:00:00
abstract::The terminal areas and cells of origin of the projection from the dorsal column nuclei to the mesencephalon were investigated by the intra-axonal transport method. Following injection of wheat germ agglutinin-horseradish peroxidase conjugate into the dorsal column nuclei, anterograde labeling was observed in several r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90086-6
更新日期:1984-10-08 00:00:00
abstract::Fluctuation analysis has been used to study the influence of temperature on the conductance and mean open time of Cl- permeable ion channels induced by gamma-aminobutyric acid (GABA) and glycine in the membrane of tissue cultured mouse spinal neurons. The conductance of GABA- and glycine-activated channels increased s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90875-1
更新日期:1981-11-16 00:00:00
abstract::Low concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) enhanced neuronal and glial survival and/or differentiation in dissociated cultures of 14-day mouse embryo brain. Posttrial intracisternal injection into the brains of mice undergoing active avoidance training alleviated amn...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90807-9
更新日期:1987-03-17 00:00:00
abstract::The regulation of corticosteroid receptor expression in the rat brain by adrenal steroids remains controversial. The results of in vivo studies [Brinton and McEwen, 1988; Luttge et al., 1989] suggest that activation of type I receptors can modulate both mineralocorticoid (MR; type I) and glucocorticoid (GR; type II) r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90174-0
更新日期:1994-02-04 00:00:00
abstract::Male guinea pigs were given 3 tests for sexual behavior. Animals that never ejaculated were classified as low activity (LA), animals that ejaculated on one test were classified as medium activity (MA), and animals that ejaculated on two or more tests were classified as high activity (HA). Subsequently, animals from ea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90929-x
更新日期:1976-03-19 00:00:00