The postnatal development of refractory periods and threshold potentials at cerebellar Purkinje neurons.

Abstract:

:Cerebellum is involved in the motion coordination and working memory, to which spike programming at Purkinje neurons are essential. The development of Purkinje neurons in the embryonic stage has been well studied. However, it is not clear about the maturation of their intrinsic property related to spike programming during postnatal period. We developed the approach to quantify the intrinsic property of sequential spikes with whole-cell recording, and analyzed the postnatal development of Purkinje neurons in cerebellar slices. Our results demonstrate that the threshold potentials shift toward more negatively than resting membrane potential, refractory periods following each of spikes decrease, as well as the relationship between refractory periods and inter-spike intervals converts to be more linear during the postnatal maturation. This postnatal plasticity of neuronal intrinsic properties enhances the firing ability and spike capacity, in turn strengthens spike programming, at cerebellar Purkinje neurons.

journal_name

Brain Res

journal_title

Brain research

authors

Guan S,Ma S,Zhu Y,Wang J

doi

10.1016/j.brainres.2006.04.092

subject

Has Abstract

pub_date

2006-06-30 00:00:00

pages

59-64

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(06)01293-5

journal_volume

1097

pub_type

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