Abstract：
:Brain edema (BE) is an uncommon but life-threatening complication of severe diabetic ketoacidosis (DKA) and its treatment. Despite advances in treatment of DKA, the pathogenesis of both initiation and progression of the associated BE is unclear. In the present study we examined the blood brain barrier (BBB) integrity and the potential involvement of the inflammatory mediators in BBB breakdown in two cases of fatal BE associated with DKA. In both cases there were typical signs of disruption of the BBB manifested by the absence of tight junction proteins (occludin, claudin-5, ZO-1 and JAM-1) in the parenchymal blood vessels, as well as albumin extravasation in examined brain areas. The neuroinflammatory markers chemokine CCL2, NF-kappaB and nitrotyrosine were localized in the perivascular areas of the disrupted BBB and diffusely distributed in the brain parenchyma. Our data indicate that neuroinflammation plays a role in the BBB disruption of the fatal BE of DKA.
journal_name
Brain Resjournal_title
Brain researchauthors
Hoffman WH,Stamatovic SM,Andjelkovic AVdoi
10.1016/j.brainres.2008.11.100subject
Has Abstractpub_date
2009-02-13 00:00:00pages
138-48eissn
0006-8993issn
1872-6240pii
S0006-8993(08)02904-1journal_volume
1254pub_type
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