Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington's disease.

Abstract:

:We examined the degree of oxidative damage to the brain of mice transgenic for the mutation responsible for Huntington's disease. We found that there is a progressive increase in striatal lipid peroxidation (LP), that parallels the worsening of the neurological phenotype. We consider that these transgenic mice may provide an interesting system to test treatments aimed at protecting cells from damage induced by free radicals.

journal_name

Brain Res

journal_title

Brain research

authors

Pérez-Severiano F,Ríos C,Segovia J

doi

10.1016/s0006-8993(00)02082-5

subject

Has Abstract

pub_date

2000-04-17 00:00:00

pages

234-7

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(00)02082-5

journal_volume

862

pub_type

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