Abstract:
:We examined the degree of oxidative damage to the brain of mice transgenic for the mutation responsible for Huntington's disease. We found that there is a progressive increase in striatal lipid peroxidation (LP), that parallels the worsening of the neurological phenotype. We consider that these transgenic mice may provide an interesting system to test treatments aimed at protecting cells from damage induced by free radicals.
journal_name
Brain Resjournal_title
Brain researchauthors
Pérez-Severiano F,Ríos C,Segovia Jdoi
10.1016/s0006-8993(00)02082-5subject
Has Abstractpub_date
2000-04-17 00:00:00pages
234-7issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02082-5journal_volume
862pub_type
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