Abstract:
:Slices of rat hippocampus were exposed to 700 MHz continuous wave radiofrequency (RF) fields (25.2-71.0 V m(-1), 5-15 min exposure) in a stripline waveguide. At low field intensities, the predominant effect on the electrically evoked field potential in CA1 was a potentiation of the amplitude of the population spike by up to 20%, but higher intensity fields could produce either increases or decreases of up to 120 and 80%, respectively, in the amplitude of the population spike. To eliminate the possibility of RF-induced artefacts due to the metal stimulating electrode, the effect of RF exposure on spontaneous epileptiform activity induced in CA3 by 4-aminopyridine (50-100 microM) was investigated. Exposure to RF fields (50.0 V m(-1)) reduced or abolished epileptiform bursting in 36% of slices tested. The maximum field intensity used in these experiments, 71.0 V m(-1), was calculated to produce a specific absorption rate (SAR) of between 0.0016 and 0.0044 W kg(-1) in the slices. Measurements with a Luxtron fibreoptic probe confirmed that there was no detectable temperature change (+/- 0.1 degrees C) during a 15 min exposure to this field intensity. Furthermore, imposed temperature changes of up to 1 degrees C failed to mimic the effects of RF exposure. These results suggest that low-intensity RF fields can modulate the excitability of hippocampal tissue in vitro in the absence of gross thermal effects. The changes in excitability may be consistent with reported behavioural effects of RF fields.
journal_name
Brain Resjournal_title
Brain researchauthors
Tattersall JE,Scott IR,Wood SJ,Nettell JJ,Bevir MK,Wang Z,Somasiri NP,Chen Xdoi
10.1016/s0006-8993(01)02434-9subject
Has Abstractpub_date
2001-06-15 00:00:00pages
43-53issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(01)02434-9journal_volume
904pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::It has recently been shown that the immunosuppressant cyclosporin A (CsA) dramatically ameliorates the selective neuronal necrosis which results from 10 min of forebrain ischemia in rats. Since CsA is a virtually specific blocker of the mitochondrial permeability transition (MPT) pore which is assembled under adverse ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00005-x
更新日期:1997-04-04 00:00:00
abstract::Sensitisation to the behavioural effects of amphetamine, a phenomenon which appears to involve the potentiation of excitatory amino acid (EAA)-mediated transmission at the level of dopaminergic (DA) neurons in the ventral tegmental area (the A10 cell group), is known to be affected by corticosteroid manipulations. Sin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00722-6
更新日期:1996-10-21 00:00:00
abstract::Plectin is associated with intermediate filaments, such as glial fibrillary acidic protein (GFAP) and vimentin, which have an important role in the glial reactions after lesions. The present study investigates the plectin immunoreactivity following stab wounds in the cortex and the underlying white matter of adult rat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02399-9
更新日期:2000-02-28 00:00:00
abstract::Children with Asperger's Disorder or High Functioning Autism are included in regular education classes but find themselves excluded from the social lives of their classmates. This paper briefly reviews studies which attempt to provide them with training to overcome their social difficulties. These interventions have h...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2010.09.047
更新日期:2011-03-22 00:00:00
abstract::The organization of globus pallidus (GP) projections was studied in cats using autoradiographic and horseradish peroxidase (HRP) techniques. Both methods confirmed the existence of a topographically organized projection to subthalamic nucleus (STN). Although all but the most caudal GP projects to STN, the heaviest pro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90003-7
更新日期:1980-05-05 00:00:00
abstract::Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity and the central terminal fields of branches of the mandibular and chorda tympani nerves were visualized histochemically at the same time using transganglionic transport of wheat germ agglutinin conjugated with horseradish peroxidase. The blue NA...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01210-9
更新日期:1998-01-19 00:00:00
abstract::A site-specific antibody against the principal gap junctional protein in heart (connexin 43) was used to determine immunohistochemically the cellular localization of this protein in rat brain. Structures labelled with the antibody included gap junctional membranes between glial, ependymal, pial and arachnoid cells as ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90415-8
更新日期:1990-02-05 00:00:00
abstract::Stereotaxically placed intracerebral microinjections of 6-hydroxydopamine (6-OHDA) were used to produce selective and extensive lesions of either the dopaminergic nigro-neostriatal bundle or the dorsal and ventral noradrenergic projections in the rat. The extensive damage of the noradrenergic pathways which is typical...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90182-1
更新日期:1975-08-15 00:00:00
abstract::The effects of exo- and endogenous cGMP on the resting activity (RA) of afferent crista fibers were studied in isolated preparations of the statocysts of the cuttlefish Sepia officinalis and the squid Sepioteuthis lessoniana. Bath application of the membrane-permeable cGMP analogs 8-bromo-cGMP (B-cGMP) and N(2),2'-o-d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02777-3
更新日期:2000-10-13 00:00:00
abstract::Perinatal overfeeding is a risk factor for overweight and diabetes during life. Underlying pathophysiological mechanisms are unclear. The peptide galanin is suggested to stimulate food intake by acting within the paraventricular hypothalamic nucleus (PVN). In early postnatally overfed rats overweight and hyperinsuline...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01264-5
更新日期:1999-02-06 00:00:00
abstract::Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (APV) blocked inductio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91337-g
更新日期:1990-08-13 00:00:00
abstract::Noise analysis was used to estimate the single-channel conductance and number of channels responsible for the mechanically-activated current in the sensory neurons of a spider mechanoreceptor organ. External slits of the VS-3 slit-sense organ in the patellar cuticle of Cupiennius salei were moved with a piezoelectric ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01276-7
更新日期:1999-05-01 00:00:00
abstract::Estrogen has previously been shown to significantly change sympathetic and parasympathetic system output via an action within the central nuclei responsible for regulating autonomic tone. These estrogen-induced changes were observed within 30 min of systemic administration and could be blocked by the direct microinjec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03387-0
更新日期:2003-11-14 00:00:00
abstract::We have developed and tested the biological activity and specificity of a novel fluorescent dextran-Texas Red-nerve growth factor (DTR-NGF) conjugate. DTR-NGF was found to promote survival and neurite outgrowth in cultured dissociated sympathetic neurons similarly to native NGF. The conjugate was taken up and transpor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03099-2
更新日期:2001-11-30 00:00:00
abstract::Previous studies in piglets show that opioid-induced pial artery dilation was impaired following fluid percussion brain injury (FPI). This study was designed to determine the role of the newly described opioid nociceptin orphanin FQ (NOC/oFQ) in such impaired dilation to other opioids after FPI. CSF NOC/oFQ concentrat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02367-2
更新日期:2000-06-30 00:00:00
abstract::High-intensity stimulation of the supraorbital region elicits, together with a blink reflex, a reflex inhibition of the jaw-closing muscles in normal man. The response differs from the well known inhibition obtained by intra- and perioral stimulation in two main features. Firstly, it consists of a single late silent p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90366-5
更新日期:1986-04-23 00:00:00
abstract::The present study examined the locomotor response of rats to unilateral injections of the mixed D1/D2 agonist apomorphine, the D2 agonist quinpirole, and the D1 agonist SKF 38393 into the left or right nucleus accumbens (NA) of male Sprague-Dawley rats. There were 2 main findings. First, unilateral (left or right) inj...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91351-g
更新日期:1990-11-19 00:00:00
abstract::Veratridine-induced depolarization caused a large increase in Ca uptake in the rat hippocampal slice (30.2 vs. 9.0 nM/mg dry weight). This uptake was reduced to 18.4 nM/mg when veratridine was combined with anoxia. When compared with veratridine exposure alone, the combination of anoxia and veratridine increased intra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91547-4
更新日期:1994-01-07 00:00:00
abstract::In anesthetized rats, out of 48 paraventricular (PaV) and 19 periventricular (PeV) neurosecretory cells, 12 PaV and 6 PeV cells increased and 10 PaV cells decreased the electrical activities statically in response to preoptic and anterior hypothalamic warming. Four PaV and 2 PeV cells responded dynamically to the ther...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90036-7
更新日期:1983-12-19 00:00:00
abstract::The striatum and olfactory tubercle of 30-month-old F344 rats contain significantly (21-24%) less dopamine compared with young adult (8-month) animals. However, rats of the two age groups show identical Km and Vmax values for the kinetics of [3H]dopamine uptake into striatal homogenates; uptake into the olfactory tube...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90262-3
更新日期:1986-07-30 00:00:00
abstract::Non-peptide receptor ligands with differential affinity for the angiotensin II-1 (AII-1) receptor (EXP3312, EXP3880) or the AII-2 receptor (PD123177) and an angiotensin converting enzyme (ACE) inhibitor captopril were evaluated for the ability to protect against a renin-induced performance deficit in a passive avoidan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91599-v
更新日期:1991-10-11 00:00:00
abstract::Intracellular recordings and labelings with horseradish peroxidase (HRP) of expiratory (E) neurons were performed in decerebrate, paralyzed, and ventilated rats. A total of 37 neurons were recorded, from which 4 cells and 1 axon were labeled. They were located in two regions of the ventrolateral medulla. One was in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90687-5
更新日期:1992-04-03 00:00:00
abstract::The mRNA level of the 17-kDa protein neurogranin (NG), a postsynaptic substrate of the protein kinase C, has previously been found to be decreased in rat forebrain after 24-h sleep deprivation (SD). To investigate the functional significance of this finding in various forebrain regions, the effect of 24-h SD on the mR...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00416-n
更新日期:1995-07-10 00:00:00
abstract::The purpose of this study was to compare the relative effects of mannitol and hypertonic saline (HTS) on calpain activity, apoptosis and neuroinflammatory response induced by experimental cortical contusion. Four groups of 5 Sprague-Dawley male rats were submitted to focal brain injury produced by exposing the parieta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.045
更新日期:2006-07-26 00:00:00
abstract::Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.05.008
更新日期:2005-06-28 00:00:00
abstract::Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell res...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90081-j
更新日期:1992-03-20 00:00:00
abstract::The differential effects of the pyrethroid tetramethrin on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) single sodium channel currents in rat dorsal root ganglion (DRG) neurons were investigated using the outside-out configuration of patch-clamp technique. Channel conductances were 10.7 and 6.3 pS...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01449-7
更新日期:1996-03-18 00:00:00
abstract::Brain cortico-striatal circuits have consistently been implicated in the pathology of addiction related disorders. We applied a reliable seed-based analysis of the resting-state brain activity to comprehensively delineate the subdivisions of striatal functional connectivity implicated in internet gaming disorder. Amon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.12.042
更新日期:2015-03-30 00:00:00
abstract::The ability of neutral red to serve as an internal pH indicator in biological systems was tested in the rat brain after parenteral adminstration of the dye. The injected dye is avidly taken up by the brain cells and is distributed mainly in intracellular organelles. The ratio of optical signals recorded from the froze...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90869-0
更新日期:1980-08-11 00:00:00
abstract::In gerbils pentylenetetrazole- or handling-induced seizures were accompanied by cerebral formation of small amounts of cysteinyl-leukotrienes (LT) but large amounts of prostaglandin (PG) F2 alpha. By contrast, in rats injected with pentylenetetrazole or bicuculline very large amounts of PGF2 alpha but no cysteinyl-LT ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90519-2
更新日期:1991-02-01 00:00:00