Abstract：
:Brain cortico-striatal circuits have consistently been implicated in the pathology of addiction related disorders. We applied a reliable seed-based analysis of the resting-state brain activity to comprehensively delineate the subdivisions of striatal functional connectivity implicated in internet gaming disorder. Among twelve right-handed male adolescents with internet gaming disorder and 11 right-handed and gender-matched healthy controls, we examined group differences in the functional connectivity of dorsal and ventral subdivisions of the caudate nucleus and putamen, as well as the association of these connectivity indices with behavioral measures of internet use. Adolescents with internet gaming disorder showed significantly reduced dorsal putamen functional connectivity with the posterior insula-parietal operculum. More time spent playing online games predicted significantly greater functional connectivity between the dorsal putamen and bilateral primary somatosensory cortices in adolescents with internet gaming disorder, and significantly lower functional connectivity between the dorsal putamen and bilateral sensorimotor cortices in healthy controls. The dorsal putamen functional connectivity was significantly and specifically different in adolescents with internet gaming disorder. The findings suggest a possible biomarker of internet gaming disorder.
journal_name
Brain Resjournal_title
Brain researchauthors
Hong SB,Harrison BJ,Dandash O,Choi EJ,Kim SC,Kim HH,Shim DH,Kim CD,Kim JW,Yi SHdoi
10.1016/j.brainres.2014.12.042subject
Has Abstractpub_date
2015-03-30 00:00:00pages
85-95eissn
0006-8993issn
1872-6240pii
S0006-8993(14)01749-1journal_volume
1602pub_type
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