Abstract：
:These experiments investigated the effect of immediate posttrial administration of peripherally acting DL-4-hydroxyamphetamine on retention of a one-trial inhibitory avoidance response in intact, adrenal medullectomized, sympathectomized, and medullectomized and sympathectomized rats. In intact rats, 0.82 mg/kg of DL-4-OH-amphetamine enhanced retention performance. In rats sympathectomized by peripheral 6-hydroxydopamine, 24 h prior to training, a lower dose of 4-OH-amphetamine (0.21 mg/kg) was most effective in enhancing retention. Adrenal demedullation abolished the memory enhancing effects of DL-4-OH-amphetamine and also D-amphetamine. These findings suggest that the memory enhancing effects of DL-4-OH-amphetamine and D-amphetamine involve adrenal medullary catecholamines.
journal_name
Brain Resjournal_title
Brain researchauthors
Martinez JL Jr,Vasquez BJ,Rigter H,Messing RB,Jensen RA,Liang KC,McGaugh JLdoi
10.1016/0006-8993(80)90077-3subject
Has Abstractpub_date
1980-08-18 00:00:00pages
433-43issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(80)90077-3journal_volume
195pub_type
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