Increased ouabain binding after repeated noradrenergic stimulation.

Abstract:

:Acute noradrenergic stimulation has previously been shown to stimulate brain (Na+, K+)-adenosine triphosphatase activity. Effects of repeated stimulation with piperoxane were examined in the present study. Daily piperoxane increased ouabain binding, measured 24 h after the last dose, after 4 days or 3 weeks treatment; K+-p-nitrophenylphosphatase was increased after 3 weeks. Prazosin, which, like piperoxane, activates presynaptic noradrenergic neurons but, unlike piperoxane, blocks postsynaptic receptors, did not increase K+-p-nitrophenylphosphatase, and decreased ouabain binding after 3 weeks.

journal_name

Brain Res

journal_title

Brain research

authors

Swann AC,Grant SJ,Jablons D,Maas JW

doi

10.1016/0006-8993(81)90258-4

subject

Has Abstract

pub_date

1981-06-01 00:00:00

pages

481-5

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(81)90258-4

journal_volume

213

pub_type

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