Abstract:
:Acute noradrenergic stimulation has previously been shown to stimulate brain (Na+, K+)-adenosine triphosphatase activity. Effects of repeated stimulation with piperoxane were examined in the present study. Daily piperoxane increased ouabain binding, measured 24 h after the last dose, after 4 days or 3 weeks treatment; K+-p-nitrophenylphosphatase was increased after 3 weeks. Prazosin, which, like piperoxane, activates presynaptic noradrenergic neurons but, unlike piperoxane, blocks postsynaptic receptors, did not increase K+-p-nitrophenylphosphatase, and decreased ouabain binding after 3 weeks.
journal_name
Brain Resjournal_title
Brain researchauthors
Swann AC,Grant SJ,Jablons D,Maas JWdoi
10.1016/0006-8993(81)90258-4subject
Has Abstractpub_date
1981-06-01 00:00:00pages
481-5issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(81)90258-4journal_volume
213pub_type
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