Abstract：
:The periaqueductal gray was shown to be an important component of morphine analgesia and tolerance. Two-way analgesic cross tolerance was obtained between systemic and intracerebral morphine administrations when the intracerebral site was the periaqueductal gray. Rats were pretreated with intraperitoneal morphine and tested with intracerebral morphine in the periaqueductal gray. A dose-dependent reduction in analgesia as a function of morphine pretreatment level was obtained. Conversely, when rats were pretreated with intracerebral morphine in the periaqueductal gray and tested with intraperitoneal morphine, significant reductions in analgesia were obtained.
journal_name
Brain Resjournal_title
Brain researchauthors
Jacquet YF,Lajtha Adoi
10.1016/0006-8993(76)90448-0subject
Has Abstractpub_date
1976-02-27 00:00:00pages
501-13issue
3eissn
0006-8993issn
1872-6240pii
0006-8993(76)90448-0journal_volume
103pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Altered dopamine regulation in the medial prefrontal cortex has been linked to drug abuse and disorders such as schizophrenia. Heterogeneous expression of the dopamine transporter, as well as the ability of the norepinephrine transporter to clear dopamine in the prefrontal cortex, delineates two potential sites for th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02542-8
更新日期：2002-05-17 00:00:00
abstract：:We examined how adjective ordering is used in language comprehension by crossing order preference and concreteness in phrases consisting of two adjectives and a noun. We used both more typical phrases in which the preferred order has a concrete second adjective ("exhaustive hardback encyclopedia") and those with a con...
journal_title：Brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brainres.2012.07.050
更新日期：2012-09-26 00:00:00
abstract：:The mechanism of the Ca2+-dependent stimulation of neurotransmitter release by 4-aminopyridine in synaptosomes was studied. The stimulation of gamma-[3H]aminobutyric acid and [3H]acetylcholine release by 4-aminopyridine was not significantly affected either by tetrodotoxin or by the absence of Na+ in the medium, where...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91307-1
更新日期：1985-12-30 00:00:00
abstract：:The effects of acute and chronic phencyclidine (PCP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in discrete regions of rat brain. Both acute and chronic administration of PCP induced high locomotor activity, stereotypy and ataxia. On PCP administration, NTLI decreased significantly in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91601-4
更新日期：1985-05-06 00:00:00
abstract：:The current study assessed the influence of excitotoxic lesions of the insular cortex (IC) on taste-potentiated odor aversion (TPOA) learning. Water-deprived rats initially received a single odor-toxicosis or odor/taste-toxicosis pairing and were subsequently tested, in separate trials, with the odor and the taste sti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.051
更新日期：2009-11-10 00:00:00
abstract：:This study was performed to understand the anatomical substrates of hypothalamic modulation of jaw movements. After cholera toxin B subunit (CTb) injection into the parvicellular reticular formation (RFp) of the rat medulla oblongata, where many trigeminal premotor neurons have been known to exist, numerous CTb-labele...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.09.076
更新日期：2008-12-09 00:00:00
abstract：:Regulation of the intracellular calcium concentration ([Ca(2+)](i)) is of critical importance for synaptic function. Therefore, neurons buffer [Ca(2+)](i) using intracellular Ca(2+)-binding proteins (CaBPs). Previous evidence suggests that Calbindin-D(28K) (CB), an abundantly expressed endogenous fast CaBP, plays an i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.036
更新日期：2012-04-23 00:00:00
abstract：:The action of 5-hydroxytryptamine (5-HT) via the 5-HT1A receptor on dissociated rat dorsal raphe neurons was characterized under the whole-cell mode by using the nystatin-perforated patch-clamp technique. Under voltage-clamp conditions, 5-HT induced an inwardly rectifying K+ current (I5-HT) in a concentration-dependen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01141-9
更新日期：1997-01-16 00:00:00
abstract：:Recent evidence has suggested that cholecystokinin (CCK) may act as a physiological opiate antagonist. Both the overlap of CCK and opiate systems within the central nervous system and the fact that exogenous CCK can antagonize opiate analgesia suggest that endogenous CCK systems interact with opiate-mediated pain inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91511-2
更新日期：1985-02-18 00:00:00
abstract：:Rat pinealocytes use L-glutamate as a modulator for melatonin synthesis. Upon binding of L-glutamate to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity and melatonin output. Although L-gluta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02102-2
更新日期：1999-12-11 00:00:00
abstract：:We investigated the effect of repetitive transcranial magnetic stimulation (rTMS) on long-term potentiation (LTP) in the rat hippocampus. Rats were magnetically stimulated at a rate of 1000 pulses/day for 7 days by a round coil, in which the peak magnetic fields at the center of the coil were 0.75 and 1.00 T. LTP enha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.009
更新日期：2003-12-12 00:00:00
abstract：:The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.058
更新日期：2007-01-12 00:00:00
abstract：:Manipulations of either discrete emotions (e.g. happiness) or affective dimensions (e.g. positivity) have a long tradition in emotion research, but interactive effects have never been studied, based on the assumption that the two underlying theories are incompatible. Recent theorizing suggests, however, that the human...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.03.045
更新日期：2014-05-20 00:00:00
abstract：:A small, unilateral, penetrating wound was placed in the dorsolateral portion of the lumbosacral spinal cord in immature rats. Although this wound did not extend into the central canal area, some cells forming the walls of this canal underwent proliferative activity as demonstrated by [3H]thymidine autoradiography. Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90783-0
更新日期：1980-11-10 00:00:00
abstract：:The accessibility of macromolecules to the postnatal mammalian central nervous system is a subject of controversy and importance. One of the biologically important macromolecules in neural development, nerve growth factor (NGF), is thought to be unable to cross the blood-brain barrier in postnatal mammals. In this stu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91775-n
更新日期：1993-05-14 00:00:00
abstract：:Amyloid-beta protein (A beta) deposition in the cerebral vascular walls is one of the key features of Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). A beta(1-40) carrying the 'Dutch' mutation (HCHWA-D A beta(1-40)) induces pronounced degeneration of cultured human brain p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03218-3
更新日期：2002-10-11 00:00:00
abstract：:Power spectral analysis of the electroencephalogram (EEG) is a non-invasive method to examine infant brain maturation. Preterm fetal growth restricted (p-FGR) neonates display an altered EEG power spectrum compared to appropriate-for-gestational-age (AGA) peers, suggesting delayed brain maturation. Longitudinal studie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.10.010
更新日期：2018-01-01 00:00:00
abstract：:The low, middle, and high molecular mass neurofilament subunit proteins (NF-L, NF-M, and NF-H) co-polymerize to form neurofilaments (NFs). During development, NF subunit expression is highly regulated, and in neurodegenerative disease, aberrant regulation of this expression can lead to the formation of harmful aggrega...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.012
更新日期：2008-01-16 00:00:00
abstract：:The effect of valproic acid (VPA) on synaptic transmission was investigated at the frog neuromuscular junction using electrophysiological methods. The drug caused a dose-dependent decrease in the quantal content of the endplate potential (EPP) and a significant reduction in the input resistance of the postjunctional m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90393-7
更新日期：1984-07-23 00:00:00
abstract：:A startle-like response can be evoked at low currents by one-pulse electrical stimulation of reticular formation sites from the rostrolateral pons to the caudomedial medulla. To test whether this response is mediated by the same reticular formation neurons as those that mediate the acoustic startle, we delivered a bri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91100-7
更新日期：1993-07-23 00:00:00
abstract：:The known neurochemical effect of most currently available antidepressants is the enhancement of the synaptic levels of monoamine neurotransmitters. However, the existence of other mechanisms has been suggested to justify the significant delay between the modulation of the monoaminergic system and the clinical effects...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.12.008
更新日期：2007-03-02 00:00:00
abstract：:Adult Long-Evans female rats sustained electrolytic fimbria-fornix lesions and, two weeks later, received intrahippocampal suspension grafts of fetal septal tissue. Sham-operated and lesion-only rats served as controls. Between 6.5 and 8 months after grafting, both the [3H]choline accumulation and the electrically evo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01092-0
更新日期：1995-12-18 00:00:00
abstract：:The petrosal ganglia contain the somata of the sensory fibers of the glossopharyngeal nerves, innervating structures of the tongue, pharynx, carotid sinus and carotid body. Petrosal ganglia were excised from adult cats and their neurons were dissociated and kept in tissue culture for 7-12 days. Intracellular recording...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02817-1
更新日期：2000-11-03 00:00:00
abstract：:Prostaglandins are now thought to play an important role in nociceptive information transmission in the spinal cord. Prostaglandins are known to be produced by cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid. Two forms of COX have been identified: COX-1, which is constitutively expressed in mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00817-7
更新日期：1996-11-11 00:00:00
abstract：:The analgesia induced by 30-s footshock (1 mA) is enhanced and attenuated by decreasing and increasing the extraneuronal availability of serotonin (5-HT), respectively. In the present work we have shown the effect to be mediated by spinal 5-HT systems as the response was increased by depletion of spinal but not brain ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90448-6
更新日期：1982-04-15 00:00:00
abstract：:Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrilla...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90914-0
更新日期：1987-07-28 00:00:00
abstract：:We have successfully constructed a mouse neuronal N1E-115 cell line stably expressing a fully functional human dopamine transporter (hDAT). Previous studies in our laboratory have produced several anti-idiotypic Ab2beta antibodies that mimic the configuration of the cocaine molecule at their antigen-combining site. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02491-4
更新日期：2000-07-28 00:00:00
abstract：:In order to improve clinical trial design and translation of normobaric oxygen (NBO) treatment of ischemic stroke, NBO treatment parameters need to be better understood. This study investigated NBO treatment efficacy at two different stroke severities and two NBO treatment durations in rats. For the 60-min middle cere...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.01.030
更新日期：2016-03-15 00:00:00
abstract：:Purkinje cells are the sole output from the cerebellar cortex and play a critical role during classical eyeblink conditioning. The present study revealed for the first time a learning-related change in individual Purkinje cell activity during successive eyeblink conditioning in decerebrate guinea pigs which permitted ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.090
更新日期：2006-01-12 00:00:00
abstract：:Pretreatment with recombinant human interleukin-1 alpha (rhIL-1 alpha) 20 h before irradiation attenuates radiation-induced hyperthermia. Experiments were conducted to determine the role of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) in rhIL-1 alpha-induced attenuation of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91576-e
更新日期：1993-03-19 00:00:00
