Potentiation of morphine analgesia by the cholecystokinin antagonist proglumide.


:Recent evidence has suggested that cholecystokinin (CCK) may act as a physiological opiate antagonist. Both the overlap of CCK and opiate systems within the central nervous system and the fact that exogenous CCK can antagonize opiate analgesia suggest that endogenous CCK systems interact with opiate-mediated pain inhibitory systems. In the present series of experiments, we examined the effect of the CCK receptor antagonist proglumide on various forms of morphine analgesia. We have observed that proglumide can potentiate morphine analgesia following systemic, intrathecal or intracerebral administration of these drugs. Endogenous CCK systems do not appear to be tonically active since neither systemic, intrathecal nor intracerebral proglumide typically produced measurable analgesia in the absence of morphine. These data suggest that CCK may be released in response to opiate administration and acts to return the organism toward its basal level of pain sensitivity. If such a hypothesis is in fact true, then CCK blockade may be of clinical value in the treatment of pain.


Brain Res


Brain research


Watkins LR,Kinscheck IB,Mayer DJ




Has Abstract


1985-02-18 00:00:00














  • Effects of alpha-noradrenergic substances on the optokinetic and vestibulo-ocular responses in the rabbit: a study with systemic and intrafloccular injections.

    abstract::The effects of microinjection of alpha-noradrenergic agonists and antagonists in the flocculus on the basic gain and adaptibility of vestibulo-ocular and optokinetic responses were investigated. A complementary, previous investigation had shown that the adaptation, but not the basic performance, of compensatory oculom...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tan HS,van Neerven J,Collewijn H,Pompeiano O

    更新日期:1991-10-25 00:00:00

  • The effects of various lesions and knife-cuts on septal and amygdala kindling in the rat.

    abstract::Large bilateral aspiration lesions of the hippocampus had no significant effect on septal kindling, whereas large bilateral DC lesions of the pyriform lobe resulted in a small but significant increase in the number of septal stimulations required to complete kindling. Bilateral aspiration lesions of the dorsal hippoca...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Racine RJ,Paxinos G,Mosher JM,Kairiss EW

    更新日期:1988-06-28 00:00:00

  • Relation of uptake and metabolism of (1,2,6,7-3H)testosterone to individual differences in sexual behavior in male guinea pigs.

    abstract::Male guinea pigs were given 3 tests for sexual behavior. Animals that never ejaculated were classified as low activity (LA), animals that ejaculated on one test were classified as medium activity (MA), and animals that ejaculated on two or more tests were classified as high activity (HA). Subsequently, animals from ea...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Harding CF,Feder HH

    更新日期:1976-03-19 00:00:00

  • Evidence to suggest that extracellular acetate is accumulated by rat hippocampal cholinergic nerve terminals for acetylcholine formation and release.

    abstract::It is well established that extracellular choline is transported into central cholinergic nerve terminals by 'high' and 'low' affinity processes to form the neurotransmitter acetylcholine (ACh). The intent of the present investigation was to ascertain whether extracellular acetate might also be transported into centra...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Carroll PT

    更新日期:1997-04-04 00:00:00

  • An endogenous inhibitory factor for choline acetyltransferase.

    abstract::Chromatography of partially purified choline acetyltransferase (CAT) over carboxymethyl cellulose may result in the loss of up to 95% of the enzyme activity. This loss of activity can be prevented by running the chromatographs at low protein concentration with a large gradient volume suggesting that interactions betwe...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cozzari C,Hartman BK

    更新日期:1983-10-03 00:00:00

  • Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats.

    abstract::Kainic acid (KA) injections destroy hippocampal pyramidal cells, induce recurrent collateral sprouting of the hilar mossy fibers (MFs), and lead to chronic seizures. In the present study, rats were injected systemically with KA (14 mg/kg) to determine whether the subsequent occurrence of seizures was correlated with M...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cronin J,Dudek FE

    更新日期:1988-11-22 00:00:00

  • Rodent models of TDP-43: recent advances.

    abstract::Recently, missense mutations in the gene TARDBP encoding TDP-43 have been linked to familial ALS. The discovery of genes encoding these RNA binding proteins, such as TDP-43 and FUS/TLS, raised the notion that altered RNA metabolism is a major factor underlying the pathogenesis of ALS. To begin to unravel how mutations...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Tsao W,Jeong YH,Lin S,Ling J,Price DL,Chiang PM,Wong PC

    更新日期:2012-06-26 00:00:00

  • Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the rat.

    abstract::Light microscopic double labeling immunocytochemistry for vasoactive intestinal peptide (VIP) and gonadotrophin-releasing hormone (GnRH) was carried out on the hypothalami of male and female rats. It was found that the number of VIP boutons that terminate on GnRH neurons and the percentage of GnRH neurons contacted by...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Horvath TL,Cela V,van der Beek EM

    更新日期:1998-06-08 00:00:00

  • Brain microsomal metabolism of phencyclidine in male and female rats.

    abstract::These studies examined the microsomal brain metabolism of phencyclidine (PCP) in male and female Sprague-Dawley rats. Several monohydroxylated metabolites of PCP were detected including cis- and trans-1-(1-phenyl-4-hydroxycyclohexyl)piperidine (c-PPC and t-PPC) and 1-(1-phenylcyclohexyl)-4-hydroxypiperidine (PCHP). Th...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Laurenzana EM,Owens SM

    更新日期:1997-05-09 00:00:00

  • Effects of stroke severity and treatment duration in normobaric hyperoxia treatment of ischemic stroke.

    abstract::In order to improve clinical trial design and translation of normobaric oxygen (NBO) treatment of ischemic stroke, NBO treatment parameters need to be better understood. This study investigated NBO treatment efficacy at two different stroke severities and two NBO treatment durations in rats. For the 60-min middle cere...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tiwari YV,Jiang Z,Sun Y,Du F,Rodriguez P,Shen Q,Duong TQ

    更新日期:2016-03-15 00:00:00

  • Ontogenesis of muscarinic receptors in cultured rat hippocampal cells.

    abstract::The ontogeny of muscarinic cholinergic receptors was studied in primary cultures of dissociated rat hippocampal cells. The specific [3H]quinuclidinyl benzilate [( 3H]QNB) to intact cells was detected after two days in culture. Scatchard analysis revealed only a unique binding site at all of the days tested, with a ver...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fernandez-Tomé P,Segal M

    更新日期:1987-09-01 00:00:00

  • Melatonin attenuates neuronal NADPH-d/NOS expression in the hypoglossal nucleus of adult rats following peripheral nerve injury.

    abstract::Oxidative stress and massive production of nitric oxide (NO) have been implicated in the neuropathogenesis following peripheral nerve injury. This study was aimed to ascertain whether melatonin would exert its neuroprotective effect on the lesioned hypoglossal neurons after peripheral axotomy, since it is known to red...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chang HM,Ling EA,Lue JH,Wen CY,Shieh JY

    更新日期:2000-08-11 00:00:00

  • Involvement of nociceptin/orphanin FQ and its receptor in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation.

    abstract::The neuropeptide nociceptin/orphanin FQ (N/OFQ), the endogenous agonist of the N/OFQ peptide receptor (NOP receptor), has been demonstrated to be involved in many physiological and pathological functions including pain regulation. In the present study, the involvement of N/OFQ-NOP receptor system in electroacupuncture...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fu X,Wang YQ,Wu GC

    更新日期:2006-03-17 00:00:00

  • Establishment of Muller cell cultures from adult rat retina.

    abstract::During a recent study of the effects of photoreceptor degeneration on Muller cells, we observed that unlike glia from normal adult retinas, glia from degenerating rat retinas could be cultured and maintained in vitro for several weeks. Using a variety of cell type specific antisera, we show that at least 70% of cells ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sarthy PV

    更新日期:1985-06-24 00:00:00

  • Single unit responses of substantia nigra pars reticulata neurons to apomorphine: effects of striatal lesions and anesthesia.

    abstract::Many of the behavioral consequences of dopamine system activation are thought to be mediated by substantia nigra pars reticulata output pathways. Extracellular, single unit recording studies were conducted to determine how i.v. administration of the dopamine agonist, apomorphine, affects the activity of these pars ret...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Waszczak BL,Lee EK,Ferraro T,Hare TA,Walters JR

    更新日期:1984-07-23 00:00:00

  • Oral delivery of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics: Immunofluorescent localization in the mouse hypothalamus.

    abstract::This study describes the localization of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics, in the hypothalamus of Swiss Webster and C57BL/6J wild-type mice, leptin-deficient ob/ob mice, and leptin-resistant diet-induced obese (DIO) mice. The mice were given [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in 0.3...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Anderson BM,Jacobson L,Novakovic ZM,Grasso P

    更新日期:2017-06-01 00:00:00

  • Aluminum citrate uptake by immortalized brain endothelial cells: implications for its blood-brain barrier transport.

    abstract::The objective was to further test the hypothesis that aluminum (Al) citrate transport across the blood-brain barrier is mediated by a monocarboxylate transporter (MCT). Speciation calculations showed that Al citrates were the predominant Al species under the conditions employed. Al citrate did not inhibit lactate upta...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yokel RA,Wilson M,Harris WR,Halestrap AP

    更新日期:2002-03-15 00:00:00

  • Ischemic preconditioning reduces infarct volume after subdural hematoma in the rat.

    abstract::The aim of the present study was to investigate the effects of ischemic preconditioning on infarct volume in a rat model of subdural hematoma (SDH). Ischemic preconditioning was induced by 15 min transient middle cerebral artery (MCA) occlusion followed 3 days later by the injection of 300 microl of autologous venous ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mackay KB,Stiefel TH,Foster AC

    更新日期:2002-03-15 00:00:00

  • Locus coeruleus lesions decrease norepinephrine input into the medial preoptic area and medial basal hypothalamus and block the LH, FSH and prolactin preovulatory surge.

    abstract::The aim of this work was to study the role of the dorsal noradrenergic ascending pathway (DNAP), which originates in the locus coeruleus (LC) on the preovulatory surge of luteinizing hormone (LH) follicle-stimulating hormone (FSH) and prolactin (PRL) by producing bilateral electrolytic lesions (cathodal or anodal) in ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Anselmo-Franci JA,Franci CR,Krulich L,Antunes-Rodrigues J,McCann SM

    更新日期:1997-09-05 00:00:00

  • Phosphorylation characteristics of the A68 protein in Alzheimer's disease.

    abstract::As a first step in understanding the function of the 68-kDa Alz-50 antigen (A68) in the pathophysiology of Alzheimer's disease (AD), we have reexamined preliminary observations in our laboratory (Wolozin and Davies, 1986) of a protein kinase activity associated with crude preparations of the protein. This study was un...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vincent IJ,Davies P

    更新日期:1990-10-29 00:00:00

  • PhTx4, a new class of toxins from Phoneutria nigriventer spider venom, inhibits the glutamate uptake in rat brain synaptosomes.

    abstract::We report the characterization of a new class of glutamate uptake inhibitors isolated from Phoneutria nigriventer venom. Glutamate transport activity was assayed in rat cerebrocortical synaptosomes by using [(3)H]-L-glutamate. PhTx4 inhibited glutamate uptake in a dose dependent manner. The IC(50) value obtained was 2...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mafra RA,Figueiredo SG,Diniz CR,Cordeiro MN,Cruz JD,De Lima ME

    更新日期:1999-06-12 00:00:00

  • Spinal projections of renal afferent nerves in the rat.

    abstract::This study was designed to describe renal afferent information with respect to its intraspinal projections, convergence with cutaneous inputs, ascending projections, and modulation by descending fiber tracts. Extracellular recordings were made from neurons in the spinal gray while electrically stimulating the renal ne...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Knuepfer MM,Akeyson EW,Schramm LP

    更新日期:1988-04-12 00:00:00

  • Neural correlates of acoustic reasoning.

    abstract::We report an fMRI experiment on deductive reasoning with acoustically presented problems. Twelve volunteers received problems in which an acoustic stimulus came from the left or the right of another stimulus. The participants then heard a third stimulus coming from the left or the right of one of the proceeding stimul...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fangmeier T,Knauff M

    更新日期:2009-01-16 00:00:00

  • Rat strain differences in nicotine self-administration using an unlimited access paradigm.

    abstract::An effective animal model for elucidating the neurobiological basis of human smoking should simulate important aspects of this behavior. Therefore, a 23 h unlimited access nicotine self-administration model was used to compare inbred Lewis rats, which have a propensity to self-administer drugs of abuse, to inbred Fish...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brower VG,Fu Y,Matta SG,Sharp BM

    更新日期:2002-03-15 00:00:00

  • Microvillar cells of the olfactory epithelium: morphology and regeneration following exposure to toxic compounds.

    abstract::In recent years microvillar cells (MVC) have been identified in the olfactory epithelium of numerous species, including rodents, canines, and primates. However, there is no consensus on the morphologic or histochemical features of this cell, nor is the function of these cells currently known. Previous studies have exa...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Miller ML,Andringa A,Evans JE,Hastings L

    更新日期:1995-01-09 00:00:00

  • Retinotopically inappropriate synapses of subnormal density formed by surgically misdirected optic fibers in goldfish tectum.

    abstract::Selected optic fibers were surgically deflected from one tectum onto the opposite host tectum which was denervated by eye enucleation. At 6-8 months, deflected fibers were labeled with horseradish peroxidase and the retinotopically inappropriate part of tectum was examined using electron microscopy. Numerous (labeled)...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hayes WP,Meyer RL

    更新日期:1988-02-01 00:00:00

  • In vivo and in vitro labelling of perineuronal nets in rat brain.

    abstract::Previous lectin-histochemical and immunocytochemical investigations using fixed tissue revealed perineuronal nets as lattice-like accumulations of extracellular matrix proteoglycans at the surface of several types of neurons. In the present study, perineuronal nets in the rat brain were labelled for the first time in ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brückner G,Bringmann A,Köppe G,Härtig W,Brauer K

    更新日期:1996-05-13 00:00:00

  • Immunoreactive interleukin-1 beta localization in the rat forebrain.

    abstract::To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lechan RM,Toni R,Clark BD,Cannon JG,Shaw AR,Dinarello CA,Reichlin S

    更新日期:1990-04-23 00:00:00

  • Interindividual sleep spindle differences and their relation to learning-related enhancements.

    abstract::We reported earlier that overnight change in explicit memory is positively related to the change in sleep spindle activity (between a control and a learning night). However, it remained unclear whether this effect was restricted to good memory performers and whether a general association of sleep spindles and a "sleep...

    journal_title:Brain research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Schabus M,Hoedlmoser K,Pecherstorfer T,Anderer P,Gruber G,Parapatics S,Sauter C,Kloesch G,Klimesch W,Saletu B,Zeitlhofer J

    更新日期:2008-01-29 00:00:00

  • Sleep-awake responses elicited from medial preoptic area on application of norepinephrine and phenoxybenzamine in free moving rats.

    abstract::The study makes an attempt to find out the action of norepinephrine (NE) and phenoxybenzamine (PB), applied at medial preoptic area (mPOA), in altering the sleep-awake responses, in free moving rats, which has not yet been reported. Effects of application of NE during day and PB during night, at mPOA, on sleep-awake r...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mohan Kumar V,Datta S,Chhina GS,Gandhi N,Singh B

    更新日期:1984-11-26 00:00:00