Abstract：
:Infection of neonatal mice with ts1, the neuropathogenic mutant of the Moloney murine leukemia virus, results in motor neuronal death in the brainstem and the spinal cord, with gliosis and demyelination, but no inflammatory cell infiltration into the CNS. To evaluate the possible mechanism(s) of ts1-induced neuropathogenesis, we measured CNS expression of cytokines and cell death-related genes in ts1-infected mice with neurological signs and compared with control uninfected mice. In the brainstem, the expression of Fas and tumor necrosis factor alpha (TNF-alpha) was increased in the ts1-infected mice. Both TNF-alpha and Fas were detected in astrocytes, and Fas was also detected in neurons in the brainstem. Some TNF-alpha-immunolabeled cells also appeared to be microglial cells. Most Fas-positive cells, including astrocytes and neurons, showed cytoplasmic vacuolization and other degenerative changes. In addition, Fas ligand-immunolabeled cells were also detected in sites where spongiform degeneration occurred. This study suggests that neural cell death in ts1-induced neurodegeneration is likely due to Fas- and TNF-alpha-mediated cell death mechanisms.
journal_name
Brain Resjournal_title
Brain researchauthors
Choe W,Stoica G,Lynn W,Wong PKdoi
10.1016/s0006-8993(97)00929-3subject
Has Abstractpub_date
1998-01-01 00:00:00pages
1-8issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00929-3journal_volume
779pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Previous evidence suggests that preterm newborns with intrauterine growth restriction (IUGR) have specific neurostructural and neurodevelopmental anomalies, but it is unknown whether these effects persist in early childhood. We studied a sample of 18 preterm IUGR, 15 preterm AGA - born between 26 and 34 weeks of gesta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.032
更新日期：2011-03-25 00:00:00
abstract：:The distribution of substance P (SP) immunoreactivity in the spinal nucleus of the rat trigeminal nerve and in the skin of the lower lip was examined following (a) unilateral electrolytic lesions of the trigeminal ganglion, (b) trigeminal rhizotomy, and (c) unilateral interruption of the mental nerve, the sensory bran...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)91105-8
更新日期：1978-09-08 00:00:00
abstract：:Cross-sectional areas of the forebrain ventricles were measured from coronal sections in spontaneously hypertensive rats (SHRs) 4, 8, 12, 16, 21 and 56 weeks of age and in age-matched Wistar--Kyoto (WKY) and Sprague--Dawley (SD) normotensive rats. Progressive ventricular dilation and associated attrition of brain tiss...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90488-9
更新日期：1986-04-09 00:00:00
abstract：:A transplantable mouse testicular teratoma (OTT 6050) which displays a spectrum of neuroepithelial differentiation was evaluated biochemically for concentrations of cyclic AMP (cAMP), serotonin (5-HT), and enzymes involved in the metabolism of the biogenic amines and acetylcholine. These values were compared between t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90268-7
更新日期：1976-01-16 00:00:00
abstract：:Cortical Spreading Depression (CSD) is a well-studied model of preconditioning that provides a high degree of tolerance to a subsequent ischemic event in the brain. The present study was undertaken in order to determine whether the release of ATP during CSD could contribute to the induction of ischemic tolerance. Dire...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.070
更新日期：2007-09-07 00:00:00
abstract：:The effects of dexmedetomidine, a highly selective alpha(2)-adrenoceptor agonist, on extracellular dopamine (DA) concentrations in the nucleus accumbens of awake rats were collected via in vivo cerebral microdialysis and measured using HPLC with electrochemical detection. The administration of dexmedetomidine (DEX) at...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03012-8
更新日期：2001-11-16 00:00:00
abstract：:Defeat stress in mice, a model of social stress, increases benzodiazepine receptor binding as measured by specific [3H]Ro15-1788 binding in vivo, but not by [3H]flunitrazepam binding in vitro. This increase occurs rapidly, by 20 min following exposure to stress, and resolves by 60 min. Increased benzodiazepine recepto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90023-0
更新日期：1987-06-30 00:00:00
abstract：:Using a combination of in situ hybridization and immunohistochemistry, the development of somatostatin (SS)-containing neurons and fibers was examined in the rat dorsal hippocampus and dentate gyrus. The major development of this hippocampal peptidergic system occurs postnatally. At postnatal day 1 (P1), neurons conta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90013-2
更新日期：1988-05-01 00:00:00
abstract：:Following transection of a peripheral nerve in mice, a newly synthesized neurotropic pyrimidine compound, MS-818 was administered intraperitoneally at a dose of 1 mg kg-1 b.wt. day-1. The film model experiments for analyzing the early growth of axonal regeneration suggested that MS-818 activated Schwann cells which mi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01491-1
更新日期：1998-03-23 00:00:00
abstract：:Sex hormone binding globulin (SHBG) is produced in brain where it is often co-localized with oxytocin. Infusions of SHBG into the medial preoptic area-anterior hypothalamus facilitate female sexual receptivity. SHBG has receptors on plasma membranes of the prostate gland where binding of the 5alpha-reduced androgen di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02956-6
更新日期：2002-09-06 00:00:00
abstract：:Intraocular injections of several different retrograde tracers were made in albino rats. Retrogradely filled neurons were observed in two locations: the medial pretectal area and the contralateral periaqueductal grey matter, indicating that the pretectum and the mesencephalon are sources of centrifugal innervation to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90046-0
更新日期：1985-02-11 00:00:00
abstract：:Pericyte coverage on the endothelial tubes leads to the formation of a mature and stable microvessel system, which is critical for brain repair after intracerebral hemorrhage (ICH). We report herein that thrombin promotes pericyte coverage by activating Tie2 and the downstream signaling pathway PI3K/Akt in a rat model...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.12.003
更新日期：2019-04-01 00:00:00
abstract：:Prairie voles are socially monogamous mammals that form pair bonds and display paternal care. This study was focused on the male prairie vole's neuronal responses to infant-related odors. Using the fos protein as a measure of neuronal activation, we examined the brain responses of males to infant-related odors. Prior ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.02.023
更新日期：2019-07-01 00:00:00
abstract：:The present study was designed to investigate the role of activation of Kca+2 channels and cAMP in opioid-induced pial artery dilation in newborn pigs equipped with closed cranial windows. Methionine enkephalin, an endogenous mu agonist, elicited dilation that was modestly attenuated by the Kca+2 channel antagonist, i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01284-x
更新日期：1997-02-07 00:00:00
abstract：:The presence of adrenocorticotropic hormone (ACTH)-immunoreactive cells and melanocortin (MC) receptors (MC4 and to a lesser extent MC3) has been demonstrated in the medullary reticular formation in the general area where rostral ventrolateral medullary pressor area (RVLM) is located. The importance of RVLM in the reg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.002
更新日期：2006-08-02 00:00:00
abstract：:Cannabinoids and opioids are distinct drug classes historically used in combination to treat pain. Delta(9)-THC, an active constituent in marijuana, releases endogenous dynorphin A and leucine enkephalin in the production of analgesia. The endocannabinoid, anandamide (AEA), fails to release dynorphin A. The synthetic ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01908-3
更新日期：1999-11-27 00:00:00
abstract：:Amphetamine-induced locomotion and stereotypy were concurrently evaluated in order to determine if pretreatment with para-chlorophenylalanine (PCPA) (which is reported to facilitate some of the effects of amphetamine) results in a behavioral pattern similar to the augmentation previously reported to occur with repeate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90904-5
更新日期：1976-11-05 00:00:00
abstract：:This study was designed to evaluate the role of spinal glutamatergic receptors in the antinociception elicited by agmatine in mice. Intraperitoneal (i.p.) administration of agmatine (1.0-100.0 mg/kg) dose dependently inhibited the nociceptive response induced by intrathecal (i.t.) injection of glutamate, N-methy-D-asp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.087
更新日期：2006-06-06 00:00:00
abstract：:The cholinergic innervation of the mediodorsal (MD) nucleus of the thalamus was visualized immunohistochemically in human brain postmortem, using an antibody against human choline acetyltransferase (ChAT). The ChAT staining of the MD nucleus was more intense than in the surrounding thalamic nuclei but weaker than that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90585-y
更新日期：1990-05-07 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by upper and lower motor neuron death with ascending paralysis leading to death. In a transgenic mouse model of ALS (SOD1-G93A) weakness appears at 3 months of age, and because of progressive paralysis leads to death by 5 months. Cyclospo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02012-1
更新日期：2001-03-16 00:00:00
abstract：:Performance on object recognition and object placement memory tasks was evaluated after a short-dosing model of methamphetamine (MA) regime and monoamines and metabolites were measured post-testing. Adult male rats received three injections of 10 mg/kg at 2-h intervals. In striatum DA and 5-HT were depleted by 65% and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02599-4
更新日期：2002-06-14 00:00:00
abstract：:This study compared whether activation of muscle ergoreceptor afferents caused by isometric muscle contraction, activation of baroreceptor afferents induced by i.v. infusion of phenylephrine, or baroreceptor afferent inactivation, caused by carotid artery occlusion, elicit similar patterns of c-Fos induction in brains...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02217-9
更新日期：2000-01-10 00:00:00
abstract：:Cerebrovascular carbon dioxide (CO2) reactivity is an important hemodynamic index in cerebrovascular disease. In the present study T2*-weighted magnetic resonance image (T2* WI) was evaluated as a non-invasive method to investigate changes in CO2 reactivity. Fourteen rats were subjected to permanent or, 30 and 90 min ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/S0006-8993(96)01079-7
更新日期：1997-01-09 00:00:00
abstract：:Several studies have reported transient expression of tyrosine hydroxylase in a subpopulation of neurons in the bed nucleus of stria terminalis of preadolescent rats. The tyrosine hydroxylase immunoreactive (TH) neurons, which are of small to medium size and often display a typical bipolar configuration, are confined ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01175-7
更新日期：1996-01-08 00:00:00
abstract：:Lithium and valproic acid are mood-stabilizing agents that are often used to manage the episodes of mania and depression that characterize bipolar disorder. These agents develop clinical efficacy with chronic treatment, but the neurobiological actions that contribute to their therapeutic effects remain unclear. The pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.102
更新日期：2006-06-06 00:00:00
abstract：:Few clinical or experimental studies have carried out systematic investigations of cutaneous and deep sensibility in areas with referred muscle pain. Therefore, no clear signs of increased or decreased psychophysical responses to various somatosensory stimuli are found in referred pain areas. In the present study, a t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01077-3
更新日期：1997-01-02 00:00:00
abstract：:In this microdialysis study we measured the extracellular neuropeptide Y (NPY) levels in the dorsal hippocampus of conscious rats. During potassium-induced depolarisations, a 93% increase in extracellular levels of NPY was observed. NPY has been demonstrated to reduce kainic acid-induced convulsions in rats, but it is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01374-7
更新日期：1998-01-19 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) is a family of neurotrophins that plays crucial roles in neural development, survival, maintenance and regeneration both in central and peripheral nervous systems. To examine the effects of BDNF on mastication, jaw movement trajectories and masticatory muscle activities were el...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.04.061
更新日期：2004-07-30 00:00:00
abstract：:The aim of the present study was to investigate the anxiolytic effects of long-term treatment with fluoxetine in rats. Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are used to treat anxiety and panic disorders, in addition to treating depression. A major concern with SSRIs is a 2-3-week delay i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02289-1
更新日期：2000-02-07 00:00:00
abstract：:The termination of a pathway recently discovered in monkey, from the external cuneate nucleus (ECN) to the thalamus, has been investigated with the degeneration method. A previous HRP study showed that the projection is crossed. The ECN fibers terminate a wedge-shaped zone located dorsally in the rostral half of the c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90856-8
更新日期：1981-11-16 00:00:00
