Rapid increase in brain benzodiazepine receptor binding following defeat stress in mice.

abstract：:The A-ring reduced metabolite of deoxycorticosterone, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) was recently shown to act at the gamma-aminobutyric acid receptor-chloride ion channel complex in rat brain. The behavioral profile of THDOC was investigated using two animal models of anxiety, the two-chambere...

journal_title：Brain research

authors： Crawley JN,Glowa JR,Majewska MD,Paul SM

更新日期：1986-11-29 00:00:00

abstract：:The influence of the inhibitory transmitter gamma-aminobutyric acid (GABA) on depolarizations elicited by the excitatory amino acid N-methyl-D-aspartate (NMDA) was tested in neurons of organotypic neocortical tissue cultures (newborn rat) and in CA3 neurons of the hippocampal slice (guinea pig). Drugs were applied thr...

journal_title：Brain research

authors： Walden J,Speckmann EJ,Bingmann D,Straub H

更新日期：1990-02-26 00:00:00

abstract：:YM-14673 is a thyrotropin-releasing hormone (TRH) analog that has a modification of the N-terminal (pyroglutamyl) moiety of the tripeptide. It is longer acting than TRH and has substantially greater potency with regard to central facilitatory activity. In the present studies, the effect of YM-14673 was examined in rat...

journal_title：Brain research

authors： Faden AI

更新日期：1989-05-08 00:00:00

abstract：:Mild cognitive impairment (MCI) is considered the transitional stage between normal cognition and dementia. The aim of this study was to use tractography based analysis to elucidate alterations in subjects with MCI compared with subjects with early Alzheimer's disease (AD) and controls. Seventeen subjects with early A...

journal_title：Brain research

authors： Kiuchi K,Morikawa M,Taoka T,Nagashima T,Yamauchi T,Makinodan M,Norimoto K,Hashimoto K,Kosaka J,Inoue Y,Inoue M,Kichikawa K,Kishimoto T

更新日期：2009-09-01 00:00:00

abstract：:Hypothalamic stimulation generally inhibits baroreflex-induced bradycardia. However, we have noted discrete areas of the rat hypothalamus which facilitate reflex bradycardia. The effects of hypothalamic stimulation on baroreflex-induced changes in heart rate were investigated in urethane-anesthetized rats (1.2 g/kg, i...

journal_title：Brain research

authors： Pardini BJ,Patel KP,Schmid PG,Lund DD

更新日期：1986-10-08 00:00:00

abstract：:The tumor promoting compound 12-O-tetradecanoyl-phorbol-13-acetate (TPA) specifically binds to and activates protein kinase C (PKC). This enzyme is widely distributed in the brain. It plays a pivotal role in transmembrane signalling. Arachidonic acid conversion is a common cellular response to membrane perturbation. W...

journal_title：Brain research

authors： Hartung HP,Toyka KV

更新日期：1987-08-11 00:00:00

abstract：:In alert monkeys, some prefrontal neurons located in the superior dorsolateral area were activated to acoustic stimuli delivered in a restricted range of directions with respect to the animal's head. The effective direction was usually contralateral to the animal. The function of the auditory neurons in connection to ...

journal_title：Brain research

authors： Azuma M,Suzuki H

更新日期：1984-04-30 00:00:00

abstract：:The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less tha...

journal_title：Brain research

authors： Savage DD,Nadler JV,McNamara JO

更新日期：1984-12-03 00:00:00

abstract：:Individual neurons were recorded extracellularly in the nucleus accumbens (NAcc) of rats during cocaine self-administration sessions. NAcc neurons exhibited a variety of phasic changes in firing rate within the few seconds before and/or after cocaine self-infusion. Analysis of the topographical distribution of the pha...

journal_title：Brain research

authors： Uzwiak AJ,Guyette FX,West MO,Peoples LL

更新日期：1997-09-05 00:00:00

abstract：:Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects of their conditio...

journal_title：Brain research

authors： Lee M,Suk K,Kang Y,McGeer E,McGeer PL

更新日期：2011-07-11 00:00:00

abstract：:Peripheral nerve fascicles are deliberately impaled during microneurography experiments. We have assessed conduction block under these circumstances. First we recorded compound action potentials (CAP) in the sural nerve following stimulation of the sciatic nerve. The insertion of injection and microneurography electro...

journal_title：Brain research

authors： Rice AS,McMahon SB,Wall PD

更新日期：1993-12-24 00:00:00

abstract：:Extracellular recordings of action potentials were made from neurones antidromically identified as neurosecretory cells in the paraventricular and supraoptic nuclei of urethane-anesthetized female rats. Eighty-six neurones were examined for their responsiveness to 10 ng of angiotensin II (AII) injected into the third ...

journal_title：Brain research

authors： Akaishi T,Negoro H,Kobayasi S

更新日期：1980-04-28 00:00:00

abstract：:We studied the effects of nitric oxide (NO) and the NO-releasing agents sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) and isosorbide dinitrate (ISDN) on N-methyl-D-aspartate (NMDA)-induced increases in intracellular Ca2+ ([Ca2+]i), whole-cell patch-clamp currents and on glutamate-stimulated [3H]di...

journal_title：Brain research

authors： Hoyt KR,Tang LH,Aizenman E,Reynolds IJ

更新日期：1992-10-02 00:00:00

abstract：:Neonatal MK-801 treatment from postnatal day 8-19 leads to long-term effects on brain function, suggesting that exposure to this drug leads to the development of a brain with immature network properties. One aspect of this hypothesis, that the NMDA receptors preserve their immature state after the treatment, has been ...

journal_title：Brain research

authors： Gorter JA,Brady RJ

更新日期：1994-11-28 00:00:00

abstract：:In the adult rabbit, the somatostatin-immunoreactive neurons are seen in all visual cortical layers, with the majority of them being found in layers II-III, V and VI. During postnatal development, we can see labeled cells in layer VI at birth and in layers V and VI on the 3rd day. The labeled cells are seen in layers ...

journal_title：Brain research

authors： Ramón y Cajal-Agüeras S,Contamina P,Parra P,Martinez-Millán L,De Carlos JA,Ramo C

更新日期：1985-12-16 00:00:00

abstract：:Ethanol and nerve growth factor (NGF) affect the survival of cholinergic neurons in the rat medial septum. To investigate whether calcium (Ca2+) homeostasis in these neurons is affected by ethanol or NGF treatment, changes in intracellular free Ca2+ concentration ([Ca2+]i) were studied in embryonic (E21) cultured medi...

journal_title：Brain research

authors： Webb B,Suarez SS,Heaton MB,Walker DW

更新日期：1995-12-01 00:00:00

abstract：:Reflexes evoked by applying non-painful taps to an incisor tooth were recorded from the jaw closing masseter and temporal muscles of 21 human subjects. A series of inhibitory, excitatory, inhibitory and excitatory waves (the 'Q, R, S and T' waves of the post-stimulus electromyographic complex (PSEC)) occurred in full-...

journal_title：Brain research

authors： Cadden SW,van der Glas HW,Lobbezoo F,van der Bilt A

更新日期：1996-07-08 00:00:00

abstract：:We measured the effect of high PCO (500-550 Torr) on the pHi and [Ca2+]i in cultured glomus cells of adult rat carotid body (CB) as a test of the two models currently proposed for the mechanism of CB chemoreception. The metabolic model postulates that the rise in glomus cell [Ca2+]i, the initiating reaction in the sig...

journal_title：Brain research

authors： Mokashi A,Roy A,Rozanov C,Osanai S,Storey BT,Lahiri S

更新日期：1998-08-24 00:00:00

abstract：:The levels of N-acetyl-aspartate (NAA) and N-acetyl-aspartyl-glutamate (NAAG) were measured in several regions and in whole brain of rats from 15 days of gestation (DG) to adulthood by means of an isocratic HPLC method. The levels of NAAG in whole brain increased 3-fold between 15 DG and birth, which was 90% of the ad...

journal_title：Brain research

authors： Koller KJ,Coyle JT

更新日期：1984-07-01 00:00:00

abstract：:The ontogeny of muscarinic cholinergic receptors was studied in primary cultures of dissociated rat hippocampal cells. The specific [3H]quinuclidinyl benzilate [( 3H]QNB) to intact cells was detected after two days in culture. Scatchard analysis revealed only a unique binding site at all of the days tested, with a ver...

journal_title：Brain research

authors： Fernandez-Tomé P,Segal M

更新日期：1987-09-01 00:00:00

abstract：:Aluminum (Al) is among the most abundant elements on earth, it has been associated with the etiology of Alzheimer's disease. In the present study, AlCl(3) was administered with the dose of 10, 50 or 300 mg/kg b.wt/day through diet for 100 days. On day 101, overnight-fasted animals were sacrificed, the whole brains wer...

journal_title：Brain research

authors： Rui D,Yongjian Y

更新日期：2010-04-09 00:00:00

abstract：:The amplitude of the acoustic startle reflex can be modulated by exposure to aversive stimuli or other conditions which evoke a state of fear. The neurotransmitters involved in this modulation are currently being investigated. Unilateral local infusion of corticotropin-releasing hormone (CRH; 0, 10, 20, 40 and 80 ng) ...

journal_title：Brain research

authors： Birnbaum SG,Davis M

更新日期：1998-01-26 00:00:00

abstract：:Secondary hemorrhage after thrombolysis in ischemic stroke is an important complication, which has been difficult to study in preclinical disease models. We have established and characterized a model of thromboembolic middle cerebral artery occlusion in rats. Advantages of this model include a very low rate of spontan...

journal_title：Brain research

authors： Sun L,Zhou W,Heiland S,Marti HH,Veltkamp R

更新日期：2011-01-12 00:00:00

abstract：:During aerobic incubation at 37 degrees C, active uptake of labeled non-metabolizable alpha-aminoisobutyric acid (AIB) into isolated nodose ganglia (NG) excised from adult rats was accelerated to nearly twice that of the control, by the addition of glia maturation factor (GMF, 5 micrograms/ml) in a dose-dependent mann...

journal_title：Brain research

authors： Ando M,Kato T,Tanaka R,Nagata Y

更新日期：1986-05-14 00:00:00

abstract：:Accumulating evidence suggests that dopamine (DA) neurons in the ventral tegmental area (VTA) contribute to the complex amygdala-based neurocircuitry that mediates fear-motivated behaviors. Because of acetylcholine's (ACh) role in DA neuronal activation, the involvement of VTA cholinergic muscarinic receptors in Pavlo...

journal_title：Brain research

authors： Greba Q,Munro LJ,Kokkinidis L

更新日期：2000-07-07 00:00:00

abstract：:Behavioral studies have shown that the hyperalgesia arising from inflammatory agents, such as prostaglandin E(2) (PGE(2)), can be antagonized by activators of the ATP-sensitive potassium current (K(ATP)). This observation raises questions as to whether this suppression results from a direct action on sensory neurons a...

journal_title：Brain research

authors： Chi XX,Jiang X,Nicol GD

更新日期：2007-05-11 00:00:00

abstract：:A push-pull cannula supplied with artificial CSF was implanted in the striatum of anaesthetized rats, and the basal extracellular DA and DOPAC was assayed in the superfusates using HPLC and electrochemical detection. Simultaneously, a carbon fibre electrode was implanted in close proximity of the cannula and the evoke...

journal_title：Brain research

authors： Olivier V,Guibert B,Leviel V

更新日期：1995-10-09 00:00:00

abstract：:Proliferating astrocytes and proliferating neuroblasts have been observed in the subgranular zone (SGZ) of the dentate gyrus (DG) in the hippocampus of adult rats under normal conditions. However, whether these proliferating cells are stimulated by running has not been determined. Using immunohistochemical techniques,...

journal_title：Brain research

authors： Uda M,Ishido M,Kami K,Masuhara M

更新日期：2006-08-09 00:00:00

abstract：:We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was de...

journal_title：Brain research

authors： Noh HS,Kim DW,Kang SS,Cho GJ,Choi WS

更新日期：2005-04-25 00:00:00

abstract：:In monkeys (Macaca fuscata and mulatta), horseradish peroxidase (HRP) was injected in the cerebral cortices, areas 4 (medial and lateral parts), 5, 6 and 9 (a part just rostral to area 6), in which stimulation of cerebellar nuclei was known to elicit superficial or deep thalamocortical responses. Retrogradely labelled...

journal_title：Brain research

authors： Miyata M,Sasaki K

更新日期：1983-09-12 00:00:00