Neurons in accumbens subterritories of the rat: phasic firing time-locked within seconds of intravenous cocaine self-infusion.

abstract：:This study describes the localization of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics, in the hypothalamus of Swiss Webster and C57BL/6J wild-type mice, leptin-deficient ob/ob mice, and leptin-resistant diet-induced obese (DIO) mice. The mice were given [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in 0.3...

journal_title：Brain research

authors： Anderson BM,Jacobson L,Novakovic ZM,Grasso P

更新日期：2017-06-01 00:00:00

abstract：:The study makes an attempt to find out the action of norepinephrine (NE) and phenoxybenzamine (PB), applied at medial preoptic area (mPOA), in altering the sleep-awake responses, in free moving rats, which has not yet been reported. Effects of application of NE during day and PB during night, at mPOA, on sleep-awake r...

journal_title：Brain research

authors： Mohan Kumar V,Datta S,Chhina GS,Gandhi N,Singh B

更新日期：1984-11-26 00:00:00

abstract：:The polar head group of the phospholipid phosphatidylserine is similar in structure to the glutamate analogue 2-amino-4-phosphonobutyric acid (APB), an antagonist of excitatory transmission in the brain. When tested in ligand binding assays phosphatidylserine and its polar head group components O-phosphoserine and L-a...

journal_title：Brain research

authors： Foster AC,Fagg GE,Harris EW,Cotman CW

更新日期：1982-06-24 00:00:00

abstract：:We previously reported that reactive oxygen species (ROS) in paraventricular nucleus (PVN) modulated cardiac sympathetic afferent reflex (CSAR) and mediated the effect of angiotensin II (Ang II) in the PVN on the CSAR. In the present study, we investigated whether the NAD(P)H oxidase in the PVN was a key source of ROS...

journal_title：Brain research

authors： Zhang Y,Yu Y,Zhang F,Zhong MK,Shi Z,Gao XY,Wang W,Zhu GQ

更新日期：2006-04-12 00:00:00

abstract：:The 'commissural' innervation of the dentate gyrus molecular layer has been analyzed in normal adult rats and in those in which the ipsilateral entorhinal cortex had been removed by aspiration at 14 days post-natal. This ablation severely deafferents the distal two-thirds of the molecular layer and induces 'sprouting'...

journal_title：Brain research

authors： Gall C,McWilliams R,Lynch G

更新日期：1979-10-12 00:00:00

abstract：:A series of ballistic, unidirectional arm movements were studied to evaluate the electromyographic (EMG) and neuromuscular force patterns that occur when a limb is unexpectedly perturbed. Multiple training trials were continued with a control load spring attached to the apparatus until a pre-specified criterion for le...

journal_title：Brain research

authors： Richardson C,Simmons RW

更新日期：1985-09-23 00:00:00

abstract：BACKGROUND:Toll-like receptor 4 (TLR4) is an important mediator of the innate immune response. It significantly contributes to neuroinflammation and may be involved in ischemic tolerance. It is unknown how cerebral ischemia in the cortex and postconditioning might affect inflammatory reactions in the hippocampus or whe...

journal_title：Brain research

authors： Feng R,Li S,Li F

更新日期：2011-04-12 00:00:00

abstract：:Animal models of cerebral infarction are crucial to understanding the mechanisms of neuronal survival following ischemic brain injury and to the development of therapeutic interventions for victims of all types of stroke. Rodents have been used extensively in such research. One rodent model of stroke utilizes either p...

journal_title：Brain research

authors： Duckworth EA,Butler TL,De Mesquita D,Collier SN,Collier L,Pennypacker KR

更新日期：2005-04-25 00:00:00

abstract：:Cholecystokinin octapeptide (CCK-8) is colocalized within a majority of dopamine (DA)-containing neurons of the rat midbrain. Exogenous CCK-8 can modulate the electrophysiological activity of DA neurons, at least in part, by direct actions on the somatodendritic region of these cells. If CCK-8 is somatodendritically r...

journal_title：Brain research

authors： Freeman AS,Chiodo LA,Lentz SI,Wade K,Bannon MJ

更新日期：1991-08-02 00:00:00

abstract：:Nitric oxide (NO) can have opposite effects on peripheral sensory neuron sensitivity depending on the concentration and source of NO, and the experimental setting. The aim of this study was to determine the role of endogenous NO production in the regulation of mechanosensitive Ca(2+) influx of dorsal root ganglion (DR...

journal_title：Brain research

authors： Chaban VV,McRoberts JA,Ennes HS,Mayer EA

更新日期：2001-06-08 00:00:00

abstract：:Available evidence suggests that a portion of the septohippocampal pathway may form inhibitory synapses on inhibitory interneurons in the dentate gyrus. In contrast, a portion of the commissural input from the contralateral hilus may form excitatory synapses on inhibitory interneurons. To ascertain whether these pathw...

journal_title：Brain research

authors： Bilkey DK,Goddard GV

更新日期：1987-03-10 00:00:00

abstract：:Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...

journal_title：Brain research

authors： McCown TJ,Xiao X,Li J,Breese GR,Samulski RJ

更新日期：1996-03-25 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) isolated from the brain and pituitary, has been shown to induce cell divisions in a variety of cell types. It also acts as a potent stimulator of angiogenesis, and it is important in the survival of several types of cultured neurons. Despite considerable information on the functio...

journal_title：Brain research

authors： Matsuda S,Desaki J,Okumura N,Shiosaka S,Imaoka S,Sakanaka M

更新日期：1992-04-10 00:00:00

abstract：:Repeated exposure to stressful stimuli or psychostimulants increases sensitivity to the motoric effects of these drugs, i.e. behavioral sensitization. The objective of the present experiment was to determine the interaction between factors that modulate psychostimulant sensitivity, i.e. sex and circulating gonadal hor...

journal_title：Brain research

authors： Haney M,Castanon N,Cador M,Le Moal M,Mormède P

更新日期：1994-05-09 00:00:00

abstract：:The resurgent Na(+) current (I(NaR)) is a component of neuronal voltage-dependent Na(+) currents that is activated by repolarization and is believed to result from an atypical path of Na(+)-channel recovery from inactivation. So far, I(NaR) has only been identified in a small number of central neuronal populations in ...

journal_title：Brain research

authors： Castelli L,Nigro MJ,Magistretti J

更新日期：2007-08-13 00:00:00

abstract：:The purpose of the present investigation was to record electrophysiological responses from single fibers in the hamster superior laryngeal nerve (SLN) that were responsive to chemical stimulation of the larynx. Twenty chemical solutions, commonly used in studies of mammalian gustatory physiology, were applied to taste...

journal_title：Brain research

authors： Dickman JD,Smith DV

更新日期：1988-05-31 00:00:00

abstract：:A lesion of the septum or a transection of the fimbria-fornix diminishes most, but not all, acetylcholinesterase (AChE) staining in the hippocampal formation. The residual AChE is located in the outer part of the molecular layer of the hippocampal CA1 zone and adjacent subicular field (zone 31). We report that followi...

journal_title：Brain research

authors： Chen LL,Van Hoesen GW,Barnes CL,West JR

更新日期：1983-08-08 00:00:00

abstract：:Administration of sheep red blood cells (10(6) cells, i.p.) resulted in central norepinephrine (NE) and dopamine (DA) changes which corresponded with the time of the peak immune response. These amine variations, however, appeared to be specific to certain brain regions. The increased accumulation of the NE metabolite,...

journal_title：Brain research

authors： Zalcman S,Shanks N,Anisman H

更新日期：1991-08-23 00:00:00

abstract：:The localization of immunoreactive glutamic acid decarboxylase (GAD) and enkephalin-like immunoreactivity was examined in serial, 4-micron frozen sections of the caudate nucleus from rats pretreated with colchicine. Colocalization was found in numerous caudate neurons of medium size. Cell counts of corresponding label...

journal_title：Brain research

authors： Aronin N,Difiglia M,Graveland GA,Schwartz WJ,Wu JY

更新日期：1984-05-23 00:00:00

abstract：:Bilateral microinjections of the neuroleptic, cis-flupenthixol, were made into 56 forebrain targets distributed across various dopamine (DA) terminal fields in the forebrain. Drug effects on medial forebrain bundle (MFB) stimulation-produced reward were assessed with a rate-frequency procedure implemented in a runway ...

journal_title：Brain research

authors： Stellar JR,Corbett D

更新日期：1989-01-16 00:00:00

abstract：:Multiple retrograde fluorescent tracing was employed to investigate the organization of the rat entopeduncular nucleus projections to the lateral habenula, ventral anterior-ventral lateral thalamus, parafasicular-centre median complex, and tegmenti pedunculopontis area of the brain stem. The results indicate that neur...

journal_title：Brain research

authors： van der Kooy D,Carter DA

更新日期：1981-04-27 00:00:00

abstract：:This study examined the projection from the rostral nucleus of the solitary tract (rNST) to the medial parabrachial nucleus (mPBN) in male Wistar rats using DiI as a retrograde tracer and biotinylated dextran as an anterograde tracer. Following successful unilateral injection of DiI into the mPBN (n = 8), retrogradely...

journal_title：Brain research

authors： Williams JB,Murphy DM,Reynolds KE,Welch SJ,King MS

更新日期：1996-10-21 00:00:00

abstract：:The patch-clamp technique was used to characterize the single channel ion currents in primary cultures of rat astrocytes. The most dominant channel type, which was found in over half of the inside-out membrane patches, was a potassium channel. The measured reversal potential was -67 mV, which is close to the calculate...

journal_title：Brain research

authors： Jalonen T,Holopainen I

更新日期：1989-04-10 00:00:00

abstract：:The 2,3-benzodiazepine derivative GYKI 52466 has been well characterized as a negative modulator of AMPA-type glutamate receptors. The present study re-examined the effects of GYKI 52466 on AMPA receptor-mediated currents in patches excised from pyramidal neurons in the hippocampal CA1 field and found that this drug h...

journal_title：Brain research

authors： Arai AC

更新日期：2001-02-23 00:00:00

abstract：:The aim of this work was to study the role of the dorsal noradrenergic ascending pathway (DNAP), which originates in the locus coeruleus (LC) on the preovulatory surge of luteinizing hormone (LH) follicle-stimulating hormone (FSH) and prolactin (PRL) by producing bilateral electrolytic lesions (cathodal or anodal) in ...

journal_title：Brain research

authors： Anselmo-Franci JA,Franci CR,Krulich L,Antunes-Rodrigues J,McCann SM

更新日期：1997-09-05 00:00:00

abstract：:The nitric oxide (NO) metabolome and the NO metabolite-based neurovascular protective pathways are dysregulated after stroke. The major NO metabolite S-nitrosoglutahione (GSNO) is essential for S-nitrosylation-based signaling events and the inhibition of S-nitrosoglutahione (GSNO)-metabolizing enzyme GSNO reductase (G...

journal_title：Brain research

authors： Khan M,Kumar P,Qiao F,Islam SMT,Singh AK,Won JS,Feng W,Singh I

更新日期：2020-08-15 00:00:00

abstract：:Endoplasmic reticulum (ER) and mitochondria dysfunction contribute to insulin resistance generation during obesity and diabetes. ER and mitochondria interact through Mitofusin 2 (MTF2), which anchors in the outer mitochondrial and ER membranes regulating energy metabolism. Ablation of MTF2 leads to ER stress activatio...

journal_title：Brain research

authors： Diaz B,Fuentes-Mera L,Tovar A,Montiel T,Massieu L,Martínez-Rodríguez HG,Camacho A

更新日期：2015-11-19 00:00:00

abstract：:To investigate the possible GABAergic nature of somatostatin-immunoreactive neurons of the larval tiger salamander retina, somatostatin immunocytochemistry was combined with either gamma-aminobutyric acid (GABA) immunocytochemistry or autoradiography of GABA high-affinity uptake. A total of 1,062 somatostatin cells we...

journal_title：Brain research

authors： Watt CB,Florack VJ

更新日期：1993-07-16 00:00:00

abstract：:The patch clamp technique has been used to study ion channel activity in the apical (ventricular) membrane of epithelial cells from the rat choroid plexus. Two different classes of Cl(-)-selective channel were identified. A low conductance (26 pS) channel which was the predominant feature in cell-attached and inside-o...

journal_title：Brain research

authors： Garner C,Brown PD

更新日期：1992-09-18 00:00:00

abstract：:Six cats were trained to eat while partially restrained and while thermal pulse stimuli (43-60 degrees C, 5 s duration) were delivered to the upper hindlimbs. Food and stimulus delivery were under programmed electronic control. The probability and latency of 3 natural, unlearned nocifensive behaviors were electronical...

journal_title：Brain research

authors： Casey KL,Morrow TJ

更新日期：1989-10-30 00:00:00