Abstract：
:The polar head group of the phospholipid phosphatidylserine is similar in structure to the glutamate analogue 2-amino-4-phosphonobutyric acid (APB), an antagonist of excitatory transmission in the brain. When tested in ligand binding assays phosphatidylserine and its polar head group components O-phosphoserine and L-alpha-glycerophosphoserine were good displacers of APB-sensitive L-glutamate binding. The polar head group components were also antagonists of synaptic field potentials in the rat dentate gyrus evoked by stimulation of a presumed glutamate-using pathway. These results suggest that phosphatidylserine may regulate the activity of synaptic L-glutamate receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Foster AC,Fagg GE,Harris EW,Cotman CWdoi
10.1016/0006-8993(82)90328-6subject
Has Abstractpub_date
1982-06-24 00:00:00pages
374-7issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(82)90328-6journal_volume
242pub_type
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