Substance P and neurokinin A, two coexisting tachykinins stimulating the release of [3H]5-HT from rat cerebral cortical slices.

abstract：:This review provides a snapshot of the current ethical issues related to research with human brain organoids. The issues fall into the following main themes: research oversight; human biomaterials procurement and donor consent; translational delivery; animal research; and organoid consciousness and moral status. Each ...

journal_title：Brain research

authors： Hyun I,Scharf-Deering JC,Lunshof JE

更新日期：2020-04-01 00:00:00

abstract：:Interpretation of the cellular and molecular pathogenic basis of post-minimal traumatic brain injury is a significant clinical and scientific problem, especially due to the high prevalence of motor vehicle--and other accidents. Pathogenetic brain mechanisms following traumatic impact are usually investigated by using ...

journal_title：Brain research

authors： Tashlykov V,Katz Y,Gazit V,Zohar O,Schreiber S,Pick CG

更新日期：2007-01-26 00:00:00

abstract：:In normal adult rats, intense immunostaining for the 75 kDa low-affinity receptor for nerve growth factor and other neurotrophins (p75NGFR) is concentrated in the middle region of the cuneate nucleus (CN), distributed in a blotchy pattern similar to that of cytochrome oxidase (CO) activity. In the adult rats, partial ...

journal_title：Brain research

authors： Foschini DR,Egger MD,Crockett DP

更新日期：1994-05-16 00:00:00

abstract：:The release of [3H]acetylcholine (ACh) from 6-, 8-, 10-, 12-, 14- and 16-day chick embryo neural retina layers was determined using a perfusion system to collect the released neurotransmitter. After labeling the tissue with [3H]choline, samples of [3H]ACh released before and after stimulation by 80 mM KCl or 5 mM glut...

journal_title：Brain research

authors： Thompson JM

更新日期：1982-07-01 00:00:00

abstract：:The distribution of glucagon-like peptide-1-(7-36)amide like immunoreactivity (GLP-1-(7-36)NH2 IR) in rat brain was determined. Highest concentrations were found in the hypothalamus. A combination of gel chromatography and anion exchange chromatography showed that the majority of hypothalamic immunoreactivity exactly ...

journal_title：Brain research

authors： Kreymann B,Ghatei MA,Burnet P,Williams G,Kanse S,Diani AR,Bloom SR

更新日期：1989-11-20 00:00:00

abstract：:Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Our laboratory has shown that infusion of human umbilical cord blood (HUCB) cells protects striatal white ...

journal_title：Brain research

authors： Rowe DD,Leonardo CC,Hall AA,Shahaduzzaman MD,Collier LA,Willing AE,Pennypacker KR

更新日期：2010-12-17 00:00:00

abstract：:Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extra...

journal_title：Brain research

authors： Missale C,Govoni S,Castelletti L,Spano PF,Trabucchi M

更新日期：1983-02-28 00:00:00

abstract：:The time course of autoradiographic binding of major second messengers in the rat brain was studied at 2, 7, and 24 h after withdrawal from butorphanol infusion. [3H]Forskolin and [3H]phorbol 12,13-dibutyrate (PDBu) were used to label adenylate cyclase and protein kinase C (PKC), respectively. Rats were rendered depen...

journal_title：Brain research

authors： Jang CG,Rockhold RW,Ho IK

更新日期：1999-03-13 00:00:00

abstract：:We measured expression of the oxytocin gene in the supraoptic nucleus (SON) during pregnancy, parturition and lactation to examine its relationship to states of accumulation or depletion of oxytocin stores and to conditions of strong excitation of oxytocin neurons. The primary transcript (heterogeneous nuclear RNA, hn...

journal_title：Brain research

authors： Douglas AJ,Meeren HK,Johnstone LE,Pfaff DW,Russell JA,Brooks PJ

更新日期：1998-01-26 00:00:00

abstract：:Biocytin is useful for intracellular filling in living slices because it is soluble, has high electrophoretic mobility and a high affinity for avidin. In fixed slices, however, membrane potential cannot be used to signify that a cell is impaled. Thus, it is necessary to inject a fluorescent molecule so that impalement...

journal_title：Brain research

authors： Liu WL,Behbehani MM,Shipley MT

更新日期：1993-04-09 00:00:00

abstract：:Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein a...

journal_title：Brain research

authors： Parati EA,Bez A,Ponti D,de Grazia U,Corsini E,Cova L,Sala S,Colombo A,Alessandri G,Pagano SF

更新日期：2002-01-25 00:00:00

abstract：:Photic entrainment of the circadian oscillator located in the hypothalamic suprachiasmatic nucleus (SCN) is considered to be mediated at least partly by release of glutamate from the retinal presynaptic nerve terminals acting via a NMDA receptor. Several NMDA receptor subtypes have been cloned and expressed in model s...

journal_title：Brain research

authors： Mikkelsen JD,Larsen PJ,Ebling FJ

更新日期：1993-12-31 00:00:00

abstract：:In order to establish the cellular and subcellular localization of the chemokine protein, vascular endothelial growth factor (VEGF) or vascular permeability factor, in adult human retina, we employed immunocytochemistry with double immunolabeling, using a primary antibody to amino acids 1-10 of VEGF, together with ant...

journal_title：Brain research

authors： Famiglietti EV,Stopa EG,McGookin ED,Song P,LeBlanc V,Streeten BW

更新日期：2003-04-18 00:00:00

abstract：:An apparent binding activity of [3H]glutathione was examined by using synaptic membrane preparations of the rat brain. The activity was found to be more than two times as high at 30 degrees C as that found at 2 degrees C. At 2 degrees C, the apparent binding sites consisted of a single component with a Kd of 0.77 micr...

journal_title：Brain research

authors： Ogita K,Yoneda Y

更新日期：1988-10-25 00:00:00

abstract：:We have studied magnetic and electrical fields of the brain in normal subjects during the performance of an auditory verbal short-term memory task. On each trial 3 digits, selected from the numbers 'one' through 'nine', were presented for memorization followed by a probe number which could or could not be a member of ...

journal_title：Brain research

authors： Starr A,Kristeva R,Cheyne D,Lindinger G,Deecke L

更新日期：1991-09-06 00:00:00

abstract：:Axonal projections of ganglion cells to the superior colliculus (SC) and to the nucleus of the optic tract (NOT) were re-examined physiologically in the cat's retina. Taking care to minimize current spreads around the stimulating electrodes placed in the NOT or the SC, we reached a conclusion that a substantial propor...

journal_title：Brain research

authors： Sawai H,Fukuda Y,Wakakuwa K

更新日期：1985-08-19 00:00:00

abstract：:Brief force perturbations were applied 30-120 ms prior to onset of step-tracking forearm movements by normal humans. The perturbations altered the first agonist burst of the movement-related triphasic EMG pattern. Perturbations opposing the movement resulted in an increase in the magnitude of the late part of the firs...

journal_title：Brain research

authors： Brown SH,Cooke JD

更新日期：1981-09-14 00:00:00

abstract：:The ventral tegmental area (VTA) is a brain region centrally involved in the development and expression of a variety of behaviors associated with drug use. Orexin/hypocretin (ox/hcrt) and corticotropin releasing factor (CRF) are both peptides released into the VTA, and an increasing number of studies show that both ox...

journal_title：Brain research

authors： Borgland SL,Ungless MA,Bonci A

更新日期：2010-02-16 00:00:00

abstract：:We studied the effects of transcranial magnetic stimulation (TMS) on muscle activation patterns and joint kinematics during oscillatory movements of a joint within a two-joint (elbow-wrist) synergy. Healthy young adults (N=8) performed cyclic movements in one of the joints while the other joint was or was not involved...

journal_title：Brain research

authors： Latash ML,Danion F,Bonnard M

更新日期：2003-01-31 00:00:00

abstract：:Pupil dilatation (PD) was produced by vaginocervical mechanical stimulation (VCMS) in intact rats, and in rats with spinal cord (SC) transection at level T7 (i.e., above the level of entry into SC of all genitospinal nerves). After transection of SC, bilateral vagotomy abolished PD in response to VCMS, providing evide...

journal_title：Brain research

authors： Bianca R,Komisaruk BR

更新日期：2007-10-26 00:00:00

abstract：:Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...

journal_title：Brain research

authors： McCown TJ,Xiao X,Li J,Breese GR,Samulski RJ

更新日期：1996-03-25 00:00:00

abstract：:Effects of nitric oxide on glutamate (Glu) release in long-term potentiation (LTP) were investigated by superfusion of conventional (P2) and large (P3) synaptosomes prepared from the rat hippocampus. Basal releasing rates of endogenous Glu from P2 and P3 fractions were 103.6 and 85.2 pmol/min/mg protein, respectively....

journal_title：Brain research

authors： Kamisaki Y,Maeda K,Ishimura M,Omura H,Moriwaki Y,Itoh T

更新日期：1994-04-25 00:00:00

abstract：:We have recently characterized the histopathological changes in an experimental model of mesial temporal lobe epilepsy (MTLE) induced by the intrahippocampal injection of low dose of kainate in mice. Although cerebral metabolism and blood flow are extensively studied and used in human MTLE to locate the regions involv...

journal_title：Brain research

authors： Bouilleret V,Boyet S,Marescaux C,Nehlig A

更新日期：2000-01-10 00:00:00

abstract：:Perceptual performance in persons with hearing loss, especially those using devices to restore hearing, is not fully predicted by traditional audiometric measurements designed to evaluate the status of peripheral function. The integrity of auditory brainstem synapses may vary with different forms of hearing loss, and ...

journal_title：Brain research

authors： McGuire B,Fiorillo B,Ryugo DK,Lauer AM

更新日期：2015-04-24 00:00:00

abstract：:The analysis of the dynamic properties of epileptiform activity in vitro has led to a better understanding of the time course of neural synchronization and seizure states. Nonlinear analysis is thus potentially useful for the prediction of seizure onset. We have used nonlinear analysis methods to investigate the devel...

journal_title：Brain research

authors： Lian J,Shuai J,Hahn P,Durand DM

更新日期：2001-02-02 00:00:00

abstract：:By the use of anti-omega-CTx antibodies in indirect immunofluorescence we demonstrated the presence of omega-CTx binding sites in the presynaptic compartment of frog nerve-muscle preparations. The images we obtained indicate that omega-CTx-sensitive channels are clustered at discrete sites corresponding in distributio...

journal_title：Brain research

authors： Torri Tarelli F,Passafaro M,Clementi F,Sher E

更新日期：1991-05-03 00:00:00

abstract：:In albino rats the superior colliculus was stimulated and evoked potentials were explored in the cerebellar hemisphere including the paramedian lobule, and crura I and II. Climbing fiber responses were identified in a strip (ca. 1 mm wide) in the medial region of crus II, extending to both folia a and b. In the tector...

journal_title：Brain research

authors： Akaike T

更新日期：1986-07-16 00:00:00

abstract：:The effects of caffeine ingestion and exposure to bright light, both separately and in combination, on salivary melatonin and tympanic temperature were assessed in humans. Four treatments during a 45.5 h sleep deprivation period were compared: Dim Light-Placebo, Dim Light-Caffeine, Bright Light-Placebo and Bright-Ligh...

journal_title：Brain research

authors： Wright KP Jr,Badia P,Myers BL,Plenzler SC,Hakel M

更新日期：1997-01-30 00:00:00

abstract：:(1) Changes during development in the levels of proteinases and peptidases were measured in brain homogenates. At all ages di- and tripeptidase levels were 7-15-fold higher than proteinase activity. (2) Cathepsin A and D and neutral proteinase activity first decreased (during the 5 days before birth) and then increase...

journal_title：Brain research

authors： Marks N,Stern F,Lajtha A

更新日期：1975-03-21 00:00:00

abstract：:Although cocaine shares the ability of fenfluramine to inhibit the synaptic reuptake of serotonin, previous observations from our group suggest that the genomic effects of fenfluramine in the rat striatum are primarily mediated by dopaminergic rather than serotonergic mechanisms. To compare and further understand the ...

journal_title：Brain research

authors： Torres G,Rivier C

更新日期：1994-05-30 00:00:00