Abstract：
:Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extracts indicates that the composition of the immunoreactive material is similar in the two age-groups investigated. At the thoracic level opiate receptor binding was also measured. Opiate receptor number is increased in the thoracic segments of the spinal cord from older rats. These age-related changes in immunoreactive Met-enkephalin content and opiate receptor number at spinal levels may contribute to determine an altered pain sensitivity during aging.
journal_name
Brain Resjournal_title
Brain researchauthors
Missale C,Govoni S,Castelletti L,Spano PF,Trabucchi Mdoi
10.1016/0006-8993(83)90481-xsubject
Has Abstractpub_date
1983-02-28 00:00:00pages
160-2issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(83)90481-Xjournal_volume
262pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Transgenic mice expressing human APPswe and PS1-A264E mutations mimic certain neuropathological features of Alzheimer's disease (AD). These mice have elevated levels of the highly fibrillogenic amyloid beta1-42 peptide (Abeta42) and develop amyloid plaques around the age of 9 months. Our aim was to find whether these ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02617-3
更新日期：2002-07-12 00:00:00
abstract：:mRNA prepared from rat small intestine was injected into Xenopus oocytes. The injected oocytes showed a clear electrical response to D-glucose (Glu) in the form of membrane depolarization and conductance increase, while none was shown to D-fructose. The membrane electrical response of the injected oocytes evoked by Gl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(87)90033-7
更新日期：1987-09-01 00:00:00
abstract：:Qualitative and computer-assisted analyses were performed on Golgi-impregnated neurons which were serially reconstructed in 3 dimensions. Analysis of the temporal pattern of growth indicated that the initial outgrowth, formation of the adult number of dendrites and virtually all dendritic branching occurred in the pre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90192-6
更新日期：1986-01-01 00:00:00
abstract：:Blockade of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors with 6-nitro-7-sulfamoyl-benzo-[f]quinoxaline-2,3(1H,4H)-dione (NBQX) activates tuberoinfundibular (TIDA) and periventricular-hypophysial dopaminergic (PHDA) neurons suggesting that these neurons are tonically inhibited by endogenous...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91305-6
更新日期：1994-10-17 00:00:00
abstract：:The opioid peptides Leu-enkephalin, Met-enkephalin and D-Ala2-Met-enkephalinamide were injected at various concentrations into the neocortex and hippocampus of rats to examine their effects on EEG activity and DC potentials. All three compounds were found to elicit spreading depression (SD) in both structures. Higher ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90897-0
更新日期：1981-04-06 00:00:00
abstract：:The binding characteristics of [3H]cytisine, a putative CNS nicotinic receptor ligand, were examined in 4 regions of the human brain. [3H]Cytisine was found to bind non-cooperatively with high affinity to a single site in tissue homogenates and to exhibit low non-specific association. The binding characteristics of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90410-o
更新日期：1993-01-08 00:00:00
abstract：:We examined the expression of IL-6 in the substantia nigra pars reticulata (SNr) at various time points after transient (3 h) middle cerebral artery occlusion (MCAO) in rats. The animals were killed at 1, 3, 7 or 14 days following operation. Coronal brain sections were processed for immunohistochemistry with antibodie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03129-2
更新日期：2001-01-19 00:00:00
abstract：:It has recently been shown that the immunosuppressant cyclosporin A (CsA) dramatically ameliorates the selective neuronal necrosis which results from 10 min of forebrain ischemia in rats. Since CsA is a virtually specific blocker of the mitochondrial permeability transition (MPT) pore which is assembled under adverse ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00005-x
更新日期：1997-04-04 00:00:00
abstract：:Intracellular recordings were obtained from CA1 pyramidal neurons in obliquely cut in vitro hippocampal slices. Recurrent IPSPs were elicited by antidromic stimulation of alvear fibers. The mechanisms by which IPSPs depress pyramidal cell excitability were investigated. Recurrent IPSPs could be reversed in sign by sma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91068-9
更新日期：1980-03-10 00:00:00
abstract：:In freely-moving female rats the effects of intraventricular infusion of norepinephrine (NE) on multiunit activity (MUA) were examined in the Diagonal Band of Broca (DBB), medial preoptic area (MPOA) and anterior hypothalamic area (AHA), regions containing neurons producing luteinizing hormone-releasing hormone (LHRH)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91089-1
更新日期：1981-12-07 00:00:00
abstract：:Single unit activities of Y, X and W cells were recorded in the cat lateral geniculate nucleus to study how their responses to stationary light spots change with the cortical EEG. The shift from desynchronized to synchronized EEG drastically suppressed W cell activities, depressed both transient and sustained componen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90102-3
更新日期：1988-07-12 00:00:00
abstract：:The purpose of this study was to ascertain whether visual acuity or contrast sensitivity function (CSF) is proportional to visual cortical function based on fMRI volume and level of activation or Z-score. Forced choice procedures were utilized to measure the monocular log minimal angle of resolution (logMAR) visual ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.10.082
更新日期：2011-01-07 00:00:00
abstract：:The technique of intracellular recording was used to assess the effect of SR 31742A, a selective sigma receptor ligand, on N-methyl-d-aspartate (NMDA) and (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated responses in pyramidal cells of the rat medial prefrontal cortex in vitro br...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00797-5
更新日期：1998-10-05 00:00:00
abstract：:An acute pain animal model for fMRI study would provide useful spatial and temporal information for studying the supraspinal nociceptive neuronal responses. The aim of the present study was to investigate whether the nociceptive responses in different brain areas can be differentiated by using functional magnetic reso...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02094-7
更新日期：2001-04-06 00:00:00
abstract：:Bcl-2 has been hypothesized to regulate many cellular functions in addition to its well-characterized role in the prevention of programmed cell death. To understand the role of Bcl-2 in regulating cell morphology and to explore the mechanism of this effect, we examined the effects of Bcl-2 overexpression on the morpho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.017
更新日期：2006-09-27 00:00:00
abstract：:Anandamide, the ethanolamide of arachidonic acid, is an endogenous cannabinoid. It is an agonist at CB1 and CB2 cannabinoid receptors as well as the vanilloid receptor, VR1. It is analgesic in inflammatory and neuropathic pain. Both central and peripheral mechanisms are considered to participate in its analgesia. Prim...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.004
更新日期：2005-11-16 00:00:00
abstract：:Sensitisation to the behavioural effects of amphetamine, a phenomenon which appears to involve the potentiation of excitatory amino acid (EAA)-mediated transmission at the level of dopaminergic (DA) neurons in the ventral tegmental area (the A10 cell group), is known to be affected by corticosteroid manipulations. Sin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00722-6
更新日期：1996-10-21 00:00:00
abstract：:Convulsions were induced in young rats (1-21 days) with pentylenetetrazol or hyperthermia. As adults, these animals were kindled electrically in the basolateral or cortical amygdala, the hippocampus, or the pyriform cortex. Fewer amygdala stimulations were required to evoke major motor seizures in subjects treated at ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90168-3
更新日期：1985-10-01 00:00:00
abstract：:In the present study fast axonal transport was examined in streptozotocin rats with 4 weeks duration in diabetes. Tritiated leucine and 14C-labelled glucosamine were injected into the fifth lumbar ganglion and TCA-soluble as well as insoluble activity were measured in segments of the sciatic nerve at various time inte...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90631-0
更新日期：1979-09-14 00:00:00
abstract：:We investigated the bilateral organization of the descending spinal sympathetic projections that subserve adrenomedullary stimulation caused by insulin hypoglycemia or 2-deoxyglucose (2DG) cellular glucopenia in adult rats with right-sided hemisection of the cord at C6-C7 (i.e. above the site of origin of the adrenal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90315-4
更新日期：1985-01-28 00:00:00
abstract：BACKGROUND:Chronic exposure to estradiol-17β (E2) in adult female rats increases mean arterial pressure by stimulating superoxide production in the rostral ventrolateral medulla (RVLM). However the mechanisms behind this phenomenon are unknown. We hypothesized that E2 exposure induces the gene expression of cytokines, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.09.007
更新日期：2015-11-19 00:00:00
abstract：:The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90800-o
更新日期：1992-03-06 00:00:00
abstract：:Recent anatomical evidence suggests that the shell of the nucleus accumbens, the bed nucleus of the stria terminalis, and the central nucleus of the amygdala, together referred to as the extended amygdala, may play a role in opiate dependence. The bed nucleus of the stria terminalis and the shell of the nucleus accumb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02288-x
更新日期：2000-01-31 00:00:00
abstract：:DL-N-(2-Hydroxy-3-napthyloxypropyl)-N'-dansylethylenediamine, dansyl analogue of propranolol (DAPN) is a novel fluorescent beta-adrenergic antagonist with high affinity to beta-receptors. The distribution pattern of DAPN fluorescence was studied in the rat central nervous system subsequent to its intravenous administr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90288-3
更新日期：1978-07-14 00:00:00
abstract：:Glucose transporter (GLUT) 4 plays an important role in insulin-induced glucose uptake in skeletal muscle and white adipose tissue. Although GLUT4 is abundant in the hypothalamus as well as in these peripheral tissues, little is known about the role of GLUT4 in the hypothalamus. In this study, we examined the subcellu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.079
更新日期：2005-07-05 00:00:00
abstract：:Determining the mechanism by which fluorescent retrograde neuronal tracers are taken up requires knowledge of their composition. It has been claimed that Fluoro-Gold, a retrogradely transported fluorescent neuronal tracer, is 2-hydroxy-4,4'-diamidinostilbene (hydroxystilbamidine), an amidine antibiotic. However, this ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90241-m
更新日期：1991-07-05 00:00:00
abstract：:Ischemic stroke brings a huge family and social burden. Although the reperfusion of ischemic cerebral tissue is the most important way to rescue ischemic stroke, ischemia-reperfusion (I/R) injury further results in brain damage and even lead to death. Recent studies demonstrated that Tongxinluo (TXL) helps to protect ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.01.036
更新日期：2018-04-15 00:00:00
abstract：:The morphological features and distribution of luteinizing hormone-releasing hormone (LHRH)-immunoreactive cell bodies and fibers of the hypothalamic and the neighboring mesencephalic regions were studied in the normal newborn infant by immunohistochemistry. Within the hypothalamus, numerous LHRH-immunoreactive like (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90929-6
更新日期：1990-05-21 00:00:00
abstract：:The dorsal lateral geniculate nucleus of tree shrews is very susceptible to the neurotoxic effects of kainic acid. In addition to neuronal loss, there is a profound loss of retinal terminals that is manifested through a disruption of anterograde transport of WGA/HRP from the retina to the kainic acid-lesioned area of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91516-2
更新日期：1987-07-21 00:00:00
abstract：:A special feature of the extracellular matrix in adult brains of various species is the concentration of certain components around different sub-populations of neurones, giving rise to net-like structures termed perineuronal nets. Recently, some of these components have been identified but the function of these nets h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01596-6
更新日期：1999-07-10 00:00:00
