Biochemical and histological modifications of the rat retina induced by the cholinergic neurotoxin AF64A.

abstract：:Neurokinin A and B (NKA and NKB) and neuropeptide K (NPK) were recently isolated from porcine spinal cord and brain, and together with substance P (SP) considerably extend the list of tachykinin-like peptides present in the mammalian nervous system. In order to investigate the distribution of tachykinins in the centra...

journal_title：Brain research

authors： Arai H,Emson PC

更新日期：1986-12-10 00:00:00

abstract：:Partial sciatic nerve ligation in mice caused a marked and persistent decrease in the latency of paw withdrawal from a thermal stimulus only on the ipsilateral side. This thermal hyperalgesia was abolished by repeated intrathecal pretreatment with a specific antibody to brain-derived neurotrophic factor (BDNF), but no...

journal_title：Brain research

authors： Yajima Y,Narita M,Narita M,Matsumoto N,Suzuki T

更新日期：2002-12-27 00:00:00

abstract：:Neonatal MK-801 treatment from postnatal day 8-19 leads to long-term effects on brain function, suggesting that exposure to this drug leads to the development of a brain with immature network properties. One aspect of this hypothesis, that the NMDA receptors preserve their immature state after the treatment, has been ...

journal_title：Brain research

authors： Gorter JA,Brady RJ

更新日期：1994-11-28 00:00:00

abstract：:Single-electrode depth profiles of the hippocampal EEG were made in urethane-anesthetized rats and rats trained in an alternating running/drinking task. Current source density (CSD) was computed from the voltage as a function of depth. A problem inherent to AC-coupled profiles was eliminated by incorporating sustained...

journal_title：Brain research

authors： Brankack J,Stewart M,Fox SE

更新日期：1993-07-02 00:00:00

abstract：:Although dendritic release was first proposed in the 1970s, the mechanism of release is still subject to debate. We have used in vivo microdialysis to study the acute effects of botulinum toxin A, B and tetanus toxin injected in the substantia nigra or striatum of freely moving rats. Spontaneous and evoked dopamine re...

journal_title：Brain research

authors： Bergquist F,Niazi HS,Nissbrandt H

更新日期：2002-09-20 00:00:00

abstract：:The turning effects of the unilateral intranigral injection of morphine and of different analogs of dynorphin and enkephalin were studied. All injections were made in awake rats through cronically implanted guide cannulae. Dynorphin1-13 at a dose of 10 micrograms (0.6 nmol) and dynorphin1-17 at a dose of 2 micrograms ...

journal_title：Brain research

authors： Morelli M,Di Chiara G

更新日期：1985-08-26 00:00:00

abstract：:Glutamic acid decarboxylase (GAD)- and gamma-aminobutyric acid (GABA)-like immunoreactivity was examined in the retina of the 13-lined ground squirrel (Spermophilus tridecemlineatus). Labeling was observed in the inner nuclear layer (INL), inner plexiform layer (IPL) and ganglion cell layer (GCL). The immunoreactive c...

journal_title：Brain research

authors： Lugo-García N,Blanco RE

更新日期：1991-11-08 00:00:00

abstract：:Retinal ganglion cells were labeled with horseradish peroxidase injected into the superior colliculus of normal pigmented rats. It is shown that virtually all ganglion cells with crossed axons project to the tectum, thus including all cell types described so far in the rat. The results contrast with the conclusion tha...

journal_title：Brain research

authors： Linden R,Perry VH

更新日期：1983-08-01 00:00:00

abstract：:Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifi...

journal_title：Brain research

authors： Zhang RX,Wang L,Liu B,Qiao JT,Ren K,Berman BM,Lao L

更新日期：2005-06-28 00:00:00

abstract：:The mismatch negativity (MMN) event-related potential is elicited by changes in repetitive auditory stimuli. The present paper suggests that: (1) an acoustic model of the auditory environment is maintained even in the absence of attention focussed on auditory stimuli, preattentively detecting repetitive features of th...

journal_title：Brain research

authors： Winkler I,Karmos G,Näätänen R

更新日期：1996-12-02 00:00:00

abstract：:Amyloid beta protein (A beta), has been reported to be toxic to neurons in vitro. However, the molecular mechanism leading to neuronal death remains unknown. Here we report protective effects of phenothiazines, a class of neuroleptic agent, against A beta toxicity in primary cultures of rat cortical neurons and PC12 c...

journal_title：Brain research

authors： Ueda K,Yagami T,Asakura K,Kawasaki K

更新日期：1997-02-14 00:00:00

abstract：:This study was performed to understand the anatomical substrates of hypothalamic modulation of jaw movements. After cholera toxin B subunit (CTb) injection into the parvicellular reticular formation (RFp) of the rat medulla oblongata, where many trigeminal premotor neurons have been known to exist, numerous CTb-labele...

journal_title：Brain research

authors： Notsu K,Tsumori T,Yokota S,Sekine J,Yasui Y

更新日期：2008-12-09 00:00:00

abstract：:The cellular and intracellular localization of the epsilon-subspecies of protein kinase C (PKC) in the rat brain was demonstrated by immunocytochemistry using specific antibodies against epsilon-PKC. The epsilon-PKC-specific immunoreactivity was most abundant in the hippocampal formation, olfactory tubercle and Callej...

journal_title：Brain research

authors： Saito N,Itouji A,Totani Y,Osawa I,Koide H,Fujisawa N,Ogita K,Tanaka C

更新日期：1993-04-02 00:00:00

abstract：:Full limbic seizures were kindled in rats by repeated, bi-daily microinjections of glutamate (1.5 mumol) into the basolateral amygdala. Co-administration of the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-7-phosphonoheptanoic acid with the glutamate, prevented the development of both electroencephalographi...

journal_title：Brain research

authors： Croucher MJ,Bradford HF

更新日期：1990-01-08 00:00:00

abstract：:Cerebral autoregulation was tested here in 3- and 18-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) was measured in each rat using radioactive micropheres under unanesthetized control conditions and after hypotension induced by ganglionic blockade. Under cont...

journal_title：Brain research

authors： Hoffman WE,Albrecht RF,Miletich DJ

更新日期：1981-06-09 00:00:00

abstract：:To evaluate a hypothesized role of the vagus in the circannual metabolic cycle of hibernators, measures of annual weight gain, weight loss and cycle period were taken for the ground squirrel, Citellus lateralis, maintained in constant environmental conditions before and after subdiaphragmatic vagotomy. The surgery did...

journal_title：Brain research

authors： Powley TL,Fox EA

更新日期：1986-01-29 00:00:00

abstract：:Cocaine (25 mg/kg i.p.) produces analgesia in the rat within 5 min and for a duration of 90 min as determined by the formalin test or for 30 min as determined by the hot plate test. Cocaine analgesia is unaffected by doses of naloxone that are sufficient to attenuate morphine analgesia in both tests. Chlorpromazine (3...

journal_title：Brain research

authors： Lin Y,Morrow TJ,Kiritsy-Roy JA,Terry LC,Casey KL

更新日期：1989-02-13 00:00:00

abstract：:Glutamate is a major neurotransmitter in the CNS. Its release activates NMDA and non-NMDA receptors on the postsynaptic membrane. NMDA receptor activation is shown to be important in physiological and pathological events. The modulatory sites on the NMDA receptor-channel ionophore complex are important in the regulati...

journal_title：Brain research

authors： Saybasili H

更新日期：1998-03-09 00:00:00

abstract：:The tegmentopontine reticular nucleus (nucleus of Bechterew) plays a crucial role in the generation of horizontal saccades and smooth pursuit movement of the eyes. The evolution of Alzheimer's disease-related cytoskeletal pathology was studied of this nucleus was studied in 27 autopsy cases at different stages of the ...

journal_title：Brain research

authors： Rüb U,Schultz C,Del Tredici K,Braak H

更新日期：2001-07-27 00:00:00

abstract：BACKGROUND:Previous studies have shown that regulating the target region by real-time fMRI-based neurofeedback training can influence the activation of other regions and the functional connectivity between them. However, it is not clear whether the training effect of neurofeedback, especially in emotion regulation, is ...

journal_title：Brain research

authors： Liu N,Yao L,Zhao X

更新日期：2020-08-01 00:00:00

abstract：:In our study, we examined middle cerebral artery (MCA) contractile responses in two animal models. After hemorrhagic disturbances in rats of Krushinsky-Molodkina strain (KMRs) a decrease in contractile responses to serotonin (5-HT) was observed. During incomplete global cerebral ischemia, MCAs had increased responsive...

journal_title：Brain research

authors： Fadyukova OE,Storozhevykh TP,Pinelis VG,Koshelev VB

更新日期：2004-01-02 00:00:00

abstract：:We investigated the projection from the infralimbic division of the prefrontal cortex (area 25) to histaminergic neurons in the posterior hypothalamic area. Phaseolus vulgaris-leucoagglutinin (PHA-L) was injected in the prefrontal cortex of rats. Frozen brain sections were subjected to combined PHA-L and histidine dec...

journal_title：Brain research

authors： Wouterlood FG,Steinbusch HW,Luiten PG,Bol JG

更新日期：1987-03-17 00:00:00

abstract：:The dipeptide N-acetylaspartylglutamate (NAAG) may be involved in the process of glutamatergic signaling by both acting at glutamate receptors and as a glutamate protransmitter. In the present study we determined the cellular localization and distribution of NAAG-like immunoreactivity (NAAG-LI) in normal human brain a...

journal_title：Brain research

authors： Passani LA,Vonsattel JP,Coyle JT

更新日期：1997-10-24 00:00:00

abstract：:Field potentials preceding vocalization were recorded with electrodes chronically implanted on the surface and at 2.0-3.0 mm depth in various cortical areas in three monkeys. Surface-negative, depth-positive (s-N, d-P) slow potentials prior to vocalization were recorded in the premotor (including the Broca's homology)...

journal_title：Brain research

authors： Gemba H,Miki N,Sasaki K

更新日期：1995-10-30 00:00:00

abstract：:Phosphorylation of cyclic AMP response element binding protein (CREB) is one of the most important mechanisms controlling various gene transcriptions. In the present study, the phosphorylation of CREB was examined immunohistochemically at 24 h of recirculation following 1.5 h of middle cerebral artery occlusion (MCAO)...

journal_title：Brain research

authors： Tanaka K,Nagata E,Suzuki S,Dembo T,Nogawa S,Fukuuchi Y

更新日期：1999-02-13 00:00:00

abstract：:Ionic currents induced by glutamate, kainate, quisqualate, and N-methyl-D-aspartate (NMDA) in cultured septal neurons were analyzed by fluctuations analysis. The power spectrum (PWS) of NMDA current fluctuations always fitted a single Lorentzian. PWSs of the other agonists fitted the sum of two Lorentzians; however, t...

journal_title：Brain research

authors： Shingai R,Ebina Y

更新日期：1988-05-10 00:00:00

abstract：:The aim of the present study was to evaluate p38 MAPK activation following focal stroke and determine whether SB 239063, a novel second generation p38 inhibitor, would directly attenuate early neuronal injury. Following permanent middle cerebral artery occlusion (MCAO), brains were dissected into ischemic and non-isch...

journal_title：Brain research

authors： Legos JJ,Erhardt JA,White RF,Lenhard SC,Chandra S,Parsons AA,Tuma RF,Barone FC

更新日期：2001-02-16 00:00:00

abstract：:The effect of immunoneutralization of hypothalamic neuropeptide Y (NPY) on food intake was examined to clarify the involvement of NPY in the control mechanism of feeding behavior. Injection of anti-NPY gamma-globulin into the bilateral hypothalamic paraventricular nuclei of 24-h food-deprived rats significantly inhibi...

journal_title：Brain research

authors： Shibasaki T,Oda T,Imaki T,Ling N,Demura H

更新日期：1993-01-22 00:00:00

abstract：:Immunohistochemistry for three calcium-binding proteins calbindin D-28k, calretinin, and parvalbumin revealed neuronal heterogeneity within the GP. Each neurone appeared to express either a single type of calcium binding protein or none at all. The co-localisation of calcium binding proteins was not observed. Combined...

journal_title：Brain research

authors： Cooper AJ,Stanford IM

更新日期：2002-03-08 00:00:00

abstract：:Alpha-bungarotoxin binding sites in chick retina from 12 days in ovo to hatching, were visualized at the ultrastructural level by use of a 1:1 conjugate of horseradish peroxidase with alpha-bungarotoxin. At all stages binding sites in the inner plexiform layer were localized in synapses, predominantly on or near the p...

journal_title：Brain research

authors： Daniels MP,Vogel Z

更新日期：1980-11-10 00:00:00