Early involvement of the tegmentopontine reticular nucleus during the evolution of Alzheimer's disease-related cytoskeletal pathology.

abstract：:Stressors produce rapid activation of the hypothalamic-pituitary-adrenal axis, which typically resolves within 60-90 min following termination of the stressor. In addition, some stressors such as inescapable tailshock (IS) also produce elevated basal levels of corticosterone (CORT), and reduced serum levels of cortico...

journal_title：Brain research

authors： Deak T,Nguyen KT,Cotter CS,Fleshner M,Watkins LR,Maier SF,Spencer RL

更新日期：1999-11-20 00:00:00

abstract：:Rab3A is a small GTP-binding synaptic vesicle protein, shown to dissociate from synaptic vesicle membranes upon depolarization-induced exocytosis. Using an antiserum raised against rab3A, we found that the antigen was localized to the neuropil of specific brain regions, but was not present in major fiber tracts or mos...

journal_title：Brain research

authors： Moya KL,Tavitian B,Zahraoui A,Tavitian A

更新日期：1992-09-11 00:00:00

abstract：:Antisense oligodeoxynucleotide (AS ODN) probes directed against the alpha-subunit of different G-proteins have been used to differentiate feeding responses in rats elicited by different opioid agonists, including morphine, beta-endorphin and dynorphin. Furthermore, antisense probes directed against G(o)alpha, but not ...

journal_title：Brain research

authors： Hadjimarkou MM,Silva RM,Rossi GC,Pasternak GW,Bodnar RJ

更新日期：2002-11-15 00:00:00

abstract：:This review examines vestibular compensation and vestibular rehabilitation from a unified translational research perspective. Laboratory studies illustrate neurobiological principles of vestibular compensation at the molecular, cellular and systems levels in animal models that inform vestibular rehabilitation practice...

journal_title：Brain research

authors： Balaban CD,Hoffer ME,Gottshall KR

更新日期：2012-10-30 00:00:00

abstract：:A push-pull perfusion technique was employed for in vivo study of adenosine 3',5'-monophosphate (cAMP) and guanosine 3',5'-monophosphate (cGMP) in the rat caudate nucleus. Addition of dopamine to the perfusion fluid elicited dose-dependent increases of both cAMP and cGMP perfusate concentrations. In separate experimen...

journal_title：Brain research

authors： Schoener EP,Hager PJ,Felt BT,Schneider DR

更新日期：1979-12-21 00:00:00

abstract：:The Mesulam technique for horseradish peroxidase was used to study the subcortical afferent projections to a location in the hypothalamus that has been shown to control the complete cardiovascular (CV) response accompanying a specific emotional behavior. Major projections common to all baboons injected included the la...

journal_title：Brain research

authors： Devito JL,Smith OA

更新日期：1982-12-09 00:00:00

abstract：:To study the regulation of striatal acetylcholine (ACH) release, adult male rat striata were dissociated and incubated with 3H-choline to synthesize 3H-ACH. Fractional 3H-ACH efflux per min during continuous perifusion was: (1) tightly regulated; (2) dependent on calcium influx; (3) stimulated by 10 mM K+ and 1 mM glu...

journal_title：Brain research

authors： Login IS,Borland K,Harrison MB,Ragozzino ME,Gold PE

更新日期：1995-10-30 00:00:00

abstract：:The aim of the present study was to show that space perception depends on sensori-motor experience. We induced spatial biases by a non-conflictual lateralized sensori-motor task on twenty seven right-handed healthy volunteers (left-to-right readers). After a pre-test and before a post-test, which assessed visuo-motor ...

journal_title：Brain research

authors： Dupierrix E,Alleysson D,Ohlmann T,Chokron S

更新日期：2008-06-12 00:00:00

abstract：:In the search for cortical mechanisms subserving psychological phenomena, a better understanding of human cortical circuitry is crucial. In this report we describe aspects of intrinsic connectivity of supragranular layers in human visual cortex, revealed by extracellular injections of the anterograde tracer biocytin i...

journal_title：Brain research

authors： Kenan-Vaknin G,Ouaknine GE,Razon N,Malach R

更新日期：1992-10-30 00:00:00

abstract：:Nestin is an embryonic intermediate filament that transiently expressed in the neural stem/progenitor cells in the developing central nervous system (CNS). Growing evidence has shown that abundant expression of nestin also occurs in both pathological glial-derived tumor cells and reactive astrocytes in various CNS inj...

journal_title：Brain research

authors： Wei LC,Shi M,Cao R,Chen LW,Chan YS

更新日期：2008-02-27 00:00:00

abstract：:Magnetic resonance spectroscopy (MRS) has demonstrated age-related changes in brain metabolites that may underlie micro-structural brain changes, but few studies have examined their relationship with cognitive decline. We performed a cross-sectional study of brain metabolism and cognitive function in 82 healthy adults...

journal_title：Brain research

authors： Charlton RA,McIntyre DJ,Howe FA,Morris RG,Markus HS

更新日期：2007-08-20 00:00:00

abstract：:Motor cortex stimulation (MCS) is a promising clinical procedure to help alleviate chronic pain. Animal models demonstrated that MCS is effective in lessening nocifensive behaviors. The present study explored the effects of MCS on cortical somatosensory evoked potentials (SEPs) recorded at the primary somatosensory co...

journal_title：Brain research

authors： Chiou RJ,Lee HY,Chang CW,Lin KH,Kuo CC

更新日期：2012-06-29 00:00:00

abstract：:Methamphetamine is a highly addictive psychostimulant that has surged in popularity worldwide in the last decade. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is widely expressed in the adult mammalian brain and plays an important role in the long-term survival, differentiation...

journal_title：Brain research

authors： Sim MS,Mohamed Z,Hatim A,Rajagopal VL,Habil MH

更新日期：2010-10-21 00:00:00

abstract：:The luteinizing hormone-releasing hormone (LHRH) system of the platyfish Xiphophorus has been studied using immunohistochemistry and retrograde transport of horseradish peroxidase (HRP). Three different populations of LHRH-positive cell bodies are present in the brain, one in the ventral telencephalon at the border to...

journal_title：Brain research

authors： Münz H,Stumpf WE,Jennes L

更新日期：1981-09-21 00:00:00

abstract：:Electroconvulsive therapy (ECT) is widely used as a treatment for drug-resistant depression. The animal analogue of ECT is electroconvulsive shock (ECS) seizures. We have recently shown that repeated ECS seizures cause a long-lasting, perhaps permanent, enhancement in entorhinal-dentate evoked potentials in the rat. O...

journal_title：Brain research

authors： Gombos Z,Mendonça A,Racine RJ,Cottrell GA,Burnham WM

更新日期：1997-08-22 00:00:00

abstract：:Previously brain norepinephrine (NE) neurons in the locus coeruleus (LC) have been shown to respond profoundly to external, environmental stimuli and are thought to be involved in behavioral functions such as vigilance, alarm and anxiety reactions to novel and, especially, threatening stimuli. Here we have used electr...

journal_title：Brain research

authors： Elam M,Thorén P,Svensson TH

更新日期：1986-06-04 00:00:00

abstract：:Effects of phenytoin (PHT) on the intracellular calcium and intracellular protein changes during pentylenetetrazole (PTZ)-induced bursting activity in the neurons of the Japanese land snail Euhadra peliomphala were examined. In the examination with a computer controlled electron probe X-ray microanalyzer, PHT clearly ...

journal_title：Brain research

authors： Sugaya E,Onozuka M,Furuichi H,Kishii K,Imai S,Sugaya A

更新日期：1985-02-18 00:00:00

abstract：:The present study examined whether morphine and morphine-6beta-glucuronide (M6G) analgesia on the tail-flick and jump tests differed in potency in the periaqueductal gray, the locus coeruleus or the rostral ventromedial medulla. Morphine and M6G significantly and dose-dependently elicited analgesia on both nociceptive...

journal_title：Brain research

authors： Krzanowska EK,Rossi GC,Pasternak GW,Bodnar RJ

更新日期：1998-07-20 00:00:00

abstract：:Opiate regulation of the nuclear proto-oncogene c-fos was studied in the locus coeruleus (LC) and other regions of rat brain by immunoblotting, northern blotting, and in situ hybridization procedures. Precipitation of opiate withdrawal in rats, which is known to increase LC firing rates 4-fold, led to a two- to three-...

journal_title：Brain research

authors： Hayward MD,Duman RS,Nestler EJ

更新日期：1990-08-20 00:00:00

abstract：:We have previously reported that intracerebroventricular injection of prostaglandin E2 (PGE2) induces hyperthermia possibly through EP1 receptors in the rat. In the present study, to determine the sites in the brain where PGE2 induces hyperthermia through EP1 receptors, we microinjected an EP1 receptor agonist, 17-phe...

journal_title：Brain research

authors： Oka K,Oka T,Hori T

更新日期：1997-08-29 00:00:00

abstract：:We previously reported that glial fibrillary acidic protein (GFAP) levels increased significantly at 3 days after stab wounds, relative to sham-operated controls, reaching a maximum of 200% of control value at 5-7 days. They then fell to near-normal values by 21 days. To determine whether these protein changes correla...

journal_title：Brain research

authors： Hozumi I,Aquino DA,Norton WT

更新日期：1990-11-26 00:00:00

abstract：:To provide evidence to support the calcium hypothesis of cerebral ischemia, we examined the effects of extracellular calcium and calcium antagonists (verapamil, flunarizine, nicardipine) on in vitro 'ischemia' using guinea pig hippocampal slices. As a model of in vivo ischemia we used a state of both glucose and oxyge...

journal_title：Brain research

authors： Amagasa M,Ogawa A,Yoshimoto T

更新日期：1990-08-27 00:00:00

abstract：:Several investigations have shown that the N-methyl-D-aspartate (NMDA) antagonist MK-801 interferes both with learning and a candidate neural mechanism for learning, the long-term potentiation (LTP) phenomenon. The low doses of MK-801 reported to block learning, however, may not be sufficient to block LTP. The present...

journal_title：Brain research

authors： Robinson GB,Reed GD

更新日期：1992-01-08 00:00:00

abstract：:Amyloid β-protein (Aβ) is the major component of extracellular plaques in the brains of patients with Alzheimer's disease. It has been suggested that the interaction of Aβ with membrane cholesterol is essential for Aβ to exert neurotoxicity; however, the effect of phospholipids, another major membrane lipid component,...

journal_title：Brain research

authors： Ko M,Hattori T,Abdullah M,Gong JS,Yamane T,Michikawa M

更新日期：2016-07-01 00:00:00

abstract：:Nerve growth factor (NGF) transported intraaxonally from the adrenergic nerve terminals in the iris to the cell bodies in the superior cervical ganglion resulted in an increase in the activity of the enzyme ornithine decarboxylase in the ganglion. This occurred in both six-day-old and adult rats with the relative effe...

journal_title：Brain research

authors： Hendry IA,Bonyhady R

更新日期：1980-10-27 00:00:00

abstract：:Myelin basic proteins (MBP) obtained from bovine, guinea pig and human nervous tissues exhibited hemagglutinating activity for erythrocytes of several animal species. The activity to each erythrocyte was actually equal among the 3 MBPs. With bovine MBP and chicken erythrocytes, the hemagglutinating activity did not re...

journal_title：Brain research

authors： Ikeda K,Yamamoto T

更新日期：1985-03-11 00:00:00

abstract：:The projections of putative dopamine containing cells within the dorsal raphe nucleus (DR) were studied using a combination of tyrosine hydroxylase (TH) immunocytochemistry and fluorescent retrograde tracing. Substantial numbers of TH-immunoreactive cells in the DR were found to project to the nucleus accumbens. Progr...

journal_title：Brain research

authors： Stratford TR,Wirtshafter D

更新日期：1990-03-12 00:00:00

abstract：:After traumatic brain injury, extracellular K(+) in brain can dramatically increase. We studied the effects of increased K(+) on the isolated pressurized rat middle cerebral artery (MCA). MCAs (200-250 microm OD) were isolated, cannulated with glass micropipettes, and pressurized. K(+) was increased in the extralumina...

journal_title：Brain research

authors： Golding EM,Steenberg ML,Johnson TD,Bryan RM Jr

更新日期：2000-10-13 00:00:00

abstract：:Fluorescence immunohistochemistry was performed to characterize the distribution and phenotype of GLUT8-positive neurons in rat brain and to compare the cellular distribution of GLUT8 with GLUT3 in the hippocampus. Based upon the absence of co-localization with the non-neuronal markers GFAP (astroglial) and OX42 (micr...

journal_title：Brain research

authors： Reagan LP,Rosell DR,Alves SE,Hoskin EK,McCall AL,Charron MJ,McEwen BS

更新日期：2002-04-05 00:00:00

abstract：:Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neuron...

journal_title：Brain research

authors： Suon S,Yang M,Iacovitti L

更新日期：2006-08-23 00:00:00