Abstract：
:Magnetic resonance spectroscopy (MRS) has demonstrated age-related changes in brain metabolites that may underlie micro-structural brain changes, but few studies have examined their relationship with cognitive decline. We performed a cross-sectional study of brain metabolism and cognitive function in 82 healthy adults (aged 50-90) participating in the GENIE (St GEorge's Neuropsychology and Imaging in the Elderly) study. Absolute metabolite concentrations were measured by proton chemical shift imaging within voxels placed in the centrum semiovale white matter. Cognitive abilities assessed were executive function, working memory, information processing speed, long-term memory and fluid intelligence. Correlations showed that all cognitive domains declined with age. Total creatine (tCr) concentration increased with age (r=0.495, p<0.001). Regression analyses were performed for each cognitive variable, including estimated intelligence and the metabolites, with age then added as a final step. A significant relationship was observed between tCr and executive function, long-term memory, and fluid intelligence, although these relationships did not remain significant after age was added as a final step in the regression. The regression analysis also demonstrated a significant relationship between N-acetylaspartate (NAA) and executive function. As there was no age-related decline in NAA, this argues against axonal loss with age; however the relationship between NAA and executive function independent of age and estimated intelligence is consistent with white matter axonal integrity having an important role in executive function in normal individuals.
journal_name
Brain Resjournal_title
Brain researchauthors
Charlton RA,McIntyre DJ,Howe FA,Morris RG,Markus HSdoi
10.1016/j.brainres.2007.06.027subject
Has Abstractpub_date
2007-08-20 00:00:00pages
108-16eissn
0006-8993issn
1872-6240pii
S0006-8993(07)01390-Xjournal_volume
1164pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The kinetic properties of the testosterone-metabolizing enzymes were studied in the hypothalamus of adult and young zebra finches of both sexes. Estradiol, 5 alpha-dihydrotestosterone, 5 beta-dihydrotestosterone and 5 beta-androstane-3 alpha,17 beta-diol were identified as metabolites of testosterone in males and fema...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90406-4
更新日期：1988-11-01 00:00:00
abstract：:The patterns of preganglionic projections in the avian sympathetic system are highly specific. Preganglionic axons arising from the T1 spinal segment, for example, project predominantly in the rostral direction, whereas T4 preganglionic axons project predominantly in the caudal direction. Moreover, each ganglion recei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90149-0
更新日期：1987-03-01 00:00:00
abstract：:The intra-axonal transport of horseradish peroxidase (HRP) has been used to trace the nodose ganglion and brain stem projections of a physiologically distinct nerve - the aortic depressor nerve - following electrophysiological identification. Tetramethyl benzidine (TMB) has been used as the substrate for demonstrating...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90553-3
更新日期：1980-04-21 00:00:00
abstract：:The human IGF2 and H19 genes are imprinted in most normal tissues. Alterations of genomic imprinting or loss of imprinting (LOI) have been observed in a number of malignant tumors. Although LOI has been linked to tumorigenesis, loss of IGF2 imprinting has also been observed in choroid plexus and leptomeninges in norma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00783-5
更新日期：1998-11-09 00:00:00
abstract：:Infusions of angiotensin II (AII) or carbachol (CBC) into the lateral ventricles of rats which had been depleted of sodium 4 h previously with either furosemide or polyethylene glycol produced significant changes in salt appetite and sodium and water balances relative to rats infused with saline vehicle. Infusions of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90860-1
更新日期：1985-11-04 00:00:00
abstract：:Olfactory bulbectomy (OBX) transects the glutamatergic efferents from the olfactory bulbs, and the changes of glutamatergic N-methyl-D-aspartate (NMDA) receptor-mediated function are though to be involved in the behavioral deficits seen in OBX rats. In the present study, irritability scores in OBX male Wistar rats wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02297-1
更新日期：2001-05-11 00:00:00
abstract：:Amphetamine releases dopamine through a transporter-mediated mechanism. The purpose of this report was to further our understanding of the intracellular pool from which amphetamine releases dopamine: the cytoplasmic pool, the vesicular pool, or both. Rats were treated with D-amphetamine (AMPH) (1.0 or 10.0 mg/kg) or a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00720-3
更新日期：1998-09-21 00:00:00
abstract：:Pretreatment with recombinant human interleukin-1 alpha (rhIL-1 alpha) 20 h before irradiation attenuates radiation-induced hyperthermia. Experiments were conducted to determine the role of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) in rhIL-1 alpha-induced attenuation of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91576-e
更新日期：1993-03-19 00:00:00
abstract：:The selective dopaminergic antagonist ligands [3H]SCH 23390 and [3H]sulpiride were used to reveal autoradiographically dopamine D1 and D2 receptors, respectively, in brain sections from rats which had received unilateral 6-hydroxydopamine (6-OHDA) injections destroying ascending nigrostriatal neurones. The binding of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90439-i
更新日期：1990-04-23 00:00:00
abstract：:Pharmacological studies using an in vitro model system were carried out to determine if naloxone, an opiate receptor antagonist, could have effects on neuronal membranes which were unrelated to its action as an opiate receptor antagonist. Intracellular recordings were made from cultured mammalian spinal cord neurons. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90747-7
更新日期：1980-10-06 00:00:00
abstract：:Focal electrical stimulation and glutamate microinjection in the nuclei reticularis gigantocellularis (NGC) and gigantocellularis pars alpha (NGC alpha) both inhibit the nociceptive tail-flick (TF) reflex in rats. The present experiments were undertaken to determine the transmitter(s) at the level of the lumbar spinal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91825-2
更新日期：1990-12-03 00:00:00
abstract：:We previously reported that angiotensin II type 2 (AT(2)) receptor signaling prevents neural damage and cognitive impairment after focal cerebral ischemia. We investigated the possible roles of the AT(2) receptor in the sex difference, focusing on cognitive function and ischemic brain damage using AT(2) receptor-defic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.068
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:Previously, we found that the inhaled anesthetic isoflurane up-regulated the transcriptional factor hypoxia inducible factor (HIF)-1α protein levels during induction of neurodegeneration in the brain of neonatal rats. Here, we investigated the role of HIF-1α and the underlying signaling pathway in the neurode...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.10.014
更新日期：2016-12-15 00:00:00
abstract：:The relationship between fiber tract formation and transverse and longitudinal borders of the diencephalon was investigated in Alligator embryos beginning when this structure was a single unit and continuing until internal subgroups were present within individual segments. At all stages of development, distinct bundle...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.081
更新日期：2010-02-08 00:00:00
abstract：:Antipsychotic drugs are the main treatment for schizophrenia, despite their adverse side effects and uncertain mode of action. Gene expression studies in the brains of rodents treated with antipsychotic drugs aim to uncover this mechanism and elucidate more specific targets for schizophrenia treatment. Previous expres...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.045
更新日期：2009-12-22 00:00:00
abstract：:Calretinin has been identified as a brain specific calcium-binding protein which appears as a prominent protein in the cochlear nucleus. We identified and localized calretinin in the guinea pig and rat inner ear using polyclonal antibodies. Immunoblot analyses of guinea pig and rat auditory nerve homogenates revealed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91224-o
更新日期：1991-09-27 00:00:00
abstract：:The effect of a dihydropyridine Ca2+ antagonist, cilnidipine, on voltage-dependent Ca2+ channels was studied in acutely dissociated rat CA1 pyramidal neurons using the nystatin-perforated patch recording configuration under voltage-clamp conditions. Cilnidipine had no effect on low-voltage-activated (LVA) Ca2+ channel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02295-7
更新日期：2000-01-31 00:00:00
abstract：:A pathway from the pretectal region to the dorsal division of the lateral geniculate body has been studied by autoradiography in adult cats following injection of tritium-labeled amino acids into the meso-diencephalic border zone. The findings suggest that the pretecto-geniculate connection arises in the ipsilateral n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90861-6
更新日期：1980-08-11 00:00:00
abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) produces symptoms similar to idiopathic Parkinson's disease in primates. A metabolite of MPTP, MPP+ (1-methyl-4-phenylpyridinium), is actively accumulated by dopaminergic (DA) terminals and selectively destroys nigrostriatal DA neurons. The mechanism of this effect r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90616-6
更新日期：1988-12-20 00:00:00
abstract：:The technique of intracranial microdialysis was used to investigate the effects of aging on the striatal dopaminergic system of the anesthetized Fischer 344 rat. Microdialysis probes were implanted into the striatum of young (2-8 months) and aged (24-28 months) urethane anesthetized rats. Striatal dialysate levels wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01095-6
更新日期：1999-01-16 00:00:00
abstract：:In order to investigate protein function in rat primary cortical neuronal cultures, we modified an adenoviral vector expression system and assessed the strength and specificity of the cytomegalovirus (CMV), rous sarcoma virus (RSV), and rat and human synapsin 1 (SYN1) promoters to drive DsRed-X expression. We also inc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.089
更新日期：2006-08-02 00:00:00
abstract：:In the present study we investigated whether nitroflurbiprofen (NFP) or nitro-aspirin can reduce the inflammatory response induced by continuous infusion of lipopolysaccharide (LPS) into the fourth ventricular space of the rat's brain for 30 days. The chronic LPS infusion produced an extensive inflammation that was pa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01081-6
更新日期：1999-01-02 00:00:00
abstract：:As in many humans suffering from lupus erythematosus, the development of systemic autoimmunity and inflammation in Fas-deficient MRL-lpr mice is accompanied by CNS dysfunction of unknown etiology. Experimental studies revealed infiltration of lymphoid cells into the choroid plexus, reduced neuronal complexity, retarde...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03980-x
更新日期：2003-02-28 00:00:00
abstract：:Repeated intracerebroventricular (i.c.v.) administration of angiotensin II (AII) and angiotensin III (AIII) induced dipsogenic tachyphylaxis in the Sprague-Dawley rat. AIII caused a rapid suppression of drinking, whereas AII showed a progressive decline of water consumption with repeated injections. Tachyphylaxis due ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90010-8
更新日期：1988-06-14 00:00:00
abstract：:The nucleus accumbens and ventral pallidum receive dopamine (DA) projections from the mesencephalon. Although DA inputs to the nucleus accumbens are implicated in both locomotion and reward processes, little is known of the behavioural significance of DA in the ventral pallidum. These studies examined the effects of D...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00633-7
更新日期：1998-09-14 00:00:00
abstract：:Swelling of glial and nerve cells is characteristic of brain damage in cerebral ischemia or trauma. The therapeutical efficiency of inhibition of Cl(-)-transport by a novel antagonist, the diuretic torasemide, on cytotoxic swelling of glial cells from lactacidosis, or glutamate was analyzed. Lactacidosis and the inter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91218-h
更新日期：1993-04-30 00:00:00
abstract：:Arginase-1, a marker for M2 phenotype alternatively activated macrophages, inhibits inflammation and is associated with phagocytosis of cell debris and apoptotic cells. We analyzed the expression of arginase-1, a competitive enzyme of inducible nitric oxide synthase (iNOS), in the spinal cords of Lewis rats with exper...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.03.023
更新日期：2012-05-09 00:00:00
abstract：:The synchronization of circadian rhythms in sleep, endocrine and metabolic functions with the environmental light cycle is essential for health, and dysfunction of this synchrony is thought to play a part in the development of many neurological disorders. There is a demonstrable need to develop new therapeutics for th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.08.034
更新日期：2014-10-17 00:00:00
abstract：:Acetylcholinesterase (AChE) histochemical staining occurred in neurons of the dentate gyrus at the day of birth and steadily increased in intensity and distribution during the first 3 postnatal weeks until the adult pattern was reached. Granule cells failed to display AChE staining; however, the somata of most non-pri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90072-1
更新日期：1987-11-01 00:00:00
abstract：:Locations of cells responsive to microiontophoretically applied angiotensin II (AII) were compared to distributions of AII receptor binding sites identified by autoradiography in the lumbar enlargement region of the rat spinal cord. Angiotensin II receptor binding sites were densely concentrated in the superficial lay...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91398-4
更新日期：1988-02-16 00:00:00
