Abstract：
:Infusions of angiotensin II (AII) or carbachol (CBC) into the lateral ventricles of rats which had been depleted of sodium 4 h previously with either furosemide or polyethylene glycol produced significant changes in salt appetite and sodium and water balances relative to rats infused with saline vehicle. Infusions of AII enhanced the salt appetite and led to rapid retention of both sodium and water. Infusions of CBC abolished the salt appetite and consequently did not produce any increase in sodium balance. Water intake was greater in both AII- and CBC-infused than in vehicle-infused rats and water balances increased during CBC infusion, causing severe dilution of plasma osmolality, sodium and potassium concentrations. Carbachol thus suppressed salt appetite, despite a considerable worsening of the condition of body sodium in these hypovolemic animals. Angiotensin II facilitated the appetite and this enhancement was not secondary to any natriuresis produced by AII infusions.
journal_name
Brain Resjournal_title
Brain researchauthors
Fitts DA,Thunhorst RL,Simpson JBdoi
10.1016/0006-8993(85)90860-1subject
Has Abstractpub_date
1985-11-04 00:00:00pages
273-80issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(85)90860-1journal_volume
346pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Inflammation and immune response have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Recently, increased TLR4 expression has been associated with the development of cerebral vasospasm in a rabbit model of SAH. Peroxisome proliferator-activated receptor gamma (PPARgamma) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.073
更新日期：2010-03-31 00:00:00
abstract：:In synaptosomal preparations from rat cerebral cortex, ouabain-sensitive Rb+ uptake was stimulated by ethanol (20-80 mM). Based on differential sensitivity to ouabain, 80% of this Na+,K(+)-ATPase activity represented activity of the alpha 1 isozyme while 20% was due to the alpha 2 and/or alpha 3 isozymes (alpha 2/ alp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90386-7
更新日期：1994-08-08 00:00:00
abstract：:This study describes the localization of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics, in the hypothalamus of Swiss Webster and C57BL/6J wild-type mice, leptin-deficient ob/ob mice, and leptin-resistant diet-induced obese (DIO) mice. The mice were given [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in 0.3...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.03.020
更新日期：2017-06-01 00:00:00
abstract：:There is much debate on the role of the superior colliculus (SC) in turning behaviour. In order to clarify this issue, unilateral kainate lesions were made by infusing 0.25 microgram of kainate at two different anterior planes (0.8 mm apart), in the lateral or in the medial aspects of the deep collicular layers (DLSC)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90557-1
更新日期：1982-04-08 00:00:00
abstract：:Wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) was used to study transneuronal transport in the developing rat visual pathways. Intraocular injections of WGA-HRP were made in neonatal albino rat pups at different ages from the day of birth, postnatal day 0 (P0), to one month of age. Transneuronal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90087-9
更新日期：1988-01-01 00:00:00
abstract：:The bag cell neurons of Aplysia are capable of generating an afterdischarge, which, in vivo, triggers egg-laying behavior. Pharmacologic elevation of cyclic AMP levels in isolated bag cell neurons has been shown to initiate repetitive firming similar to that seen during an afterdischarge, and to decrease outward curre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91733-w
更新日期：1990-11-05 00:00:00
abstract：:A hundred years after Lhx2 ortholog apterous was identified as a critical regulator of wing development in Drosophila, LIM-HD gene family members have proved to be versatile and powerful components of the molecular machinery that executes the blueprint of embryogenesis across vertebrate and invertebrate species. Here,...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.02.046
更新日期：2019-02-15 00:00:00
abstract：:Endogenous opioids play a role in the regulation of LH-RH neurosecretion throughout the estrous cycle and during the preovulatory LH surge on proestrus. Experimental evidence suggests that opioid influence may be altered with age, and it has been hypothesized that these alterations may contribute to the loss of regula...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91717-7
更新日期：1993-01-22 00:00:00
abstract：:A novel putative receptor for (3-8)angiotensin (AngIV) has recently been found in various tissues, including the brain. However, the localization of AngIV binding sites to specific types of brain cells has yet to be established. In this study tissue culture was used to determine the presence and characteristics of Ang...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00278-x
更新日期：1995-05-29 00:00:00
abstract：:The effect of different dose, mode and duration of estradiol administration was examined in the different brain catecholaminergic areas in ovariectomized (OVX) female rats. We determined changes in mRNA levels of tyrosine hydroxylase (TH), rate-limiting enzyme in catecholamine (CA) biosynthesis of GTP cyclohydrolase I...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.04.002
更新日期：2004-07-23 00:00:00
abstract：:Partial sciatic nerve ligation in mice caused a marked and persistent decrease in the latency of paw withdrawal from a thermal stimulus only on the ipsilateral side. This thermal hyperalgesia was abolished by repeated intrathecal pretreatment with a specific antibody to brain-derived neurotrophic factor (BDNF), but no...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03666-1
更新日期：2002-12-27 00:00:00
abstract：:The effects of kindling induced in developing rat pups were re-examined when the rats reached maturity. Eighteen-day-old rats, implanted with bipolar electrodes, were separated into the following 4 groups: the fully kindled group consisted of pups that developed generalized convulsions; the partially kindled group of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90097-9
更新日期：1982-05-01 00:00:00
abstract：:The effect of lowered brain glutathione content on the glutamate release following cerebral ischemia was investigated. Diethylmaleate (4 mmol/kg, i.p.), a commonly used chemical reagent for tissue glutathione depletion, significantly reduced the ischemia-induced glutamate release. The release of another excitatory ami...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00992-y
更新日期：1995-11-06 00:00:00
abstract：:Marmoset monkeys (Callithrix jacchus) with bilateral transections of the anterior temporal stem, amygdala and fornix were unable to relearn a 2-choice object discrimination first learnt prior to surgery, and were very severely impaired at relearning a concurrent object discrimination task which they had learnt and rel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02998-x
更新日期：2001-01-05 00:00:00
abstract：:The cytoplasmic adaptor protein Disabled-1 (Dab1), which is a key component of the Reelin-signaling pathway, has been suggested to be required for neuronal dendritic development. However, only data from studies on immature cultures [< or = 6 days in vitro (DIV)] and cytoarchitectural analyses of mutant mice have been ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.035
更新日期：2007-10-03 00:00:00
abstract：:Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo)....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02263-1
更新日期：2002-03-22 00:00:00
abstract：:A push-pull cannula supplied with artificial CSF was implanted in the striatum of anaesthetized rats, and the basal extracellular DA and DOPAC was assayed in the superfusates using HPLC and electrochemical detection. Simultaneously, a carbon fibre electrode was implanted in close proximity of the cannula and the evoke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00706-v
更新日期：1995-10-09 00:00:00
abstract：:The effects of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), on the fast tetrodotoxin-sensitive (TTX-S) and the slow tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons were investigated using the whole-cell patch-clamp method. Diclofenac suppressed both sodium currents in a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.048
更新日期：2003-11-28 00:00:00
abstract：:Noda epileptic rat (NER), originally found in a colony of Crj; Wistar rats, shows spontaneous tonic-clonic convulsion characterized by the appearance of high voltage polyspikes in cortical and hippocampal EEG once every 2-3 days after 2-4 months of age. Electrophysiological studies using hippocampal slice preparations...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03195-5
更新日期：2002-09-20 00:00:00
abstract：:Synaptosomes prepared from fresh human cerebral cortex were shown to be morphologically similar to those from other species. On incubation, they took up oxygen at a high and linear rate and accumulated potassium against a concentration gradient. In response to depolarization by raised extracellular K+ or addition of v...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90871-4
更新日期：1981-11-16 00:00:00
abstract：:It has been demonstrated previously that kappa opioid receptor agonists, such as dynorphin, inhibit oxytocin secretion in the rat. To determine whether kappa agonists act directly on oxytocin-containing magnocellular neurons to inhibit hormone secretion, we utilized immunofluorescence to examine the cellular localizat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02154-0
更新日期：2001-04-13 00:00:00
abstract：:The participation of glutamatergic circuits of the ventral basal ganglia in feeding-related regulatory mechanisms has been extensively indicated in primate and rodent species. In avian species, it has been shown that ICV injections of MK-801 or of CNQX increase food intake and reduce the latency of feeding initiation ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04196-3
更新日期：2003-03-14 00:00:00
abstract：:In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). In the freshwater planarian Dugesia japonica, which bel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01418-3
更新日期：1999-05-29 00:00:00
abstract：:Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03243-2
更新日期：2002-11-08 00:00:00
abstract：:The localization of the receptor for apamin, a specific toxin for one class of sensitive Ca2+-dependent K+ channel, was studied in rat brain using an in vitro autoradiographic technique. Radiolabeled monoiodoapamin binds specifically to rat brain sections with a high affinity (Kd = 25 pM) to a single class of sites. A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91333-8
更新日期：1986-09-24 00:00:00
abstract：:Hyperacusis, a marked intolerance to normal environmental sound, is a common symptom in patients with tinnitus, Williams syndrome, autism, and other neurologic diseases. It has been suggested that an imbalance of excitation and inhibition in the central auditory system (CAS) may play an important role in hyperacusis. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.008
更新日期：2012-11-16 00:00:00
abstract：:The cataleptic activity of morphine and methadone was markedly potentiated in frontally decorticated rats with no apparent changes in the onset or duration of action. Enhancement of the opioid cataleptic response was not due to changes in the availability of the drugs in the brain. The potentiation of methadone-induce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91028-1
更新日期：1988-05-24 00:00:00
abstract：:The mechanism of the Ca2+-dependent stimulation of neurotransmitter release by 4-aminopyridine in synaptosomes was studied. The stimulation of gamma-[3H]aminobutyric acid and [3H]acetylcholine release by 4-aminopyridine was not significantly affected either by tetrodotoxin or by the absence of Na+ in the medium, where...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91307-1
更新日期：1985-12-30 00:00:00
abstract：:Immobilization of frogs for 1 h induces analgesia which is blocked but not reversed by low doses of naloxone. After 9 days of daily immobilization for 1 h, the treatment fails to cause analgesia thus indicating that tolerance has developed. Animals tolerant to immobilization-induced analgesia do not show cross-toleran...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90073-8
更新日期：1984-04-02 00:00:00
abstract：:In nondiabetic animals, estrogen has been shown to provide significant neuroprotection in focal and transient forebrain ischemia models. However, that neuroprotection may be diminished or lost in the diabetic. In this study, we compared the level of brain damage in intact, ovariectomized (OVX) and 17beta-estradiol (E(...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03484-4
更新日期：2002-11-22 00:00:00
