Abstract:
:Arginase-1, a marker for M2 phenotype alternatively activated macrophages, inhibits inflammation and is associated with phagocytosis of cell debris and apoptotic cells. We analyzed the expression of arginase-1, a competitive enzyme of inducible nitric oxide synthase (iNOS), in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis (EAE). Western blot analysis showed that both arginase-1 and iNOS significantly increased in the spinal cords of rats at the peak stage of EAE compared with the expression level in control animals (p<0.05) and declined thereafter. Immunofluorescent staining demonstrated that increased expression of arginase-1 in EAE spinal cords was confirmed in macrophages as well as in some neurons and astrocytes that were constitutively positive for arginase-1 in normal spinal cords. A semiquantitative analysis by immunofluorescence showed that in EAE lesions, an increased level of arginase-1 immunoreactivity was matched with ED1-positive macrophages, which were also positive for activin A, a marker for the M2 phenotype. Taking all of these findings into consideration, we postulate that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of neuroinflammation in EAE lesions, possibly through the reduction of nitric oxide in the lesion via competition with iNOS for the use of L-arginine.
journal_name
Brain Resjournal_title
Brain researchauthors
Ahn M,Yang W,Kim H,Jin JK,Moon C,Shin Tdoi
10.1016/j.brainres.2012.03.023subject
Has Abstractpub_date
2012-05-09 00:00:00pages
77-86eissn
0006-8993issn
1872-6240pii
S0006-8993(12)00505-7journal_volume
1453pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Emotional events are preferentially retained in episodic memory. This effect is commonly attributed to enhanced consolidation and has been linked specifically to rapid eye movement (REM) sleep physiology. While several studies have demonstrated an enhancing effect of REM sleep on emotional item memory, it has not been...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.06.020
更新日期:2018-11-01 00:00:00
abstract::The effects of exo- and endogenous cGMP on the resting activity (RA) of afferent crista fibers were studied in isolated preparations of the statocysts of the cuttlefish Sepia officinalis and the squid Sepioteuthis lessoniana. Bath application of the membrane-permeable cGMP analogs 8-bromo-cGMP (B-cGMP) and N(2),2'-o-d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02777-3
更新日期:2000-10-13 00:00:00
abstract::We have shown that high-concentration albumin therapy is markedly neuroprotective in focal cerebral ischemia. The present study was conducted to ascertain the degree to which hemodynamic alterations are responsible for this therapeutic effect. Normothermic, physiologically regulated male Sprague-Dawley rats received a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00674-x
更新日期:1998-08-31 00:00:00
abstract::Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO(2)) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO(2) treatment has a therapeutic effect on ICP dynamics and survival following seve...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.02.049
更新日期:2005-06-21 00:00:00
abstract::Previous studies in our laboratory using rat brain tissue have shown that neuropeptide Y (NPY) can enhance NMDA- and potassium-stimulated dopamine release from various brain regions and that this enhancement is reversed by sigma (sigma) receptor antagonists. In the current study, we sought to determine whether SH-SY5Y...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02722-0
更新日期:2000-09-22 00:00:00
abstract:STUDY OBJECTIVE:To examine the differential effects of acute and chronic sleep fragmentation (SF) on spatial learning and memory, and hippocampal long-term potentiation (LTP) in pubertal mice. METHODS:Two studies were performed during which adolescent C57/Bl6 mice were subjected to acute-SF 24h a day × 3 days or chron...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.04.037
更新日期:2015-07-30 00:00:00
abstract::17β-estradiol (E2 or estrogen) is an endogenous steroid hormone that is well known to exert neuroprotection. Along these lines, one mechanism through which E2 protects the hippocampus from cerebral ischemia is by preventing the post-ischemic elevation of Dkk1, a neurodegenerative factor that serves as an antagonist of...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2012.12.015
更新日期:2013-06-13 00:00:00
abstract::Onset of hearing in the ferret was judged by simple behavioral, physiological and anatomical indices. The ear canals do not open until the end of the first postnatal month. This coincides with the appearance of a startle response to loud hand claps and the recording of acoustically activated neurons in the midbrain. T...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90698-9
更新日期:1982-12-16 00:00:00
abstract::The effect of the protein kinase C enzyme inhibitor H-7 was examined on the brain edema formation evoked by bilateral occlusion of the common carotid arteries in Sprague-Dawley rats of CFY strain. Brain edema was assessed by measurement of water and electrolyte contents of the brain. The results showed that pretreatme...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90439-3
更新日期:1989-06-19 00:00:00
abstract::Traumatic brain injury (TBI) contributes to morbidity in children, and more boys experience TBI. Cerebral autoregulation is impaired after TBI, contributing to poor outcome. Cerebral Perfusion Pressure (CPP) is often normalized by use of vasoactive agents to increase mean arterial pressure (MAP). In prior studies of n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.06.010
更新日期:2017-09-01 00:00:00
abstract::The terminal areas and cells of origin of the projection from the dorsal column nuclei to the mesencephalon were investigated by the intra-axonal transport method. Following injection of wheat germ agglutinin-horseradish peroxidase conjugate into the dorsal column nuclei, anterograde labeling was observed in several r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90086-6
更新日期:1984-10-08 00:00:00
abstract::The immunocytochemical localization of the enzyme choline acetyltransferase (ChAT) was examined in the guinea pig organ of Corti to determine if both lateral and medial systems of efferents would show immunoreactive labeling for this specific enzyme marker of cholinergic neurons. Cochleae were also examined after lesi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90242-2
更新日期:1985-07-08 00:00:00
abstract::BW 1003C87, 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid, has been tested for its in vitro and in vivo effects on glutamate release in rat brain tissue, and for its cerebro-protective action in two rodent models of cerebral ischemia. In rat brain slices the release of glutamate evoked by verat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91254-c
更新日期:1992-10-09 00:00:00
abstract::Binding sites of atrial natriuretic peptide in the cerebral microvessels and choroid plexus of spontaneously hypertensive rats (SHR) and Wistar Kyoto control rats (WKY) were measured. In the microvessels, the number of ANP binding sites was lower in SHR than WKY, but there was no difference in affinity of binding site...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90984-j
更新日期:1990-06-04 00:00:00
abstract::Numerous studies of neonatal neuronal development in mammals have revealed that neuronal cell death following axotomy is apoptotic in nature. In adult animals, however, neuronal cell death following axonal injury may or may not exhibit features of apoptosis. Bcl-2 and Bax have been identified as inhibitor and promoter...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01315-3
更新日期:1999-05-08 00:00:00
abstract::It has recently been shown that the lobules 9 and 10 of the cerebellum contain high densities of dopamine D3 receptors (and almost no D2 receptors [Bouthenet, M.L., Souil, E., Martres, M.P., Sokoloff, P., Giros, B. and Schwartz, J.C., Brain Res., 564 (1991) 203-219; Sokoloff, P., Giros, B., Martres, M.P., Bouthenet, M...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00964-x
更新日期:1996-10-21 00:00:00
abstract::Adenine and guanine nucleotides have been shown to exert multiple roles in central and peripheral nervous systems, and the sequential breakdown of these nucleotides by enzymatic systems is an important step in the modulation of their extracellular effects. The aim of this study was to investigate whether nucleotide hy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02987-6
更新日期:2002-09-20 00:00:00
abstract::The formation of reactive oxygen species (ROS) has been suggested to be associated with excitotoxicity but the involvement of cytoplasmic enzymes in ROS formation is not clearly known. In the present study, we examined the role of xanthine oxidase (XO), nitric oxide synthase (NOS) and phospholipase A(2) (PLA(2)) in gl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.01.013
更新日期:2005-03-10 00:00:00
abstract::This study deals with the synaptology, morphologically identified postsynaptic targets, and origin of somatostatin (SOM) fibers in the rat lateral septal area (LSA) with special reference to those forming pericellular baskets. Septal vibratome sections were immunostained for SOM-14 in 3 experimental groups: control an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91743-k
更新日期:1991-11-22 00:00:00
abstract::In this report, using a push-pull perfusion technique, we examined in vivo the effects of exogenous dopamine (DA) on the output of neurochemical substances from the caudate nucleus (CN) of freely behaving rats. Exogenous DA, at concentrations of 10(-5) M, 5 x 10(-5) M and 10(-4) M, in modified Krebs-Ringer phosphate m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90803-2
更新日期:1989-03-06 00:00:00
abstract::Tuberohypophysial dopamine (DA) neurons terminate in the intermediate and neural lobes of the posterior pituitary. The objective of this study was to determine if concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC), a major metabolite of DA in these regions, reflect the activity of tuberohypophysial DA neurons. T...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91209-y
更新日期:1990-01-01 00:00:00
abstract::Microinjection of apomorphine into the ventral tegmental area (VTA) of male rats was previously shown to delay the onset of copulation and slow its rate, presumably by stimulating impulse-regulating autoreceptors on cell bodies of the A10 mesocorticolimbic dopamine tract. Such stimulation would be expected to slow the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90173-s
更新日期:1991-07-19 00:00:00
abstract::The localization of [3H]corticosterone in the brain and pituitary of the adrenalectomized rat was studied by autoradiography. Corticosterone was concentrated preferentially by neurons in the hippocampus, septum, amygdala, and neocortex, with the hippocampal and septal neurons having the greatest concentration. [3H]-Co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90937-3
更新日期:1975-01-10 00:00:00
abstract::The outer plexiform layer (OPL) of the retina has been studied in the developing cat, from E (embryonic day) 30. Prior to E51 the layer could not be detected, the retina comprising two cell layers, an inner layer which becomes the ganglion cell layer of the adult, and an outer 'neuroblast' layer. The OPL was first det...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90126-2
更新日期:1982-11-01 00:00:00
abstract::The subthalamic nucleus receives serotonergic projections from the dorsal raphe nucleus. However, the role of serotonergic innervation in the activity of subthalamic neurons in vivo is unknown. The aim of the present work is to study the changes in the firing of subthalamic neurons in rats with 5,7-dihydroxytryptamine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.02.052
更新日期:2007-05-29 00:00:00
abstract::Autoradiographic analysis of [(35)S]GTPgammaS binding was used to investigate functional activation of dopamine receptors in rat striatum. Dopamine-stimulated [(35)S]GTPgammaS binding was observed with a maximal increase of 38% over basal activity. A similar stimulatory response was obtained with the D(2) agonist quin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02981-4
更新日期:2000-12-01 00:00:00
abstract::The role of bulbospinal neuropeptide Y (NPY)-containing neurons of the rostral ventrolateral medulla in the rabbit in mediating the increase in blood pressure that occurs during inhibition of cells in the caudal ventrolateral medulla was investigated in urethane-anaesthetized rabbits. In the present experiments bilate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91261-3
更新日期:1987-09-15 00:00:00
abstract::Hydrogen-rich water (HRW) has anti-oxidant activities, and it exerts neuroprotective effects during ischemia-reperfusion brain injury. Parvalbumin and hippocalcin are two calcium buffering proteins, which are involved in neuronal differentiation, maturation and apoptosis. The aim of this study was to investigate wheth...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.04.038
更新日期:2015-07-30 00:00:00
abstract::The exposure of cultured rat striatal neurons to L-DOPA caused marked cell death. The L-DOPA cytotoxicity was inhibited by the addition of Mg2+ to and by the removal of Ca2+ from the culture medium, and also by the application of tetrodotoxin. Moreover, prolonged application of L-DOPA increased the glutamate content i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00908-6
更新日期:1997-10-10 00:00:00
abstract::In urethane-anesthetized rats, high frequency stimulation was applied to the medial perforant pathway at various time intervals (50, 100, 200, 350 and 500 ms) following stimulation of the same pathway by a single pulse of equal intensity. Recordings of dentate gyrus granule cell evoked responses were made to investiga...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91358-3
更新日期:1988-01-12 00:00:00