Abstract：
:Microinjection of apomorphine into the ventral tegmental area (VTA) of male rats was previously shown to delay the onset of copulation and slow its rate, presumably by stimulating impulse-regulating autoreceptors on cell bodies of the A10 mesocorticolimbic dopamine tract. Such stimulation would be expected to slow the firing rate of these neurons and, thereby, to impair locomotion and/or motivational processes. The present experiments tested whether the delayed onset and slowed rate of copulation were related to deficits in motor performance, sexual motivation, and/or genital reflexes. In X-maze tests the speed of running to all 4 goal boxes was slowed; however, the percentage of trials on which the male chose the female's goal box was not decreased. Examination of videotaped copulation tests revealed that the male showed fewer complete copulatory behaviors (mounts, intromissions, and ejaculations), but more misdirected or incomplete copulatory attempts after apomorphine in the VTA. There were also fewer scores of active, as opposed to inactive, behaviors, and the onset and rate of copulation were slowed. The total number of female directed behaviors was not different in apomorphine tests, compared to vehicle. Finally, tests of ex copula genital reflexes revealed no significant effects of apomorphine in the VTA on erections, penile movements, or seminal emissions. These data suggest a role of the VTA in the motor aspects and/or sensorimotor integration of copulation. Sexual motivation and ex copula genital reflexes appeared to be unaffected by apomorphine in the VTA.
journal_name
Brain Resjournal_title
Brain researchauthors
Hull EM,Weber MS,Eaton RC,Dua R,Markowski VP,Lumley L,Moses Jdoi
10.1016/0006-8993(91)90173-ssubject
Has Abstractpub_date
1991-07-19 00:00:00pages
72-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90173-Sjournal_volume
554pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Ia synapses in laminae VI and IX of the cat's spinal cord were examined in the electron microscope following iontophoretic injection of horseradish peroxidase (HRP) into single, identified, Ia afferent fibers from gastrocnemius muscles. Ia boutons contacting motoneuron dendrites in lamina IX contained spherical synapt...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90831-x
更新日期：1984-05-23 00:00:00
abstract：:We have recently demonstrated that the formation of myelin sheaths in the optic nerve of young postnatal mice deficient in the myelin-associated glycoprotein (MAG) is retarded when compared to age-matched wild-type mice. In the present study, we analyzed whether impaired myelination of retinal ganglion cell axons is d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00484-8
更新日期：1997-07-11 00:00:00
abstract：:Intracellular recordings were obtained from CA1 pyramidal neurons in obliquely cut in vitro hippocampal slices. Recurrent IPSPs were elicited by antidromic stimulation of alvear fibers. The mechanisms by which IPSPs depress pyramidal cell excitability were investigated. Recurrent IPSPs could be reversed in sign by sma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91068-9
更新日期：1980-03-10 00:00:00
abstract：:Ontogenic development of the dopaminergic system in rat brain was investigated. This was accomplished by monitoring changes in postsynaptic dopamine receptor formation and presynaptic dopamine content in the midbrain tegmentum, frontal cortex and corpus striatum from the 18th day of gestation through adulthood. The do...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90186-1
更新日期：1988-06-01 00:00:00
abstract：:Axonal and glial cell development within rat optic nerve in which gliogenesis was altered by systemic injection of 5-azacytidine (5-AZ) was examined by quantitative electron microscopy. In neonatal (0-2 days) rat optic nerves, all fibers are premyelinated, and they exhibit a fairly uniform diameter (approximately 0.22...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91436-8
更新日期：1986-08-13 00:00:00
abstract：:NO (nitric oxide) produced in limbic brain regions has important roles in the regulation of autonomic nervous system and HPA axis activity, anxiety, fear learning, long-term memory formation, and depression. NO is synthesized from l-arginine in a reaction catalyzed by nitric oxide synthase (NOS). Neuronal nitric oxide...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.10.090
更新日期：2011-01-12 00:00:00
abstract：:Rat hippocampal slices were perfused with epidermal growth factor (EGF) at a concentration of 10(-8) M. EGF is a well known mitogen which exhibits neurotrophic action on neurons of the CNS. During extra- and intracellular recordings in the pyramidal cell body layer of the CA1-region no influence of EGF on evoked poten...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90380-6
更新日期：1989-04-10 00:00:00
abstract：:The retrogradely-transported tracer, rhodamine-tagged microspheres was injected into the pressor region of the rostral ventrolateral medulla (RVLM) to enable detection of paraventricular neurons in the hypothalamus that project to the RVLM. The protein, Fos, was detected immunohistochemically and used to highlight neu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00560-5
更新日期：1998-08-10 00:00:00
abstract：:The triggering of ectopic action potentials (APs) at axon terminals in a chronic epileptic cobalt focus was investigated in thalamocortical (TC) neurons of rats under urethane anesthesia. TC cells which were in register with an active epileptic aggregate discharged bursts of 2-11 APs. According to the rules of the col...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90628-m
更新日期：1992-03-27 00:00:00
abstract：:Previous work had indicated that animals that were sleep-deprived and then trained on a passive avoidance task show poor retention of the task 24 h later after being allowed to sleep freely again. Cholinergic involvement is suggested by the fact that this effect is prevented by treatment with the muscarinic agonist pi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02688-x
更新日期：2003-07-04 00:00:00
abstract：:The ionic basis of norepinephrine (NE) action was studied with intracellular recording techniques in the rat hippocampal slice. Topical application of NE caused, in CA1 neurons, a 3-4 mV hyperpolarization associated with a 10-20% decrease in input resistance. This effect was accompanied by a decrease in spontaneous ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90104-9
更新日期：1981-02-09 00:00:00
abstract：:Arginase-1, a marker for M2 phenotype alternatively activated macrophages, inhibits inflammation and is associated with phagocytosis of cell debris and apoptotic cells. We analyzed the expression of arginase-1, a competitive enzyme of inducible nitric oxide synthase (iNOS), in the spinal cords of Lewis rats with exper...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.03.023
更新日期：2012-05-09 00:00:00
abstract：:Conditioned place preference and locomotor sensitization are rodent behavioral models commonly used to investigate the actions of drugs of abuse. However, few studies have examined both paradigms in the same group of animals. We were interested in developing a combined protocol which successfully induced both conditio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.03.054
更新日期：2008-06-05 00:00:00
abstract：:To investigate whether atypical antipsychotic drugs exert an effect on the neuroprotective protein Bcl-2, rats were chronically treated with clozapine or olanzapine for 28 days. The expression of bcl-2 mRNA and Bcl-2 protein was determined, respectively, by in situ hybridization in tissue sections and Western blot on ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.02.064
更新日期：2004-06-04 00:00:00
abstract：:Previous studies have shown that preganglionic nerve stimulation in vitro increases acutely the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, in sympathetic neuronal cell bodies in the rat superior cervical ganglion (SCG). In the present study, we have examined whether ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90506-7
更新日期：1990-07-30 00:00:00
abstract：:Perinatal overfeeding is a risk factor for overweight and diabetes during life. Underlying pathophysiological mechanisms are unclear. The peptide galanin is suggested to stimulate food intake by acting within the paraventricular hypothalamic nucleus (PVN). In early postnatally overfed rats overweight and hyperinsuline...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01264-5
更新日期：1999-02-06 00:00:00
abstract：:Low concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) enhanced neuronal and glial survival and/or differentiation in dissociated cultures of 14-day mouse embryo brain. Posttrial intracisternal injection into the brains of mice undergoing active avoidance training alleviated amn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90807-9
更新日期：1987-03-17 00:00:00
abstract：:Calcium-binding proteins play a critical role in vertebrate sensory cells, and some of them have been detected in mechanosensory and chemosensory cells of bony and cartilaginous fishes. In this study immunohistochemistry and Western blot were used to investigate the occurrence and the distribution of S100 protein and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.070
更新日期：2007-08-08 00:00:00
abstract：:The postnatal development of retinogeniculate, retinopretectal and retinotectal projections has been studied by the anterograde transport of proline-labeled proteins in 20 pouch young opossums aged from 10 to 60 days. Radioautographical findings suggest delayed development of uncrossed as compared to crossed projectio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90971-x
更新日期：1978-05-12 00:00:00
abstract：:Previous studies focusing on the relationship between lateralization of language function and age suffer from lack of a balanced distribution of age and handedness among participants, especially in the extremes of age. This limits our understanding of the influence of these factors on lateralization of language circui...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.08.021
更新日期：2017-11-01 00:00:00
abstract：:We previously reported that glial fibrillary acidic protein (GFAP) levels increased significantly at 3 days after stab wounds, relative to sham-operated controls, reaching a maximum of 200% of control value at 5-7 days. They then fell to near-normal values by 21 days. To determine whether these protein changes correla...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90142-x
更新日期：1990-11-26 00:00:00
abstract：:The distribution of antidiabetic sulfonylurea [( 3H]glibenclamide) binding sites is heterogeneous in rat brain. Pyramidal and extrapyramidal motor system contain the highest densities of sites, particularly in the substantia nigra and in the globus pallidus. Only low levels are present in the hypothalamic nuclei and t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91288-2
更新日期：1989-05-01 00:00:00
abstract：:Electrical stimulation of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Fisher rats reduced, by approximately 50%, the infarctions produced by occlusion of the middle cerebral artery. Blockade of ATP-dependent potassium (K-ATP) channels with glibenclamide (i.c.v.) ab...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01871-5
更新日期：1999-09-25 00:00:00
abstract：:The present study attempts to elucidate the possible role of adenosine 3',5'-monophosphate (cAMP) and prostaglandin E2 (PGE2) in the function of the neural luteinizing hormone-releasing hormone (LH-RH) apparatus. To this end, in vitro LH-RH release from superfused hypothalamic fragments and cAMP production by hypothal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90162-9
更新日期：1986-10-29 00:00:00
abstract：:We monitored biosynthetic activity of optic tract glia during regeneration of retinal ganglion cell axons in the goldfish and found that the greatest level of incorporated [3H]thymidine and [3H]leucine occurred in glia by 10-15 days after axotomy. During this period there was a marked increase in the number of oligode...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90624-9
更新日期：1985-07-22 00:00:00
abstract：:Onset of hearing in the ferret was judged by simple behavioral, physiological and anatomical indices. The ear canals do not open until the end of the first postnatal month. This coincides with the appearance of a startle response to loud hand claps and the recording of acoustically activated neurons in the midbrain. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90698-9
更新日期：1982-12-16 00:00:00
abstract：:In a previous study the collateralization of the rubrospinal tract in the spinal cord of rat, cat and monkey was studied by means of the fluorescent retrograde double labeling technique. In the present study the existence of rubrospinal collaterals to the cerebellar interpositus nucleus (NI) has been studied using the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90816-8
更新日期：1983-04-04 00:00:00
abstract：:Genetic abnormalities in amyloid precursor protein (APP) are associated with Down's syndrome and familial Alzheimer's disease where hallmark plaques contain A beta peptides derived from APP. Both APP and its derivatives are implicated in neurodegenerative processes and may play important physiological and pathophysiol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.09.024
更新日期：2008-12-03 00:00:00
abstract：:We compared the laminar location and morphology of superior colliculus cells projecting to the dorsal and ventral lateral geniculate nuclei (LGd, LGv), the pretectum (PT), the parabigeminal nucleus (Pb), and nucleus lateralis posterior (LP) in the ground squirrel Spermophilus tridecemlineatus. Horseradish peroxidase w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90432-x
更新日期：1987-11-17 00:00:00
abstract：:The retinoblastoma protein (pRb) is a key regulator of cell growth, differentiation and survival. pRb(-/-) mice show abnormal neuronal cell death in the developing brain. The function of pRb is regulated by its phosphorylation state. In this study, the phosphorylation of pRb during retinoic acid (RA)-induced neuronal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01844-2
更新日期：1999-09-25 00:00:00
