Inhibition of vasodepressor neurons in the caudal ventrolateral medulla of the rabbit increases both arterial pressure and the release of neuropeptide Y-like immunoreactivity from the spinal cord.

abstract：:Mouse brain was found by immunoblot analysis to have a protein of Mr 23,000 (P23k) that was clearly different from recoverin and was labeled with an antiserum raised against the NH2-terminus of recoverin. P23k could not be detected by an antiserum raised against the COOH-terminus of recoverin. Blots with 45Ca demonstr...

journal_title：Brain research

authors： Takamatsu K,Uyemura K

更新日期：1992-02-07 00:00:00

abstract：:Samples of 14 brains of autopsied patients suffering from dementia of the Alzheimer type were examined. In Congo red-hemalum stained 14-microns-thick sections of the hippocampus 15 tangle-bearing and 25-30 unaffected nerve cells of area CA1 per case were measured for cell size and nucleolar size utilizing an interacti...

journal_title：Brain research

authors： Gertz HJ,Schoknecht G,Krüger H,Cervos-Navarro J

更新日期：1989-05-22 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) is a 38-amino-acid polypeptide, first isolated from hypothalamus, which directly stimulates in vitro the production of cAMP as well as the release of several pituitary hormones, such as growth hormone and luteinizing hormone. In vivo, PACAP has been shown to stimu...

journal_title：Brain research

authors： Grinevich V,Fournier A,Pelletier G

更新日期：1997-10-31 00:00:00

abstract：:Fractionated partial or whole-brain irradiation (fWBI) is a widely used, effective treatment for primary and metastatic brain tumors, but it also produces radiation-induced brain injury, including cognitive impairment. Radiation-induced neural changes are particularly problematic for elderly brain tumor survivors who ...

journal_title：Brain research

authors： Shi L,Olson J,D'Agostino R Jr,Linville C,Nicolle MM,Robbins ME,Wheeler KT,Brunso-Bechtold JK

更新日期：2011-04-18 00:00:00

abstract：:Propofol is an intravenous anesthetic with neuroprotective effects against cerebral ischemia-reperfusion (I/R) injury. Few studies regarding the neuroprotective and neurobehavioral effects of propofol have been conducted, and the underlying mechanisms are still unclear. Because I/R may result in neuronal apoptosis, th...

journal_title：Brain research

authors： Xi HJ,Zhang TH,Tao T,Song CY,Lu SJ,Cui XG,Yue ZY

更新日期：2011-09-02 00:00:00

abstract：:Animal models of cerebral infarction are crucial to understanding the mechanisms of neuronal survival following ischemic brain injury and to the development of therapeutic interventions for victims of all types of stroke. Rodents have been used extensively in such research. One rodent model of stroke utilizes either p...

journal_title：Brain research

authors： Duckworth EA,Butler TL,De Mesquita D,Collier SN,Collier L,Pennypacker KR

更新日期：2005-04-25 00:00:00

abstract：:Glioblastoma multiform is the most common malignant primary brain tumor in adults, but there remains no effective therapeutic approach. 2-methoxyestradiol (2-ME), which is a naturally occurring metabolite of 17beta-estradiol, was shown to enhance radiotherapeutic effect in certain tumors; however, whether 2-ME can als...

journal_title：Brain research

authors： Zou H,Zhao S,Zhang J,Lv G,Zhang X,Yu H,Wang H,Wang L

更新日期：2007-12-14 00:00:00

abstract：:This study examined the projection from the rostral nucleus of the solitary tract (rNST) to the medial parabrachial nucleus (mPBN) in male Wistar rats using DiI as a retrograde tracer and biotinylated dextran as an anterograde tracer. Following successful unilateral injection of DiI into the mPBN (n = 8), retrogradely...

journal_title：Brain research

authors： Williams JB,Murphy DM,Reynolds KE,Welch SJ,King MS

更新日期：1996-10-21 00:00:00

abstract：:This study examines the preventive and therapeutic effects of curcumin on brain edema after hypoxic-ischemic brain damage (HIBD) in a rat model. Male Sprague-Dawley rats were divided into four groups: a sham group (SH), a hypoxic-ischemic group (HI) without drug treatment, a hypoxic-ischemic group (CU) with curcumin i...

journal_title：Brain research

authors： Yu L,Yi J,Ye G,Zheng Y,Song Z,Yang Y,Song Y,Wang Z,Bao Q

更新日期：2012-09-26 00:00:00

abstract：:The D stereoisomer of dihydroxyphenylalanine (D-DOPA) and its alpha-keto acid metabolite 3,4-dihydroxyphenylpyruvic acid (DHPPA) when infused into the striatum, significantly increased in vivo extracellular dopamine levels. Following D-DOPA administration, the cumulative increase in dopamine levels was 30% of the incr...

journal_title：Brain research

authors： Brannan T,Prikhojan A,Yahr MD

更新日期：1996-04-29 00:00:00

abstract：:Using quantitative receptor radioautography, binding sites for the 'peripheral-type' benzodiazepine receptor ligand [3H]PK 11195 were studied in rats 4 week after end-to-side portacaval anastomosis and in sham-operated controls. Portacaval anastomosis resulted in region-selective increases in density of [3H]PK 11195 b...

journal_title：Brain research

authors： Giguère JF,Hamel E,Butterworth RF

更新日期：1992-07-10 00:00:00

abstract：:Deferoxamine (DFO) has shown therapeutic promise for the treatment of Parkinson׳s disease (PD) as it has reduced both behavioral and biochemical deficits when injected into the brain of rodent models of PD. Intranasally administered DFO targets the brain directly but non-invasively and has been effective in animal mod...

journal_title：Brain research

authors： Fine JM,Forsberg AC,Renner DB,Faltesek KA,Mohan KG,Wong JC,Arneson LC,Crow JM,Frey WH 2nd,Hanson LR

更新日期：2014-07-29 00:00:00

abstract：:Rats were given sham, cortical, or hippocampal lesions and sacrificed 7 or 28 days following surgery. Levels of norepinephrine, dopamine, and the major dopamine metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid (HVA), were assayed in 3 brain regions. At day 7 there was a decrease in dopamine utilizatio...

journal_title：Brain research

authors： Springer JE,Isaacson RL

更新日期：1982-12-02 00:00:00

abstract：:Traumatic brain injury (TBI) contributes to morbidity in children, and more boys experience TBI. Cerebral autoregulation is impaired after TBI, contributing to poor outcome. Cerebral Perfusion Pressure (CPP) is often normalized by use of vasoactive agents to increase mean arterial pressure (MAP). In prior studies of n...

journal_title：Brain research

authors： Curvello V,Hekierski H,Pastor P,Vavilala MS,Armstead WM

更新日期：2017-09-01 00:00:00

abstract：:The glutaminase activity in rat and guinea pig retina is twice as high in photoreceptor inner segments as in any other layer. Since the inner segments are involved in non-transmitter-related metabolic functions, it is suggested that glutaminase should not necessarily be taken to imply glutamatergic neurotransmission u...

journal_title：Brain research

authors： Ross CD,Bowers M,Godfrey DA

更新日期：1987-01-13 00:00:00

abstract：:The uptake and efflux of 36Cl in the lateral ventricle choroid plexus of 1-7-week-old rats were measured to determine if Cl transport changed with age and if such transport responded to inhibitors of CSF secretion and ion transport. The steady-state (30 min) Cl uptakes were 148 +/- 9.4 nmol.mg-1 dry weight at 1 week a...

journal_title：Brain research

authors： Preston JE,Dyas M,Johanson CE

更新日期：1993-10-08 00:00:00

abstract：:This research examined the electrophysiological, behavioral and neuroanatomical changes following an injection of kainic acid (KA) which destroyed most of the CA3 pyramidal cells in the hippocampus. For 5 days following the injection of KA, the evoked potential (EP) in the CA1 pyramidal cells produced by stimulation o...

journal_title：Brain research

authors： Fowler KR,Olton DS

更新日期：1984-10-29 00:00:00

abstract：:The effects of midazolam, one of the most popular benzodiazepines, on synaptic transmissions were compared with intracellular recordings between CA1 pyramidal cells (CA1-PCs) and dentate gyrus granule cells (DG-GCs) in rat hippocampal slices. First, we studied the effects of midazolam on orthodromically evoked spikes,...

journal_title：Brain research

authors： Sato Y,Fujito Y,Aoki M

更新日期：1997-10-31 00:00:00

abstract：:Outbred rat lines such as Wistar rats are commonly used for models of depressive disorders. Such rats arise from random mating schedules. Hence, genetic drift occurs in outbred populations which could lead to genotypic and phenotypic heterogeneity between rats from different vendors. Additionally, vendor specific rear...

journal_title：Brain research

authors： Theilmann W,Kleimann A,Rhein M,Bleich S,Frieling H,Löscher W,Brandt C

更新日期：2016-07-01 00:00:00

abstract：:Microencephalic rats induced by methylazoxymethanol (MAM) were observed to have notable hyperactivity compared to control rats, as measured by several behavioral parameters in an automated field apparatus. Acute injection of the stimulant drug, methamphetamine (MAP), produced an increase in the incidence of locomotion...

journal_title：Brain research

authors： Watanabe M,Shimizu K,Kodama Y,Takishima K,Mamiya G,Ichinowatari N

更新日期：1995-01-23 00:00:00

abstract：:Horizontal eye movements, elicited by sinusoidal rotation in darkness, were recorded with a magnetic search coil technique in pigmented rats, hemilabyrinthectomised 8-12 weeks before the investigation. Separate gains during rotation towards the lesioned side (LS) and the intact side (IS) were calculated by a computer ...

journal_title：Brain research

authors： Magnusson AK,Eriksson B,Tham R

更新日期：1998-06-08 00:00:00

abstract：:The aim of this work was to investigate the modulation of the cardiovascular effects of neuropeptide Y (NPY) in the nucleus tractus solitarii (NTS) by angiotensin II (Ang II) and to determine the NPY receptor subtype involved in this modulation. Anesthesized Sprague-Dawley rats received microinjections in the NTS of A...

journal_title：Brain research

authors： Díaz-Cabiale Z,Fuxe K,Coveñas R,González-Barón S,Narváez JA

更新日期：2003-09-05 00:00:00

abstract：:In adult cats, we have investigated how nerve cross-union between slow and fast muscle affects twitch contraction and half-relaxation times in the presence and absence of motor disuse, produced by complete decerebellation. Cerebellectomy abolished the slowing of cross-innervated fast muscle and diminished the amount o...

journal_title：Brain research

authors： Eerbeek O,Stenvers JW,de Jong JM

更新日期：1982-02-18 00:00:00

abstract：:Two experiments were undertaken to investigate dopaminergic involvement in the local rate of responding on a fixed ratio 5 (FR5) instrumental lever pressing schedule. Rats were trained to press a lever for food reinforcement on a FR5 schedule, and a computer program was used to record the interresponse time (IRT) for ...

journal_title：Brain research

authors： Salamone JD,Kurth PA,McCullough LD,Sokolowski JD,Cousins MS

更新日期：1993-11-19 00:00:00

abstract：:Five complete poles of long nuclear chain intrafusal fibers of cat tenuissimus muscle spindles embedded in a plastic medium were cut in serial, 1 micron thick transverse sections and stained with toluidine blue. Each fiber pole displayed one plate-type motor ending positioned outside the encapsulated part of the spind...

journal_title：Brain research

authors： Kucera J,Hughes R

更新日期：1983-03-07 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) are thought to mediate diverse processes in brain including synaptic plasticity and excitotoxicity. These receptors are often divided into three groups by their pharmacological profiles. [3H]Glutamate binding in the presence of compounds selective for ionotropic glutamate rece...

journal_title：Brain research

authors： Testa CM,Hollingsworth ZR,Shinozaki H,Penney JB Jr,Young AB

更新日期：1997-10-31 00:00:00

abstract：:Retinal afferents to the dorsal raphe nucleus (DRN) have been described in a number of species, including Mongolian gerbils, but functional correlates of this optic pathway are unknown at present. To determine whether temporally modulated photostimulation can affect c-Fos expression in the gerbil DRN, quantitative ana...

journal_title：Brain research

authors： Fite KV,Wu PS,Bellemer A

更新日期：2005-01-21 00:00:00

abstract：:Kernicterus is a bilirubin-induced encephalopathy in newborn. Its spectrum ranges from subtle extrapyramidal to acute encephalopathy and chronic posticteric sequelae. Current treatment of this serious problem is far from optimal. Taurine has been documented to have protective effects on neuronal cells against ischemia...

journal_title：Brain research

authors： Zhang B,Yang X,Gao X

更新日期：2010-03-12 00:00:00

abstract：:Axons in the adult mammalian CNS normally do not regenerate following axotomy even though they retain the capacity for growth under certain experimental conditions. Although this implies that the regeneration of adult axons is under regulative control, very little is known about the signaling pathways "responsible" fo...

journal_title：Brain research

authors： Bates CA,Meyer RL

更新日期：1996-04-01 00:00:00

abstract：:Alterations in protein phosphorylation may be important in the pathogenesis of Alzheimer's disease and recent observations suggest that a subset of protein kinase pathways may be selectively altered. Calcium/calmodulin-dependent protein kinase II CaM kinase II) is the most abundant protein kinase in the brain and is b...

journal_title：Brain research

authors： Simonian NA,Elvhage T,Czernik AJ,Greengard P,Hyman BT

更新日期：1994-09-19 00:00:00