Differential effects of a benzodiazepine on synaptic transmissions in rat hippocampal neurons in vitro.

abstract：:The chronic dietary intake of essential polyunsaturated fatty acids (PUFAs) can modulate learning and memory by being incorporated into neuronal plasma membranes. Representatives of two PUFA families, the n-3 and n-6 types become integrated into membrane phospholipids, where the actual (n-6)/(n-3) ratio can determine ...

journal_title：Brain research

authors： Farkas E,de Wilde MC,Kiliaan AJ,Meijer J,Keijser JN,Luiten PG

更新日期：2002-11-01 00:00:00

abstract：:The localization of vasoactive intestinal peptide (VIP)-like immunoreactivity was investigated in the brain, olfactory system and retina of the zebrafish, Danio rerio, during development and in juvenile specimens, by using the indirect immunofluorescence and the peroxidase-antiperoxidase methods. In 24 h post fertiliz...

journal_title：Brain research

authors： Mathieu M,Tagliafierro G,Angelini C,Vallarino M

更新日期：2001-01-12 00:00:00

abstract：:The control of hypoglossal motoneurons during sleep is important from a basic science perspective as well as to understand the bases for pharyngeal occlusion which results in the obstructive sleep apnea syndrome. In the present work, we used intracellular recording techniques to determine changes in membrane propertie...

journal_title：Brain research

authors： Fung SJ,Yamuy J,Xi MC,Engelhardt JK,Morales FR,Chase MH

更新日期：2000-12-08 00:00:00

abstract：:Dynamin-1 is a multi-domain GTPase that is crucial for the fission stage of synaptic vesicle recycling and vesicle trafficking. In this study, we constructed prokaryotic expression plasmids for the four functional domains of dynamin-1, which are pGEX-4T-2-PH, pGEX-4T-2-PRD, pGEX-4T-2-GED and pGEX-4T-2-GTPase. Glutathi...

journal_title：Brain research

authors： Zhang C,Omran AG,He F,Deng X,Wu L,Peng J,Yin F

更新日期：2014-01-16 00:00:00

abstract：:Human truncated tau protein is an active constituent of the neurofibrillary degeneration in sporadic Alzheimer's disease. We have shown that modified tau protein, when expressed as a transgene in rats, induced AD characteristic tau cascade consisting of tau hyperphosphorylation, formation of argyrophilic tangles and s...

journal_title：Brain research

authors： Hrnkova M,Zilka N,Minichova Z,Koson P,Novak M

更新日期：2007-01-26 00:00:00

abstract：:The present study has examined the involvement of sensory neurotransmitters in activating neurones in the trigeminal nucleus caudalis following stimulation of the trigeminovascular system in anaesthetised guinea-pigs. Electrical stimulation of the right trigeminal ganglion produced a unilateral expression of Fos-like ...

journal_title：Brain research

authors： Clayton JS,Gaskin PJ,Beattie DT

更新日期：1997-11-14 00:00:00

abstract：:Bradykinin is known to rapidly elevate intracellular calcium leading to secretion of neurotransmitters and short term activation of tyrosine hydroxylase (TH). In this study we examined the effect of bradykinin on mRNA levels of two catecholamine biosynthetic enzymes. Treatment of PC12 cells with 1 microM bradykinin fo...

journal_title：Brain research

authors： Gebreyesus K,Kilbourne EJ,Sabban EL

更新日期：1993-04-16 00:00:00

abstract：:Since it has been proposed that oxidized protein accumulation plays a critical role in brain aging, we have investigated their contents in synaptic mitochondria from five age groups of mice. Protein carbonyl content in synaptic mitochondria showed a significant positive correlation with age (r = 0.95, P = 0.01). A lin...

journal_title：Brain research

authors： Martinez M,Hernández AI,Martínez N,Ferrándiz ML

更新日期：1996-08-26 00:00:00

abstract：:We examined whether mild brain hypothermia during pretreatment with sublethal 2-min ischemia affected the tolerance to subsequent lethal 5-min ischemia. The neuronal densities in the hippocampal CA1 sector of gerbils preconditioned at mild brain hypothermia (32% of normal) were significantly lower than those in gerbil...

journal_title：Brain research

authors： Wada K,Miyazawa T,Katoh H,Nomura N,Yano A,Shima K,Chigasaki H

更新日期：1997-01-23 00:00:00

abstract：:5-HT2 receptor binding sites were measured (by saturation binding of [3H]ketanserin) in brain tissue obtained at postmortem from 19 suicide victims with definite evidence of depression and 19 sex and age-matched control subjects. Five of the suicide victims were receiving antidepressant drugs prior to death; 13 suicid...

journal_title：Brain research

authors： Cheetham SC,Crompton MR,Katona CL,Horton RW

更新日期：1988-03-08 00:00:00

abstract：:Brain edema is a serious consequence of hemispheric stroke and traumatic brain injury and contributes significantly to patient mortality. In the present study, we measured water contents in hippocampal slices as an in vitro model of edema formation. Excitotoxic conditions induced by N-methyl-D-aspartate (NMDA, 300 mic...

journal_title：Brain research

authors： Kumar V,Naik RS,Hillert M,Klein J

更新日期：2006-11-29 00:00:00

abstract：:Male rats were treated with barbital supplied in their drinking water (daily dose around 200 mg/kg) for 50 weeks. When the treatment was stopped (day 0) spontaneous convulsions were monitored for the first 3 days of the abstinence. On day 3 a convulsion was induced by electricity in half of the rats (controls and barb...

journal_title：Brain research

authors： Wahlström G

更新日期：1983-05-05 00:00:00

abstract：:The purpose of this work was to characterize the gap junctions between cultured glomus cells of the rat carotid body and to assess the effects of acidity and accompanying changes in [Ca(2+)](i) on electric coupling. Dual voltage clamping of coupled glomus cells showed a mean macrojunctional conductance (G(j)) of 1.16 ...

journal_title：Brain research

authors： Abudara V,Jiang RG,Eyzaguirre C

更新日期：2001-10-19 00:00:00

abstract：:Alterations occurring in the antioxidant enzymes, copper, zinc-dependent superoxide dismutase (Cu,Zn-SOD) and glutathione peroxidase (GPX) following nigral dopaminergic denervation are unclear. We now report on the distribution and levels of m-RNA for Cu,Zn-SOD and GPX in basal ganglia of normal and 1-methyl-4-phenyl-...

journal_title：Brain research

authors： Kunikowska G,Jenner P

更新日期：2003-04-11 00:00:00

abstract：:Cocaine increases dopamine concentration in the nucleus accumbens through competitive binding to the dopamine transporter (DAT). However, it also increases the frequency of dopamine release events, a finding that cannot be explained by action at the DAT alone. Rather, this effect may be mediated by cocaine-induced mod...

journal_title：Brain research

authors： Gerth AI,Alhadeff AL,Grill HJ,Roitman MF

更新日期：2017-01-15 00:00:00

abstract：:The VIIIth cranial nerve projections in the hagfish, which has only one circular canal in the ear, were studied by transganglionic HRP transport. This nerve has two branches, the nervus utricularis (N. utr.) and the nervus saccularis (N. sac.), each with its own ganglion, the ganglion utriculare (G. utr.) and the gang...

journal_title：Brain research

authors： Amemiya F,Kishida R,Goris RC,Onishi H,Kusunoki T

更新日期：1985-06-24 00:00:00

abstract：:Oxygen therapy (OT) with hyperbaric oxygen (HBO) or normobaric hyperoxia (NBO) improves the oxygenation of penumbral tissue in experimental ischemic stroke. However, whether this results in the improvement of energy metabolism is unclear. We investigated the effect of both OTs on tissue acidosis and on ATP production....

journal_title：Brain research

authors： Sun L,Strelow H,Mies G,Veltkamp R

更新日期：2011-09-30 00:00:00

abstract：:Synaptic responses evoked in phrenic motoneurones (PMNs) by stimulation of the superior laryngeal nerve (SLN) were analysed in anaesthetised cats. Stimulation of the SLN was followed by inhibition of ipsilateral phrenic nerve discharge with the latency of 9.5 +/- 2.3 ms (mean +/- S.D.) and hyperpolarizations of ipsila...

journal_title：Brain research

authors： Bellingham MC,Lipski J,Voss MD

更新日期：1989-05-08 00:00:00

abstract：:In the developing vertebrate retina, precise coordination of retinal progenitor cell proliferation and cell-cycle exit is essential for the formation of a functionally mature retina. Unregulated or disrupted cell proliferation may lead to dysplasia, retinal degeneration or retinoblastoma. Both cell-intrinsic and -extr...

journal_title：Brain research

authors： Martins RA,Pearson RA

更新日期：2008-02-04 00:00:00

abstract：:Horizontal eye movements, elicited by sinusoidal rotation in darkness, were recorded with a magnetic search coil technique in pigmented rats, hemilabyrinthectomised 8-12 weeks before the investigation. Separate gains during rotation towards the lesioned side (LS) and the intact side (IS) were calculated by a computer ...

journal_title：Brain research

authors： Magnusson AK,Eriksson B,Tham R

更新日期：1998-06-08 00:00:00

abstract：:The peak-to-peak amplitude of temporal middle latency response (MLR) of the guinea pig, evoked by a click in the contralateral ear, according to the recording side, is increased with the presence of continuous white noise (CWN) in the ipsilateral ear and this specialty is defined as the white noise enhancement (WNE). ...

journal_title：Brain research

authors： Goksoy C,Demirtas S,Ungan P

更新日期：2004-08-13 00:00:00

abstract：:Brain serotonin (5-HT) uptake sites were quantitated, by saturation binding of [3H]paroxetine, in 10 brain regions from 22 suicide victims and 20 control subjects. Suicide victims were restricted to those subjects in whom a firm retrospective diagnosis of depression was established and who had not recently been prescr...

journal_title：Brain research

authors： Lawrence KM,De Paermentier F,Cheetham SC,Crompton MR,Katona CL,Horton RW

更新日期：1990-08-27 00:00:00

abstract：:Previous neuroimaging studies provided evidence that visual mental imagery relies, in part, on the primary visual cortex. We hypothesized that, analogous to the finding that motor imagery increases the excitability of motor cortex, visual imagery should increase visual cortex excitability, as indexed by a decrease in ...

journal_title：Brain research

authors： Sparing R,Mottaghy FM,Ganis G,Thompson WL,Töpper R,Kosslyn SM,Pascual-Leone A

更新日期：2002-05-31 00:00:00

abstract：:The effects of VIP and of peptides of the VIP family: secretin, glucagon, the porcine histidine isoleucine containing peptide (PHI) and the rat hypothalamic growth hormone-releasing hormone (rhGRF) on the cyclic AMP and inositol phosphate contents of isolated rat superior cervical ganglia were investigated. We demonst...

journal_title：Brain research

authors： Audigier S,Barberis C,Jard S

更新日期：1986-06-25 00:00:00

abstract：:In neuronal cultures, glycogen synthase kinase 3(GSK3) is truncated at the N-terminal end by calpain downstream of activated glutamate receptors. However, the in vivo biological significance of that truncation has not been explored. In an attempt to elucidate if GSK3 truncation has a pathophysiological relevance, we h...

journal_title：Brain research

authors： Jurado-Arjona J,Goñi-Oliver P,Rodríguez-Prada L,Engel T,Henshall DC,Ávila J,Hernández F

更新日期：2015-06-22 00:00:00

abstract：:Propofol is an intravenous anesthetic with neuroprotective effects against cerebral ischemia-reperfusion (I/R) injury. Few studies regarding the neuroprotective and neurobehavioral effects of propofol have been conducted, and the underlying mechanisms are still unclear. Because I/R may result in neuronal apoptosis, th...

journal_title：Brain research

authors： Xi HJ,Zhang TH,Tao T,Song CY,Lu SJ,Cui XG,Yue ZY

更新日期：2011-09-02 00:00:00

abstract：:We measured the release of neuropeptide Y (NPY) from hippocampal slices of rats at various times after limbic seizures induced by a subcutaneous injection of 12 mg/kg kainic acid (KA). Two days after KA, 100 mM KCl induced a 1.6 +/- 0.2-fold increase in NPY release compared to saline-injected rats (P < 0.05), while sp...

journal_title：Brain research

authors： Vezzani A,Civenni G,Rizzi M,Monno A,Messali S,Samanin R

更新日期：1994-10-10 00:00:00

abstract：:In the striatum and hippocampus, there is a loss of sensitivity to muscarinic agonists with age which has been traced to events early in the signal transduction pathway. Our laboratory has therefore focussed on investigations at this level. The current experiments investigate the effects of age on G-protein/receptor i...

journal_title：Brain research

authors： Anson RM,Cutler R,Joseph JA,Yamagami K,Roth GS

更新日期：1992-12-11 00:00:00

abstract：:In anesthetized rats, out of 48 paraventricular (PaV) and 19 periventricular (PeV) neurosecretory cells, 12 PaV and 6 PeV cells increased and 10 PaV cells decreased the electrical activities statically in response to preoptic and anterior hypothalamic warming. Four PaV and 2 PeV cells responded dynamically to the ther...

journal_title：Brain research

authors： Matsumura K,Nakayama T,Ishikawa Y

更新日期：1983-12-19 00:00:00

abstract：:(1) The levels of glycolytic intermediates in the brain tissue of 15-day-old homozygous and heterozygous Gunn rats were determined with or without novobiocin treatment in vivo, and the inhibitory effects of bilirubin on the glycolytic activity and the key glycolytic enzyme activities were investigated in vitro. (2) t...

journal_title：Brain research

authors： Katoh-Semba R

更新日期：1976-08-27 00:00:00