Abstract：
:Since it has been proposed that oxidized protein accumulation plays a critical role in brain aging, we have investigated their contents in synaptic mitochondria from five age groups of mice. Protein carbonyl content in synaptic mitochondria showed a significant positive correlation with age (r = 0.95, P = 0.01). A linear inverse relationship was observed between protein carbonyl content and complex IV/complex I ratio (which was used as an index of imbalance between mitochondrial respiratory complexes) in synaptic mitochondria in the five age groups (r = -0.99, P < 0.001). We suggest that age-related accumulation of oxidized proteins in synaptic mitochondria may be the result of an age-dependent increase in reactive oxygen species generation because of a disarrangement of mitochondrial oxidative phosphorylation.
journal_name
Brain Resjournal_title
Brain researchauthors
Martinez M,Hernández AI,Martínez N,Ferrándiz MLdoi
10.1016/0006-8993(96)00708-1subject
Has Abstractpub_date
1996-08-26 00:00:00pages
246-8issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00708-1journal_volume
731pub_type
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