Potentiating effects of methamphetamine on the hyperactivity of microencephalic rats treated prenatally with methylazoxymethanol: possible implication of hyperdopaminergia.

Abstract:

:Microencephalic rats induced by methylazoxymethanol (MAM) were observed to have notable hyperactivity compared to control rats, as measured by several behavioral parameters in an automated field apparatus. Acute injection of the stimulant drug, methamphetamine (MAP), produced an increase in the incidence of locomotion and rearing in control rats, and this stimulatory effect of MAP on motor activity was markedly potentiated in MAM rats. Chronic MAP treatment did not change D1 or D2 dopamine receptor densities in either control or MAM rats. From these results, it was suggested that augmented dopaminergic functions may contribute to the hyperactivity seen in MAM rats.

journal_name

Brain Res

journal_title

Brain research

authors

Watanabe M,Shimizu K,Kodama Y,Takishima K,Mamiya G,Ichinowatari N

doi

10.1016/0006-8993(94)01307-4

subject

Has Abstract

pub_date

1995-01-23 00:00:00

pages

173-80

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(94)01307-4

journal_volume

670

pub_type

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