Abstract:
:Microencephalic rats induced by methylazoxymethanol (MAM) were observed to have notable hyperactivity compared to control rats, as measured by several behavioral parameters in an automated field apparatus. Acute injection of the stimulant drug, methamphetamine (MAP), produced an increase in the incidence of locomotion and rearing in control rats, and this stimulatory effect of MAP on motor activity was markedly potentiated in MAM rats. Chronic MAP treatment did not change D1 or D2 dopamine receptor densities in either control or MAM rats. From these results, it was suggested that augmented dopaminergic functions may contribute to the hyperactivity seen in MAM rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Watanabe M,Shimizu K,Kodama Y,Takishima K,Mamiya G,Ichinowatari Ndoi
10.1016/0006-8993(94)01307-4subject
Has Abstractpub_date
1995-01-23 00:00:00pages
173-80issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(94)01307-4journal_volume
670pub_type
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