Abstract：
:Samples of 14 brains of autopsied patients suffering from dementia of the Alzheimer type were examined. In Congo red-hemalum stained 14-microns-thick sections of the hippocampus 15 tangle-bearing and 25-30 unaffected nerve cells of area CA1 per case were measured for cell size and nucleolar size utilizing an interactive image processing unit. In affected cells tangle size was measured too. There was no significant difference in neuron size and nucleolar size between affected and unaffected cells. In tangle-bearing cells nucleolar size and cell size were not correlated with tangle size. Since nucleolar volume can serve as an indicator of RNA synthesis of a cell, tangles themselves seem not to disturb nerve cell metabolism.
journal_name
Brain Resjournal_title
Brain researchauthors
Gertz HJ,Schoknecht G,Krüger H,Cervos-Navarro Jdoi
10.1016/0006-8993(89)90843-3subject
Has Abstractpub_date
1989-05-22 00:00:00pages
373-5issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(89)90843-3journal_volume
487pub_type
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