Modulation of long-term potentiation by peripherally administered amphetamine and epinephrine.

Abstract:

:Long-term potentiation (LTP) has received considerable attention as a neurophysiological model for studying the biology of memory. The present experiments examined the susceptibility of LTP in the dentate gyrus to modification by peripheral injections of amphetamine and epinephrine. Both drugs enhanced the development of LTP in a dose-related manner comparable to that seen previously in behavioral studies. Such results suggest that the development of this long-lasting electrophysiological change can be regulated by peripheral catecholamine levels in a manner analogous to that seen in behavioral studies of memory.

journal_name

Brain Res

journal_title

Brain research

authors

Gold PE,Delanoy RL,Merrin J

doi

10.1016/0006-8993(84)91124-7

subject

Has Abstract

pub_date

1984-07-02 00:00:00

pages

103-7

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(84)91124-7

journal_volume

305

pub_type

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