Demonstration and localization of neuronal degeneration in the rat forebrain following a single exposure to MDMA.

Abstract:

:Methylenedioxymethamphetamine (MDMA, Ecstasy) is a powerful releaser of serotonin. Increasing recreational use of this stimulant and hallucinogenic drug has raised concerns about its potential to produce brain damage. The vast majority of previous research studies have focused on the compound's ability to deplete serotonin (5-hydroxytryptamine, 5-HT) from axon terminals. Despite extensive research on this '5-HT terminal neurotoxicity', a much less studied aspect of MDMA toxicity involves its ability to actually kill nerve cells. Only two prior studies mention the existence of MDMA-induced neuronal degeneration, as reflected by a limited number of argyrophylic neurons within the somatosensory cortex, following very high doses of MDMA. The development of Fluoro-Jade B as a simple and reliable marker of neuronal degeneration has allowed us to conduct the first comprehensive localization of MDMA induced neuronal degeneration throughout the entire rat forebrain. In addition to the previously reported neuronal degeneration within parietal cortex, degenerating neurons were also observed in the insular/perirhinal cortex, the ventromedial/ventrolateral thalamus, and the tenia tecta. The extent of neuronal degeneration observed generally correlated with the degree of hyperthermia achieved.

journal_name

Brain Res

journal_title

Brain research

authors

Schmued LC

doi

10.1016/s0006-8993(03)02563-0

subject

Has Abstract

pub_date

2003-06-06 00:00:00

pages

127-33

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006899303025630

journal_volume

974

pub_type

杂志文章
  • The action of MPTP on synaptic transmission is affected by changes in Ca2+ concentrations.

    abstract::1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes a disruption of nigrostriatal dopaminergic function which resembles parkinsonism. On the cellular level, the disruption involves a Ca2+ independent release of dopamine, depletion of nigral and striatal dopamine, and the death of dopaminergic neurons. We have p...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91035-y

    authors: Wilson JA,Lau YS,Gleeson JG,Wilson JS

    更新日期:1991-02-15 00:00:00

  • The role of altered sodium currents in action potential abnormalities of cultured dorsal root ganglion neurons from trisomy 21 (Down syndrome) human fetuses.

    abstract::Trisomy 21 (Down syndrome) results in abnormalities in electrical membrane properties of cultured human fetal dorsal root ganglion (DRG) neurons. Action potentials have faster rates of depolarization and repolarization, with decreased spike duration, compared to diploid neurons. In order to analyze the faster depolari...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91372-n

    authors: Caviedes P,Ault B,Rapoport SI

    更新日期:1990-03-05 00:00:00

  • Catecholaminergic activation of G-protein coupling in rat spinal cord: further evidence for the existence of dopamine and noradrenaline receptors in spinal grey and white matter.

    abstract::[35S]GTPgammaS autoradiography of slide-mounted tissue sections was used to examine G-protein coupling in the rat spinal cord, as stimulated by dopamine, the D1 receptor agonist SKF 38393, noradrenaline, and noradrenaline in the presence of the alpha adrenoceptor antagonist, phentolamine. Measurements were obtained fr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.10.101

    authors: Venugopalan VV,Ghali Z,Sénécal J,Reader TA,Descarries L

    更新日期:2006-01-27 00:00:00

  • Thyrotropin-releasing hormone (TRH) blocks glucagon-induced hyperglycemia in mice: dissociation of the antihyperglycemic and pituitary actions of TRH.

    abstract::Thyrotropin-releasing hormone (TRH) prevents the development of drug- or stress-induced hyperglycemia in mice through action at central sites. To study the role of the pituitary in mediating this action, we have evaluated the effect of TRH analogs lacking hypophysiotropic activity, acid-TRH and DN 1417, in blocking gl...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90135-7

    authors: Amir S

    更新日期:1988-07-05 00:00:00

  • Localization of oxytocin binding sites in the human brainstem and upper spinal cord: an autoradiographic study.

    abstract::Two different ligands, tritiated oxytocin and a newly synthesized and monoiodinated oxytocin antagonist, were used to reveal sites which bind oxytocin in the brainstem and upper spinal cord of 12 human subjects. Tissue sections were incubated with either ligand at a concentration close to their respective dissociation...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90317-x

    authors: Loup F,Tribollet E,Dubois-Dauphin M,Pizzolato G,Dreifuss JJ

    更新日期:1989-10-23 00:00:00

  • Neocortical molecular layer heterotopia in substrains of C57BL/6 and C57BL/10 mice.

    abstract::Abnormal development of the neocortex is often associated with cognitive deficits and epilepsy. Rodent models are widely used to study normal and abnormal cortical development and have revealed the roles of many important genetic and environmental factors. Interestingly, several inbred mouse strains commonly used in b...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.03.026

    authors: Lipoff DM,Bhambri A,Fokas GJ,Sharma S,Gabel LA,Brumberg JC,Richfield EK,Ramos RL

    更新日期:2011-05-19 00:00:00

  • Physical aggression and attentional bias to angry faces: An event related potential study.

    abstract::This study aimed to identify the neural correlates of aggression-related attentional selectivity to angry faces in physical aggression. Physical aggression in a non-clinical sample of young men (N = 36) was measured using an aggression questionnaire. Visual attentional bias to angry faces was assessed using a dot-prob...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.146387

    authors: Crago RV,Renoult L,Biggart L,Nobes G,Satmarean T,Bowler JO

    更新日期:2019-11-15 00:00:00

  • Aging and SB-269970-A, a selective 5-HT7 receptor antagonist, attenuate circadian phase advances induced by microinjections of serotonergic drugs in the hamster dorsal raphe nucleus.

    abstract::Aging leads to many changes in the circadian timekeeping system, including reduced sensitivity to phase-resetting signals such as systemic administration of the serotonergic agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). In previous studies, we observed an age-related decrease in 5-HT7 receptor binding s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.02.025

    authors: Duncan MJ,Grear KE,Hoskins MA

    更新日期:2004-05-15 00:00:00

  • Analysis of resurgent sodium-current expression in rat parahippocampal cortices and hippocampal formation.

    abstract::The resurgent Na(+) current (I(NaR)) is a component of neuronal voltage-dependent Na(+) currents that is activated by repolarization and is believed to result from an atypical path of Na(+)-channel recovery from inactivation. So far, I(NaR) has only been identified in a small number of central neuronal populations in ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.05.065

    authors: Castelli L,Nigro MJ,Magistretti J

    更新日期:2007-08-13 00:00:00

  • Modulation of salt appetite by lateral ventricular infusions of angiotensin II and carbachol during sodium depletion.

    abstract::Infusions of angiotensin II (AII) or carbachol (CBC) into the lateral ventricles of rats which had been depleted of sodium 4 h previously with either furosemide or polyethylene glycol produced significant changes in salt appetite and sodium and water balances relative to rats infused with saline vehicle. Infusions of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90860-1

    authors: Fitts DA,Thunhorst RL,Simpson JB

    更新日期:1985-11-04 00:00:00

  • Effects of angiotensin II and AIII microinjections into the zona incerta after intra- and extracellular fluid loss.

    abstract::Our recent results showed that angiotensin II or III (AII, AIII) microinjected into the zona incerta (ZI) significantly increased water intake. The most effective doses of AII and AIII were also defined. The two neuropeptides had their effects differently on drinking via different receptors. AII bound to AT(1) that wa...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.01.002

    authors: Bagi EE,Fekete E,Bányai D,Lénárd L

    更新日期:2004-03-26 00:00:00

  • Dynamic responses of presynaptic terminal membrane pools following KCl and sucrose stimulation.

    abstract::The cholinergic presynaptic terminals of Torpedo electric organ have been examined morphometrically following stimulation by KCI and sucrose. The objective was to confirm correlations predicted by the vesicle hypothesis between miniature end-plate potentials (MEPPs) and morphometric changes in terminal ultrastructure....

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00109-1

    authors: Fox GQ,Kriebel ME

    更新日期:1997-04-25 00:00:00

  • Electrical activity of neurosecretory axons from the brain of Rhodnius prolixus: relation of changes in the pattern of activity to endocrine events during the moulting cycle.

    abstract::Ongoing electrical activity was recorded from the axons of neurosecretory cells from the brain of 5th instar Rhodnius prolixus throughout the moulting cycle. Dramatic changes in both the frequency and pattern of electrical activity occur at specific times during the cycle, enabling the timing of release of neurohormon...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90314-5

    authors: Orchard I,Steel CG

    更新日期:1980-06-02 00:00:00

  • mu-Opioid receptor activation decreases N-type Ca2+ current in magnocellular neurons of the rat basal forebrain.

    abstract::Opioid modulation of calcium currents was studied in acutely dissociated rat basal forebrain neurons using the whole cell patch-clamp recording technique. The mu-opioid receptor agonist DAGO reversibly suppressed high-voltage activated calcium currents and slowed their rate of activation, while neither delta- nor kapp...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00206-0

    authors: Soldo BL,Moises HC

    更新日期:1997-05-30 00:00:00

  • Evidence for motility and pinocytosis in ramified microglia in tissue culture.

    abstract::Ramified microglial cells were investigated in primary cultures of dissociated cerebral cortical tissue from rats. The identification of these cells was confirmed through immunohistochemical staining with 7 monoclonal antibodies selective for microglia. While there was significant variation in staining intensity with ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91118-k

    authors: Booth PL,Thomas WE

    更新日期:1991-05-10 00:00:00

  • Subcutaneous rotenone rat model of Parkinson's disease: Dose exploration study.

    abstract::Subcutaneous administration of rotenone has recently attracted attention because of its convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in animal models. However, the wide range of doses reported in the literature makes it difficult to evaluate the effectiveness of this techniq...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.11.020

    authors: Zhang ZN,Zhang JS,Xiang J,Yu ZH,Zhang W,Cai M,Li XT,Wu T,Li WW,Cai DF

    更新日期:2017-01-15 00:00:00

  • The paragigantocellular nucleus of the ventral medulla: a secondary source of cholinergic innervation of rat brainstem nuclei.

    abstract::Many parts of the brainstem are known to be innervated by the cholinergic neurons of the pontomesencephalic tegmentum, but other possible sources of this innervation have rarely been considered. We sought to examine whether other cells in the brainstem were responsible for this cholinergic input using axonal tract tra...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90185-6

    authors: Sherriff FE,Henderson Z

    更新日期:1994-02-04 00:00:00

  • Facilitation of baroreflex-induced bradycardia by stimulation of specific hypothalamic sites in the rat.

    abstract::Hypothalamic stimulation generally inhibits baroreflex-induced bradycardia. However, we have noted discrete areas of the rat hypothalamus which facilitate reflex bradycardia. The effects of hypothalamic stimulation on baroreflex-induced changes in heart rate were investigated in urethane-anesthetized rats (1.2 g/kg, i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91163-7

    authors: Pardini BJ,Patel KP,Schmid PG,Lund DD

    更新日期:1986-10-08 00:00:00

  • beta-Phenylethylamine reversal of chlorpromazine-induced activation of striatal tyrosine hydroxylase and catalepsy.

    abstract::The ability of beta-phenylethylamine (PEA) to reverse (1) chlorpromazine-induced activation of striatal tyrosine hydroxylase, and (2) catalepsy produced by chlorpromazine, was examined. PEA, in a dose of 75 mg/kg, caused approximately 50% reduction in the degree of tyrosine hydroxylase stimulation produced by 20 mg/kg...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90979-3

    authors: Stoff DM,Gale K

    更新日期:1981-05-04 00:00:00

  • The structure of cerebral cortex in the rat following prenatal administration of 6-hydroxydopamine.

    abstract::The early, prenatal formation of noradrenergic projections to the forebrain has led to the proposition that these axons exert a trophic influence on cerebral cortex during ontogeny. To test this hypothesis, we have examined a number of different structural features of cortical development following prenatal lesions of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(82)90077-3

    authors: Lidov HG,Molliver ME

    更新日期:1982-01-01 00:00:00

  • The organization of the efferent projections and striatal afferents of the entopeduncular nucleus and adjacent areas in the rat.

    abstract::Multiple retrograde fluorescent tracing was employed to investigate the organization of the rat entopeduncular nucleus projections to the lateral habenula, ventral anterior-ventral lateral thalamus, parafasicular-centre median complex, and tegmenti pedunculopontis area of the brain stem. The results indicate that neur...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90064-0

    authors: van der Kooy D,Carter DA

    更新日期:1981-04-27 00:00:00

  • Responses to force perturbations preceding voluntary human arm movements.

    abstract::Brief force perturbations were applied 30-120 ms prior to onset of step-tracking forearm movements by normal humans. The perturbations altered the first agonist burst of the movement-related triphasic EMG pattern. Perturbations opposing the movement resulted in an increase in the magnitude of the late part of the firs...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)91224-5

    authors: Brown SH,Cooke JD

    更新日期:1981-09-14 00:00:00

  • Vasopressinergic neurons in the magnocellular nuclei of the human basal forebrain.

    abstract::Vasopressinergic structures were examined within the magnocellular nuclei of the human basal forebrain. Vasopressinergic neurons were found in all parts of the diagonal band nucleus, and less frequently in the anteromedial subnucleus of the basal nucleus (Meynert). They belong to the group of large multipolar neurons,...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90678-5

    authors: Ulfig N,Braak E,Ohm TG,Pool CW

    更新日期:1990-10-15 00:00:00

  • ADAM17 promotes U87 glioblastoma stem cell migration and invasion.

    abstract::Glioblastoma stem cells (GSCs) are thought to contribute to the diffuse invasiveness of malignant gliomas. Emerging evidence supports a role for a disintegrin and metalloproteinase 17 (ADAM17) in proteolytic ectodomain shedding of several EGFR-binding ligands, which subsequently activate PI3K/AKT and MEK/ERK pathways ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.02.025

    authors: Chen X,Chen L,Chen J,Hu W,Gao H,Xie B,Wang X,Yin Z,Li S,Wang X

    更新日期:2013-11-13 00:00:00

  • Diencephalic amnesia: a reorientation towards tracts?

    abstract::The principal thalamic and hypothalamic structures implicated in mnemonic information processing are the mediodorsal nucleus of the thalamus, the pulvinar, anterior thalamus, and laterodorsal nucleus, the mamillary body, and the mamillothalamic tract and internal medullary lamina. Determining the contribution of an in...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/0006-8993(88)91226-7

    authors: Markowitsch HJ

    更新日期:1988-12-01 00:00:00

  • Effects of 4-aminopyridine, GABA and bicuculline on cutaneous receptive fields of cat dorsal horn neurons.

    abstract::4-Aminopyridine (4-AP), bicuculline and GABA were applied locally to dorsal horn cells in the lumbar spinal cord in Nembutal-anaesthetized cats and in spinal cats. 4-AP expanded the cutaneous receptive field of 29 of 33 cells tested. Bicuculline and GABA had little or no effect on receptive field size. ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90814-5

    authors: Saadé N,Jabbur SJ,Wall PD

    更新日期:1985-10-07 00:00:00

  • Noradrenergic lesion of the locus coeruleus increases the firing activity of the medial prefrontal cortex pyramidal neurons and the role of alpha2-adrenoceptors in normal and medial forebrain bundle lesioned rats.

    abstract::Degeneration of noradrenergic neurons in the locus coeruleus (LC) and dysfunction of the prefrontal cortex were regarded as playing a specific role in the occurrence of non-motor symptoms in Parkinson's disease. The present study examined the spontaneous firing rate and firing pattern of medial prefrontal cortex (mPFC...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.02.009

    authors: Wang Y,Zhang QJ,Liu J,Ali U,Gui ZH,Hui YP,Wang T,Chen L,Li Q

    更新日期:2010-04-09 00:00:00

  • Synaptic connections between pars compacta and pars reticulata neurones: electrophysiological evidence for functional modules within the substantia nigra.

    abstract::Intracellular recordings were performed in vitro from both pars compacta and pars reticulata neurones of the substantia nigra, and their postsynaptic responses to electrical stimulation within the nucleus were analysed. Intracellular staining by biocytin was used to reveal the morphology and location of the recorded n...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91292-0

    authors: Hajós M,Greenfield SA

    更新日期:1994-10-17 00:00:00

  • Adenosine depresses induction of LTP at the mossy fiber-CA3 synapse in vitro.

    abstract::Using the hippocampal slice preparation, extracellular recordings of CA3 field excitatory postsynaptic potentials (fEPSPs) were performed to assess the effects of adenosine on the induction of mossy fiber long-term potentiation (LTP). When present during tetanization, adenosine (50 microM) significantly suppressed mos...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91061-5

    authors: Alzheimer C,Röhrenbeck J,ten Bruggencate G

    更新日期:1991-03-08 00:00:00

  • Effect of lavender oil (Lavandula angustifolia) on cerebral edema and its possible mechanisms in an experimental model of stroke.

    abstract::Lavender belongs to the family Labiatae and has a variety of cosmetic uses as well as therapeutic purposes in herbal medicine. The present study was conducted to evaluate the protective effect of lavender oil against brain edema and its possible mechanisms in an experimental model of stroke. Under Laser-Doppler Flowme...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.12.019

    authors: Vakili A,Sharifat S,Akhavan MM,Bandegi AR

    更新日期:2014-02-22 00:00:00