Abstract：
BACKGROUND:An important part of the medical treatment of many cerebrovascular diseases is the occlusion of brain supplying arteries. Until now, the risk of this intervention can only be estimated by invasive diagnostics including the risk of cerebrovascular accidents. METHODS AND RESULTS:As a supporting tool, a computer model of the circle of Willis was designed. The model is based upon linear differential equations describing electrotechnical circuits extended non-linearly. By these means, time continuous simulations of different states and the online observation of all calculated state variables such as blood pressure and blood flow in every modeled vessel became feasible. For individual simulations, model parameters were determined by MR-angiography and boundary values by simultaneous Duplex-measurements in both carotid and vertebral arteries. State variables generated by the model behaved physiologically and the reaction of individual cerebrovascular systems in critical situations could be investigated by special scenarios. Inaccuracies concerning the determination of model parameters and boundary values of the used differential equations are likely to be resolved in the near future through a more careful and technically improved determination of these values. CONCLUSIONS:Computer models of subjects were created taking in account the individual anatomical and non-linear physical properties of real vascular systems supplying the brain. Thereby information could be obtained concerning the hemodynamic effects of an iatrogenic vascular occlusion.
journal_name
Brain Resjournal_title
Brain researchauthors
Roessler FC,Reith W,Siegel Gdoi
10.1016/j.brainres.2006.08.021subject
Has Abstractpub_date
2006-11-06 00:00:00pages
183-91issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)02380-8journal_volume
1118pub_type
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