Abstract：
:Nerve cell dissociated from the cerebral cortex of mice were co-cultured with isolated pancreatic islets of Langerhans. After two weeks of co-culture, numerous axons had invaded the islets and differentiated nerve endings were closely juxtaposed to the endocrine islet cells. In contrast, no remnants of nerve cells were observed in isolated islets cultured alone for the same duration. The attachment and/or survival and differentiation of nerve cells were markedly promoted in the presence of islets. The latter effects were probably due to insulin secreted by the islets in the culture medium.
journal_name
Brain Resjournal_title
Brain researchauthors
Hooghe-Peters EL,Meda P,Orci Ldoi
10.1016/0165-3806(81)90115-2subject
Has Abstractpub_date
1981-04-01 00:00:00pages
287-92issue
2eissn
0006-8993issn
1872-6240journal_volume
227pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The tegmentopontine reticular nucleus (nucleus of Bechterew) plays a crucial role in the generation of horizontal saccades and smooth pursuit movement of the eyes. The evolution of Alzheimer's disease-related cytoskeletal pathology was studied of this nucleus was studied in 27 autopsy cases at different stages of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02598-7
更新日期：2001-07-27 00:00:00
abstract：:Putative serotonergic dorsal raphe (DRN) neurons display a dramatic state-related change in behaviour, discharging regularly at a high rate during waking and at progressively slower rates during slow-wave sleep (SWS) and ceasing firing during paradoxical sleep (PS). Using the antidromic latency technique and extracell...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02210-7
更新日期：2001-04-20 00:00:00
abstract：:Hippocampal CA1 pyramidal neurons undergo delayed neurodegeneration after transient forebrain ischemia, and the phenomenon is dependent upon hyperactivation of l-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subtype of glutamate receptors, resulting in aberrant intracellular calcium influx. The GluR2 sub...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.123
更新日期：2006-02-23 00:00:00
abstract：:To test the hypothesis that enkephalins, substance P, bradykinin and angiotensin II could act as neurohumoral modulators of hypothalamic function, these peptides (0.01-20 microgram) were injected into the general circulation of anesthetized rats, and changes in hypothalamo-neurohypophysial activity were determined by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90214-6
更新日期：1981-09-07 00:00:00
abstract：:Recent anatomic studies indicate that the nucleus paragigantocellularis (PGi), located in the rostral ventrolateral medulla, strongly innervates the locus coeruleus (LC) while no such input derives from the more caudally located lateral reticular nucleus (LRN). In the present study, focal electrical stimulation of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90510-5
更新日期：1987-11-10 00:00:00
abstract：:Emotional events are preferentially retained in episodic memory. This effect is commonly attributed to enhanced consolidation and has been linked specifically to rapid eye movement (REM) sleep physiology. While several studies have demonstrated an enhancing effect of REM sleep on emotional item memory, it has not been...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.06.020
更新日期：2018-11-01 00:00:00
abstract：:Previous reports from this laboratory have indicated that fetal rat striatal grafts have the major types of neuronal and glial components known to be involved in Huntington's chorea. In this study a number of major afferent and efferent innervations seen in normal striatum were examined in the striatal grafts and were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91592-8
更新日期：1989-12-11 00:00:00
abstract：:We investigated the effect of high dose tetrodotoxin (TTX) on microdialysis measurements of extracellular striatal glutamate and dopamine in normal female rats. Both halothane-anesthetized rats with acutely implanted microdialysis probes and awake rats with microdialysis probes implanted for 24 h were tested. Glutamat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00258-8
更新日期：1997-06-13 00:00:00
abstract：OBJECTIVE:The purpose of this study is to characterize functional connectivity changes in mild cognitive impaired Alzheimer's disease (MCI-AD) under resting and cognitive task conditions. METHOD:EEG signals were recorded under resting states (Eyes closed (EC) and Eyes open (EO)) and cognitive states (Mental Arithmetic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146743
更新日期：2020-05-15 00:00:00
abstract：:In rat hippocampal slices, the novel metabotropic glutamate receptor (mGluR) ligand, (1S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV) enhanced the stimulation of polyphosphoinositide (PPI) hydrolysis elicited by quisqualate or by submaximal concentrations of ibotenate or (1S,3R)-1-aminocyclopentane-1,3-di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90857-5
更新日期：1994-10-03 00:00:00
abstract：:Hamsters exhibited a circadian variation in metabolic activity determined by [14C]2-deoxyglucose uptake in the suprachiasmatic nuclei, as has been previously reported for rats. The 13-line ground squirrel, a diurnal rodent, did not show a circadian variation in metabolic activity. The data are consistent with the hypo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90626-6
更新日期：1982-01-28 00:00:00
abstract：:We measured the uptake of a radiolabeled analogue of glucose ([3H]FDG) into muscles during treadmill walking so as to determine whether sensory deafferentation of a limb affects the muscles' metabolic response to the exercise. The muscles on the deafferented side took up less tracer than those in the intact side with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91526-4
更新日期：1985-02-18 00:00:00
abstract：:Diffuse white matter (WM) response to traumatic brain injury (TBI) and transplantation of human bone marrow stromal cells (hMSCs) after the injury were non-invasively and dynamically investigated. Male Wistar rats (300-350 g) subjected to TBI were intravenously injected with 1 ml of saline (n = 10) or with hMSCs in su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.04.020
更新日期：2019-08-15 00:00:00
abstract：:The effects of intracerebroventricular injections of 8-OH-DPAT (a 5-HT1A agonist; 3, 15 or 30 nmol) or GR46611 (a 5-HT1B/1D agonist; 3, 15 or 30 nmol) on feeding, drinking, preening and sleep-like behaviors were investigated in free-feeding (FF) pigeons. The effects of these 5-HT agonists on blood glucose and free fat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.08.031
更新日期：2004-11-12 00:00:00
abstract：:Regulation of the intracellular calcium concentration ([Ca(2+)](i)) is of critical importance for synaptic function. Therefore, neurons buffer [Ca(2+)](i) using intracellular Ca(2+)-binding proteins (CaBPs). Previous evidence suggests that Calbindin-D(28K) (CB), an abundantly expressed endogenous fast CaBP, plays an i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.036
更新日期：2012-04-23 00:00:00
abstract：:A phosphorylated, approximately 110 kDa laminin-binding protein (110 kDa LBP) from mouse brain has been previously identified. This protein recognizes a neurite-outgrowth promoting 19-amino acid synthetic peptide (PA 22-2) derived from the laminin A chain. In the present study, an antibody against the 110 kDa LBP was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90356-z
更新日期：1991-08-02 00:00:00
abstract：:A correlated intracellular and extracellular study of lumbar motoneuron excitability during sleep and wakefulness was performed in the chronic, unanesthetized, undrugged, normally respiring cat. Experiments were designed to reveal the extent to which hypotonia during active sleep in mammals is dependent on postsynapti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90836-2
更新日期：1981-11-30 00:00:00
abstract：:The suprachiasmatic nuclei receive photic input information directly through a retinohypothalamic tract (RHT) and indirectly through a projection from the intergeniculate leaflet of the lateral geniculate complex, the geniculohypothalamic tract (GHT). Prior work has established that the RHT is sufficient for entrainme...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90374-5
更新日期：1988-09-20 00:00:00
abstract：:The effect of hippocampal kindling on neuronal and glial marker proteins was studied in the rat by immunochemical methods. In hippocampus, pyriform cortex and amygdala there was an increase in glial fibrillary acidic protein (GFAP), indicating reactive gliosis, and an increase in the glycolytic enzyme NSE, suggesting ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90791-9
更新日期：1990-10-29 00:00:00
abstract：:The electrophysiological effects of the non-competitive N-methyl-D-aspartate (NMDA) antagonist (+)-MK-801 (MK-801) on nigrostriatal and mesoaccumbal dopaminergic (DA) neurons were evaluated in chloral hydrate-anesthetized rats. MK-801 (0.05-3.2 mg/kg, i.v.) stimulated the firing rates of 14 (74%) of 19 nigrostriatal D...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91091-r
更新日期：1992-09-11 00:00:00
abstract：:The low, middle, and high molecular mass neurofilament subunit proteins (NF-L, NF-M, and NF-H) co-polymerize to form neurofilaments (NFs). During development, NF subunit expression is highly regulated, and in neurodegenerative disease, aberrant regulation of this expression can lead to the formation of harmful aggrega...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.012
更新日期：2008-01-16 00:00:00
abstract：:The importance of Na+/Ca2+ exchangers in the regulation of the physiological and pathological functions of the nervous system has been widely recognized. In this study, we used primary cultured E14.5 cortical neurons as a model system to study the possible roles of the reverse mode Na+/Ca2+ exchange activity in neurot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.042
更新日期：2008-03-27 00:00:00
abstract：:Huntington׳s Disease (HD) is a fatal neurodegenerative disorder caused by expanded polyglutamine repeats in the Huntingtin (HTT) gene. While the gene was identified over two decades ago, it remains poorly understood why mutant HTT (mtHTT) is initially toxic to striatal medium spiny neurons (MSNs). Models of HD using n...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.10.001
更新日期：2017-02-01 00:00:00
abstract：:The endocrine disruptor Bisphenol-A (BPA) has been shown to modulate estrogenic, androgenic, and anti-androgenic effects. The effects of BPA exposure during early organizational periods of development have been well documented. The current study focuses on the effects of short term, low-dose BPA exposure on anxiety, s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.07.018
更新日期：2013-09-05 00:00:00
abstract：:Alterations in brain high energy phosphate compounds, using 31P-NMR (nuclear magnetic resonance) spectroscopy, were measured in vivo in young adult (3-4 months) rats following prenatal exposure to ligands acting specifically at benzodiazepine (BDZ) binding sites. The exposure induced a decrease in intracellular pH tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91202-r
更新日期：1990-01-01 00:00:00
abstract：:In zebra finches, androgens stimulate song production and promote growth of the neural regions controlling song. Early exposure to estrogen establishes this sensitivity to androgens and increases the number of androgen-accumulating cells in two song regions, the hyperstriatum ventralis pars caudalis (HVc) and the magn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90715-4
更新日期：1989-05-29 00:00:00
abstract：:The outgrowth region of the regenerating frog sciatic nerve shows an increased permeability for various drugs, which has been utilized for pharmacological studies of axonal transport. Six days after a bilateral crush lesion, the nerves, including the spinal ganglia, were incubated in a compartmented chamber. Orthograd...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91160-7
更新日期：1987-01-13 00:00:00
abstract：:The cytoplasmic adaptor protein Disabled-1 (Dab1), which is a key component of the Reelin-signaling pathway, has been suggested to be required for neuronal dendritic development. However, only data from studies on immature cultures [< or = 6 days in vitro (DIV)] and cytoarchitectural analyses of mutant mice have been ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.035
更新日期：2007-10-03 00:00:00
abstract：:The suprachiasmatic nucleus of the hypothalamus receives dense serotonergic projections from the raphe nuclei. This input may be involved in the transmission of photic information with activation of 5-HT receptors at night having a photo-mimetic effect. 5-HT2C receptors have been implicated in this role, with 5-HT2C r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.091
更新日期：2008-05-13 00:00:00
abstract：:Previously brain norepinephrine (NE) neurons in the locus coeruleus (LC) have been shown to respond profoundly to external, environmental stimuli and are thought to be involved in behavioral functions such as vigilance, alarm and anxiety reactions to novel and, especially, threatening stimuli. Here we have used electr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90964-9
更新日期：1986-06-04 00:00:00
