Abstract:
:In rat hippocampal slices, the novel metabotropic glutamate receptor (mGluR) ligand, (1S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV) enhanced the stimulation of polyphosphoinositide (PPI) hydrolysis elicited by quisqualate or by submaximal concentrations of ibotenate or (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). The enhancing effect of DCG-IV was (i) specific for mGluR agonists, (ii) restricted to hippocampal slice preparation, (iii) reversible, and (iv) not subject to homologous desensitization, in addition, DCG-IV did not interact with L-2-amino-4-phosphonobutanoate (AP4), a noncompetitive antagonist of mGluRs coupled to PPI hydrolysis in brain slices [32]. The action of DCG-IV on quisqualate-stimulated PPI hydrolysis was insensitive to antagonists of ionotropic glutamate receptors and did not appear to be a consequence of a reduction in the intracellular levels of cAMP [14]. When the stimulation of PPI hydrolysis was measured as a function of the incubation time, DCG-IV potentiated quisqualate-stimulated PPI hydrolysis after 60 min of incubation, when quisqualate had already reached its maximal effect. Knowing that activation of protein kinase C (PKC) limits the extent of mGluR agonist-stimulated PPI hydrolysis over time, we have studied the enhancing effect of DCG-IV in the presence of the PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA). As expected [9], TPA reduced quisqualate-stimulated PPI hydrolysis in control slices, but was inactive in slices incubated in the presence of DCG-IV. Taken collectively, these results suggest that DCG-IV positively modulates the activity of mGluRs coupled to PPI hydrolysis through a mechanism, which involves PKC-mediated phosphorylation processes.
journal_name
Brain Resjournal_title
Brain researchauthors
Genazzani AA,L'Episcopo MR,Casabona G,Shinozaki H,Nicoletti Fdoi
10.1016/0006-8993(94)90857-5subject
Has Abstractpub_date
1994-10-03 00:00:00pages
10-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)90857-5journal_volume
659pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The motivational effects of exclusively peripheral or central opiate receptor blockade were studied using place conditioning. Place aversions were observed with intraventricular (i.c.v.) methylnaloxone (MN) in both naive (200-1000 ng) and morphine-dependent rats (50-500 ng). Subcutaneous MN (0.03-10 mg/kg) was ineffec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90452-0
更新日期:1988-12-06 00:00:00
abstract::The time course and the relation to dose of regional cerebral metabolic rates for glucose (rCMRglc) were measured in awake male adult Fischer-344 rats after administration of quipazine, a serotonin 5-HT2-3 receptor agonist. rCMRglc was determined, using the quantitative autoradiographic [14C]deoxyglucose technique, in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91380-b
更新日期:1993-01-15 00:00:00
abstract::The modulation of tetrodotoxin-sensitive (TTX-S) and slow tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons by ATP was studied using the whole-cell patch-clamp method. The effects of ATP on two types of sodium currents were either stimulatory or inhibitory depending on the kinetic para...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04218-x
更新日期:2003-04-04 00:00:00
abstract::It is now well documented that optogenetics brings to neuroscience a long sought-after foothold to study the causal role of millisecond-scale activity of genetically or anatomically defined populations of neurons. Progress is rapid, and, as evidenced by the work collected in this Special Issue, the possibilities of wh...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2013.01.008
更新日期:2013-05-20 00:00:00
abstract::5-Hydroxytryptamine (5-HT) has been shown to activate the hypothalamo-pituitary-adrenal axis, possibly by a direct action on hypothalamic CRF synthesis and release. In order to study the mechanisms involved in this effect, foetal hypothalamic cells were cultured and corticotropin-releasing factor-41 (CRF) release was ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90826-u
更新日期:1992-03-06 00:00:00
abstract::Previous studies suggest that brainstem catecholamine (CA) fibers which mediate amphetamine (AMPH)-induced anorexia ascend through the midlateral medical forebrain bundle and perifornical region and terminate in the perifornical hypothalamic region (PFH) at the level of the hypothalamic ventromedial nucleus. Through s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90085-4
更新日期:1984-10-08 00:00:00
abstract::As a model of chronic inflammatory pain, Freund's adjuvant-induced polyarthritis has been shown to be associated with marked alterations in the activity of opioid- and calcitonin gene-related peptide (CGRP)-containing neurons in the dorsal horn of the spinal cord in rats. Possible changes in the interactions between t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00350-3
更新日期:1998-06-15 00:00:00
abstract::Evolutionary selection pressures have been one of the factors proposed to underlie sex differences in inhibitory control. Consequently, inhibitory control may vary as a function of the menstrual cycle and may be modulated by the stimuli being processed if these stimuli are related to reproductive success. We used func...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.061
更新日期:2008-08-11 00:00:00
abstract::To examine the role played by the basal forebrain cholinergic system in cortical activation, neuronal activity was investigated in the globus pallidus and substantia innominata of urethane-anaesthetized rats during large cortical slow waves and spontaneous or elicited low voltage fast activity. An effort was made to i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91521-6
更新日期:1987-12-22 00:00:00
abstract::Selective lesions of the noradrenergic systems of the paraventricular nucleus (PVN) of the hypothalamus with 6-hydroxydopamine (6-OHDA) lengthen the periodicity of the migrating myoelectric complex (MMC), an index of intestinal motility, in rats. These lengthening effects resemble those obtained after lesions of the l...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(10)80045-9
更新日期:1992-06-26 00:00:00
abstract::Recently it was reported that there is an increase in monoamine oxidase B (MAO-B) activity in post-mortem brains of patients with Alzheimer's disease. It was postulated that this increase in MAO-B activity was due to gliosis associated with neuronal degeneration. The aim of the present investigation was to evaluate th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91249-3
更新日期:1989-01-09 00:00:00
abstract::A site-specific antibody against the principal gap junctional protein in heart (connexin 43) was used to determine immunohistochemically the cellular localization of this protein in rat brain. Structures labelled with the antibody included gap junctional membranes between glial, ependymal, pial and arachnoid cells as ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90415-8
更新日期:1990-02-05 00:00:00
abstract::Upon a physiological and pharmacological challenge, the responsiveness of extracellular glutamate levels in the prefrontal cortex, ventral tegmental area and locus coeruleus were studied using microdialysis. A 10-min handling period was used as a mild stressful stimulus. In all three brain areas, handling induced an i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01538-3
更新日期:1999-07-03 00:00:00
abstract::Oxidative stress plays an important role in the pathogenesis of neurodegeneration after the acute central nervous system injury. We reported previously that increased nitric oxide (NO) production following spinal cord hemisection tends to lead to neurodegeneration in neurons of the nucleus dorsalis (ND) that normally ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.003
更新日期:2005-09-07 00:00:00
abstract::Retrogradely labeled vestibulo-ocular neurons (VOR) that also stain with antibodies for the excitatory amino acid neurotransmitters glutamate (GLU-LI) or aspartate (ASP-LI) were studied. VOR neurons that contained GLU-LI or ASP-LI label were identified in the medial (MVN) and superior (SVN) vestibular nuclei, and cell...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90215-h
更新日期:1991-07-19 00:00:00
abstract::Auditory stimulation applied during rapid eye movement (REM) sleep enhances the duration of REM sleep in cats and humans. The present experiment investigated whether auditory stimulation would enhance REM sleep in young (3-6 months) rats, and also in old (22-24 months) rats which have impaired REM sleep. Baseline slee...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91299-t
更新日期:1992-09-04 00:00:00
abstract::GABAA receptors (GABAARs) and glycine receptors (GlyRs) are two principal inhibitory chloride ion channels in the central nervous system. The two receptors do not function independently but cross-talk to each other, i.e., the activation of one receptor would inhibit the other. This cross-talk is present in different p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147071
更新日期:2020-12-01 00:00:00
abstract::Even though animal and human studies show alterations in dopamine transporter (DAT) sites after alcohol withdrawal, the role of DAT in influencing either alcoholic or depressive behavior has not been examined extensively. Given that the Wistar-Kyoto (WKY) rat is a putative animal model of depressive behavior, the pres...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.009
更新日期:2006-02-16 00:00:00
abstract::The distribution of AMPA-type glutamate receptor (GluR) subunits was studied in the Edinger-Westphal nucleus (EW) of chicks and pigeons. GluR1, GluR2, GluR3 and GluR4 subunits appeared to be present in EW neurons of both species, but interspecific differences were observed in the abundance of the different types of su...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02919-0
更新日期:2002-08-23 00:00:00
abstract::Protein kinase C (PKC) is a family of serine/threonine kinases comprised of 10 isoforms. Although commercial antibodies are available for all 10 isoforms, the specificity of these antibodies has been questioned. We have identified immunoblot conditions in which commercially purchased PKC antibodies are specific for th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.110
更新日期:2006-04-14 00:00:00
abstract::The present electric shock (ES) schedule followed in these experiments produced different functional changes in endogenous putative opioid agonist- and antagonist-type receptors, depending on the type of receptor: the amount of antagonist binding was increased by ES application, while the amount of agonist binding was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91155-2
更新日期:1985-09-16 00:00:00
abstract::Intrathecally-administered clonidine inhibited the spontaneous firing of single neurons in the pontine nucleus locus coeruleus of rats. Such inhibition of neuron firing was not observed when the non-lipophilic alpha 2 adrenoceptor agonist (oxymetazoline) was administered intrathecally. It is concluded that lipophilic ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90752-7
更新日期:1983-10-16 00:00:00
abstract::A 'new' and orderly representation of the body surface was found in the cerebral cortex of the cat. This somatotopic map was located in the anterior ectosylvian sulcus (AES), an area known to represent several modalities, but believed to be distinguished from primary sensory cortex by its lack of sensory topographies....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90207-4
更新日期:1982-03-04 00:00:00
abstract::Neurotrophins play a crucial role in the regulation of survival and the maintenance of specific functions for various populations of neurons. Neurotrophin-4 (NT-4) is most abundant in skeletal muscle, and is thought to promote sciatic nerve sprouting, inhibit agrin-induced acetylcholine receptor (AChR) clustering, evo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02288-0
更新日期:2001-07-13 00:00:00
abstract::The location of edema and territory of extravasation of serum protein were examined in the white matter of cats with different forms of intracranial pathology following an impact-acceleration injury to the head. Edema was tested with an organic density gradient and Evans blue dye was used as a marker for breakdown of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91611-7
更新日期:1985-06-24 00:00:00
abstract::Mild footshock stress results in the metabolic activation of the prefrontal cortical dopamine (DA) innervation, but does not augment DA utilization in mesolimbic areas (such as the nucleus accumbens septi, NAS) or the striatum. However, increases in either the intensity or duration of footshock stress increase DA util...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91557-w
更新日期:1990-06-25 00:00:00
abstract::Several studies have demonstrated in the past that endogenous opioid peptides and opioid receptors may be involved as mediators of brain tissue growth and function in the neonate. Applying histological and autoradiographic methods, we have examined the effect of the mu-receptor-specific antagonist, naltrexone, on the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90515-5
更新日期:1989-05-08 00:00:00
abstract::The location of stapedius motoneurons in the rat was determined with horseradish peroxidase (HRP) retrograde tracing techniques. After injection of free HRP or wheat germ agglutinin-horseradish peroxidase (WGA-HRP) in the stapedius muscle on one side, labeled neurons were seen ipsilaterally in a region ventromedial to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91532-1
更新日期:1989-01-02 00:00:00
abstract::The intergeniculate leaflet (IGL) is a distinct division of the lateral geniculate complex that participates in the regulation of the circadian rhythm through its projections to the circadian pacemaker located in the suprachiasmatic nuclei of the hypothalamus. A high number of neuropeptide Y (NPY) cell bodies has been...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01032-4
更新日期:1998-11-30 00:00:00
abstract::Male Wistar rats were anaesthetized, injected intracisternally (i.c.) with saline or colchicine and were decapitated at various time intervals. Trunk blood was collected for the determination of immunoreactive adrenocorticotropic hormone (ACTHi) by radioimmunoassay (RIA) and of corticosterone by a fluorometric assay. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91517-x
更新日期:1988-03-01 00:00:00