Abstract：
:The endocrine disruptor Bisphenol-A (BPA) has been shown to modulate estrogenic, androgenic, and anti-androgenic effects. The effects of BPA exposure during early organizational periods of development have been well documented. The current study focuses on the effects of short term, low-dose BPA exposure on anxiety, spatial memory and sucrose preference in adolescent rats. Seven week old Sprague Dawley rats (n=18 male, n=18 female) received daily subcutaneous injections (40 µg/kg body weight) of BPA or vehicle for 12 days. Starting on day 6 of injections, subjects were tested on the elevated plus maze which provides a measure of anxiety, the open field test which provides a measure of anxiety and locomotor activity, and object placement, a measure of spatial memory. On the twelfth day of BPA administration, sucrose preference was tested using a standard two-bottle choice (tap versus sucrose solution). All rats gained weight during the study; there was a main effect of sex, but not BPA treatment on body weight. The results indicate that BPA exposure, regardless of sex, increased anxiety on both the elevated plus maze and open field. Spatial memory was impaired on the object recognition task with BPA animals spending significant less time with the object in the novel location than controls. Finally, a significant increase in sucrose consumption for both male and female subjects exposed to BPA was observed. The current data shows that short term BPA exposure, below the current reference safe daily limit of 50 µg/kg day set by the United States Environmental Protection Agency, during adolescent development increases anxiety, impairs spatial memory, and increases sucrose consumption independent of sex.
journal_name
Brain Resjournal_title
Brain researchauthors
Diaz Weinstein S,Villafane JJ,Juliano N,Bowman REdoi
10.1016/j.brainres.2013.07.018subject
Has Abstractpub_date
2013-09-05 00:00:00pages
56-65eissn
0006-8993issn
1872-6240pii
S0006-8993(13)00983-9journal_volume
1529pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Visually identified and electrophysiologically characterized sympathetic preganglionic neurons (SPNs) were recorded using the whole-cell voltage clamp technique in slices of neonatal rat spinal cord. Monosynaptic excitatory postsynaptic currents (EPSCs) were evoked by electrical stimulation of the nucleus intercalatus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01549-7
更新日期：1998-04-20 00:00:00
abstract：:The effects of hypothermia on caspase-3 activation were investigated in the newborn rat brain after hypoxia-ischemia (HI). Intense caspase-3 activation was observed in the control brains after HI, but this activation was significantly reduced by postischemic hypothermia. These findings suggest that the inhibition of c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02659-2
更新日期：2001-08-10 00:00:00
abstract：:The central myelin sheaths of the recessive autosomal mutant mouse, Shiverer, were investigated by electron microscopy with special reference to the pattern of myelin formation. The results obtained may be summarized as follows: (1) the major dense line of myelin lamellae generally failed to be formed, but the axons w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90269-9
更新日期：1981-08-24 00:00:00
abstract：:Bone marrow-derived mesenchymal stem cells (BMSCs) are a promising source for cell-based treatment of brain injury, but the therapy of BMSCs is restricted by low cell survival. We examined whether nerve growth factor (NGF) improve BMSCs viability in the brain with Fimbria-Fornix lesion (FF). After transduction of NGF ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.010
更新日期：2009-01-19 00:00:00
abstract：:EEG power spectra exhibit site-specific and state-related differences in specific frequency bands. In the present study we investigated the effect of total sleep deprivation on sleep EEG topography. Eight healthy, young, right-handed subjects were recorded during baseline sleep and recovery sleep after sleep deprivati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02796-2
更新日期：2001-09-21 00:00:00
abstract：:Light-microscopical measurements have been made on teased pulpal nerve fibers from young adult cat canine teeth. In the root canal portion (apical to first branching point) the mean internodal length was approximately 250 micron. In the pulpal chamber portion (coronal to the first branching point) the pulpal nerve fib...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90221-x
更新日期：1984-06-11 00:00:00
abstract：:Chick neural cultures were used to study effects of insulin, thyrotropin releasing hormone, growth hormone and glucagon on myelin lipid synthesis in vitro. The incorporation of [3H]galactose into myelin associated lipids such as cerebroside and sulfatide was used as an index for various hormonal effects on myelination...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90831-0
更新日期：1986-04-16 00:00:00
abstract：:Ibogaine, a naturally occurring iboga alkaloid, has been claimed to be effective in treating addiction to opioids and stimulants, and has been reported to inhibit morphine and cocaine self-administration in rats. However, ibogaine also has acute nonspecific side effects (e.g. tremors, decreased motivated behavior in g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00056-x
更新日期：1996-05-06 00:00:00
abstract：:The present study aimed to employ an electrophysiological approach to evaluate the adaptive task-set inhibition hypothesis. According to the adaptive task-set inhibition hypothesis, task switching should depend on whether the previous trial is univalent or bivalent. This study employed a pairwise task-switching paradi...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/j.brainres.2008.11.103
更新日期：2009-02-19 00:00:00
abstract：:Projections to the rostral ventrolateral medulla (RVLM) and nucleus raphe magnus (NRM) appear to originate from neurones with overlapping distributions in the periaqueductal grey (PAG) as demonstrated by the retrograde transport of red and green fluorescent latex microspheres. Furthermore, double-labelling studies dem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00784-6
更新日期：1996-09-09 00:00:00
abstract：:The number of viable neurones calculated as soon as adult mollusc ganglia tissue was digested and over different periods of cultivation, show that elevated K+ prevents degradation of intercellular contacts, preserves neurones against lysis, prolongs the time course of neurone survival in culture and inhibits neurite f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90044-0
更新日期：1982-03-18 00:00:00
abstract：:Neurturin (NTN) is a recently discovered neurotrophic factor related to glial cell line-derived neurotrophic factor (GDNF) and has a wide spectrum of biological roles in different types of neurons in the central and peripheral nervous systems. However, information on its expression in peripheral tissues has been limit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01590-5
更新日期：1999-07-24 00:00:00
abstract：:To determine the involvement of the hippocampal regions in a operant-type delayed alternation task of short delay or long delay, microinjections of muscimol into the hippocampus were used for temporal inactivation during the behavioral test in each rat. Dorsal hippocampal inactivation impaired the correct ratio of lon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02084-4
更新日期：2001-03-23 00:00:00
abstract：:The expressions of mRNAs encoding G protein alpha subunits were analyzed in the cerebral cortex of amygdaloid kindled rats. A remarkable increase in Gsalpha mRNA were observed on the bilateral cerebral cortex at 24 h after the last generalized seizure and persisted 3 weeks on the unstimulated side. Gi2alpha mRNA level...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01309-2
更新日期：1999-02-13 00:00:00
abstract：:The hypothesis that early social isolation results in long-term alterations in dopamine receptor sensitivity was tested using older adult rhesus monkeys. Isolated and control monkeys were challenged with apomorphine (0.1 and 0.3 mg/kg), and the drug effects on spontaneous blink rate, stereotyped behavior, and self-inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91089-y
更新日期：1990-04-09 00:00:00
abstract：:Mammalian vestibular type I hair cells (VIHCs) are innervated by an afferent synaptic calyx which contains vesicles and is immunoreactive for GABA. We describe here the effects of GABA on electrophysiological properties and on cytosolic free-calcium levels ([Ca2+]i) of VIHCs isolated from guinea-pig ampullae. Whole-ce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90882-n
更新日期：1993-04-23 00:00:00
abstract：:Previous studies showed the role of basolateral amygdala (BLA) in cannabinoid-induced antinociception. Furthermore, the nucleus accumbens (NAc) plays an important role in mediating the suppression of pain in animal models. The present study extended the role of dopamine receptors within the NAc in antinociceptive effe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.06.023
更新日期：2012-08-30 00:00:00
abstract：:Field potentials preceding vocalization were recorded with electrodes chronically implanted on the surface and at 2.0-3.0 mm depth in various cortical areas in three monkeys. Surface-negative, depth-positive (s-N, d-P) slow potentials prior to vocalization were recorded in the premotor (including the Broca's homology)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00797-t
更新日期：1995-10-30 00:00:00
abstract：:The activities of tyrosine hydroxylase and dopamine-beta-hydroxylase were measured in the medial basal hypothalamus and remaining hyothalamic tissue of female rats at various times during diestrus 2, proestrus and estrus. Tyrosine hydroxylase activity in the medial basal hypothalamus was significantly lower at 12.00 h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90407-2
更新日期：1980-09-08 00:00:00
abstract：:α4βδ GABA(A) receptors (GABARs) have low CNS expression, but their expression is increased by 48h exposure to the neurosteroid THP (3α-OH-5α[β]-pregnan-20-one). THP also increases the efficacy of δ-containing GABARs acutely, where GABA is a partial agonist. Thus, we examined effects of THP (100 nM) and full GABA agoni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.047
更新日期：2012-06-29 00:00:00
abstract：:The block of the transient outward K-current, I(K(A)) by 4-aminopyridine (4-AP) and blood-depressing substances (BDS) was investigated in identified Helix pomatia neurons (LPa3) using the two microelectrode voltage-clamp technique. The present study shows that 4-AP inhibits I(K(A)) in snail neurons in a voltage- and c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03351-0
更新日期：2002-02-15 00:00:00
abstract：:We have recently reported that hypothyroidism increases immunoreactive (IR)-vasoactive intestinal polypeptide (VIP) and VIP mRNA content in both parvocellular and magnocellular neurons of the rat, hypothalamic paraventricular nucleus (PVN). As VIP can stimulate vasopressin (AVP) secretion, we conducted an anatomical i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00340-v
更新日期：1995-06-05 00:00:00
abstract：:To examine the hypothesis that the increased adrenocortical activity during lactation induced the loss of the prolactin (PRL) -releasing effect of morphine, we studied the effect of morphine in adrenalectomized (ADX) and sham-operated primiparous lactating Wistar rats. Animals were adrenalectomized 4 days after delive...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91530-e
更新日期：1991-11-01 00:00:00
abstract：:Small injections of the lectin Phaseolus vulgaris-leucoagglutinin (PHA-L) in the external segment of the pallidum (GPe) in the squirrel monkey (Saimiri sciureus) and in the rhesus monkey (Macaca mulatta) led to anterograde labeling of fibers in the internal segment of the pallidum (GPi). These fibers formed numerous l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91813-v
更新日期：1990-11-12 00:00:00
abstract：:Multiple lines of evidence indicate that hypocretin/orexin (HCRT) participates in the regulation of arousal and arousal-related process. For example, HCRT axons and receptors are found within a variety of arousal-related systems. Moreover, when administered centrally, HCRT exerts robust wake-promoting actions. Finally...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2009.09.019
更新日期：2010-02-16 00:00:00
abstract：:The known neurochemical effect of most currently available antidepressants is the enhancement of the synaptic levels of monoamine neurotransmitters. However, the existence of other mechanisms has been suggested to justify the significant delay between the modulation of the monoaminergic system and the clinical effects...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.12.008
更新日期：2007-03-02 00:00:00
abstract：:Available evidence suggests that regular, moderate-intensity exercise has beneficial effects on neural health, perhaps including neuroprotection. To evaluate this idea further, we compared the severity of kainate-induced neuronal loss in exercised versus sedentary female rats. Stereological estimations of neuron numbe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02365-5
更新日期：2003-05-09 00:00:00
abstract：:Neuronal activity in the nucleus parabrachialis medialis (NPBM) was examined in unanesthetized, unrestrained cats during each sleep-waking state. Discharge related to the cardiac cycle was assessed by calculating cross-correlation functions between neuronal and cardiac events (using the peak of the EKG 'R' wave as a r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90696-4
更新日期：1980-10-20 00:00:00
abstract：:Systemic administration of the protein synthesis inhibitor, cycloheximide, induced both phase advances and phase delays in the circadian rhythm of wheel-running activity in hamsters (Mesocricetus auratus) maintained in constant darkness or constant light. The magnitude and direction of the phase shifts were dependent ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91053-6
更新日期：1989-09-04 00:00:00
abstract：:Plasma concentrations of beta-endorphin were measured by radioimmunoassay in cats prepared chronically for sleep-waking polygraphic recordings and blood collection. beta-Endorphin (beta-END) levels were found to be stable in baseline conditions and were used as an index of stress. After habituation of each cat to expe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91207-6
更新日期：1983-03-14 00:00:00
