Abstract：
:The expressions of mRNAs encoding G protein alpha subunits were analyzed in the cerebral cortex of amygdaloid kindled rats. A remarkable increase in Gsalpha mRNA were observed on the bilateral cerebral cortex at 24 h after the last generalized seizure and persisted 3 weeks on the unstimulated side. Gi2alpha mRNA level was also increased on the stimulated side at 24 h and persisted 3 weeks. These result suggest that dysfunction of Gs and Gi2 might relate to the basic mechanisms of seizure generation and the maintenance of epileptogenesis.
journal_name
Brain Resjournal_title
Brain researchauthors
Iwasa H,Kikuchi S,Miyagishima H,Mine S,Koseki K,Hasegawa Sdoi
10.1016/s0006-8993(98)01309-2subject
Has Abstractpub_date
1999-02-13 00:00:00pages
570-4issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)01309-2journal_volume
818pub_type
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