Abstract:
:In degenerating frog sciatic nerves an in situ perfusion technique was used to measure the permeability coefficient-surface area product (PA) of endoneurial capillaries to [14C]sucrose, and the endoneurial vascular space (V). Both PA and V started to increase after the 3rd day of degeneration. The increase in PA peaked around the 14th day of degeneration and then declined to reach near normal levels at 6 weeks post-transection. V increased until about the end of the 3rd week of degeneration and then declined to near normal levels at 6 weeks after transection. The delayed increase in capillary permeability may reflect an adaptive reorganization of endoneurial capillary structure and function in response to altered conditions of the endoneurial microenvironment, and it is suggested that this permeability increase is induced by breakdown products of axons or chemical signals from Schwann cells enveloping transected axons. Fluid extravasation from these leaking capillaries is probably responsible for the endoneurial oedema observed in Wallerian degeneration. The recovery of endoneurial capillary tone to near-normal levels at 6 weeks after transection leads to the intriguing conclusion that healthy nerve fibers are not essential for the maintenance of normal endoneurial capillary permeability.
journal_name
Brain Resjournal_title
Brain researchauthors
Weerasuriya Adoi
10.1016/0006-8993(88)91091-8subject
Has Abstractpub_date
1988-03-29 00:00:00pages
181-7issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)91091-8journal_volume
445pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Serotonin (5-HT) immunostained sections were analyzed using integrated optical density (IOD) measures obtained throughout the dorsal raphe nucleus (DRN) in Mongolian gerbils at selected times during a 12:12 h light:dark cycle. Substantial diurnal variation occurred in 5-HT neuronal staining density, with lowest and hi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.11.053
更新日期:2005-02-09 00:00:00
abstract::Prostaglandin E2 (PGE2) and proton are typical inflammatory mediators. They play a major role in pain processing and hypersensitivity through activating their cognate receptors expressed in terminals of nociceptive sensory neurons. However, it remains unclear whether there is an interaction between PGE2 receptors and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146442
更新日期:2019-12-01 00:00:00
abstract::We analyzed flotillin-1 expression in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis (EAE). Western blot analysis showed that flotillin-1 expression increased significantly in the spinal cords from rats at the peak stage of EAE compared with the levels in control animals (p<0.05) and dec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.07.054
更新日期:2006-10-09 00:00:00
abstract::Oxidative stress plays an important role in the pathogenesis of neurodegeneration after the acute central nervous system injury. We reported previously that increased nitric oxide (NO) production following spinal cord hemisection tends to lead to neurodegeneration in neurons of the nucleus dorsalis (ND) that normally ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.003
更新日期:2005-09-07 00:00:00
abstract::Brain extracellular matrix (ECM) is highly degraded after cerebral ischemia. The perlecan c-terminal fragment LG3 is generated at increased levels by proteolytic processing as long as 3 days after ischemia. It has previously been shown that oxygen-glucose deprivation (OGD), reperfusion and interleukin-1 α (IL-1α) stim...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.12.027
更新日期:2012-02-15 00:00:00
abstract::Glucagon like peptide-1 (7-36) amide (GLP-1), a potent regulator of glucose homeostasis, is also produced in the central nervous system and has been implicated in the control of hypothalamic-pituitary function and food intake. GLP-1 immunoreactive (IR) fibers and terminals are widely distributed in the septum, hypotha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03117-2
更新日期:2003-09-26 00:00:00
abstract::The purpose of the present investigation was to record electrophysiological responses from single fibers in the hamster superior laryngeal nerve (SLN) that were responsive to chemical stimulation of the larynx. Twenty chemical solutions, commonly used in studies of mammalian gustatory physiology, were applied to taste...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91541-7
更新日期:1988-05-31 00:00:00
abstract::The effect of stimulating the dorsal raphe nucleus (DRN) on the activity of single relay neurons in the dorsal lateral geniculate nucleus (LGNd) was studied in rats anesthetized with urethane. The position of stimulating electrodes was confirmed on histological sections processed with NADPH-diaphorase histochemistry w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90002-4
更新日期:1989-06-05 00:00:00
abstract::The misfolding and aggregation of the Aβ peptide - a fundamental event in the pathogenesis of Alzheimer׳s disease - can be instigated in the brains of experimental animals by the intracranial infusion of brain extracts that are rich in aggregated Aβ. Recent experiments have found that the peripheral (intraperitoneal) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.06.047
更新日期:2015-10-05 00:00:00
abstract::These studies examined the microsomal brain metabolism of phencyclidine (PCP) in male and female Sprague-Dawley rats. Several monohydroxylated metabolites of PCP were detected including cis- and trans-1-(1-phenyl-4-hydroxycyclohexyl)piperidine (c-PPC and t-PPC) and 1-(1-phenylcyclohexyl)-4-hydroxypiperidine (PCHP). Th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00203-5
更新日期:1997-05-09 00:00:00
abstract::Starvation inhibits egg-laying in the snail, Lymnaea stagnalis. In starved animals the neurosecretory Caudo-Dorsal Cells (CDC), which produce the egg-laying hormone, are hyperpolarized as compared to the CDC of controls. However, they are more responsive to repetitive intracellular stimulation, which induces the hormo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90528-5
更新日期:1982-05-13 00:00:00
abstract::The spinothalamic projection in an avian species, the pigeon, was studied both with anterograde and retrograde means. Anterograde transport of wheatgerm agglutinin conjugated horseradish peroxidase (WGA-HRP) was used in order to determine the termination of the spinothalamic tract in the thalamus. Application to the l...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90356-9
更新日期:1989-04-10 00:00:00
abstract::The distribution of avian pancreatic polypeptide (APP)-like immunoreactivity (APP-IR) in the chicken retina was investigated by means of immunohistochemistry. The observation from frozen sections showed that APP-IR is localized in the stratified amacrine cells of the first sublayer. Examination of whole-mounts reveale...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90022-2
更新日期:1984-09-17 00:00:00
abstract::Murine cortical cell cultures deprived of glucose for 6-8 h developed extensive neuronal degeneration, apparent both morphologically and by efflux of lactate dehydrogenase to the bathing medium. This neuronal damage could be substantially reduced by addition of D-2-amino-5-phosphonovalerate (D-APV), in a concentration...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90179-0
更新日期:1989-04-03 00:00:00
abstract::Using in vivo microdialysis, we examined the ability of choline (Ch) chloride (120 mg/kg i.p.) to amplify basal and stimulated acetylcholine (ACh) release from rat striatum in the presence of high (10(-5) M) and low (5 x 10(-8) M) neostigmine concentration. High concentrations might suppress ACh release, and thus Ch d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91330-u
更新日期:1993-12-03 00:00:00
abstract::Both clinical and experimental studies have indicated that depression and depression-like animal conditions are associated with disruption of the intrinsic plasticity of the brain, resulting in neuronal atrophy. However, little is known about the brain glia in these conditions. Early life stress in the form of infant ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.039
更新日期:2007-04-20 00:00:00
abstract::Following infection with influenza virus, animals display decreased locomotor activity and feeding behavior and loss of body weight. It has been suggested that these effects may be mediated by cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), induced by the infe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01009-3
更新日期:1997-11-21 00:00:00
abstract::Single motor unit activity was recorded from human lower lip muscles while subjects maintained a firing rate of 20 ips using audio and visual feedback. Each motor unit was classified as belonging to one of three muscles, orbicularis oris inferior (OOI), mentalis (MENT), or depressor labii inferior (DLI). Reflex respon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)91274-4
更新日期:1982-11-11 00:00:00
abstract::Changes in the astrocytic cytoskeleton were examined in amygdala kindled rats using immunocytochemical techniques. One week following kindling, there was a dramatic increase in immunoreactivity to glial fibrillary acidic protein and vimentin in astrocytes throughout amygdala, pyriform cortex and hippocampus bilaterall...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91694-a
更新日期:1992-10-02 00:00:00
abstract::The distribution of glucagon-like peptide-1-(7-36)amide like immunoreactivity (GLP-1-(7-36)NH2 IR) in rat brain was determined. Highest concentrations were found in the hypothalamus. A combination of gel chromatography and anion exchange chromatography showed that the majority of hypothalamic immunoreactivity exactly ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90628-8
更新日期:1989-11-20 00:00:00
abstract::We utilized nylon arrays to measure gene expression in mouse brains after various postmortem intervals (PMIs). Gene expression after overnight refrigeration or 4 h at room temperature then overnight refrigeration correlated highly and approximately equivalently to that in brains processed immediately. After 8-24 h at ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02644-6
更新日期:2002-06-28 00:00:00
abstract::Our previous study reported that cathepsin L may contribute to the death of dopaminergic neurons in rodent model of Parkinson's disease (PD). In this study we detected the changes in the expression of lysosomal cathepsin L in cellular models of PD. In human neuroblastoma SH-SY5Y cells, treatment with 6-hydroxydopamine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.092
更新日期:2011-04-28 00:00:00
abstract::Intracerebral administration of 6-hydroxydopamine (6-HDA) along the dorsal noradrenergic bundle produced a gradual and long-lasting decrease of norepinephrine (NE) in hippocampus. This decrease in NE levels initially was accompanied by a parallel decrease in the activity of the rate-limiting enzyme for NE biosynthesis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90056-8
更新日期:1984-12-24 00:00:00
abstract::The neurobiology of social bonding, despite its relevance to human mental health, has been studied primarily in rodents. In this study we used position emission tomography (PET), registered with structural magnetic resonance imaging (MRI) to investigate central glucose uptake in 17 males of a monogamous primate specie...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.09.087
更新日期:2007-12-12 00:00:00
abstract::This study examined the relationship between the affinity of cholinergic drugs for muscarinic receptor subtypes and their potency in potentiating or inhibiting amphetamine-induced rotation. The ascending nigrostriatal dopaminergic pathway was unilaterally lesioned in male Wistar rats using 6-hydroxydopamine. In these ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(87)80021-5
更新日期:1987-04-28 00:00:00
abstract::Social plasticity is the ability to adaptively change the expression of social behaviour according to experience, allowing animals to optimize their social relationships in the context of previous experience and the complexities of social environments. Environmental enrichment (EE) mimics a stimulating lifestyle at th...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2019.03.033
更新日期:2019-08-15 00:00:00
abstract::To identify whether altered expressions of voltage gated Ca(2+) channel (VGCC) are linked to inhibitory transmission abnormalities in the gerbil hippocampus, we investigated the effects of GABA receptor or somatostatin receptor (SST) antagonists/agonists on VGCC immunoreactivity in vivo. VGCC immunoreactivities in the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.07.076
更新日期:2006-10-18 00:00:00
abstract::The kindling process represents a progressively augmenting electrical and behavioral response to brain stimulation, that has been proposed as a model for the development of epileptogenesis. The first experiment examined the effects of hypophysectomy on the kindling process. The effects of hypophysectomy were found to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)91032-1
更新日期:1979-06-22 00:00:00
abstract::It is known that the execution of the motor response in a simple reaction time (RT) task can be delayed by transcranial magnetic stimulation (TMS). This paper is aimed at determining the site of action where the delay in RT occurs. A delay in RT was obtained only at those TMS sites over the motor cortex contralateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01062-1
更新日期:1997-01-02 00:00:00
abstract::The present study investigated the neuroprotective potential of two novel polyamine analogues, BU43b and BU36b, when administered 30 min prior to cerebral ischaemia. Neuroprotection in a permanent and a transient focal cerebral ischaemia mouse model (induced by intraluminal middle cerebral artery occlusion (MCAO)) was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.097
更新日期:2006-03-03 00:00:00