Stability of gene expression in postmortem brain revealed by cDNA gene array analysis.

Abstract:

:We utilized nylon arrays to measure gene expression in mouse brains after various postmortem intervals (PMIs). Gene expression after overnight refrigeration or 4 h at room temperature then overnight refrigeration correlated highly and approximately equivalently to that in brains processed immediately. After 8-24 h at room temperature and overnight refrigeration gene expression correlation and equivalency declined, but 90-95% of detected genes were within +/-40% of baseline levels. Brain homogenate pH did not change with PMI.

journal_name

Brain Res

journal_title

Brain research

authors

Trotter SA,Brill LB 2nd,Bennett JP Jr

doi

10.1016/s0006-8993(02)02644-6

subject

Has Abstract

pub_date

2002-06-28 00:00:00

pages

120-3

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006899302026446

journal_volume

942

pub_type

杂志文章
  • Effect of thyrotropin releasing hormone on U-50,488H-induced pharmacological responses in mice.

    abstract::The effect of thyrotropin releasing hormone (TRH) administered either subcutaneously (s.c.) or intracerebroventricularly (i.c.v.) on the analgesic and hypothermic actions of U-50,488H, a highly selective kappa-opiate agonist, was determined in male Swiss Webster mice. Intraperitoneal administration of U-50,488H (8-32 ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90144-c

    authors: Bhargava HN,Thorat SN

    更新日期:1993-10-15 00:00:00

  • Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus.

    abstract::Transient global cerebral ischemia (TGCI) occurs during acute severe hypotension depriving the brain of oxygen and glucose for a short period of time. During reperfusion, several mechanisms can induce secondary neuronal damage, including the increased production of reactive oxygen species (ROS). Hydrogen gas-enriched ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.05.068

    authors: Hugyecz M,Mracskó E,Hertelendy P,Farkas E,Domoki F,Bari F

    更新日期:2011-08-02 00:00:00

  • Specific binding sites for (3-8)angiotensin in C6 glioma cells.

    abstract::A novel putative receptor for (3-8)angiotensin (AngIV) has recently been found in various tissues, including the brain. However, the localization of AngIV binding sites to specific types of brain cells has yet to be established. In this study tissue culture was used to determine the presence and characteristics of Ang...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00278-x

    authors: Wyse B,Greenland K,Sernia C

    更新日期:1995-05-29 00:00:00

  • Ingestive behaviors and metabolic fuels after central injections of 5-HT1A and 5-HT1D/1B receptors agonists in the pigeon.

    abstract::The effects of intracerebroventricular injections of 8-OH-DPAT (a 5-HT1A agonist; 3, 15 or 30 nmol) or GR46611 (a 5-HT1B/1D agonist; 3, 15 or 30 nmol) on feeding, drinking, preening and sleep-like behaviors were investigated in free-feeding (FF) pigeons. The effects of these 5-HT agonists on blood glucose and free fat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.08.031

    authors: Da Silva RA,de Oliveira ST,Hackl LP,Spilere CI,Faria MS,Marino-Neto J,Paschoalini MA

    更新日期:2004-11-12 00:00:00

  • Thyrotropin-releasing hormone: medullary site of action to induce gastric ulcers and stimulate acid secretion.

    abstract::This study evaluated the hypothesis that the dorsal motor nucleus (DMN) of the brainstem may mediate the ulcerogenic and acid-stimulatory effects of thyrotropin-releasing hormone (TRH) in rats. To accomplish this, intra-DMN microinjections of TRH (50 and 500 ng) were performed and their effects on acid secretion and g...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90295-8

    authors: Hernandez DE,Emerick SG

    更新日期:1988-08-30 00:00:00

  • Cardiovascular responses to L-glutamate microinjection into the hypothalamic paraventricular nucleus are mediated by a local nitric oxide-guanylate cyclase mechanism.

    abstract::It has been reported that L-glutamate (L-glu) microinjection into the hypothalamic paraventricular nucleus (PVN) evokes pressor and tachycardiac responses in unanesthetized rats. In the present study the hypothesis was tested that a local nitric oxide (NO)-guanylate cyclase interaction mediates cardiovascular effects ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.05.023

    authors: Busnardo C,Crestani CC,Tavares RF,Resstel LB,Correa FM

    更新日期:2010-07-16 00:00:00

  • White matter damage following systemic injection of the mitochondrial inhibitor 3-nitropropionic acid in rat.

    abstract::Oxidative stress has been implicated as a pathogenic mediator of neuronal perikarya cell death. Axons and oligodendrocytes, components of white matter, could also be vulnerable to oxidative damage. An experimental model of oxidative stress was induced by systemic injection of 3-nitropropionic acid (3-NPA). Animals rec...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)03266-2

    authors: McCracken E,Dewar D,Hunter AJ

    更新日期:2001-02-23 00:00:00

  • Preferential occupation of mineralocorticoid receptors by corticosterone enhances glutamate-induced burst firing in rat midbrain dopaminergic neurons.

    abstract::Sensitisation to the behavioural effects of amphetamine, a phenomenon which appears to involve the potentiation of excitatory amino acid (EAA)-mediated transmission at the level of dopaminergic (DA) neurons in the ventral tegmental area (the A10 cell group), is known to be affected by corticosteroid manipulations. Sin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00722-6

    authors: Overton PG,Tong ZY,Brain PF,Clark D

    更新日期:1996-10-21 00:00:00

  • A re-evaluation of the role of superior colliculus in turning behaviour.

    abstract::There is much debate on the role of the superior colliculus (SC) in turning behaviour. In order to clarify this issue, unilateral kainate lesions were made by infusing 0.25 microgram of kainate at two different anterior planes (0.8 mm apart), in the lateral or in the medial aspects of the deep collicular layers (DLSC)...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90557-1

    authors: Di Chiara G,Morelli M,Imperato A,Porceddu ML

    更新日期:1982-04-08 00:00:00

  • A quantitative electron microscopic study on synapse formation in dissociated fetal rat cerebral cortex in vitro.

    abstract::Occipital cortex of 19-day-old fetal rats was dissociated and cultured in vitro for 2-5 weeks in horse serum supplemented Eagle's MEM. The outgrowing neurons rapidly formed a dense network which started to degenerate after 3 weeks in vitro. By means of electron microscopy the numerical development of 6 different categ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(81)90011-0

    authors: Romijn HJ,Mud MT,Habets AM,Wolters PS

    更新日期:1981-07-01 00:00:00

  • Alterations in the cortical thickness and the amplitude of low-frequency fluctuation in patients with post-traumatic stress disorder.

    abstract::The core neuropsychological processes underlying post-traumatic stress disorder (PTSD) have yet to be elucidated, and the association between anatomical and functional deficits in PTSD remains largely unknown. The aim of our study was to investigate the alterations in cortical thickness and amplitude of low-frequency ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.10.048

    authors: Bing X,Ming-Guo Q,Ye Z,Jing-Na Z,Min L,Han C,Yu Z,Jia-Jia Z,Jian W,Wei C,Han-Jian D,Shao-Xiang Z

    更新日期:2013-01-15 00:00:00

  • An in vitro circadian rhythm of melatonin sensitivity in the suprachiasmatic nucleus of the djungarian hamster, Phodopus sungorus.

    abstract::Past studies in the rat and Syrian hamster show that metabolic and electrical activity of the suprachiasmatic nuclei (SCN) is inhibited by melatonin (MEL) at about circadian time (ct) 8-11 h. The present experiment examined the effect of MEL on the firing frequency of SCN cells in brain slices prepared from long day (...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90853-f

    authors: Margraf RR,Lynch GR

    更新日期:1993-04-23 00:00:00

  • Reformulation of the Papez circuit: absence of hippocampal influence on cingulate cortex unit activity in the primate.

    abstract::Cingulate cortex (CC) unit responses to hippocampal volleys and afterdischarges were studied in 4 awake unsedated squirrel monkeys using extracellular microelectrodes. Stimuli were delivered via bipolar electrodes chronically implanted bilaterally in anterior and posterior hippocampus. A total of 412 units in 21 track...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)91253-2

    authors: Dagi TF,Poletti CE

    更新日期:1983-01-24 00:00:00

  • Early effect of an ACTH4-9 analog (Org.2766) on regenerative sprouting demonstrated by the use of neurofilament-binding antibodies isolated from a serum raised by alpha-MSH immunization.

    abstract::Antibodies binding to the 150 kDa neurofilament protein NF150 have been purified from a serum raised by immunizing a rabbit with alpha-MSH. The NF150-binding antibodies were purified by affinity chromatography on a column of cytoskeletal proteins coupled to CNBr-activated Sepharose-4B. Immunocytochemical application o...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91365-5

    authors: Verhaagen J,Edwards PM,Jennekens FG,Schotman P,Gispen WH

    更新日期:1987-02-24 00:00:00

  • Methionine-free brain-derived neurotrophic factor in wobbler mouse motor neuron disease: dose-related effects and comparison with the methionyl form.

    abstract::We compared the clinical and pharmacodynamic effects of N-terminal methionine brain-derived neurotrophic factor (met-BDNF) and endogenous met-free BDNF in wobbler mouse motor neuron disease (MND). Met- or met-free BDNF at 5 or 20 mg/kg was subcutaneously injected daily, six times/week for 4 weeks. At 20 mg/kg, grip st...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02881-0

    authors: Ishiyama T,Ogo H,Wong V,Klinkosz B,Noguchi H,Nakayama C,Mitsumoto H

    更新日期:2002-07-19 00:00:00

  • The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages.

    abstract::The endocannabinoid system is a promising therapeutic target in a wide variety of diseases. However, the non-desirable psychotropic effects of natural and synthetic cannabinoids have largely counteracted their clinical usefulness. These effects are mostly mediated by cannabinoid receptors of the CB(1) type, that exhib...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.05.098

    authors: Tolón RM,Núñez E,Pazos MR,Benito C,Castillo AI,Martínez-Orgado JA,Romero J

    更新日期:2009-08-04 00:00:00

  • Anticipatory changes of long-latency stretch responses during preparation for directional hand movements.

    abstract::We have investigated, in 9 normal subjects, the time course of amplitude changes in the automatic long latency stretch reflex of wrist flexors during the preparatory period as a function of the precued direction of hand movement. Subjects maintained right hand position against a weak force and learned to compensate pr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)91172-1

    authors: Bonnet M

    更新日期:1983-11-28 00:00:00

  • Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord.

    abstract::In the adult brain, γ-amino butyric acid (GABA) is an inhibitory neurotransmitter, whereas it acts as an excitatory transmitter in the immature brain, and may be involved in morphogenesis. In the present study, we immunohistochemically examined the developmental changes in GABA signaling in the embryonic mouse cervica...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.10.003

    authors: Kosaka Y,Kin H,Tatetsu M,Uema I,Takayama C

    更新日期:2012-11-27 00:00:00

  • The influence of striatal stimulation and putative neurotransmitters on identified neurones in the rat substantia nigra.

    abstract::The response of two populations of neurones in the substantia nigra (nigro-striatal compacta neurones and reticulata neurones) to microelectrophoretically administered putative neurotransmitters and stimulation of the ipsilateral striatum has been investigated in anaesthetized rats. There were marked differences betwe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90467-4

    authors: Collingridge GL,Davies J

    更新日期:1981-05-18 00:00:00

  • Chronological alterations of neurofilament 150 immunoreactivity in the gerbil hippocampus and dentate gyrus after transient forebrain ischemia.

    abstract::In this study, we observed the chronological alterations of neurofilament 150 (NF-150) immunoreactivity in the gerbil hippocampus and dentate gyrus after 5 min transient forebrain ischemia. NF-150 immunoreactivity in the sham-operated group was mainly detected in mossy fibers and in the hilar region of the dentate gyr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.05.001

    authors: Hwang IK,Do SG,Yoo KY,Kim DS,Cho JH,Kwon YG,Lee JY,Oh YS,Kang TC,Won MH

    更新日期:2004-07-30 00:00:00

  • Mechanical hyperalgesia in rat models of systemic and local hyperglycemia.

    abstract::Mechanical hyperalgesia is an early symptom of diabetic neuropathy. To evaluate the mechanisms underlying this symptom, it was studied and compared in rat models of systemic and local hyperglycemia. Systemic hyperglycemia was induced by a single injection of streptozotocin (STZ, 50 mg/kg). Local hyperglycemia either i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03828-3

    authors: Dobretsov M,Hastings SL,Romanovsky D,Stimers JR,Zhang JM

    更新日期:2003-01-17 00:00:00

  • Identification of response properties of ascending axons from dorsal cochlear nucleus.

    abstract::Electrical stimulation in the dorsal acoustic stria (DAS) and the posterior and dorsal part of the ventral cochlear nucleus (VCN) was used to identify the response properties of efferent axons from the dorsal cochlear nucleus (DCN) in unanesthetized, decerebrate cats. Responses recorded in the DCN of this preparation ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)91091-4

    authors: Young ED

    更新日期:1980-10-27 00:00:00

  • Increase of dendritic branching of CA3 neurons of hippocampus and self-stimulation areas in subjects experiencing self-stimulation of lateral hypothalamus and substantia nigra-ventral tegmental area.

    abstract::Golgi examination of neurons of self-stimulation areas of the lateral hypothalamus and substantia nigra-ventral tegmental areas of adult Wistar rats that had experienced self-stimulation for 10 days revealed a significantly higher number of dendritic branching points in the two self-stimulation areas, and also in the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91079-v

    authors: Bindu PN,Desiraju T

    更新日期:1990-09-10 00:00:00

  • Effects of the Ca2+ antagonist nimodipine on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats.

    abstract::Diabetes mellitus can lead to functional and structural deficits in both the peripheral and central nervous system. The pathogenesis of these deficits is multifactorial, probably involving, among others, microvascular dysfunction and alterations in intracellular calcium homeostasis. The present study examined the effe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.12.025

    authors: Biessels GJ,ter Laak MP,Kamal A,Gispen WH

    更新日期:2005-02-21 00:00:00

  • Cysteinyl-leukotriene production during limbic seizures triggered by kainic acid.

    abstract::In rats kainic acid-induced seizures were accompanied by time-dependent cerebral cysteinyl-leukotriene (LT) and prostaglandin (PG) F2 alpha formation. Cysteinyl-LT were identified in the rat brain tissue extracts by their immunoreactive properties and their retention times upon reversed phase HPLC profiling. In perfus...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90579-z

    authors: Simmet T,Tippler B

    更新日期:1990-05-07 00:00:00

  • Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease.

    abstract::The dipeptide N-acetylaspartylglutamate (NAAG) may be involved in the process of glutamatergic signaling by both acting at glutamate receptors and as a glutamate protransmitter. In the present study we determined the cellular localization and distribution of NAAG-like immunoreactivity (NAAG-LI) in normal human brain a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00784-1

    authors: Passani LA,Vonsattel JP,Coyle JT

    更新日期:1997-10-24 00:00:00

  • Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism.

    abstract::Early brain injury (EBI) plays a pivotal role in the prognosis of patients with subarachnoid haemorrhage (SAH). Dexmedetomidine (DEX), a highly selective α2 receptor agonist, is reported to exert multiple protective effects in many neurological diseases. This study was designed to investigate whether DEX had neuroprot...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2018.05.040

    authors: Yin D,Zhou S,Xu X,Gao W,Li F,Ma Y,Sun D,Wu Y,Guo Q,Liu H,Han L,Wang Z,Wang Y,Zhang J

    更新日期:2018-11-01 00:00:00

  • Three-dimensional organization of the endoplasmic reticulum in supraoptic neurons of the rat. A structural functional correlation.

    abstract::Double impregnation staining of tissue was used to study on thick sections the three-dimensional configuration of the peripheral endoplasmic reticulum in neurosecretory neurons of the supraoptic nucleus in control and water-deprived rats. According to the spatial organization of the endoplasmic reticulum, two types of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90105-7

    authors: Alonso G,Assenmacher I

    更新日期:1979-07-13 00:00:00

  • Histamine regulates food intake through modulating noradrenaline release in the para-ventricular nucleus.

    abstract::Histamine is one of the neurotransmitters suppressing appetite, but the interactions of histaminergic neurons with other neurons in satiety centers have not been clarified. Noradrenaline in the para-ventricular nucleus (PVN) has been shown to stimulate feeding. This study was designed to determine whether histamine mo...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01339-6

    authors: Kurose Y,Terashima Y

    更新日期:1999-05-15 00:00:00

  • Short-term and long-term effects of p-chloroamphetamine on hippocampal serotonin and corticosteroid receptor levels.

    abstract::Hippocampal corticosteroid receptors are regulated by corticosterone as well as by neurotransmitters, such as serotonin (5-HT). Studies have demonstrated that long-term changes in 5-HT levels are associated with alterations in hippocampal glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) number. However...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00371-v

    authors: Novotney S,Lowy MT

    更新日期:1995-06-26 00:00:00