Abstract：
:This study evaluated the hypothesis that the dorsal motor nucleus (DMN) of the brainstem may mediate the ulcerogenic and acid-stimulatory effects of thyrotropin-releasing hormone (TRH) in rats. To accomplish this, intra-DMN microinjections of TRH (50 and 500 ng) were performed and their effects on acid secretion and gastric ulcer formation evaluated in the pylorus-ligation model. The high (500 ng), but not the low dose of TRH (50 ng) produced gastric glandular lesions in 64% of the rats with a mean severity index (no. of ulcers/rat) of 6.4 +/- 0.98 and significantly increased gastric acid output. The ulcerogenic and gastric secretory response to intra-DMN TRH was site-specific. We conclude that presynaptic TRH fibers may modulate vagal activity at the level of the DMN and propose that descending TRH pathways may play a role in experimental ulcerogenesis through acid hypersecretion.
journal_name
Brain Resjournal_title
Brain researchauthors
Hernandez DE,Emerick SGdoi
10.1016/0006-8993(88)90295-8subject
Has Abstractpub_date
1988-08-30 00:00:00pages
148-52issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)90295-8journal_volume
459pub_type
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