Abstract：
:Acute hyperammonemia is associated with motor disturbances that are thought to involve striatal dopaminergic dysfunction. Discharge of striatal dopaminergic neurons is controlled by N-methyl-D-aspartate (NMDA) receptors, the excessive activation of which contributes to ammonia neurotoxicity. Here we show that ammonium chloride ("ammonia", extracellular concentration 5 mM) or NMDA (1 mM), when directly administered to the rat striatum via a microdialysis probe, evoke a prompt accumulation of dopamine (DA) in the microdialysates. However, while ammonia increases, NMDA decreases, the extracellular dihydroxyphenylacetate (DOPAC) level. The results point to the NMDA receptor-mediated enhancement of DA release and increased DA metabolism as two independent ways by which ammonia affects the striatal dopaminergic system. Taurine (extracellular concentration 10 mM) attenuated the NMDA- and ammonia-evoked DA release and ammonia-induced accumulation of DOPAC, reflecting two different neuroprotective mechanisms of this amino acid.
journal_name
Brain Resjournal_title
Brain researchauthors
Anderzhanova E,Oja SS,Saransaari P,Albrecht Jdoi
10.1016/s0006-8993(03)02777-xsubject
Has Abstractpub_date
2003-07-11 00:00:00pages
290-3issue
2eissn
0006-8993issn
1872-6240pii
S000689930302777Xjournal_volume
977pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The putative role of the opioid system in cognitive and memory functions prompted us to search for possible changes in the cohort of the major opioid receptors, mu, delta and kappa, in Alzheimer's disease. The present study examines alterations in opioid receptor levels by quantitative autoradiography. These experimen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03302-3
更新日期：2001-03-02 00:00:00
abstract：:Several studies, using electrical stimulation of parts of the hypothalamus, have shown, that different parts of the hypothalamus yield different behavioural responses upon stimulation. In order to differentiate between stimulation of neuronal cell bodies and passing fibres and to investigate the role of GABA in hypoth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91122-9
更新日期：1993-06-25 00:00:00
abstract：:The amygdala plays an important role in the regulation of motivational states, especially those associated with addiction. The amygdala also expresses high levels of brain-derived neurotrophic factor (BDNF), an activity-dependent neurotrophin that can influence the reinforcing and locomotor activating properties of ps...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03160-8
更新日期：2002-09-13 00:00:00
abstract：:The effect of repetitive stimulation of the locus coeruleus (LC) on the discharge rate of spontaneously active neurons of the visual, rostral and cingulate cortex was investigated in untreated and catecholamine-depleted rats under chloral hydrate anesthesia. In untreated animals, the inhibitory transsynaptic effects p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90251-6
更新日期：1980-03-17 00:00:00
abstract：:Spatial learning and memory in rodents represent close equivalents of human episodic declarative memory, which is especially sensitive to cerebral aging, neurodegeneration, and various neuropsychiatric disorders. Many tests and protocols are available for use in laboratory rodents, but Morris water maze and radial-arm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.01.015
更新日期：2015-09-24 00:00:00
abstract：:The role of perceptual load in selective attention to multidimensional objects was investigated by independently manipulating the load along the task-relevant and the task-irrelevant dimensions in the central search array, which was flanked by congruent, incongruent, or neutral peripheral distractors. The relative bot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.071
更新日期：2006-10-09 00:00:00
abstract：:We cloned the genes for the mouse homologue of the neuromedin B receptor (NMB-R) and the bombesin receptor subtype 3 (BRS-3). Both receptor genes consist of three exons with well-conserved intron-exon borders. Although the NMB-R gene spans more than 10 kb, the BRS-3 gene spans only about 4 kb. Comparison of the mouse ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00380-6
更新日期：1997-07-11 00:00:00
abstract：:Chronic vitamin B12 (cobalamin) deficiency in the mammalian central nervous system causes degenerative damage, especially in the spinal cord. Previous studies have shown that cobalamin status alters spinal cord expression of epidermal growth factor (EGF) and its receptor in rats. Employing a mouse model of cobalamin-d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.01.050
更新日期：2013-03-29 00:00:00
abstract：:The hallucinogen d-lysergic acid diethylamide (d-LSD) evokes dramatic somatic and psychological effects. In order to analyze the neural activation induced by this unique psychoactive drug, we tested the hypothesis that expression of the immediate-early gene product c-Fos is induced in specific regions of the rat foreb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03548-5
更新日期：2002-12-27 00:00:00
abstract：:An acute pain animal model for fMRI study would provide useful spatial and temporal information for studying the supraspinal nociceptive neuronal responses. The aim of the present study was to investigate whether the nociceptive responses in different brain areas can be differentiated by using functional magnetic reso...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02094-7
更新日期：2001-04-06 00:00:00
abstract：:The respiratory role of GABA(A), GABA(B) and glycine receptors within the Bötzinger complex (BötC) and the pre-Bötzinger complex (preBötC) was investigated in alpha-chloralose-urethane anesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinjections (30-50 nl) of GABA and gly...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.032
更新日期：2010-07-16 00:00:00
abstract：:Placental Opioid-Enhancing Factor (POEF) is a substance found in amniotic fluid (AF) that, when ingested, potentiates opioid-mediated, but not non-opioid-mediated, hypoalgesia. Vaginal-cervical stimulation (VCS) produces a stimulus-bound, partially opioid-mediated hypoalgesia that previous research has shown to be pot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.055
更新日期：2011-02-28 00:00:00
abstract：:Tetanic but not low frequency stimulation of the perforant path in rat hippocampal slices results in changes in the metabolism of phosphoinositides and phosphatidic acid. The phosphorylation of other, non-inositol lipids was not affected by the high frequency stimulation. The observed changes in phosphoinositide metab...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90198-7
更新日期：1984-11-12 00:00:00
abstract：:We investigated the effects of pituitary adenylate cyclase-activating polypeptide (PACAP38) on cytosolic free calcium ([Ca2+]i) at a single cell level in both type-1 and type-2 cultured rat astrocytes using a calcium-sensitive fluorescent dye, fura-2. Type-1 astrocytes were relatively silent during the 20 min observat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90790-0
更新日期：1994-10-31 00:00:00
abstract：:The motoneurons innervating the orbicularis oculi muscle from a subgroup within the facial nucleus, called the intermediate facial subnucleus. This makes it possible to study afferents to these motoneurons by means of autoradiographical tracing techniques. Many different injections were made in the brainstem and dienc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90425-7
更新日期：1986-05-28 00:00:00
abstract：:Alpha-synuclein is a natively unfolded protein playing a key role in the regulation of several neuronal synaptic functions in physiological and pathological conditions. Many studies, over the past years, have shown that it is actively involved in PD pathophysiology. Alpha-synuclein is integrated in a complex network o...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2012.04.014
更新日期：2012-10-02 00:00:00
abstract：:Recently, much attention has focused on the role of the melanocortin system in the regulation of energy homeostasis, especially the satiety effects of the pro-opiomelanocortin (POMC)-derived peptide alpha-melanocyte stimulating hormone (alpha-MSH). We have found that POMC mRNA levels are similar in fat and thin sheep ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02918-3
更新日期：2001-11-09 00:00:00
abstract：:The rostral brainstem and thalamus of awake cats were studied for depth correlates of a surface-recorded midlatency auditory evoked potential, wave "A', with a latency range of 17-25 ms. In response to clicks or pure tones, midlatency potentials were recorded from the level of the cuneiform nucleus (14-15 ms latencies...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91120-4
更新日期：1983-03-28 00:00:00
abstract：:In pentobarbitone-anesthetized cats, the spike sequences of dorsal horn neurons were recorded in response to random stimulation of branches of the suralis nerve. Combined frequency- and time-domain analysis was performed on the stimulus and spike trains. Coherence function estimates computed by spectral analysis were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90598-7
更新日期：1988-10-11 00:00:00
abstract：:Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. Previous MRI studies have revealed that POAG can be associated with alterations in hippocampal function. Thus, the aim of this study was to investigate a relationship between chronic high intraocular pressure (IOP) and hippocamp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.09.001
更新日期：2017-11-15 00:00:00
abstract：:Protein kinase C (PKC) activity was measured in rat brain with 2 h of middle cerebral artery (MCA) and common carotid artery (CCA) occlusion, using dual autoradiography of [14C]iodoantipyrine (IAP) and [3H]phorbol-12,13-dibutyrate (PDBu). In the ischemic brain, it required more than 120 min of incubation to obtain a p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01342-x
更新日期：1997-03-07 00:00:00
abstract：:Retinal and tectal potentials to alternating gratings were recorded in pigeons raised monocularly deprived. Deprived eyes showed consistent myopia and anterior-posterior axis elongation. In addition, vitreal opacities were observed in 70% of the deprived eyes. In pigeons with vitreal opacities, a reduction of retinal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90165-9
更新日期：1985-07-15 00:00:00
abstract：:Pharmacological characteristics of native neuronal nicotinic acetylcholine receptor-mediated ion currents in mouse N1E-115 neuroblastoma cells have been investigated by superfusion of voltage clamped cells with known concentrations of the agonists acetylcholine, nicotine and cytisine, and the antagonists alpha-bungaro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90493-6
更新日期：1994-08-22 00:00:00
abstract：:Although much is known regarding the modulation of ion channels through protein phosphorylation, little is known about their dephosphorylation by protein phosphatases (PrPs). To address this issue we examined the effects of a phosphatase inhibitor, okadaic acid (OA), and protein phosphatases obtained from rabbit skele...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90611-x
更新日期：1991-05-17 00:00:00
abstract：:A subset of olfactory receptor neurons of the Caribbean spiny lobster Panulirus argus possesses receptors for L-glutamate that can mediate both excitatory and inhibitory responses (P.C. Daniel, M.F. Burgess, C.D. Derby, Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable usi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00816-0
更新日期：1997-10-17 00:00:00
abstract：:Progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta is the main histopathological characteristic of Parkinson's disease. We studied the electrophysiological characteristics of the spontaneous activity of substantia nigra pars compacta dopaminergic neurons in rats with a partial, unil...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.052
更新日期：2006-04-21 00:00:00
abstract：:The release of [3H]acetylcholine (ACh) from 6-, 8-, 10-, 12-, 14- and 16-day chick embryo neural retina layers was determined using a perfusion system to collect the released neurotransmitter. After labeling the tissue with [3H]choline, samples of [3H]ACh released before and after stimulation by 80 mM KCl or 5 mM glut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90137-7
更新日期：1982-07-01 00:00:00
abstract：:Cajal-Retzius (CR) cells of the mammalian neocortex co-express the extracellular matrix protein Reelin and p73, a transcription factor involved in cell death and survival. Most neocortical CR cells derive from the cortical hem, with minor additional sources. We analyzed the distribution of Reelin and p73 immunoreactiv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.015
更新日期：2007-02-09 00:00:00
abstract：:By means of the [14C]deoxyglucose method the local cerebral glucose utilization (LCGU) was measured in the lateral geniculate nucleus and the superior colliculus of rats with a simultaneous double enucleation, animals with an enucleation of the right eye between neonatal and adult stages followed by an enucleation of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90688-4
更新日期：1989-05-29 00:00:00
abstract：:The accumulation of amyloid-β (Aβ) peptides in the brain of Alzheimer disease patients is associated to cognitive deficit, increased oxidative stress, and alterations in the circadian rhythms. Brain-derived neurotrophic factor (BDNF) and Neurogranin (RC3), play an important role in the synaptic plasticity underlying m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.01.033
更新日期：2017-04-01 00:00:00
