Abstract：
:Traumatic brain injury (TBI) causes impairments of both motor and spatial memory performances. Research is only beginning to reveal the biochemical mechanism(s) underlying these deficits. It has been postulated that reactive oxygen species such as the superoxide and hydroxyl radicals, as well as the peroxynitrite anion, are generated by injury and may play a critical role in the observed memory deficits. The highly reactive hydroxyl radical, which is thought to contribute to neuronal toxicity, can be generated by an iron-catalyzed reaction. The source of this iron (or iron-bound proteins) could be a compromise of the blood-brain barrier, which can occur following TBI. In this report, we investigate the ability of deferoxamine, a scavenger of free iron, the hydroxyl radical and the peroxynitrite anion, to facilitate behavioral recovery following a controlled cortical impact of rats. Intraperitoneal administration of this drug prior to the injury did not affect the rate of recovery from motor deficits in comparison to vehicle (saline)-injected animals. However, deferoxamine-treated animals showed significant improvement in spatial memory performance in a Morris water maze task. Volumetric analysis of cortical tissue loss showed no significant differences between vehicle- and drug-injected animals. Similarly, histological examination of the hippocampus did not reveal any gross differences between the two groups. These results indicate that deferoxamine improves spatial memory performance, possibly through protection from neuronal dysfunction.
journal_name
Brain Resjournal_title
Brain researchauthors
Long DA,Ghosh K,Moore AN,Dixon CE,Dash PKdoi
10.1016/0006-8993(95)01500-0subject
Has Abstractpub_date
1996-04-22 00:00:00pages
109-17issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)01500-0journal_volume
717pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The central nervous system of the mollusc Helix pomatia was stimulated with NO donors sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) or hydroxylamine, in the presence of a phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine (IBMX). Radioimmunoassay revealed that all of the three NO donors signi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01147-5
更新日期：1998-01-12 00:00:00
abstract：:Ibogaine, a naturally occurring iboga alkaloid, has been claimed to be effective in treating addiction to opioids and stimulants, and has been reported to inhibit morphine and cocaine self-administration in rats. However, ibogaine also has acute nonspecific side effects (e.g. tremors, decreased motivated behavior in g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00056-x
更新日期：1996-05-06 00:00:00
abstract：:The effects of continuous clonidine infusion (10 micrograms/kg/h for 10 days) and the cessation of this infusion on the circadian body temperature rhythm of the spontaneously hypertensive (SH) rat were examined. This circadian rhythm was blunted significantly during the infusion of clonidine. The fall in body temperat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91088-7
更新日期：1986-10-22 00:00:00
abstract：:30-Day-old male Wistar rats were tested for acquisition and retention of operant conditioned behavior after bilateral subicular lesions made either electrolytically or chemically (ibotenic acid). The acquisition of operant learning was carried out in lesioned rats by assessing the number of sessions required to learn ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01135-3
更新日期：1997-01-16 00:00:00
abstract：:Double immunostaining for c-fos and oxytocin (OXY) was used to study the topography and time course of the metabolic activation of the hypothalamic oxytocinergic system upon osmotic stress in the male rat. Animals injected i.p. with hypertonic saline expressed c-fos-like immunoreactivity (FLI) in the paraventricular (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91342-c
更新日期：1992-08-14 00:00:00
abstract：:Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans. In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene. To investigate whether the distribution of M6a correl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.066
更新日期：2008-03-04 00:00:00
abstract：:We characterized acute intracerebral hemorrhage (ICH) in the rat by sequential magnetic resonance imaging (MRI) and correlated MRI findings with neurobehavior and histopathology. In addition, we investigated whether albumin treatment would reduce ICH-induced brain injury. ICH was produced in rats by a double-injection...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.077
更新日期：2007-07-09 00:00:00
abstract：:The effect of suprachiasmatic nucleus (SCN) ablation on rhythms in brain neurotransmitter receptors was studied. In control animals, the rhythms in the number of alpha-adrenergic and benzodiazepine receptors were circadian, whereas the rhythms in beta-adrenergic and acetylcholine receptors were ultradian. SCN ablation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91533-1
更新日期：1985-02-18 00:00:00
abstract：:Axon-to-myelin transfer of lipids precursors have been studied in the rabbit optic system by intraocular injection of [32P]orthophosphate, [14C]glycerol and [3H]glycerol. Choline and ethanolamine phosphoglycerides and myelin showed increasing [32P]-radioactivity between 7 and 21 days following injection, while [3H]- a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90136-1
更新日期：1983-06-20 00:00:00
abstract：:The chronic dietary intake of essential polyunsaturated fatty acids (PUFAs) can modulate learning and memory by being incorporated into neuronal plasma membranes. Representatives of two PUFA families, the n-3 and n-6 types become integrated into membrane phospholipids, where the actual (n-6)/(n-3) ratio can determine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03300-0
更新日期：2002-11-01 00:00:00
abstract：:In intracellular recordings from the CA1 region of the hippocampal slice preparation, an infrequent cell type different from the predominant pyramidal cell has been characterized. The cells have very brief spikes, hyperpolarizing after-potentials, and tend to fire at a high spontaneous rate; unitary synaptic potential...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90991-5
更新日期：1978-11-17 00:00:00
abstract：:A procedure is described which allows for the selective and non-injectional staining of the three-dimensional microvasculatory bed (MVB) in thick sections (60-140 microm) of formalin-fixed brain tissue of white rats Rattus norvegicus. This histochemical method detects ATPase activity and takes place between pH 10.5 an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.11.059
更新日期：2006-01-27 00:00:00
abstract：:Diverse neuropsychiatric diseases were recently linked to specific anti-neuronal autoantibodies targeting synaptic proteins. Symptoms can range from epileptic seizures to cognitive impairment to movement disorders, commonly responding to treatment with immunotherapy. Several of these autoantibodies target inhibitory s...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.09.009
更新日期：2018-12-15 00:00:00
abstract：:The effects of local and global context on concurrent sound segregation were examined using a mistuned harmonic paradigm. Presented with the same sounds over three conditions, participants were asked to either categorise the incoming complex according to pitch or harmonicity (active listening) or watch a muted subtitl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.093
更新日期：2008-01-16 00:00:00
abstract：:When a pair of stimuli separated by an appropriate interval is given to the right visceropleural connective of Aplysia californica the amplitude of the second EPSP elicited in cell R15 is usually smaller than the amplitude of the first EPSP. In the present paper we show that this phenomenon, synaptic depression, can b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90379-6
更新日期：1976-06-04 00:00:00
abstract：:The present study sought to determine if axonal connectivity is established between 6-month-old neostriatal transplants and the host substantia nigra. Cell suspensions of fetal neostriatum were transplanted into the adult rat neostriatum lesioned previously by kainic acid. Horseradish peroxidase injections into the ip...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91256-0
更新日期：1989-01-09 00:00:00
abstract：:Whether functional changes of the non-primary motor areas, e.g., dorsal premotor (PMd) and supplementary motor (SMA) areas, after stroke, reflect reorganization phenomena or recruitment of a pre-existing motor network remains to be clarified. We hypothesized that cellular changes in these areas would be consistent wit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.052
更新日期：2012-06-29 00:00:00
abstract：:The present study examined the effect of chronic paroxetine (10 mg/kg p.o., 21 days) on the 5-HT1B and 5-HT1D autoreceptors controlling 5-HT efflux in slices of rat ventrolateral geniculate nucleus. Electrically stimulated 5-HT efflux (10 pulses, 200 Hz, 0.1 ms, 10 mA) was measured using fast cyclic voltammetry. Peak ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00289-8
更新日期：1997-06-20 00:00:00
abstract：:After a moderate global cerebral ischemia, two hypothetical populations of pyramidal neurons are present among the hippocampal CA1 pyramidal neurons: one that will die and another one that will survive. Prior analysis of dissected hippocampal CA1 regions has shown a reduction of the GluR1-3 mRNA following ischemia. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)01985-0
更新日期：2001-03-09 00:00:00
abstract：:Gonadal steroids have previously been shown to enhance neuritic outgrowth from mouse preoptic area explants in vitro. To examine effects within the explant proper, dendritic fields of Golgi-stained neurons of estradiol-treated and untreated cultures were compared quantitatively. Neurons of gonadal steroid-treated cult...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90085-8
更新日期：1983-03-01 00:00:00
abstract：:The rat medial prefrontal cortex is known to have diverse brain functions such as learning and memory, attention, and behavioral flexibility. Although these functions are affected by monoamines (dopamine (DA), noradrenaline (NA) and serotonin (5-HT)) and acetylcholine (ACh), the detailed mechanisms remain unclear. The...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.039
更新日期：2004-06-25 00:00:00
abstract：:Antipsychotic drugs are the main treatment for schizophrenia, despite their adverse side effects and uncertain mode of action. Gene expression studies in the brains of rodents treated with antipsychotic drugs aim to uncover this mechanism and elucidate more specific targets for schizophrenia treatment. Previous expres...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.045
更新日期：2009-12-22 00:00:00
abstract：:An extensive exploration of the discriminating properties of olfactory receptors cells has been conducted in our laboratory through the statistical processing of single cell responses recorded in the frog's olfactory epithelium. Similarities between odorant stimulating properties could be demonstrated by comparing the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90764-9
更新日期：1984-02-06 00:00:00
abstract：:Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO(2)) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO(2) treatment has a therapeutic effect on ICP dynamics and survival following seve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.049
更新日期：2005-06-21 00:00:00
abstract：:Blockade of gamma-aminobutyric acid (GABA) function in the posterior hypothalamus of rats elicits a pattern of physiological and behavioral arousal consisting of increases in heart rate, respiration and blood pressure as well as intense locomotor stimulation and a selective enhancement of avoidance responding. The pre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91173-e
更新日期：1990-03-26 00:00:00
abstract：:The development of bombesin-like peptides and their receptors was determined in 9 different rat brain regions. The concentration of immunoreactive bombesin increased dramatically in all brain regions examined during the third week after birth. In contrast, the density of [125I-Tyr4]bombesin binding sites was near maxi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90107-x
更新日期：1984-08-01 00:00:00
abstract：:The postnatal development of the terminal Schwann cell, an analogue of the lamellar cell in cutaneous sensory receptors, was examined by histochemistry for non-specific cholinesterase and immunohistochemistry for S-100 protein in the periodontal Ruffini endings of the rat incisor. Double immunohistochemistry for S-100...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02463-4
更新日期：2000-03-06 00:00:00
abstract：:Prefrontal impairments have been hypothesized to be most strongly associated with the cognitive and emotional dysfunction in depression. Recently, white matter microstructural abnormalities in prefrontal lobe have been reported in elderly patients with major depressive disorder (MDD) using diffusion tensor imaging (DT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.094
更新日期：2007-09-07 00:00:00
abstract：:We monitored the protein expression profiles of collapsin response mediator protein 2 and 4 (CRMP2 and CRMP4) throughout cat primary visual area 17 at different postnatal ages. Single immunocytochemical stainings revealed a clear effect of cortical maturation on the spatial and laminar distribution profile of CRMP2 an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.028
更新日期：2006-05-09 00:00:00
abstract：:The neurons that produce gonadotrophin-releasing hormone (GnRH) are mainly found in the medial preoptic area (MPOA) and constitute a common final pathway to the control of luteinizing hormone (LH) surge on proestrus. The control of GnRH secretion depends on several neurotransmitters, such as serotonin (5-HT), noradren...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.045
更新日期：2007-04-20 00:00:00
