Abstract：
:When a pair of stimuli separated by an appropriate interval is given to the right visceropleural connective of Aplysia californica the amplitude of the second EPSP elicited in cell R15 is usually smaller than the amplitude of the first EPSP. In the present paper we show that this phenomenon, synaptic depression, can be analyzed in terms of the material flow model of neurotransmitter economics developed in our preceding publications. We specifically show how changes in the 4 model parameters; A, the available pool of transmitter; F, the fraction of the available pool released by a presynaptic action potential; M, the rate of transmitter mobilization into the available pool; and D, the rate constant of demobilization of transmitter from the available pool, all effect synaptic depression. In addition, we show how transient changes in F and M, that are observed immediately and for seconds after a stimulus, influence the time course of synaptic depression. Using this analysis we then tested our previous inferences about changes in the model parameters produced either by pharmacological manipulations or repetitive stimulation, by comparing the observed effects of these manipulations on synaptic depression with the theoretical predictions. The theoretical and experimental findings agreed, thereby strengthening both our previous conclusions of the mode of action of these manipulations and the model itself.
journal_name
Brain Resjournal_title
Brain researchauthors
Woodson PB,Schlapfer WT,Tremblay JP,Barondes SHdoi
10.1016/0006-8993(76)90379-6subject
Has Abstractpub_date
1976-06-04 00:00:00pages
41-59issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(76)90379-6journal_volume
109pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The misfolding and aggregation of the Aβ peptide - a fundamental event in the pathogenesis of Alzheimer׳s disease - can be instigated in the brains of experimental animals by the intracranial infusion of brain extracts that are rich in aggregated Aβ. Recent experiments have found that the peripheral (intraperitoneal) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.06.047
更新日期：2015-10-05 00:00:00
abstract：:The regenerating optic nerve of goldfish first reestablishes a rough retinotopic map on the tectum, then goes through an activity dependent refinement that appears to involve the elimination of inappropriate branches from early regenerated arbors. Retinotopically appropriate branches and synapses may be stabilized bec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90886-4
更新日期：1988-04-19 00:00:00
abstract：:The transcription factor Phox2b is necessary for the development of the nucleus of the solitary tract (NTS). In this brainstem nucleus, Phox2b is expressed exclusively within a subpopulation of glutamatergic neurons. The present experiments in the adult rat were designed to test whether this subpopulation includes the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.072
更新日期：2008-08-21 00:00:00
abstract：:The pathological process in Alzheimer's disease (AD) involves amyloid beta (Abeta) deposition and neuronal cell degeneration. The neurotoxic Abeta peptide is derived from the amyloid precursor protein (APP), a member of a larger gene family including the amyloid precursor-like proteins, APLP1 and APLP2. The APP and AP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01861-2
更新日期：1999-09-25 00:00:00
abstract：:The purpose of this study was to determine if motoneurons in the spinal ventral horn express the muscarinic m2 acetylcholine receptor. Motoneurons were retrogradely labelled in adult rats by intramuscular injection of Fluorogold and examined with confocal microscopy for evidence of immunoreactivity for the receptor. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01208-6
更新日期：1999-01-30 00:00:00
abstract：:Recently the nuclear proto-oncogene c-fos has been shown to be rapidly and transiently expressed following seizures in many types of epilepsies. Until now, immunohistochemical as well as in situ hybridization studies have reported that the dentate gyrus of the hippocampus and most of the cortical areas were invariably...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90988-n
更新日期：1990-06-04 00:00:00
abstract：:Horeradish peroxidase was injected at multiple sites in the mandibular and sublingual salivary glands in order to label the preganglionic salivatory neurons in the brain stem. The same injections resulted in retrograde labeling of the sympathetic and sensory neurons that project to these glands. Labeled fusiform and m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90092-x
更新日期：1980-05-12 00:00:00
abstract：:We examined for immediate and persistent changes in nAChRs in cerebral cortex, thalamus and striatum of male rats caused by prenatal exposure to nicotine from gestational day 3 to postnatal day 10 (PN10), and how such exposure affected the responses of adolescents to subsequent nicotine challenge. Receptor numbers wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.076
更新日期：2009-01-23 00:00:00
abstract：:The capacity of the dopaminergic nerve system to reinnervate the denervated adult striatum was analyzed in a model of partial 6-hydroxydopamine-induced unilateral lesion of rat substantia nigra pars compacta. Sprouting of dopaminergic fibers entering the ventrolateral part of the striatum from a narrow zone of the ext...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01391-1
更新日期：1996-02-19 00:00:00
abstract：:Afferent pathways innervating the urinary bladder consist of myelinated Adelta- and unmyelinated C-fibers, the neuronal cell bodies of which correspond to medium and small-sized cell populations of dorsal root ganglion (DRG) neurons, respectively. Since hyperpolarization-activated cyclic nucleotide-gated cation (HCN) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.052
更新日期：2006-11-13 00:00:00
abstract：:Calbindin D28k (CaBP)-containing splanchnic and cutaneous sensory neurons in the rat dorsal root ganglia (DRGs) were investigated immunocytochemically in combination with a fluorescent dye tracer (Fluoro gold). About 15% of the DRG neurons at Th9-10 levels showed CaBP-like immunoreactivity. Eighty-four % of the splanc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91673-5
更新日期：1990-10-01 00:00:00
abstract：:A number of studies describe strain-related differences in the motor behavior of rats. Inbred albino F344 rats are found to be impaired in procedural spatial learning, skilled reaching, and over ground locomotion in relation to pigmented out bred Long Evans (LE) rats. These deficits could be related to the functional ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.019
更新日期：2004-12-10 00:00:00
abstract：:Acute administration of diazepam (2 mg/kg i.p.) to rats decreased the number of head-dips, locomotor activity and the number of rears made in the holeboard apparatus, indicating sedative effects. After daily treatment for 7 days with diazepam (2 mg/kg) tolerance developed to all these behavioural effects, despite seru...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-09-23 00:00:00
abstract：:Because considerable work has implicated the basal ganglia in oral-ingestive behavior, an assessment was made of the effects of trigeminal stimuli upon entopeduncular single units. Units wre recorded extracellularly in awake, paralyzed and locally anesthetized cats. The effects of two types of sensory input were teste...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90194-4
更新日期：1978-02-10 00:00:00
abstract：:A possible functional relationship between corticotropin-releasing factor (CRF) and opiate peptide neuronal systems (beta-endorphin, dynorphin1-17 and Met-enkephalin) and their interactions with gonadotropin releasing hormone (GnRH) in the mesencephalic central gray (MCG) for the regulation of lordosis behaviour was a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90414-7
更新日期：1985-06-10 00:00:00
abstract：:Stroke is the major cause of acquired epilepsy in the adult population. The mechanisms of ischemia-induced epileptogenesis are not completely understood, but glutamate is associated with both ischemia-induced injury and epileptogenesis. The objective of this study was to develop an in vitro model of epileptogenesis in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.065
更新日期：2011-01-31 00:00:00
abstract：:The production and localization of cell-associated forms of beta-amyloid precursor protein (APP) of Alzheimer's disease was investigated in primary cultures of mouse glial cells. In both oligodendrocytes and astrocytes, immunofluorescence staining with an antibody against the carboxy terminus of APP revealed an intens...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90898-j
更新日期：1992-07-03 00:00:00
abstract：:Exposure of organotypic dorsal root ganglion-spinal cord cultures to taxol, a potent microtubule promoting and stabilizing agent, results in an unusual abundance of microtubules in neurons, and the presence of microtubule-endoplasmic reticulum arrays in their perikarya and processes. Ordered concentric arrays of micro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90017-2
更新日期：1981-08-03 00:00:00
abstract：:In the present research the role of gender in MDMA-induced hyperthermia and serotonin depletion is studied by injecting male and female male rats with MDMA or saline 3 times (i.p.) with 3h interval at dosages of 0.3, 1, 3 or 9 mg/kg at an ambient temperature of 25°C. The acute hyperthermia following the higher dosages...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.04.039
更新日期：2011-06-29 00:00:00
abstract：:Using one microelectrode inserted into a Limulus retinular cell, simultaneous recordings were made of the receptor potential evoked by light falling on that retinular cell and of the optic nerve action potentials generated in the eccentric cell coupled to that retinular cell. The postreceptor transfer function for sen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91320-4
更新日期：1985-02-25 00:00:00
abstract：:Past research investigating the rostral ventromedial medulla (RVM) in anesthetized animals has found two distinct classes of cells, ON and OFF, noted for their distinct responses to noxious stimuli and to morphine. However, only one class (ON) has been found in the awake animal paradigm. We report in this paper that w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90385-z
更新日期：1993-02-26 00:00:00
abstract：:Male laboratory rats were raised in two colonies, each of 27 rats, and then given intraventricular injections of the norepinephrine neurotoxin 6-hydroxydopamine (6-OHDA) or the serotonin neurotoxin 5,6-dihydroxytryptamine (5,6-DHT) or saline. They were then returned to their enclosure and behavior during the next 50 d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90688-0
更新日期：1976-02-13 00:00:00
abstract：:We have shown that high-concentration albumin therapy is markedly neuroprotective in focal cerebral ischemia. The present study was conducted to ascertain the degree to which hemodynamic alterations are responsible for this therapeutic effect. Normothermic, physiologically regulated male Sprague-Dawley rats received a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00674-x
更新日期：1998-08-31 00:00:00
abstract：:Endothelin-1 (ET-1) has been implicated in hematoma-induced cerebral vasoconstriction and modification of cerebral microvascular reactivity, particularly attenuation of vasodilation to cAMP-dependent dilators and enhanced vasoconstriction to ET-1. We examined effects of the ET-1 antagonist, BQ-123, on hematoma-induced...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-09-23 00:00:00
abstract：:The olfactory sensory neurons are unique in the vertebrate nervous system in that they are replaced following experimentally induced degeneration. Unilateral removal of the olfactory bulb in hamster results in degeneration of all mature receptor neurons followed by a neurogenesis and partial replacement of the recepto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90483-9
更新日期：1984-07-30 00:00:00
abstract：:Norepinephrine (NE) and 3-methoxy-4-hydroxyphenylglycol (MOPEG) were determined in medio-basal hypothalamus of adult male rats using high-performance liquid chromatography to study nutritional modulation of noradrenergic turnover. Acute starvation, as well as 3 weeks of semistarvation with a low-protein high-carbohydr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90471-8
更新日期：1985-06-03 00:00:00
abstract：:The aim of this investigation was to determine the incidence of seizure activity in the acute phase following traumatic brain injury. Compression contusion trauma was produced in the right parietal cortex in 19 artificially ventilated rats. Electroencephalographic recordings were carried out in 17 of the animals for 2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91237-8
更新日期：1994-02-21 00:00:00
abstract：:Slices of the molecular layer of the dentate gyrus of the hippocampal formation were incubated with either [14C]glucose, [14C]pyruvate or 14C glutamine and the efflux of endogenous and radioactive glutamate was monitored under various conditions. After prelabeling with either [14C]glutamine or [14C]glucose elevation o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90306-8
更新日期：1979-06-08 00:00:00
abstract：:Structural and functional alterations of the putamen have been reported in patients with attention deficit hyperactivity disorder (ADHD), but the functional relationships between this area and other brain regions are seldom explored. In the present study, seed-based correlation analyses were performed in the resting-s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.029
更新日期：2009-12-15 00:00:00
abstract：:Electrical stimulation of the mesencephalic locomotor region (MLR) in the precollicular-postmammillary transected cat is known to induce controlled locomotion on a treadmill. We have been able to induce and block locomotion in this preparation by using localized infusions of transmitters and their agonists and antagon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90006-x
更新日期：1985-03-18 00:00:00
